Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance

Role of Insulin Resistance in Human Disease

Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154

Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement

Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961

The phosphoinositide 3-kinase pathway

Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621

Inflammation and insulin resistance

Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844

Banting lecture 1988. Role of insulin resistance in human disease.

Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543

NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease

Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886

Critical nodes in signalling pathways: insights into insulin action

Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760

Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655

Metabolic syndrome: definitions and controversies

Kassi, E., Pervanidou, P., Kaltsas, G., & Chrousos, G. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-48 · Cited by 1,565

Role of Mitochondrial Dysfunction in Insulin Resistance

Kim, J.-A., Wei, Y., & Sowers, J. R. (2008) · Circulation Research · doi:10.1161/circresaha.107.165472 · Cited by 1,103

Cardiovascular consequences of metabolic syndrome

Tune, J. D., Goodwill, A. G., Sassoon, D., & Mather, K. J. (2017) · Translational research · doi:10.1016/j.trsl.2017.01.001 · Cited by 645

Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease

Ren, J. T., Pulakat, L., Whaley‐Connell, A. T., & Sowers, J. R. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0663-9 · Cited by 373

Narrative Review: The Emerging Clinical Implications of the Role of Aldosterone in the Metabolic Syndrome and Resistant Hypertension

Sowers, J. R., Whaley-Connell, A., & Epstein, M. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-11-200906020-00005 · Cited by 351

Type 2 Diabetes Mellitus and Hypertension

Lastra, G., Syed, S., Kurukulasuriya, L. R., Manrique, C., & Sowers, J. R. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.09.005 · Cited by 307

Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension

Muñoz‐Durango, N., Fuentes, C., Castillo, A., González-Gómez, L. M., Vecchiola, A., Fardella, C., & Kalergis, A. M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17070797 · Cited by 297

Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species

Wei, Y., Chen, K., Whaley‐Connell, A. T., Stump, C. S., Ibdah, J. A., & Sowers, J. R. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00561.2007 · Cited by 270

Aldosterone, Inflammation, Immune System, and Hypertension

Ferreira, N. S., Tostes, R. C., Paradis, P., & Schiffrin, E. L. (2020) · American Journal of Hypertension · doi:10.1093/ajh/hpaa137 · Cited by 268

Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease

Boese, A. C., Kim, S. C., Yin, K., Lee, J., & Hamblin, M. H. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00217.2016 · Cited by 241

Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice

Hirata, A., Maeda, N., Hiuge, A., Hibuse, T., Fujita, K., Okada, T., Kihara, S., Funahashi, T., & Shimomura, I. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp191 · Cited by 241

The Renin Angiotensin Aldosterone System in Hypertension: Roles of Insulin Resistance and Oxidative Stress

Manrique, C. M., Lastra, G., Gardner, M., & Sowers, J. R. (2009) · Medical Clinics of North America · doi:10.1016/j.mcna.2009.02.014 · Cited by 232

The Triglyceride-Glucose Index Predicts Coronary Artery Disease Severity and Cardiovascular Outcomes in Patients with Non-ST-Segment Elevation Acute Coronary Syndrome

Mao, Q., Zhou, D., Li, Y., Wang, Y., Xu, S., & Zhao, X. (2019) · Disease Markers · doi:10.1155/2019/6891537 · Cited by 213

Link between insulin resistance and hypertension: What is the evidence from evolutionary biology?

Zhou, M.-S., Wang, A., & Yu, H. (2014) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-6-12 · Cited by 217

Link between the renin–angiotensin system and insulin resistance: Implications for cardiovascular disease

Zhou, M.-S., Schulman, I. H., & Zeng, Q. (2012) · Vascular Medicine · doi:10.1177/1358863x12450094 · Cited by 214

A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes

Jha, J. C., Ho, F., Dan, C., & Jandeleit-Dahm, K. A. M. (2018) · Clinical Science · doi:10.1042/cs20171459 · Cited by 207

