Deficient BH4production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes
Open accessAbstract
Adult rat cardiac myocytes typically display a phenotypic response to cytokines manifested by low or no increases in nitric oxide (NO) production via inducible NO synthase (iNOS) that distinguishes them from other cell types. To better characterize this response, we examined the expression of tetrahydrobiopterin (BH 4)-synthesizing and arginine-utilizing genes in cytokine-stimulated adult cardiac myocytes. Intracellular BH 4 and 7,8-dihydrobiopterin (BH 2) and NO production were quantified. Cytokines induced GTP cyclohydrolase and its feedback regulatory protein but with deficient levels of BH 4 synthesis. Despite the induction of iNOS protein, cytokine-stimulated adult cardiac myocytes produced little or no increase in NO versus unstimulated cells. Western blot analysis under nonreducing conditions revealed the presence of iNOS monomers. Supplementation with sepiapterin (a precursor of BH 4) increased BH 4 as well as BH 2, but this did not enhance NO levels or eliminate iNOS monomers. Similar findings were confirmed in vivo after treatment of rat cardiac allograft recipients with sepiapterin. It was found that expression of dihydrofolate reductase, required for full activity of the salvage pathway, was not detected in adult cardiac myocytes. Thus, adult cardiac myocytes have a limited capacity to synthesize BH 4 after cytokine stimulation. The mechanisms involve posttranslational factors impairing de novo and salvage pathways. These conditions are unable to support active iNOS protein dimers necessary for NO production. These findings raise significant new questions about the prevailing understanding of how cytokines, via iNOS, cause cardiac dysfunction and injury in vivo during cardiac inflammatory disease states since cardiac myocytes are not a major source of high NO production.
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In conditions in which dihydrofolate reductase is inactive or absent, recovery of eNOS coupling by sepiapterin supplementation is ineffective.
“In conditions in which dihydrofolate reductase is inactive or absent, the recovery of eNOS coupling by sepiapterin supplementation is ineffective (452).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [452]
Cites
Tetrahydrobiopterin biosynthesis, regeneration and functions
Thöny, B., Auerbach, G., & Blau, N. (2000) · Biochemical Journal · doi:10.1042/bj3470001 · Cited by 867 · see citing works
Nitric Oxide and Cardiac Function
Kelly, R. A., Balligand, J., & Smith, T. W. (1996) · Circulation Research · doi:10.1161/01.res.79.3.363 · Cited by 710 · see citing works
Nitric Oxide and Cardiac Function
Massion, P. B., Féron, O., Dessy, C., & Balligand, J. (2003) · Circulation Research · doi:10.1161/01.res.0000088351.58510.21 · Cited by 566 · see citing works
Chalupský, K., & Cai, H. “. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409594102 · Cited by 338 · see citing works
Wang, S., Kotamraju, S., Konorev, E. A., Kalivendi, S. V., Joseph, J., & Kalyanaraman, B. (2002) · Biochemical Journal · doi:10.1042/bj20020752 · Cited by 286 · see citing works
Modulation of Cytokine-Induced Cardiac Myocyte Apoptosis by Nitric Oxide, Bak, and Bcl-x
Ing, D. J., Zang, J., Dzau, V. J., Webster, K. A., & Bishopric, N. H. (1999) · Circulation Research · doi:10.1161/01.res.84.1.21 · Cited by 281 · see citing works
Pinsky, D. J., Cai, B., Yang, X., Rodriguez, C., Sciacca, R. R., & Cannon, P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117713 · Cited by 248 · see citing works
Therapeutic Use of Citrulline in Cardiovascular Disease
Romero, M. J., Platt, D. H., Caldwell, R. B., & Caldwell, R. W. (2006) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2006.00275.x · Cited by 231 · see citing works
Nitric oxide and mitochondrial respiration in the heart
Brown, G. C., & Borutaite, V. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.03.022 · Cited by 213 · see citing works
