Chemerin promotes the proliferation and migration of vascular smooth muscle and increases mouse blood pressure

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Chemerin Activation by Serine Proteases of the Coagulation, Fibrinolytic, and Inflammatory Cascades

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Mast cell–expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis

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Chemerin Connects Fat to Arterial Contraction

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Expression, Regulation, and Function of Atypical Chemerin Receptor CCRL2 on Endothelial Cells

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Gpr1 is an active chemerin receptor influencing glucose homeostasis in obese mice

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Chemerin reveals its chimeric nature

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Chemerin Regulates NK Cell Accumulation and Endothelial Cell Morphogenesis in the Decidua during Early Pregnancy

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Oxidative stress mediates chemerin-induced autophagy in endothelial cells

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Proteolytic regulatory mechanism of chemerin bioactivity

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Histone Deacetylase 4 Controls Neointimal Hyperplasia via Stimulating Proliferation and Migration of Vascular Smooth Muscle Cells

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Chemerin reduces vascular nitric oxide/cGMP signalling in rat aorta: a link to vascular dysfunction in obesity?

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EXPRESSION AND FUNCTIONAL ANALYSIS OF CHEMOKINE RECEPTORS IN HUMAN PERIPHERAL BLOOD LEUKOCYTE POPULATIONS

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Up‐regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis

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Death-Associated Protein Kinase 3 Mediates Vascular Inflammation and Development of Hypertension in Spontaneously Hypertensive Rats

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The adipokine chemerin augments vascular reactivity to contractile stimuli via activation of the MEK-ERK1/2 pathway

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Chemerin regulates proliferation and differentiation of myoblast cells via ERK1/2 and mTOR signaling pathways

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Serum chemerin levels are associated with the presence and extent of coronary artery disease

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A novel adipocytokine, omentin, inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell migration through antioxidative mechanism

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Induction of glial L‐CCR mRNA expression in spinal cord and brain in experimental autoimmune encephalomyelitis

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Eukaryotic elongation factor 2 kinase controls proliferation and migration of vascular smooth muscle cells

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Mechanisms Underlying Pioglitazone-Mediated Relaxation in Isolated Blood Vessel

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Death-associated protein kinase 3 mediates vascular structural remodelling via stimulating smooth muscle cell proliferation and migration

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Chemerin: a multifaceted adipokine involved in metabolic disorders

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Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue

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Chemerin Isoforms and Activity in Obesity

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Chemerin Elicits Potent Constrictor Actions via Chemokine‐Like Receptor 1 (CMKLR1), not G‐Protein‐Coupled Receptor 1 (GPR1), in Human and Rat Vasculature

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Pro‐contractile effects of perivascular fat in health and disease

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Chemerin as a Driver of Hypertension: A Consideration

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Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II–Induced Hypertensive Mice

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Chemerin-9, a potent agonist of chemerin receptor (ChemR23), prevents atherogenesis

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The adipokine chemerin amplifies electrical field-stimulated contraction in the isolated rat superior mesenteric artery

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Role of Chemerin in Cardiovascular Diseases

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Chemerin – exploring a versatile adipokine

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Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary arterial hypertension by serum proteome analysis

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Chemerin-induced arterial contraction is Gi- and calcium-dependent

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Chemerin acts via CMKLR1 and GPR1 to stimulate migration and invasion of gastric cancer cells: putative role of decreased TIMP-1 and TIMP-2

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Chemerin Forms: Their Generation and Activity

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Role of Chemerin/ChemR23 axis as an emerging therapeutic perspective on obesity-related vascular dysfunction

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Prochemerin cleavage by factor XIa links coagulation and inflammation

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Association of Chemerin and Vascular Endothelial Growth Factor (VEGF) with Diabetic Nephropathy

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Parental Dietary Protein Source and the Role of CMKLR1 in Determining the Severity of Dahl Salt-Sensitive Hypertension

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Chemerin in atherosclerosis

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Chemerin stimulates aortic smooth muscle cell proliferation and migration via activation of autophagy in VSMCs of metabolic hypertension rats.