Angiotensin-(1–7) Prevents Activation of NADPH Oxidase and Renal Vascular Dysfunction in Diabetic Hypertensive Rats

Benter, I. F., Yousif, M. H. M., Dhaunsi, G. S., Kaur, J., Chappell, M. C., & Diz, D. I. (2007) · American Journal of Nephrology · doi:10.1159/000108758 · Cited by 204

Angiotensin II and the development of insulin resistance: Implications for diabetes

Olivares-Reyes, J. A., Arellano-Plancarte, A., & Castillo-Hernández, J. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.12.011 · Cited by 208

Molecular and metabolic mechanisms of cardiac dysfunction in diabetes

Mandavia, C. H., Aroor, A. R., DeMarco, V. G., & Sowers, J. R. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.10.028 · Cited by 198

Insulin says NO to cardiovascular disease

Yu, Q., Gao, F., & Ma, X. L. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq349 · Cited by 172

The Renin Angiotensin Aldosterone System in Obesity and Hypertension

Cabandugama, P. K., Gardner, M. J., & Sowers, J. R. (2017) · Medical Clinics of North America · doi:10.1016/j.mcna.2016.08.009 · Cited by 168

Pathophysiology of essential hypertension: an update

Saxena, T. K., Ali, A. O., & Saxena, M. (2018) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2018.1540301 · Cited by 181

Aldosterone and arterial hypertension

Tomaschitz, A., Pilz, S., Ritz, E., Obermayer-Pietsch, B. M., & Pieber, T. R. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.263 · Cited by 155

Increased prevalence of diabetes mellitus and the metabolic syndrome in patients with primary aldosteronism of the German Conn's Registry

Hanslik, G., Wallaschofski, H., Dietz, A., Riester, A., Reincke, M., Allolio, B., Lang, K., Quack, I., Rump, L. C., Willenberg, H. S., et al. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0450 · Cited by 155

The impact of reactive oxygen species in the development of cardiometabolic disorders: a review

Akhigbe, R. E., & Ajayi, A. F. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01435-7 · Cited by 165

Aldosterone: Role in the Cardiometabolic Syndrome and Resistant Hypertension

Whaley‐Connell, A. T., Johnson, M. S., & Sowers, J. R. (2010) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2009.12.004 · Cited by 155

Salt, aldosterone, and insulin resistance: impact on the cardiovascular system

Lastra, G., Dhuper, S., Johnson, M. S., & Sowers, J. R. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2010.123 · Cited by 159

Optimization of Cardiac Metabolism in Heart Failure

Nagoshi, T., Yoshimura, M., Rosano, G. M. C., Lopaschuk, G. D., & Mochizuki, S. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798357773 · Cited by 151

The Role of Oxidative Stress in the Metabolic Syndrome

Whaley‐Connell, A. T., McCullough, P. A., & Sowers, J. R. (2011) · Reviews in Cardiovascular Medicine · doi:10.3909/ricm0555 · Cited by 146

Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management

Scaroni, C., Zilio, M., Foti, M., & Boscaro, M. (2017) · Endocrine Reviews · doi:10.1210/er.2016-1105 · Cited by 140

Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice

Huynh, K., Kiriazis, H., Du, X., Love, J. E., Gray, S. P., Jandeleit-Dahm, K. A. M., McMullen, J. R., & Ritchie, R. H. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.021 · Cited by 128

Vascular inflammation, insulin resistance, and endothelial dysfunction in salt-sensitive hypertension: role of nuclear factor kappa B activation

Zhou, M.-S., Schulman, I. H., & Raij, L. R. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283340da8 · Cited by 127

Activation of mTOR/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation

Kim, J., Jang, H.-J., Martinez‐Lemus, L. A., & Sowers, J. R. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00497.2011 · Cited by 126

Exercise in the Metabolic Syndrome

Golbidi, S., Mesdaghinia, A., & Laher, I. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/349710 · Cited by 127

Matrix metalloproteinase-2 and -9 exacerbate arterial stiffening and angiogenesis in diabetes and chronic kidney disease

