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Cited by 463Thermoregulation and physiological responsesNitric Oxide and Endothelin EffectsCardiovascular and exercise physiology

Role of nitric oxide in the vascular effects of local warming of the skin in humans

Kellogg, D. L., Liu, Y., Kosiba, I. F., O’Donnell, D.·1999·Journal of Applied Physiology
DOI 10.1152/jappl.1999.86.4.1185
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Abstract

Local warming of skin induces vasodilation by unknown mechanisms. To test whether nitric oxide (NO) is involved, we examined effects of NO synthase (NOS) inhibition with N G -nitro-l-arginine methyl ester (l-NAME) on vasodilation induced by local warming of skin in six subjects. Two adjacent sites on the forearm were instrumented with intradermal microdialysis probes for delivery ofl-NAME and sodium nitroprusside. Skin blood flow was monitored by laser-Doppler flowmetry (LDF) at microdialysis sites. Local temperature (T loc ) of the skin at both sites was controlled with special LDF probe holders. Mean arterial pressure (MAP; Finapres) was measured and cutaneous vascular conductance calculated (CVC = LDF/MAP = mV/mmHg). Data collection began with a control period (T loc at both sites = 34°C). One site was then warmed to 41°C while the second was maintained at 34°C. Local warming increased CVC from 1.44 ± 0.41 to 4.28 ± 0.60 mV/mmHg ( P < 0.05). Subsequent l-NAME administration reduced CVC to 2.28 ± 0.47 mV/mmHg ( P < 0.05 vs. heating), despite the continued elevation of T loc . At a T loc of 34°C,l-NAME reduced CVC from 1.17 ± 0.23 to 0.75 ± 0.11 mV/mmHg ( P < 0.05). Administration of sodium nitroprusside increased CVC to levels no different from those induced by local warming. Thus NOS inhibition attenuated, and sodium nitroprusside restored, the cutaneous vasodilation induced by elevation of T loc ; therefore, the mechanism of cutaneous vasodilation by local warming requires NOS generation of NO.

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  • Impaired endothelium-dependent vasodilation results not only in impaired macrovascular function, but also in microvascular dysfunction, as measured by retinal artery vasodilation and heat-induced skin hyperemia.

    “Impaired endothelium-dependent vasodilation results not only in impaired macrovascular function, but also in microvascular dysfunction, as measured by retinal artery vasodilation and heat-induced skin hyperemia.”

    From The Vasculature in Prediabetes (2018) · cites this paper as [107]

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Authors
Kellogg, D. L., Liu, Y., Kosiba, I. F., & O’Donnell, D.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1999-04-01
Volume
86
Issue
4
Pages
1185-1190
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1999.86.4.1185
OpenAlex
W2134850367
Cited by
463
References
23
Citations by year
2026: 7 · 2025: 11 · 2024: 11 · 2023: 15 · 2022: 8 · 2021: 12 · 2020: 15 · 2019: 19 · 2018: 13 · 2017: 15 · 2016: 21 · 2015: 22 · 2014: 25 · 2013: 15 · 2012: 28
FWCI
5.22
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
nitric oxide, nitric oxide synthase, cutaneous vasodilation, skin blood flow, cutaneous vascular conductance, L-NAME, sodium nitroprusside, forearm skin, thermoregulation
MeSH terms
Adult, Blood Pressure, Female, Hot Temperature, Humans, Male, Nitric Oxide, Nitroprusside, Regional Blood Flow, Skin, Skin Temperature, Laser-Doppler Flowmetry, Microdialysis, NG-Nitroarginine Methyl Ester

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