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Adipokine Chemerin Stimulates Progression of Atherosclerosis in ApoE−/− Mice

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The chemerin knockout rat reveals chemerin dependence in female, but not male, experimental hypertension

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Adipocytokine Involvement in Innate Immune Mechanisms

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Vaspin prevents elevation of blood pressure through inhibition of peripheral vascular remodelling in spontaneously hypertensive rats

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Association of Circulating Chemerin With Subclinical Parameters of Atherosclerosis

Zylla, S., Dörr, M., Völzke, H., Schminke, U., Felix, S. B., Nauck, M. A., & Friedrich, N. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311219 · Cited by 25 · see citing works

Immunometabolic Regulation of Vascular Redox State: The Role of Adipose Tissue

Oikonomou, E. K., & Antoniades, C. A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7017 · Cited by 24 · see citing works

The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Aβ Deposition through p38 MAPK Pathway

Chen, Y., Liu, Z., Gong, P., Zhang, H., Chen, Y., Yao, S., Li, W., Zhang, Y., & Yu, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169041 · Cited by 25 · see citing works

Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats

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Circulating chemerin level is associated with metabolic, biochemical and haematological parameters—A population‐based study

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Chemerin Stimulates Vascular Smooth Muscle Cell Proliferation and Carotid Neointimal Hyperplasia by Activating Mitogen-Activated Protein Kinase Signaling

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Canstatin stimulates migration of rat cardiac fibroblasts via secretion of matrix metalloproteinase-2

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Chemerin influences endothelin- and serotonin-induced pulmonary artery vasoconstriction in rats

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Vasculo-protective effect of BMS-309403 is independent of its specific inhibition of fatty acid-binding protein 4

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Chemerin Regulates the Proliferation and Migration of Pulmonary Arterial Smooth Muscle Cells via the ERK1/2 Signaling Pathway

Peng, L., Chen, Y., Li, Y., Feng, P., Zheng, Y., Dong, Y., Yang, Y., Wang, R., Li, A., Yan, J., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.767705 · Cited by 19 · see citing works

Vascular effects of perivascular adipose tissue-derived chemerin in obesity-associated cardiovascular disease

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Vascular chemerin from PVAT contributes to norepinephrine and serotonin-induced vasoconstriction and vascular stiffness in a sex-dependent manner

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Circulating chemerin level may be associated with early vascular pathology in obese children without overt arterial hypertension – preliminary results

Wójcik, M., Kozioł-Kozakowska, A., Januś, D., Furtak, A., Małek, A., Sztefko, K., & Starzyk, J. (2020) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2019-0460 · Cited by 18 · see citing works

Increased circulating chemerin in patients with advanced carotid stenosis

Kammerer, A., Staab, H., Herberg, M., Kerner, C., Klöting, N., & Aust, G. (2018) · BMC Cardiovascular Disorders · doi:10.1186/s12872-018-0803-7 · Cited by 18 · see citing works

Endogenous Chemerin from PVAT Amplifies Electrical Field-Stimulated Arterial Contraction: Use of the Chemerin Knockout Rat

Flood, E. D., & Watts, S. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176392 · Cited by 16 · see citing works

Chemerin-9 stimulates migration in rat cardiac fibroblasts in vitro

Yamamoto, A., Sagara, A., Otani, K., Okada, M., & Yamawaki, H. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174566 · Cited by 15 · see citing works

Postnatal and Adult Aortic Heart Valves Have Distinctive Transcriptional Profiles Associated With Valve Tissue Growth and Maintenance Respectively

Nordquist, E., LaHaye, S., Nagel, C., & Lincoln, J. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00030 · Cited by 15 · see citing works

Chemerin as a Driver of Cardiovascular Diseases: New Perspectives and Future Directions

Imiela, A. M., Stępnicki, J., Zawadzka, P. S., Bursa, A., & Pruszczyk, P. (2025) · Biomedicines · doi:10.3390/biomedicines13061481 · Cited by 13 · see citing works

Chemerin Added to Endothelin-1 Promotes Rat Pulmonary Artery Smooth Muscle Cell Proliferation and Migration

Hanthazi, A., Jespers, P., Vegh, G., Dubois, C., Hubesch, G., Springael, J., Dewachter, L., & Entee, K. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00926 · Cited by 13 · see citing works

Understanding the Role of Chemerin in the Pathophysiology of Pre-Eclampsia

Pankiewicz, K., & Issat, T. (2023) · Antioxidants · doi:10.3390/antiox12040830 · Cited by 13 · see citing works

Acute intracerebroventricular injection of chemerin-9 increases systemic blood pressure through activating sympathetic nerves via CMKLR1 in brain

Yamamoto, A., Matsumoto, K., Hori, K., Kameshima, S., Yamaguchi, N., Okada, S., Okada, M., & Yamawaki, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02391-4 · Cited by 13 · see citing works

Circulating chemerin levels are determined through circulating platelet counts in nondiabetic Taiwanese people: A bidirectional Mendelian randomization study

Hsu, L., Chou, H., Teng, M., Wu, S., & Ko, Y. (2021) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2021.01.014 · Cited by 12 · see citing works