Chung, A. W. Y., Yang, H. H. C., Sigrist, M. K., Brin, G., Chum, E., Gourlay, W. A., & Levin, A. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp242 · Cited by 116

Modulation of glucose metabolism by the renin-angiotensin-aldosterone system

Favre, G. A., Esnault, V. L. M., & Van Obberghen, E. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00391.2014 · Cited by 114

Mineralocorticoid Receptor Antagonism Treats Obesity-Associated Cardiac Diastolic Dysfunction

Bender, S. B., DeMarco, V. G., Padilla, J., Jenkins, N. T., Habibi, J., Garro, M., Pulakat, L., Aroor, A. R., Jaffe, I. Z., & Sowers, J. R. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.04912 · Cited by 109

Insulin's actions on vascular tissues: Physiological effects and pathophysiological contributions to vascular complications of diabetes

Fu, J., Yu, M. G., Li, Q., Park, K., & King, G. L. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101236 · Cited by 112

Stressed brain, diseased heart: A review on the pathophysiologic mechanisms of neurocardiology

Pereira, V., Cerqueira, J., Palha, J. A., & Sousa, N. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.03.165 · Cited by 107

The insulin-like growth factor I system: Physiological and pathophysiological implication in cardiovascular diseases associated with metabolic syndrome

Ren, J. T., & Anversa, P. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.12.006 · Cited by 100

An association of metabolic syndrome and chronic kidney disease from a 10-year prospective cohort study

Huh, J. H., Yadav, D., Kim, J. S., Son, J., Choi, E. H., Kim, S. H., Shin, C., Sung, K., & Kim, J. (2016) · Metabolism · doi:10.1016/j.metabol.2016.11.003 · Cited by 102

Is Primary Aldosteronism Associated with Diabetes Mellitus? Results of the German Conn's Registry

Reincke, M., Meisinger, C., Holle, R., Quinkler, M. O., Hahner, S., Beuschlein, F., Bidlingmaier, M., Seißler, J., & Endres, S. (2010) · Hormone and Metabolic Research · doi:10.1055/s-0029-1246189 · Cited by 98

Direct Renin Inhibition Improves Systemic Insulin Resistance and Skeletal Muscle Glucose Transport in a Transgenic Rodent Model of Tissue Renin Overexpression

Lastra, G., Habibi, J., Whaley‐Connell, A. T., Manrique, C. M., Hayden, M. R., Rehmer, J. M., Patel, K., Ferrario, C. M., & Sowers, J. R. (2009) · Endocrinology · doi:10.1210/en.2008-1391 · Cited by 97

Adipose tissue renin–angiotensin–aldosterone system (RAAS) and progression of insulin resistance

Marcus, Y., Shefer, G., & Stern, N. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.021 · Cited by 92

Metabolic actions of angiotensin II and insulin: A microvascular endothelial balancing act

Muniyappa, R., & Yavuz, S. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.05.017 · Cited by 96

Influence of the Mediterranean Diet on Healthy Aging

Andreo-López, M. C., Contreras-Bolívar, V., Muñoz‐Torres, M., García-Fontana, B., & García‐Fontana, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054491 · Cited by 94

Cardiac Dimensions Are Largely Determined by Dietary Salt in Patients with Primary Aldosteronism: Results of a Case-Control Study

Pimenta, E., Gordon, R. D., Ahmed, A. H., Cowley, D., Leano, R., Marwick, T. H., & Stowasser, M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0354 · Cited by 83

Characteristics of resistant hypertension: ageing, body mass index, hyperaldosteronism, cardiac hypertrophy and vascular stiffness

Martins, L. C., Figueiredo, V. N., Quinaglia, T., Boer‐Martins, L., Yugar‐Toledo, J. C., Vilela-Martin, J. F., Demacq, C., Pimenta, E., Calhoun, D. A., & Moreno, H. (2010) · Journal of Human Hypertension · doi:10.1038/jhh.2010.95 · Cited by 82

