The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes
Open accessAbstract
Erythrocytes release ATP in response to exposure to the physiological stimulus of lowered oxygen (O 2) tension as well as pharmacological activation of the prostacyclin receptor (IPR). ATP release in response to these stimuli requires activation of adenylyl cyclase, accumulation of cAMP, and activation of protein kinase A. The mechanism by which ATP, a highly charged anion, exits the erythrocyte in response to lowered O 2 tension or receptor-mediated IPR activation by iloprost is unknown. It was demonstrated previously that inhibiting pannexin 1 with carbenoxolone inhibits hypotonically induced ATP release from human erythrocytes. Here we demonstrate that three structurally dissimilar compounds known to inhibit pannexin 1 prevent ATP release in response to lowered O 2 tension but not to iloprost-induced ATP release. These results suggest that pannexin 1 is the conduit for ATP release from erythrocytes in response to lowered O 2 tension. However, the identity of the conduit for iloprost-induced ATP release remains unknown.
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Citations
Cites
The red blood cell as an oxygen sensor: what is the evidence?
Ellsworth, M. L. (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00708.x · Cited by 186
Self-citationRed not dead: signaling in and from erythrocytes
Sprague, R. S., Stephenson, A. H., & Ellsworth, M. L. (2007) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2007.08.008 · Cited by 124
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Cited by
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Allard, B., Longhi, M. S., Robson, S. C., & Stagg, J. (2017) · Immunological Reviews · doi:10.1111/imr.12528 · Cited by 927
Intercellular Ca2+Waves: Mechanisms and Function
Leybaert, L., & Sanderson, M. J. (2012) · Physiological Reviews · doi:10.1152/physrev.00029.2011 · Cited by 331
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
Role of erythrocyte-released ATP in the regulation of microvascular oxygen supply in skeletal muscle
Ellsworth, M. L., Ellis, C. G., & Sprague, R. S. (2016) · Acta Physiologica · doi:10.1111/apha.12596 · Cited by 81
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Metadata
- Authors
- Sridharan, M., Adderley, S. P., Bowles, E. A., Egan, T. M., Stephenson, A. H., Ellsworth, M. L., & Sprague, R. S.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2010-10
- Volume
- 299
- Issue
- 4
- Pages
- H1146-H1152
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2161898317
- Cited by
- 183
- References
- 2
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Sridharan, M., Adderley, S. P., Bowles, E. A., Egan, T. M., Stephenson, A. H., Ellsworth, M. L., & Sprague, R. S. (2010). Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.00301.2010
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