The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Three-dimensional transmural organization of perimysial collagen in the heart
Open accessAbstract
There is strong support for the view that the ventricular myocardium has a laminar organization in which myocytes are grouped into branching layers separated by cleavage planes. However, understanding of the extent and functional implications of this architecture has been limited by the lack of a systematic three-dimensional description of the organization of myocytes and associated perimysial collagen. We imaged myocytes and collagen across the left ventricular wall at high resolution in seven normal rat hearts using extended volume confocal microscopy. We developed novel reconstruction and segmentation techniques necessary for the quantitative analysis of three-dimensional myocyte and perimysial collagen organization. The results confirm that perimysial collagen has an ordered arrangement and that it defines a laminar organization. Perimysial collagen is composed of three distinct forms: extensive meshwork on laminar surfaces, convoluted fibers connecting adjacent layers, and longitudinal cords. While myolaminae are the principal form of structural organization throughout most of the wall, they are not seen in the subepicardium, where perimysial collagen is present only as longitudinal cords.
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“In the native heart, overlapping myocardial fibers are arranged into distinct laminae four to six myocytes thick and separated from adjacent laminae by an extracellular collagen network42.”
From A tissue-engineered scale model of the heart ventricle (2018) · cites this paper as [42]
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Self-citationCollagen remodeling of the pressure-overloaded, hypertrophied nonhuman primate myocardium.
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Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle.
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Shear properties of passive ventricular myocardium
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Self-citationCellular mechanisms of myocardial infarct expansion.
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Self-citationLaminar fiber architecture and three-dimensional systolic mechanics in canine ventricular myocardium
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Biomechanical properties and microstructure of human ventricular myocardium
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Biomimetic gradient hydrogels for tissue engineering
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Metadata
- Authors
- Pope, A. J., Sands, G. B., Smaill, B. H., & LeGrice, I. J.
- Affiliations
- University of Auckland (NZ)
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2008-09
- Volume
- 295
- Issue
- 3
- Pages
- H1243-H1252
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- PMC
- PMC2544485
- OpenAlex
- W2117433444
- Cited by
- 205
- References
- 51
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 16 · 2020: 16 · 2019: 14 · 2018: 12 · 2017: 10 · 2016: 11 · 2015: 15 · 2014: 12 · 2013: 15 · 2012: 18
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Funders
- National Heart Foundation of New Zealand
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- left ventricular wall, 3D reconstruction, collagen fiber arrangement, subepicardium, rat heart
- MeSH terms
- Animals, Collagen, Endocardium, Heart Ventricles, Image Processing, Computer-Assisted, Male, Myocardium, Pericardium, Rats, Inbred WKY, Rats, Wistar, Microscopy, Confocal, Myocytes, Cardiac, Rats
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