Meininger, C. J., MARINOS, R. S., Hatakeyama, K., Martı́nez–Zaguilán, R., Rojas, J. D., Kelly, K. A., & Wu, G. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3490353 · Cited by 189 · see citing works
Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failure
Razavi, H. M., HAMILTON, J., & Feng, Q. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.11.006 · Cited by 181 · see citing works
El-Gayar, S., Thüring, H., Pfeilschifter, J. M., Röllinghoff, M., & Bogdan, C. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.9.4561 · Cited by 180 · see citing works
Cytokines and Insulin Induce Cationic Amino Acid Transporter (CAT) Expression in Cardiac Myocytes
Simmons, W. W., Closs, E. I., Cunningham, J. M., Smith, T. W., & Kelly, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.20.11694 · Cited by 177 · see citing works
Tzeng, E., Billiar, T. R., Robbins, P. D., Loftus, M., & Stuehr, D. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11771 · Cited by 174 · see citing works
Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells
Kanno, S., Kim, P. K. M., Sallam, K., Lei, J., Billiar, T. R., & Shears, L. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401557101 · Cited by 165 · see citing works
Tatsumi, T., Matoba, S., Kawahara, A., Keira, N., Shiraishi, J., Akashi, K., Kobara, M., Tanaka, T., Katamura, M., Nakagawa, C., et al. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00526-x · Cited by 165 · see citing works
Dhanasekaran, A., Gruenloh, S. K., Buonaccorsi, J. N., Zhang, R., Gross, G. J., Falck, J. R., Patel, P. K., Jacobs, E. R., & Medhora, M. M. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00979.2007 · Cited by 164 · see citing works
Self-citationFeedback Regulation Mechanisms for the Control of GTP Cyclohydrolase I Activity
Harada, T., Kagamiyama, H., & Hatakeyama, K. (1993) · Science · doi:10.1126/science.8502995 · Cited by 163 · see citing works
New Tetrahydrobiopterin-Dependent Systems
Kaufman, S. (1993) · Annual Review of Nutrition · doi:10.1146/annurev.nu.13.070193.001401 · Cited by 147 · see citing works
New Tetrahydrobiopterin-Dependent Systems
Kaufman, S. (1993) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.13.1.261 · Cited by 147 · see citing works
Nitric oxide synthase expression and role during cardiomyogenesis
Bloch, W. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00160-1 · Cited by 138 · see citing works
Louis, C. A., Reichner, J. S., Henry, W. L., Mastrofrancesco, B., Gotoh, T., Mori, M., & Albina, J. E. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.3.r775 · Cited by 136 · see citing works
Pieper, G. M., & Dondlinger, L. A. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37043-0 · Cited by 124 · see citing works
Self-citationMeininger, C. J., MARINOS, R. S., Hatakeyama, K., et al. (2000) · Biochemical Journal · doi:10.1042/bj3490353 · Cited by 121 · see citing works
Nichol, C. A., Lee, C. L., EDELSTEIN, M. P., Chao, J. Y., & Duch, D. S. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.6.1546 · Cited by 120 · see citing works
Activities of arginase I and II are limiting for endothelial cell proliferation
Li, H. Z., Meininger, C. J., Kelly, K. A., Hawker, J. R., Morris, S. M., & Wu, G. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2002.282.1.r64 · Cited by 111 · see citing works
Positive effects of nitric oxide on left ventricular function in humans
Rassaf, T. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl096 · Cited by 102 · see citing works
Whitsett, J., Picklo, M. J., & Vasquez-Vivar, J. M. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.153742 · Cited by 92 · see citing works
Self-citationPurification and Cloning of the GTP Cyclohydrolase I Feedback Regulatory Protein, GFRP
Milstien, S., Jaffe, H., Kowlessur, D., & Bonner, T. I. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.33.19743 · Cited by 90 · see citing works
The Role of NOS in Heart Failure: Lessons from Murine Genetic Models
Mungrue, I. N., Husain, M., & Stewart, D. J. (2002) · Heart Failure Reviews · doi:10.1023/a:1020762401408 · Cited by 89 · see citing works