The association of triglyceride-glucose index and related parameters with hypertension and cardiovascular risk: a cross-sectional study

Miao, H., Zhou, Z., Yang, S., & Zhang, Y. (2023) · Hypertension Research · doi:10.1038/s41440-023-01502-9 · Cited by 82

Heart of the matter: Coronary dysfunction in metabolic syndrome

Berwick, Z. C., Dick, G. M., & Tune, J. D. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.06.025 · Cited by 78

Garlic extract reduces serum angiotensin converting enzyme (ACE) activity in nondiabetic and streptozotocin-diabetic rats

Hosseini, M., Shafiee, S. M., & Baluchnejadmojarad, T. (2007) · Pathophysiology · doi:10.1016/j.pathophys.2007.07.002 · Cited by 76

Impact of aldosterone antagonists on the substrate for atrial fibrillation: Aldosterone promotes oxidative stress and atrial structural/electrical remodeling

Mayyas, F., Alzoubi, K. H., & Wagoner, D. R. V. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.08.022 · Cited by 78

Prolonged fasting does not increase oxidative damage or inflammation in postweaned northern elephant seal pups

Vázquez‐Medina, J. P., Crocker, D. E., Forman, H. J., & Ortiz, R. M. (2010) · Journal of Experimental Biology · doi:10.1242/jeb.041335 · Cited by 78

Metabolic Syndrome: A Narrative Review from the Oxidative Stress to the Management of Related Diseases

Martemucci, G., Fracchiolla, G., Muraglia, M., Tardugno, R., Dibenedetto, R. S., & D‘Alessandro, A. G. (2023) · Antioxidants · doi:10.3390/antiox12122091 · Cited by 89

Angiotensin 1-7 as Means to Prevent the Metabolic Syndrome

Marcus, Y., Shefer, G., Sasson, K., Kohen, F., Limor, R., Pappo, O., Nevo, N., Biton, I. E., Bach, M. Y., Berkutzki, T., et al. (2012) · Diabetes · doi:10.2337/db12-0792 · Cited by 75

Renin Inhibition Attenuates Insulin Resistance, Oxidative Stress, and Pancreatic Remodeling in the Transgenic Ren2 Rat

Habibi, J., Whaley‐Connell, A. T., Hayden, M. R., DeMarco, V. G., Schneider, R. I., Sowers, S. D., Karuparthi, P. R., Ferrario, C. M., & Sowers, J. R. (2008) · Endocrinology · doi:10.1210/en.2008-0070 · Cited by 76

Oxidative Stress in the Cardiorenal Metabolic Syndrome

Whaley‐Connell, A. T., & Sowers, J. R. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0279-2 · Cited by 75

ACE2 exerts anti-obesity effect via stimulating brown adipose tissue and induction of browning in white adipose tissue

Kawabe, Y., Mori, J., Morimoto, H., Yamaguchi, M., Miyagaki, S., Ota, T., Tsuma, Y., Fukuhara, S., Nakajima, H., Oudit, G. Y., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00311.2019 · Cited by 74

Adipocytokines in Atherothrombosis: Focus on Platelets and Vascular Smooth Muscle Cells

Anfossi, G., Russo, I., Doronzo, G., Pomero, A., & Trovati, M. (2010) · Mediators of Inflammation · doi:10.1155/2010/174341 · Cited by 76

AMPK: a balancer of the renin–angiotensin system

Liu, J., Li, X., Lü, Q., Ren, D., Sun, X., Rousselle, T. V., Li, J., & Leng, J. (2019) · Bioscience Reports · doi:10.1042/bsr20181994 · Cited by 72

NLRP3 Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus

Ferreira, N. S., Bruder-Nascimento, T. B., Pereira, C. A., Zanotto, C. Z., Prado, D. D. S., da Silva, J. F., Rassi, D. M., Foss‐Freitas, M. C., Alves-Filho, J. C., Carlos, D., et al. (2019) · Cells · doi:10.3390/cells8121595 · Cited by 70

