Cited by 205Cardiac Fibrosis and RemodelingCardiomyopathy and Myosin StudiesCardiac electrophysiology and arrhythmias

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Three-dimensional transmural organization of perimysial collagen in the heart

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Pope, Adèle J., Sands, Gregory B., Smaill, Bruce H., LeGrice, Ian J.·2008·American Journal of Physiology-Heart and Circulatory Physiology

DOI 10.1152/ajpheart.00484.2008PMC PMC2544485

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Abstract

There is strong support for the view that the ventricular myocardium has a laminar organization in which myocytes are grouped into branching layers separated by cleavage planes. However, understanding of the extent and functional implications of this architecture has been limited by the lack of a systematic three-dimensional description of the organization of myocytes and associated perimysial collagen. We imaged myocytes and collagen across the left ventricular wall at high resolution in seven normal rat hearts using extended volume confocal microscopy. We developed novel reconstruction and segmentation techniques necessary for the quantitative analysis of three-dimensional myocyte and perimysial collagen organization. The results confirm that perimysial collagen has an ordered arrangement and that it defines a laminar organization. Perimysial collagen is composed of three distinct forms: extensive meshwork on laminar surfaces, convoluted fibers connecting adjacent layers, and longitudinal cords. While myolaminae are the principal form of structural organization throughout most of the wall, they are not seen in the subepicardium, where perimysial collagen is present only as longitudinal cords.

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Self-citation

Authors: Pope, A. J., Sands, G. B., Smaill, B. H., & LeGrice, I. J.
Affiliations: University of Auckland (NZ)
ORCID: Pope, Adèle J.
Sands, Gregory B.
LeGrice, Ian J.
Venue: American Journal of Physiology-Heart and Circulatory Physiology
Publisher: American Physiological Society
Published: 2008-09
Volume: 295
Issue: 3
Pages: H1243-H1252
ISSN: 0363-6135 (ISSN-L)
1522-1539
DOI: 10.1152/ajpheart.00484.2008
PMC: PMC2544485
OpenAlex: W2117433444
Cited by: 205
References: 51
Citations by year: 2026: 7 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 16 · 2020: 16 · 2019: 14 · 2018: 12 · 2017: 10 · 2016: 11 · 2015: 15 · 2014: 12 · 2013: 15 · 2012: 18
FWCI: 7.55
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ResearchSpace (University of Auckland) (submittedVersion)
Funders: National Heart Foundation of New Zealand
National Institutes of Health
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: left ventricular wall, 3D reconstruction, collagen fiber arrangement, subepicardium, rat heart
MeSH terms: Animals, Collagen, Endocardium, Heart Ventricles, Image Processing, Computer-Assisted, Male, Myocardium, Pericardium, Rats, Inbred WKY, Rats, Wistar, Microscopy, Confocal, Myocytes, Cardiac, Rats

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Three-dimensional transmural organization of perimysial collagen in the heart

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