Cytokine-Stimulated Nitric Oxide Production Inhibits Mitochondrial Activity in Cardiac Myocytes
Oddis, C. V., & Finkel, M. S. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2228 · Cited by 79 · see citing works
Hasegawa, H., Sawabe, K., Nakanishi, N., & Wakasugi, O. K. (2005) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2005.09.002 · Cited by 79 · see citing works
Huang, A., Zhang, Y., Chen, K., Hatakeyama, K., & Keaney, J. F. (2004) · Circulation Research · doi:10.1161/01.res.0000153669.24827.df · Cited by 79 · see citing works
Sawabe, K., Wakasugi, K. O., & Hasegawa, H. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0040280 · Cited by 75 · see citing works
MYOCARDIAL NUCLEAR FACTOR-??B ACTIVITY AND NITRIC OXIDE PRODUCTION IN REJECTING CARDIAC ALLOGRAFTS1
COOPER, M. M., Lindholm, P. F., Pieper, G. M., Seibel, R., Moore, G. H., Nakanishi, A. L., Dembny, K., KOMOROWSKI, R. A., Johnson, C. P., Adams, M. B., et al. (1998) · Transplantation · doi:10.1097/00007890-199810150-00005 · Cited by 64 · see citing works
Self-citationIGF-I alleviates diabetes-induced RhoA activation, eNOS uncoupling, and myocardial dysfunction
Ren, J. T., Duan, J., Thomas, D. P., Yang, X., Sreejayan, N., Sowers, J. R., Leri, A., Kajstura, J., Gao, F., & Anversa, P. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00713.2007 · Cited by 63 · see citing works
Coito, A. J., Binder, J., Brown, L. F., de Sousa, M. A. B., Water, L. V. D., & Kupiec‐Weglinski, J. W. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.6.2949 · Cited by 57 · see citing works
Zhu, J., Liu, M., Kennedy, R. H., & Liu, S. J. (2006) · Cytokine · doi:10.1016/j.cyto.2006.04.010 · Cited by 56 · see citing works
Cytokine-Induced Endothelial Arginase Expression Is Dependent on Epidermal Growth Factor Receptor
Nelin, L. D., Chicoine, L. G., Reber, K. M., English, B. K., Young, T. L., & Liu, Y. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0039oc · Cited by 53 · see citing works
Role of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolism
Gesierich, A., Niroomand, F., & Tiefenbacher, C. (2003) · Basic Research in Cardiology · doi:10.1007/s00395-003-0394-y · Cited by 53 · see citing works
Phosphoinositide 3-Kinase in Nitric Oxide Synthesis in Macrophage
Sakai, K., Suzuki, H., Oda, H., Akaike, T., Azuma, Y., Murakami, T., Sugi, K., Ito, T., Ichinose, H., Koyasu, S., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601896200 · Cited by 53 · see citing works
Maita, N., Hatakeyama, K., Okada, K., & Hakoshima, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409440200 · Cited by 51 · see citing works
Tetrahydrobiopterin levels regulate endothelial cell proliferation
MARINOS, R. S., Zhang, W., Wu, G., Kelly, K. A., & Meininger, C. J. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.2.h482 · Cited by 48 · see citing works
Sanders, D. B., Larson, D. F., Hunter, K., Gorman, M., & Yang, B. (2001) · Perfusion · doi:10.1177/026765910101600110 · Cited by 46 · see citing works
Kalivendi, S. V., Hatakeyama, K., Whitsett, J., Konorev, E. A., Kalyanaraman, B., & Vasquez-Vivar, J. M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.004 · Cited by 45 · see citing works
Self-citationLinscheid, P., Schaffner, A., Blau, N., & Schoedon, G. (1998) · Circulation · doi:10.1161/01.cir.98.17.1703 · Cited by 43 · see citing works
Treacher, D., Sabbato, M., Brown, K. A., & Gant, V. A. (2001) · Perfusion · doi:10.1177/026765910101600i110 · Cited by 42 · see citing works
Non-heme iron protein: A potential target of nitric oxide in acute cardiac allograft rejection
Pieper, G. M., Halligan, N. L. N., Hilton, G., Konorev, E. A., Felix, C. C., Roza, A. M., Adams, M. B., & Griffith, O. W. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0636938100 · Cited by 37 · see citing works
Self-citationLepic, E., Burger, D. E., Lu, X., Song, W., & Feng, Q. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00092.2006 · Cited by 36 · see citing works
Lethal Effect of Cytokine-induced Nitric Oxide and Peroxynitrite on Cultured Rat Cardiac Myocytes