Association of Leukocyte Telomere Length With Echocardiographic Left Ventricular Mass

Vasan, R. S., Demissie, S., Kimura, M., Cupples, L. A., White, C. C., Gardner, J. P., Cao, X., Levy, D. A., Benjamin, E. J., & Aviv, A. (2009) · Circulation · doi:10.1161/circulationaha.109.853895 · Cited by 69

Perivascular adipose tissue, inflammation and insulin resistance: link to vascular dysfunction and cardiovascular disease

Lastra, G., & Manrique, C. M. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0010 · Cited by 70

Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects

Barbieri, M., Paolisso, G., Kimura, M., Gardner, J. P., Boccardi, V., Papa, M., Hjelmborg, J., Christensen, K., Brimacombe, M. B., Nawrot, T. S., et al. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.10.002 · Cited by 66

Nebivolol Reduces Proteinuria and Renal NADPH Oxidase-Generated Reactive Oxygen Species in the Transgenic Ren2 Rat

Whaley‐Connell, A. T., Habibi, J., Johnson, M. S., Tilmon, R. D., Rehmer, N., Rehmer, J. M., Wiedmeyer, C. E., Ferrario, C. M., & Sowers, J. R. (2009) · American Journal of Nephrology · doi:10.1159/000229305 · Cited by 65

Free Fatty Acid Causes Leukocyte Activation and Resultant Endothelial Dysfunction Through Enhanced Angiotensin II Production in Mononuclear and Polymorphonuclear Cells

Azekoshi, Y., Yasu, T., Watanabe, S., Tagawa, T., Abe, S., Yamakawa, K., Uehara, Y., Momomura, S., Urata, H., & Ueda, S. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.153056 · Cited by 65

Inhibition of Angiotensin-1-Converting Enzyme Activity by Two Varieties of Ginger ( Zingiber officinale ) in Rats Fed a High Cholesterol Diet

Akinyemi, A. J., Ademiluyi, A. O., & Oboh, G. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0264 · Cited by 62

Role of the vascular endothelium and plaque in acute ischemic stroke

Madden, J. A. (2012) · Neurology · doi:10.1212/wnl.0b013e3182695836 · Cited by 62

Nutrition, Bioenergetics, and Metabolic Syndrome

García‐García, F. J., Monistrol-Mula, A., Cardellach, F., & Garrabou, G. (2020) · Nutrients · doi:10.3390/nu12092785 · Cited by 71

Role of angiotensin II and oxidative stress in vascular insulin resistance linked to hypertension

Zhou, M.-S., Schulman, I. H., & Raij, L. R. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01096.2008 · Cited by 60

Therapeutic Strategies for Mitochondrial Dysfunction and Oxidative Stress in Age-Related Metabolic Disorders

Bhatti, J. S., Kumar, S., Vijayan, M., Bhatti, G. K., & Reddy, P. H. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.012 · Cited by 61

Bedtime ingestion of hypertension medications reduces the risk of new-onset type 2 diabetes: a randomised controlled trial

Hermida, R. C., Ayala, D. E., Mojón, A., & Fernández, J. R. (2015) · Diabetologia · doi:10.1007/s00125-015-3749-7 · Cited by 60

Non-dipping pattern relates to endothelial dysfunction in patients with uncontrolled resistant hypertension

Quinaglia, T., Martins, L. C., Figueiredo, V. N., Santos, R. C., Yugar-Toledo, J. C., Martin, J. F. V., Demacq, C., Pimenta, E., Calhoun, D. A., & Moreno, H. (2011) · Journal of Human Hypertension · doi:10.1038/jhh.2011.43 · Cited by 57

Renoprotective effects of the direct renin inhibitor aliskiren on gentamicin-induced nephrotoxicity in rats

Bae, E. H., Kim, I. J., Joo, S. Y., Kim, E. Y., Choi, J. S., Kim, C. S., Kwon, S., Lee, J., & Kim, S. W. (2013) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320312474853 · Cited by 57