Novel Targets for Hypertension Drug Discovery

Bhatt, L. K., Selokar, I., Raut, D., & Hussain, T. (2021) · Current Hypertension Reports · doi:10.1007/s11906-021-01137-6 · Cited by 11 · see citing works

Chemerin is resident to vascular tunicas and contributes to vascular tone

Wabel, E., Orr, A., Flood, E. D., Thompson, J., Xie, H., Demireva, E. Y., Abolibdeh, B., Hulbert, D. H., Mullick, A. E., Garver, H. S., et al. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00239.2023 · Cited by 11 · see citing works

Adipocytokine, progranulin, augments acetylcholine‐induced nitric oxide‐mediated relaxation through the increases of cGMP production in rat isolated mesenteric artery

Kazama, K., Hoshino, K., Kodama, T., Okada, M., & Yamawaki, H. (2016) · Acta Physiologica · doi:10.1111/apha.12739 · Cited by 11 · see citing works

Chemerin in the Spotlight: Revealing Its Multifaceted Role in Acute Myocardial Infarction

Mitsis, A., Khattab, E., Myrianthefs, M. M., Tzikas, S., Kadoglou, N. P. E., Fragakis, N., Ziakas, A., & Kassimis, G. (2024) · Biomedicines · doi:10.3390/biomedicines12092133 · Cited by 9 · see citing works

Arterial Hypertension: Novel Pharmacological Targets and Future Perspectives

Popa, I. P., Clim, A., Pînzariu, A. C., Lazăr, C. I., Popa, Ș., Tudorancea, I. M., Moscalu, M., Șerban, D. N., Șerban, I. L., Costache-Enache, I.-I., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13195927 · Cited by 10 · see citing works

MicroRNA-7 overexpression positively regulates the CD8+ SP cell development via targeting PIK3R1

Hu, L. T., Zhou, Y., Yang, J., Zhao, X., Mao, L., Zheng, W., Zhao, J., Guo, M., Chen, C., He, Z., et al. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112824 · Cited by 9 · see citing works

Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive Rats Mediates Systemic Hypertension

Yamamoto, A., Otani, K., Okada, M., & Yamawaki, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111812 · Cited by 9 · see citing works

Chemokine-Like Receptor 1 Regulates the Proliferation and Migration of Vascular Smooth Muscle Cells

Liu, H., Xiong, W. G., Liu, Q., Zhang, J., & Dong, S. (2016) · Medical Science Monitor · doi:10.12659/msm.897832 · Cited by 9 · see citing works

Chemerin as a Mediator of Hypertension and Cardiometabolic Diseases (A Comprehensive Review)

McMillan, R. K., & Kirabo, A. (2025) · Current Hypertension Reports · doi:10.1007/s11906-025-01354-3 · Cited by 8 · see citing works

Chemerin Regulates Epithelial Barrier Function of Mammary Glands in Dairy Cows

Suzuki, Y., Chiba, S., Nishihara, K., Nakajima, K., Hagino, A., Kim, W.-S., Lee, H., Nochi, T., Suzuki, T., & Roh, S. (2021) · Animals · doi:10.3390/ani11113194 · Cited by 7 · see citing works

MTMR7 attenuates the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary hypertension by suppressing ERK/STAT3 signaling

Wang, J., Xuan, B., Song, B., Wang, T., Lan, C., Guo, W., Yang, Y., & Sun, X. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05217-y · Cited by 5 · see citing works

Prognostic Utility Of Novel Biomarkers in Aortic Valve Stenosis

Tretjakovs, P., Hofmanis, J., Hofmane, D., Krieviņa, G., Blumfelds, L., Mackēvičs, V., Lejnieks, A., & Bahs, G. (2019) · Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences · doi:10.2478/prolas-2019-0016 · Cited by 4 · see citing works

α-NETA down-regulates CMKLR1 mRNA expression in ileum and prevents body weight gains collaborating with ERK inhibitor PD98059 in turn to alleviate hepatic steatosis in HFD-induced obese mice but no impact on ileal mucosal integrity and steatohepatitis progression

Zheng, C., Zheng, Y., Chen, X., Zhong, X.-Y., Zheng, X., Yang, S., & Zheng, Z. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-023-01267-9 · Cited by 4 · see citing works

Chemerin promotes microangiopathy in diabetic retinopathy via activation of ChemR23 in rat primary microvascular endothelial cells.