Keira, N., Tatsumi, T., Matoba, S., Shiraishi, J., Yamanaka, S., Akashi, K., Kobara, M., Asayama, J., Fushiki, S., Fliss, H., et al. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2002.1539 · Cited by 34 · see citing works
Werner, E. R., Bahrami, S., Heller, R., & Werner‐Felmayer, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107326200 · Cited by 32 · see citing works
The role of inducible nitric oxide synthase in cardiac allograft rejection
Cannon, P. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00022-4 · Cited by 31 · see citing works
Goren, N., Cuenca, J., Martín‐Sanz, P., & Boscá, L. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.06.029 · Cited by 31 · see citing works
Simeoni, E., Dudler, J., Fleury, S., Li, J., Pagnotta, M., Pascual, M. A., von Segesser, . K., & Vassalli, G. (2006) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2006.10.042 · Cited by 30 · see citing works
Nitric oxide synthase expression and function in embryonic and adult cardiomyocytes
Bloch, W., Addicks, K., Hescheler, J., & Fleischmann, B. K. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1175 · Cited by 30 · see citing works
Grosjean, S., Devaux, Y., Seguin, C., Meistelman, C., Zannad, F., Mertes, P.-M., Kelly, R. A., & Ungureanu-Longrois, D. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1356 · Cited by 29 · see citing works
Nitric oxide and promotion of cardiac myocyte apoptosis
Andreka, P. G., Tran, T., Webster, K. A., & Bishopric, N. H. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000041847.63338.b8 · Cited by 29 · see citing works
Kasai, K., Hattori, Y., Banba, N., Hattori, S., Motohashi, S., Shimoda, S., Nakanishi, N., & Gross, S. S. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.2.h665 · Cited by 26 · see citing works
Golderer, G., Werner, E. R., Heufler, C., STROHMAIER, W., Gröbner, P., & Werner‐Felmayer, G. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3550499 · Cited by 25 · see citing works
Franscini, N., Blau, N., Walter, R. B., Schaffner, A., & Schoedon, G. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000099785.65848.f1 · Cited by 25 · see citing works
Hattori, Y., Nakanishi, N., & Kasai, K. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1997.0396 · Cited by 22 · see citing works
The complex role of iNOS in acutely rejecting cardiac transplants
Pieper, G. M., & Roza, A. M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.01.020 · Cited by 22 · see citing works
Self-citationGolderer, G., Werner, E. R., Heufler, C., et al. (2001) · Biochemical Journal · doi:10.1042/bj3550499 · Cited by 16 · see citing works
Vasquez-Vivar, J. M., Whitsett, J., Ionova, I., Konorev, E. A., Zielonka, J., Kalyanaraman, B., Shi, Y., & Pieper, G. M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.06.017 · Cited by 15 · see citing works
Self-citationInteraction of human GTP cyclohydrolase I with its splice variants
Pandya, M. J., Golderer, G., Werner, E. R., & Werner‐Felmayer, G. (2006) · Biochemical Journal · doi:10.1042/bj20060765 · Cited by 15 · see citing works
Regulation of GTP cyclohydrolase I by alternative splicing in mononuclear cells
Hwu, W., Yeh, H.-Y., Fang, S.-W., Chiang, H.-S., Chiou, Y., & Lee, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01091-x · Cited by 14 · see citing works
Prolonged survival of rat cardiac allograft with proinflammatory cytokine inhibitor
Sano, I., Takahashi, T., Koji, T., Udono, H., Yui, K., & Ayabe, H. (2001) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(00)00324-7 · Cited by 12 · see citing works
Schmidt, E. E., & Merrill, G. F. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.7.3726-3734.1991 · Cited by 12 · see citing works
Nitric Oxide, Cell Death, and Heart Failure
Oyama, J., Frantz, S., Blais, C., Kelly, R. A., & Bourcier, T. (2002) · Heart Failure Reviews · doi:10.1023/a:1020758300499 · Cited by 11 · see citing works
Pieper, G. M., Nilakantan, V., Halligan, N. L. N., Khanna, A. K., Hilton, G., & Vasquez-Vivar, J. M. (2005) · Biochemical Journal · doi:10.1042/bj20050575 · Cited by 8 · see citing works