Antioxidant Peptides Identified from Ovotransferrin by the ORAC Method Did Not Show Anti-Inflammatory and Antioxidant Activities in Endothelial Cells

Jahandideh, F., Chakrabarti, S., Davidge, S. T., & Wu, J. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b04230 · Cited by 57

Linking Oxidative Stress, the Renin-Angiotensin System, and Hypertension

Fanelli, C., & Zatz, R. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.167775 · Cited by 57

Role of mineralocorticoid receptor and renin–angiotensin–aldosterone system in adipocyte dysfunction and obesity

Feraco, A., Armani, A., Mammi, C., Fabbri, A., Rosano, G. M. C., & Caprio, M. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.012 · Cited by 58

Associations of Insulin Resistance With Systolic and Diastolic Blood Pressure: A Study From the HCHS/SOL

Quesada, O., Claggett, B. L., Rodríguez, F., Cai, J., Moncrieft, A. E., Garcia, K. A., Rios, M. D., Hanna, D. B., Daviglus, M. L., Talavera, G. A., et al. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.16905 · Cited by 58

Reactive oxygen species and insulin‐resistant cardiomyopathy

Mellor, K. M., Ritchie, R. H., & Delbridge, L. M. D. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05274.x · Cited by 55

AT1 Receptor Blockade Attenuates Insulin Resistance and Myocardial Remodeling in Rats with Diet-Induced Obesity

de Oliveira-Junior, S. A., Martinez, P. F., Guizoni, D. M., Campos, D. H. S., Fernandes, T., de Oliveira, E. M., Okoshi, M. P., Okoshi, K., Padovani, C. R., & Cicogna, A. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086447 · Cited by 55

Role of the Renin-Angiotensin System and Aldosterone on Cardiometabolic Syndrome

Stiefel, P., Vallejo‐Vaz, A. J., Morillo, J. S. G., & Villar, J. (2011) · International Journal of Hypertension · doi:10.4061/2011/685238 · Cited by 56

Obesity and cardiovascular disease: role of adipose tissue, inflammation, and the renin-angiotensin-aldosterone system

Lastra, G., & Sowers, J. R. (2013) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0025 · Cited by 55

Hypertension and Insulin Resistance

Whaley‐Connell, A. T., & Sowers, J. R. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.134460 · Cited by 54

Perspectives and Potential Applications of Mitochondria‐Targeted Antioxidants in Cardiometabolic Diseases and Type 2 Diabetes

Rocha, M., Apostolova, N., Herance, J. R., Rovira‐Llopis, S., Hernández‐Mijares, A., & Víctor, V. M. (2013) · Medicinal Research Reviews · doi:10.1002/med.21285 · Cited by 51

Membrane Estrogen Receptors: Their Role in Blood Pressure Regulation and Cardiovascular Disease

Prabhushankar, R., Krueger, C., & Manrique, C. M. (2013) · Current Hypertension Reports · doi:10.1007/s11906-013-0408-6 · Cited by 51

The Ang-(1–7)/Mas-1 axis attenuates the expression and signalling of TGF-β1 induced by AngII in mouse skeletal muscle

Morales, M. G., Ábrigo, J., Meneses, C., Simón, F., Cisternas, F., Rivera, J. C. A., Vázquez, Y., & Cabello‐Verrugio, C. (2014) · Clinical Science · doi:10.1042/cs20130585 · Cited by 51

RAGE Mediates Accelerated Diabetic Vein Graft Atherosclerosis Induced by Combined Mechanical Stress and AGEs via Synergistic ERK Activation

Li, Y., Liu, S., Zhang, Z., Xu, Q., Xie, F., Wang, J., Ping, S., Li, C., 汪照静, Zhang, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035016 · Cited by 50

Ca2+ regulatory mechanisms of exercise protection against coronary artery disease in metabolic syndrome and diabetes

Sturek, M. S. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00373.2011 · Cited by 49

