The DOI matches its Crossref record; 247 of the 247 references it cites were found in a registry or an index.
Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance
Abstract
Hypertension commonly occurs in conjunction with insulin resistance and other components of the cardiometabolic syndrome. Insulin resistance plays a significant role in the relationship between hypertension, Type 2 diabetes mellitus, chronic kidney disease, and cardiovascular disease. There is accumulating evidence that insulin resistance occurs in cardiovascular and renal tissue as well as in classical metabolic tissues (i.e., skeletal muscle, liver, and adipose tissue). Activation of the renin-angiotensin-aldosterone system and subsequent elevations in angiotensin II and aldosterone, as seen in cardiometabolic syndrome, contribute to altered insulin/IGF-1 signaling pathways and reactive oxygen species formation to induce endothelial dysfunction and cardiovascular disease. This review examines currently understood mechanisms underlying the development of resistance to the metabolic actions of insulin in cardiovascular as well as skeletal muscle tissue.
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“Similarly, patients with PA had low adiponectin levels with an associated weaker insulin sensitivity ().”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [178]
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- Stas S, Whaley-Connell A, Habibi J, Appesh L, Hayden MR, Cooper SA, Stump CS, Hay M, Sowers JR.Mineralocorticoid receptor blockade attenuates chronic angiotensin-II overexpression stimulation of NADPH oxidase and cardiac remodeling.Endocrinology. In press.
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Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework
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Kaur, M. K. K., MD, D. G. A., & MD, D. M. S. (2025) · Obesity Research - Open Journal · doi:10.17140/oroj.2025.v11.i01.pp01-13.1425
Metadata
- Authors
- Cooper, S. A., Whaley-Connell, A., Habibi, J., Wei, Y., Lastra, G., Manrique, C., Stas, S., & Sowers, J. R.
- Affiliations
- University of Missouri (US)
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2007-10
- Volume
- 293
- Issue
- 4
- Pages
- H2009-H2023
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2132975480
- Cited by
- 317
- References
- 247
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 14 · 2023: 13 · 2022: 9 · 2021: 13 · 2020: 8 · 2019: 17 · 2018: 12 · 2017: 15 · 2016: 11 · 2015: 18 · 2014: 17 · 2013: 21 · 2012: 25
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- renin-angiotensin-aldosterone system, oxidative stress, insulin resistance, cardiometabolic syndrome, hypertension, type 2 diabetes, chronic kidney disease, cardiovascular disease, angiotensin II, aldosterone, IGF-1 signaling, reactive oxygen species, endothelial dysfunction, skeletal muscle insulin signaling
- MeSH terms
- Angiotensin II, Animals, Cardiovascular Diseases, Chronic Disease, Diabetes Mellitus, Type 2, Endothelium, Vascular, Humans, Hypertension, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Kidney Diseases, Mineralocorticoids, Myocardium, Renin-Angiotensin System, Risk Factors, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal, Metabolic Syndrome, Receptor, Angiotensin, Type 1
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