Reactive oxygen species and the control of vascular function
Open accessAbstract
This article summarizes perspectives on how reactive oxygen species (ROS) and redox signaling mechanisms participate in regulating vascular smooth muscle function that have resulted from our studies over the past 25 years in areas including oxygen sensing and the regulation of cGMP production by soluble guanylate cyclase (sGC) that were presented in the Robert M. Berne Distinguished Lectureship at the 2008 Experimental Biology Meeting. It considers mechanisms controlling the activity of sources of ROS including Nox oxidases and mitochondria by physiological stimuli, vascular diseases processes, and metabolic mechanisms linked to NAD(P)H redox and hypoxia. Metabolic interactions of individual ROS such as hydrogen peroxide with cellular peroxide metabolizing enzymes are viewed as some of the most sensitive ways of influencing cellular signaling systems. The control of cytosolic NADPH redox also seems to be a major contributor to bovine coronary arterial relaxation to hypoxia, where its oxidation functions to coordinate the lowering of intracellular calcium, whereas increased cytosolic NADPH generation in pulmonary arteries appears to maintain elevated Nox oxidase activity, and relaxation to hydrogen peroxide, which is attenuated by hypoxia. The sensitivity of sGC to nitric oxide seems to be regulated by thiol and heme redox systems controlled by cytosolic NADPH. Heme biosynthesis and metabolism are also important factors regulating the sGC system. The signaling pathways controlling oxidases and their colocalization with redox-regulated systems enables selective activation of numerous regulatory mechanisms influencing vascular function in physiological processes and the progression of aging-associated vascular diseases.
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Post-prandial hyperglycemia initiates a shift in redox systems, characterized by cellular membrane injury by free radicals, as well as reduced circulating homocysteine levels.
“It has been proposed that post-prandial hyperglycemia initiates a shift in redox systems, characterized by cellular membrane injury by free radicals, as well as reduced circulating homocysteine levels [56].”
From Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis (2014) · cites this paper as [56]
The passage labeled Abstract (page unavailable) says elevated glucose can increase reactive oxygen species in the vessel wall, and the glucose-metabolism passage links glucose pathways to cellular redox control. It does not establish the specifically post-prandial setting, free-radical injury to cell membranes, or reduced circulating homocysteine; searches for those terms did not find supporting passages. (LLM, conf=0.86)
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Cites
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952 · see citing works
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390 · see citing works
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827 · see citing works
Fridovich, I. (1975) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.44.070175.001051 · Cited by 1,735 · see citing works
The cellular production of hydrogen peroxide
Boveris, A., Oshino, N., & Chance, B. (1972) · Biochemical Journal · doi:10.1042/bj1280617 · Cited by 1,549 · see citing works
Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology
Li, J.-M., & Shah, A. M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00124.2004 · Cited by 773 · see citing works
Angiotensin II Stimulation of NAD(P)H Oxidase Activity
Seshiah, P., Weber, D. S., Ročić, P., Valppu, L., Taniyama, Y., & Griendling, K. K. (2002) · Circulation Research · doi:10.1161/01.res.0000033523.08033.16 · Cited by 709 · see citing works
Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells
Hilenski, L. L., Clempus, R. E., Quinn, M. T., Lambeth, J. D., & Griendling, K. K. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000112024.13727.2c · Cited by 573 · see citing works
Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function
Csiszár, A., Ungvari, Z. I., Edwards, J. G., Kaminski, P. M., Wolin, M. S., Koller, Á., & Kaley, G. (2002) · Circulation Research · doi:10.1161/01.res.0000020401.61826.ea · Cited by 565 · see citing works
Self-citationForman, H., Fukuto, J., & Torres, M. (2004) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00516.2003 · Cited by 538 · see citing works
PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH.
Kukreja, R. C., Kontos, H. A., Hess, M. L., & Ellis, E. F. (1986) · Circulation Research · doi:10.1161/01.res.59.6.612 · Cited by 487 · see citing works
Regulation of ROS signal transduction by NADPH oxidase 4 localization
Chen, K., Kirber, M. T., Xiao, H. Q., Yang, Y., & Keaney, J. F. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709049 · Cited by 468 · see citing works
Free radical biology and medicine: it's a gas, man!