Li, J., Song, L., & Hui, S. (2021) · Europe PMC (PubMed Central) · Cited by 4 · see citing works

Chemerin Normal Function and Roles in Metabolic and Nonmetabolic Disorders: An Up‐To‐Date Comprehensive Review

Ahmed, N. A., Hussein, A. A., Khalil, R. G., Yassin, N. Y. S., Abdelaziz, M. A., Geddawy, A., & Ahmed, O. M. (2026) · Biochemistry Research International · doi:10.1155/bri/1761697 · Cited by 3 · see citing works

Chemerin knockout reveals sex difference in the role of chemerin in blood pressure and vascular remodeling

Wabel, E., Garver, H. S., Krieger-Burke, T., Xie, F., Zeng, L., Mullick, A. E., Fink, G. D., & Watts, S. W. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00152.2026 · Cited by 2 · see citing works

Chemerin/ChemerinR1 axis and inflammation-related diseases

Li, J., Mao, C., Li, K., Huang, Y., Yang, Y., Li, K., Li, S., & Wen, L. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1785693 · Cited by 1 · see citing works

The Role of Perivascular Fat in Raising Blood Pressure in Obesity and Diabetes

Aghamohammadzadeh, R., & Heagerty, A. M. (2018) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-319-75310-2_20

Pathophysiological Mechanisms Implicated in Organ Damage and Cardiovascular Events

Aghamohammadzadeh, R., & Heagerty, A. M. (2020) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-030-47801-8_14

Españoles durante la Segunda Guerra Mundial en Francia

Chaussec, D. (2013) · UCrea (University of Cantabria)

Chemerin fragments show different effects on systemic blood pressure dependent on carboxyl-terminal cleavage site

Yamamoto, A., Kodama, T., Otani, K., Okada, M., & Yamawaki, H. (2022) · Journal of Veterinary Medical Science · doi:10.1292/jvms.22-0301

Clinical Predictive Value and Research Progress of Serum Chemerin

江, 倩. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1441341

CMKLR-1 Expression in Human Aorta Is Dominated by Smooth Muscle Cell Positivity

Öster, H., Chen, T., Mennander, A., Paavonen, T., & Kholová, I. (2025) · Journal of Histochemistry & Cytochemistry · doi:10.1369/00221554251350743

SCD1 deficiency alters the perivascular secretory function of adipocytes and induces phenotypic changes in vascular smooth muscle cells

Sówka, A., Balatskyi, V. V., Navrulin, V. O., Ntambi, J. M., & Dobrzyń, P. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117633

Chemerin, hypertension, and the imperative of sex-based analysis: lessons from Wabel et al.

Webb, R. C. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00486.2026

Self-assembled, carrier-free cyclic chemerin 9/tannic acid coating for enhanced vascular healing following stent deployment

Wen, L., Li, S., Xia, X., Huang, Y., Yang, Y., Li, K., Li, J., Xu, M., Liu, C., Liu, G., et al. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124613

Tissue-Specific Chemerin in Atherosclerosis

Chen, M., Li, Y., Linling, F., & Liu, L. (2026) · Biomolecules · doi:10.3390/biom16091327

Abstract 9701: A Novel Adipocytokine Chemerin Stimulates Proliferation and Hypercontractility of Vascular Smooth Muscle: Implication for Pathogenesis of Obesity-related Hypertension

Yamawaki, H., Takai, M., Oda, M., Okada, M., & Hara, Y. (2012) · Circulation · doi:10.1161/circ.126.suppl_21.a9701

Chemerin stimulates aortic smooth muscle cell proliferation and migration via activation of autophagy in VSMCs of metabolic hypertension rats.

Wen, J., Wang, J., Guo, L. P., Cai, W., Wu, Y., Chen, W., & Tang, X. (2019) · Europe PMC (PubMed Central) · Cited by 31 · see citing works

Chemerin Added to Endothelin-1 Promotes Rat Pulmonary Artery Smooth Muscle Cell Proliferation and Migration

Hanthazi, A., Jespers, P., Vegh, G., Dubois, C., Hubesch, G., Springael, J., Dewachter, L., & Entee, K. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00926 · Cited by 13 · see citing works

Chemerin Stimulates Vascular Smooth Muscle Cell Proliferation and Carotid Neointimal Hyperplasia by Activating Mitogen-Activated Protein Kinase Signaling

Xiong, W. G., Luo, Y., Wu, L., Liu, F., Liu, H., Li, J., Liao, B., & Dong, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165305 · Cited by 22 · see citing works

A0818 Chemerin modulates vascular remodeling via autophagy on VSMCs in metabolic hypertension rats

Juan, W., Tang, X., & Guo, L. P. (2018) · Journal of Hypertension · doi:10.1097/01.hjh.0000548003.79757.51