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Regulation of the expression of inducible nitric oxide synthase
Pautz, A., Art, J., Hahn, S., Nowag, S., Voss, C., & Kleinert, H. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.04.007 · Cited by 549 · see citing works
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works
Janaszak-Jasiecka, A., Płoska, A., Wierońska, J. M., Dobrucki, L. W., & Kalinowski, L. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00423-2 · Cited by 358 · see citing works
eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation
Karbach, S., Wenzel, P., Waisman, A., Munzel, T., & Daiber, A. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660748 · Cited by 307 · see citing works
Daiber, A., Xia, N., Steven, S., Oelze, M. W., Hanf, A., Kröller‐Schön, S., Münzel, T. F., & Li, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010187 · Cited by 311 · see citing works
Tetrahydrobiopterin in Cardiovascular Health and Disease
Bendall, J. K., Douglas, G., McNeill, E., Channon, K. M., & Crabtree, M. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5566 · Cited by 231 · see citing works
Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
Crabtree, M. J., & Channon, K. M. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.04.004 · Cited by 223 · see citing works
Crabtree, M. J., Tatham, A. L., Hale, A. B., Alp, N. J., & Channon, K. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041483 · Cited by 210 · see citing works
Nitric Oxide Synthases in Heart Failure
Carnicer, R., Crabtree, M. J., Sivakumaran, V., Casadei, B., & Kass, D. A. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4824 · Cited by 163 · see citing works
Šoškić, S., Dobutović, B. D., Sudar-Milovanovic, E. M., Obradovic, M. M., Nikolić, D., Djordjevic, J. D., Radak, D. J., Mikhailidis, D. P., & Isenović, E. R. (2011) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192401105010153 · Cited by 156 · see citing works
Crabtree, M. J., Hale, A., & Channon, K. M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.010 · Cited by 131 · see citing works
Daiber, A., Kröller‐Schön, S., Oelze, M. W., Hahad, O., Li, H., Schulz, R., Steven, S., & Münzel, T. F. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101506 · Cited by 130 · see citing works
Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase
Iwakiri, Y. (2015) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2015.21.4.319 · Cited by 119 · see citing works
Endothelial cell-derived tetrahydrobiopterin prevents aortic valve calcification
Liu, Z., Dong, N., Hui, H., Wang, Y., Liu, F., Xu, L., Liu, M., Rao, Z., Yuan, Z., Shang, Y., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac037 · Cited by 78 · see citing works
Herránz, B., Marquez, S. B., Guijarro, B., Aracil, E., Aicart-Ramos, C., Rodríguez‐Crespo, I., Serrano, I., Rodrı́guez-Puyol, M., Zaragoza, C., & Saura, M. (2011) · Circulation Research · doi:10.1161/circresaha.111.253948 · Cited by 68 · see citing works
McGing, J. J., Radford, S. J., Francis, S. T., Serres, S., Greenhaff, P. L., & Moran, G. W. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16465 · Cited by 60 · see citing works
Maintenance of cellular tetrahydrobiopterin homeostasis
Kim, H.-L., & Park, Y. S. (2010) · BMB Reports · doi:10.5483/bmbrep.2010.43.9.584 · Cited by 39 · see citing works
Regulation of the Expression of Inducible Nitric Oxide Synthase
Kleinert, H., Art, J., & Pautz, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00007-1 · Cited by 40 · see citing works
McCarty, M. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073321 · Cited by 40 · see citing works
Ge, Z., Ionova, I. A., Vladic, N., Pravdić, D., Hirata, N., Vasquez-Vivar, J. M., Pratt, P. F., Warltier, D. C., Pieper, G. M., & Kersten, J. R. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr079 · Cited by 28 · see citing works
Self-citationBerka, V., Liu, W., Wu, G., & Tsai, A.-L. (2014) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2014.06.011 · Cited by 26 · see citing works
