The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Preconditioning: a paradigm shift in the biology of myocardial ischemia
Open accessAbstract
The discovery of preconditioning (PC) has arguably been the single most important development in the field of ischemic biology in the past 20 years. The significance of this phenomenon transcends cardiovascular medicine, since it is ubiquitously observed in virtually every tissue of the body. This article reviews the pathophysiology and molecular basis of myocardial PC, with particular emphasis on the late phase of this cardioprotective adaptation. The article also discusses the exploitation of late PC for the development of novel gene therapy strategies aimed at inducing a permanently preconditioned cardiac phenotype (prophylactic cardioprotection). Besides its conceptual interest, deciphering the mechanism of late PC has considerable therapeutic reverberations, since transfer of the genes that underlie late PC would be expected to emulate the salubrious effects of this response of the heart to stress.
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Citations
Cites
Preconditioning the myocardium: from cellular physiology to clinical cardiology
YELLON, D. M., & DOWNEY, J. M. (2003) · Physiological Reviews · doi:10.1152/physrev.00009.2003 · Cited by 1,062
Myocardial Protection at a Crossroads: The Need for Translation Into Clinical Therapy
Bolli, R., Becker, L., Gross, G., Mentzer, R., Balshaw, D., & Lathrop, D. A. (2004) · Circulation Research · doi:10.1161/01.res.0000137171.97172.d7 · Cited by 428
Self-citationThe nitric oxide hypothesis of late preconditioning
Bolli, R., Dawn, B., Tang, X.-L., Qiu, Y., Ping, P., Xuan, Y.-T., Jones, W. K., Takano, H., Guo, Y., & Zhang, J. (1998) · Basic Research in Cardiology · doi:10.1007/s003950050101 · Cited by 270
Self-citation
Cited by
Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart
Chen, C.-H., Budas, G. R., Churchill, E. N., Disatnik, M.-H., Hurley, T. D., & Mochly-Rosen, D. (2008) · Science · doi:10.1126/science.1158554 · Cited by 767
Sanada, S., Komuro, I., & Kitakaze, M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00553.2011 · Cited by 381
Yamamoto, T., Byun, J., Zhai, P., Ikeda, Y., Oka, S., & Sadoshima, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098972 · Cited by 305
Exercise-induced cardioprotection against myocardial ischemia–reperfusion injury
Powers, S. K., Quindry, J. C., & Kavazis, A. N. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.02.006 · Cited by 272
Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning.
Pacher, P., & Haskó, G. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707582 · Cited by 217
Metadata
- Authors
- Bolli, R.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2007-01
- Volume
- 292
- Issue
- 1
- Pages
- H19-H27
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2119927647
- Cited by
- 201
- References
- 3
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- green
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