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Cited by 121Adipokines, Inflammation, and Metabolic DiseasesCardiovascular and exercise physiologyRegulation of Appetite and Obesity

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Subcutaneous obesity is not associated with sympathetic neural activation

Alvarez, Guy E., Ballard, Tasha P., Beske, Stacy D., Davy, Kevin P.·2004·American Journal of Physiology-Heart and Circulatory Physiology
DOI 10.1152/ajpheart.01046.2003
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Abstract

We tested the hypothesis that muscle sympathetic nerve activity (MSNA) would not differ in subcutaneously obese (SUBOB) and nonobese (NO) men with similar levels of abdominal visceral fat despite higher plasma leptin concentrations in the former. We further hypothesized that abdominal visceral fat would be the strongest body composition- or regional fat distribution-related correlate of MSNA among these individuals. To accomplish this, we measured MSNA (via microneurography), body composition (via dual-energy X-ray absorptiometry), and abdominal fat distribution (via computed tomography) in 15 NO (body mass index ≤ 25 kg/m 2; 22.4 ± 1.4 yr) and 9 SUBOB (25 ≤ body mass index ≤ 35 kg/m 2; 23.4 ± 2.1 yr) sedentary men. As expected, body mass (94 ± 4 vs. 71 ± 2 kg), total fat mass (25 ± 2 vs. 12 ± 1 kg), and abdominal subcutaneous fat (307 ± 36 vs. 132 ± 12 cm 2) were significantly higher in the SUBOB group compared with NO peers. However, the level of abdominal visceral fat did not differ significantly in the two groups (69 ± 7 vs. 55 ± 5 cm 2). MSNA was not different between SUBOB and NO men (23 ± 3 vs. 24 ± 2 bursts/min; P > 0.05, respectively) despite ∼2.6-fold higher ( P < 0.05) plasma leptin concentration in the SUBOB men. Furthermore, abdominal visceral fat was the only body composition- or regional fat distribution-related correlate ( r = 0.45; P < 0.05) of MSNA in the pooled sample. In addition, abdominal visceral fat was related to MSNA in NO ( r = 0.58; P = 0.0239) but not SUBOB ( r = 0.39; P = 0.3027) men. Taken together with our previous observations, our findings suggest that the relation between obesity and MSNA is phenotype dependent. The relation between abdominal visceral fat and MSNA was evident in NO but not in SUBOB men and at levels of abdominal visceral fat below the level typically associated with elevated cardiovascular and metabolic disease risk. Our observations do not support an obvious role for leptin in contributing to sympathetic neural activation in human obesity and, in turn, are inconsistent with the concept of selective leptin resistance.

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Metadata

Authors
Alvarez, G. E., Ballard, T. P., Beske, S. D., & Davy, K. P.
Affiliations
Virginia Tech (US)
ORCID
Davy, Kevin P.
Venue
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Published
2004-07
Volume
287
Issue
1
Pages
H414-H418
ISSN
  • 0363-6135 (ISSN-L)
  • 1522-1539
DOI
10.1152/ajpheart.01046.2003
OpenAlex
W2137441166
Semantic Scholar
b4c8c1b421291d2f249c98c28561bfb11a6096f8
Cited by
121
References
44
Citations by year
2025: 4 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 8 · 2014: 11 · 2013: 10 · 2012: 9
FWCI
4.81
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (HL62283, K02HL067227, R01HL062283, HL67227)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
muscle sympathetic nerve activity, visceral fat, leptin, sympathetic nervous system, body composition, regional fat distribution, obesity phenotypes, sedentary adults, cardiovascular risk, metabolic risk
MeSH terms
Abdomen, Adipose Tissue, Adult, Anthropometry, Body Composition, Humans, Male, Obesity, Sympathetic Nervous System, Case-Control Studies, Baroreflex, Muscle, Skeletal, Leptin, Subcutaneous Tissue

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