Daiber, A., Oelze, M. W., Daub, S., Steven, S., Schuff, A., Kröller‐Schön, S., Hausding, M., Wenzel, P., Schulz, E., Gori, T., et al. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_48 · Cited by 21 · see citing works
Sampath, C., Okoro, E. U., Gipson, M. J., Chukkapalli, S. S., Farmer‐Dixon, C. M., & Gangula, P. R. (2020) · Journal of Periodontology · doi:10.1002/jper.20-0444 · Cited by 20 · see citing works
Pieper, G. M., Ionova, I. A., Cooley, B. C., Migrino, R. Q., Khanna, A. K., Whitsett, J., & Vasquez-Vivar, J. M. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.148569 · Cited by 18 · see citing works
Self-citationRole of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats
An, J., Du, J., Wei, N., Xu, H., Pritchard, K. A., & Shi, Y. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00364.2009 · Cited by 16 · see citing works
Vujačić-Mirski, K., Oelze, M. W., Kuntić, I., Kuntić, M., Kalinovic, S., Li, H., Zielonka, J., Münzel, T. F., & Daiber, A. (2022) · Antioxidants · doi:10.3390/antiox11061182 · Cited by 10 · see citing works
Gibson, R. H., Evans, R. J., Hotham, R., Bojarczuk, A., Lewis, A., Bielska, E., May, R. C., Elks, P. M., Renshaw, S. A., & Johnston, S. A. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/131540 · Cited by 12 · see citing works
Dihydrofolate reductase and biopterin recycling in cardiovascular disease
Crabtree, M. J., & Channon, K. M. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.09.011 · Cited by 11 · see citing works
Shi, J., Li, Y., Yang, X., Yang, D., Zhang, Y., & Liu, Y. (2014) · Pediatric Transplantation · doi:10.1111/petr.12306 · Cited by 10 · see citing works
Sethumadhavan, S., Whitsett, J., Bennett, B., Ionova, I. A., Pieper, G. M., & Vasquez-Vivar, J. M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.01.019 · Cited by 10 · see citing works
Self-citationIonova, I. A., Vasquez-Vivar, J. M., Cooley, B. C., Khanna, A. K., Whitsett, J., Herrnreiter, A. M., Migrino, R. Q., Ge, Z., Regner, K. R., Channon, K. M., et al. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00203.2010 · Cited by 10 · see citing works
Self-citationWang, J., Liu, S., Qin, N., Yang, Q., Guo, H., Zhang, F., & Yin, X. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0255 · Cited by 6 · see citing works
Higgins, C. E., & Gross, S. S. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00006-x · Cited by 5 · see citing works
Nur77 is involved in graft infiltrating T lymphocyte apoptosis in rat cardiac transplantation model
Shi, J., Wu, K., Yang, X., Yan, D., Qian, L., Zhang, C., Chen, Y., Zhang, C., Wu, X., & Liu, X. (2015) · Pathology - Research and Practice · doi:10.1016/j.prp.2015.04.010 · Cited by 4 · see citing works
- Authors
- Ionova, I. A., Vásquez-Vivar, J., Whitsett, J., Herrnreiter, A., Medhora, M., Cooley, B. C., & Pieper, G. M.
- Affiliations
- Medical College of Wisconsin (US)
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2008-11
- Volume
- 295
- Issue
- 5
- Pages
- H2178-H2187
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- PMC
- PMC2614582
- OpenAlex
- W2143404494
- Cited by
- 35
- References
- 68
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 1 · 2012: 1
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL069996, HL-069996, HL078937, R01HL067244, R01HL078937, HL067244)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Keywords
- tetrahydrobiopterin, nitric oxide production, inducible nitric oxide synthase, cardiomyocytes, cytokine induction, GTP cyclohydrolase, sepiapterin, dihydrofolate reductase, 7,8-dihydrobiopterin, cardiac allograft, cardiac inflammation, cardiac dysfunction
- MeSH terms
- Alcohol Oxidoreductases, Animals, Arginase, Biopterins, Cells, Cultured, GTP Cyclohydrolase, Male, Nitric Oxide, Proteins, Pterins, Rats, Inbred Lew, Rats, Inbred WF, RNA, Messenger, Tetrahydrofolate Dehydrogenase, Time Factors, Heart Transplantation, Cytokines, Rats, Sprague-Dawley, Phosphorus-Oxygen Lyases, Myocytes, Cardiac, Intracellular Signaling Peptides and Proteins, Rats, Nitric Oxide Synthase Type II
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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