The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart
Open accessAbstract
There is substantial interest in the development of drugs that limit the extent of ischemia-induced cardiac damage caused by myocardial infarction or by certain surgical procedures. Here, using an unbiased proteomic search, we identified mitochondrial aldehyde dehydrogenase 2 (ALDH2) as an enzyme whose activation correlates with reduced ischemic heart damage in rodent models. A high-throughput screen yielded a small-molecule activator of ALDH2 (Alda-1) that, when administered to rats before an ischemic event, reduced infarct size by 60%, most likely through its inhibitory effect on the formation of cytotoxic aldehydes. In vitro, Alda-1 was a particularly effective activator of ALDH2*2, an inactive mutant form of the enzyme that is found in 40% of East Asian populations. Thus, pharmacologic enhancement of ALDH2 activity may be useful for patients with wild-type or mutant ALDH2 who are subjected to cardiac ischemia, such as during coronary bypass surgery.
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Self-citationSignaling pathways in ischemic preconditioning
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Cardiac reperfusion injury: Aging, lipid peroxidation, and mitochondrial dysfunction
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An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation
Chen, Z., Foster, M. W., Zhang, J., Mao, L., Rockman, H. A., Kawamoto, T., Kitagawa, K., Nakayama, K. I., Hess, D. T., & Stamler, J. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503723102 · Cited by 231
Preconditioning: a paradigm shift in the biology of myocardial ischemia
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Cited by
Ischemia and reperfusion—from mechanism to translation
Eltzschig, H. K., & Eckle, T. (2011) · Nature Medicine · doi:10.1038/nm.2507 · Cited by 3,382
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Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities
Chen, C.-H., Ferreira, J. C. B., Gross, E. R., & Mochly-Rosen, D. (2014) · Physiological Reviews · doi:10.1152/physrev.00017.2013 · Cited by 614
Self-citationFigueira, T. R., Barros, M. H., Camargo, A. A., Castilho, R. F., Ferreira, J. C. B., Kowaltowski, A. J., Sluse, F. E., Souza-Pinto, N. C., & Vercesi, A. E. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4729 · Cited by 419
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Metadata
- Authors
- Chen, C.-H., Budas, G. R., Churchill, E. N., Disatnik, M.-H., Hurley, T. D., & Mochly-Rosen, D.
- Venue
- Science
- Published
- 2008-09-12
- Volume
- 321
- Issue
- 5895
- Pages
- 1493-1495
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057099146
- Cited by
- 767
- References
- 19
- FWCI
- 29.07
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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