The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Costameres, focal adhesions, and cardiomyocyte mechanotransduction
Abstract
Mechanotransduction refers to the cellular mechanisms by which load-bearing cells sense physical forces, transduce the forces into biochemical signals, and generate appropriate responses leading to alterations in cellular structure and function. This process affects the beat-to-beat regulation of cardiac performance but also affects the proliferation, differentiation, growth, and survival of the cellular components that comprise the human myocardium. This review focuses on the experimental evidence indicating that the costamere and its structurally related structure the focal adhesion complex are critical cytoskeletal elements involved in cardiomyocyte mechanotransduction. Biochemical signals originating from the extracellular matrix-integrin-costameric protein complex share many common features with those signals generated by growth factor receptors. The roles of key regulatory kinases and other muscle-specific proteins involved in mechanotransduction and growth factor signaling are discussed, and issues requiring further study in this field are outlined.
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Cites
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Cited by
Appreciating force and shape—the rise of mechanotransduction in cell biology
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Intermediate filaments: from cell architecture to nanomechanics
Herrmann, H., Bär, H., Kreplak, L., Strelkov, S. V., & Aebi, U. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2197 · Cited by 698
A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart
Kalsotra, A., Xiao, X., Ward, A. J., Castle, J. C., Johnson, J. M., Burge, C. B., & Cooper, T. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809045105 · Cited by 508
Cardiac fibroblasts: friend or foe?
Baudino, T. A., Carver, W., Giles, W., & Borg, T. K. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00023.2006 · Cited by 427
Sarcomere alignment is regulated by myocyte shape
Bray, M., Sheehy, S. P., & Parker, K. K. (2008) · Cell Motility · doi:10.1002/cm.20290 · Cited by 228
Metadata
- Authors
- Samarel, A. M.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2005-12
- Volume
- 289
- Issue
- 6
- Pages
- H2291-H2301
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2112465301
- Cited by
- 300
- References
- 123
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- closed
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