Mineralocorticoid Receptor Antagonism Attenuates Vascular Apoptosis and Injury via Rescuing Protein Kinase B Activation

Wei, Y., Whaley‐Connell, A. T., Habibi, J., Rehmer, J. M., Rehmer, N., Patel, K., Hayden, M., DeMarco, V. G., Ferrario, C. M., Ibdah, J. A., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.121954 · Cited by 50

Evidence for a Causal Role of Oxidative Stress in the Myocardial Complications of Insulin Resistance

Ritchie, R. H. (2009) · Heart Lung and Circulation · doi:10.1016/j.hlc.2008.11.003 · Cited by 49

Mineralocorticoid receptor antagonism attenuates glomerular filtration barrier remodeling in the transgenic Ren2 rat

Whaley‐Connell, A. T., Habibi, J., Wei, Y., Gutweiler, A. A., Jellison, J., Wiedmeyer, C. E., Ferrario, C. M., & Sowers, J. R. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90646.2008 · Cited by 48

Beneficial Effects of Bariatric Surgery on Cardiac Structure and Function in Obesity

Shin, S., Lee, Y. J., Heo, Y., Park, S., Kwon, S., Woo, S., Kim, D., Park, K. S., & Kwan, J. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2330-x · Cited by 50

Comparison of the cardiac effects of electronic cigarette aerosol exposure with waterpipe and combustible cigarette smoke exposure in rats

Mayyas, F., Aldawod, H., Alzoubi, K. H., Khabour, O. F., Shihadeh, A., & Eissenberg, T. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117644 · Cited by 49

Excess aldosterone-induced changes in insulin signaling molecules and glucose oxidation in gastrocnemius muscle of adult male rat

Selvaraj, J., Sathish, S., Mayilvanan, C., & Balasubramanian, K. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1452-2 · Cited by 47

Endothelial dysfunction in acute ischemic stroke: a review

Kleeberg, A., Luft, T., Golkowski, D., & Purrucker, J. C. (2025) · Journal of Neurology · doi:10.1007/s00415-025-12888-6 · Cited by 47

Nebivolol Attenuates Redox-Sensitive Glomerular and Tubular Mediated Proteinuria in Obese Rats

Habibi, J., Hayden, M. R., Sowers, J. R., Pulakat, L., Tilmon, R. D., Manrique, C. M., Lastra, G., DeMarco, V. G., & Whaley‐Connell, A. T. (2010) · Endocrinology · doi:10.1210/en.2010-1038 · Cited by 47

Circulatory Estrogen Level Protects Against Breast Cancer in Obese Women

Suba, Z. (2013) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/1574892811308020004 · Cited by 49

The Insulin-Like Growth Factor System, Metabolic Syndrome, and Cardiovascular Disease Risk

Akanji, A. O., & Smith, R. J. (2011) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2011.0083 · Cited by 47

Role of aldosterone and angiotensin II in insulin resistance: an update

Lastra‐Lastra, G., Sowers, J. R., Restrepo‐Erazo, K., Manrique‐Acevedo, C., & Lastra‐González, G. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03498.x · Cited by 90

Insulin signaling in hypertension

Trimarco, B., Crispo, S., & Morisco, C. (2007) · International Congress Series · doi:10.1016/j.ics.2007.04.005 · Cited by 3

Oxidative Stress in the Cardiorenal Metabolic Syndrome

Whaley‐Connell, A. T., & Sowers, J. R. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0279-2 · Cited by 75

Insulin Resistance and the Renin-Angiotensin-Aldosterone System in Metabolic Syndrome and Obesity-Related Hypertension

Kamide, K., Rakugi, H., & Ogihara, T. (2010) · Current Hypertension Reviews · doi:10.2174/157340210791170976 · Cited by 3

Link between the renin–angiotensin system and insulin resistance: Implications for cardiovascular disease

Zhou, M.-S., Schulman, I. H., & Zeng, Q. (2012) · Vascular Medicine · doi:10.1177/1358863x12450094 · Cited by 214