Pryor, W. A., Houk, K. N., Foote, C. S., Fukuto, J. M., Ignarro, L. J., Squadrito, G. L., & Davies, K. J. A. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00614.2005 · Cited by 465 · see citing works
Interactions of oxidants with vascular signaling systems
Wolin, M. S. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.6.1430 · Cited by 463 · see citing works
Self-citationCysteine Redox Sensor in PKGIa Enables Oxidant-Induced Activation
Burgoyne, J. R., Madhani, M., Cuello, F., Charles, R. L., Brennan, J. P., Schröder, E., Browning, D. D., & Eaton, P. (2007) · Science · doi:10.1126/science.1144318 · Cited by 457 · see citing works
Stasch, J., Schmidt, P. M., Nedvetsky, P. I., Nedvetskaya, T. Y., Kumar, A. H. S., Meurer, S., Deile, M., Taye, A., Knorr, A., Lapp, H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28371 · Cited by 456 · see citing works
Hypoxic pulmonary vasoconstriction
Moudgil, R., Michelakis, E. D., & Archer, S. L. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00733.2004 · Cited by 452 · see citing works
THE OXIDATION OF DRUGS BY LIVER MICROSOMES: ON THE ROLE OF TPNH AND OXYGEN
Gillette, J. H., Brodie, B. B., & Du, B. N. L. (1957) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11915-0 · Cited by 409 · see citing works
George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury.
Kontos, H. A. (1985) · Circulation Research · doi:10.1161/01.res.57.4.508 · Cited by 392 · see citing works
Archer, S. L., Gomberg‐Maitland, M., Maitland, M. L., Rich, S., Garcia, J. G. N., & Weir, Ε. K. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01324.2007 · Cited by 366 · see citing works
A redox-based O2 sensor in rat pulmonary vasculature.
Archer, S. L., Huang, J., Henry, T., Peterson, D., & Weir, E. K. (1993) · Circulation Research · doi:10.1161/01.res.73.6.1100 · Cited by 362 · see citing works
Redox Mechanisms in Blood Vessels
Mueller, C. F. H., Laude, K. M., McNally, J. S., & Harrison, D. G. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000149143.04821.eb · Cited by 342 · see citing works
Craven, P. A., & DeRubertis, F. R. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34310-7 · Cited by 328 · see citing works
Free Radicals, Mitochondria, and Oxidized Lipids
Gutiérrez, J., Ballinger, S. W., Darley-Usmar, V. M., & Landar, A. L. (2006) · Circulation Research · doi:10.1161/01.res.0000248212.86638.e9 · Cited by 319 · see citing works
Diversity in Mitochondrial Function Explains Differences in Vascular Oxygen Sensing
Michelakis, E. D., Hampl, V., Nsair, A., Wu, X., Harry, G., Haromy, A., Gurtu, R., & Archer, S. L. (2002) · Circulation Research · doi:10.1161/01.res.0000024689.07590.c2 · Cited by 309 · see citing works
O 2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase
Archer, S. L., Reeve, H. L., Michelakis, E. D., Puttagunta, L., Waite, R. E., Nelson, D. P., Dinauer, M. C., & Weir, Ε. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7944 · Cited by 263 · see citing works
Turkseven, S., Kruger, A., Mingone, C. J., Kaminski, P., Inaba, M., Rodella, L. F., Ikehara, S., Wolin, M. S., & Abraham, N. G. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00024.2005 · Cited by 256 · see citing works
Self-citationHydrogen peroxide elicits pulmonary arterial relaxation and guanylate cyclase activation
Burke, T. M., & Wolin, M. S. (1987) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1987.252.4.h721 · Cited by 256 · see citing works
Self-citationActivation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta
Jin, L., Ying, Z., & Webb, R. C. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01006.2003 · Cited by 243 · see citing works
Modulation of Vascular Smooth Muscle Signaling by Reactive Oxygen Species
Lyle, A. N., & Griendling, K. K. (2006) · Physiology · doi:10.1152/physiol.00004.2006 · Cited by 239 · see citing works
Constraints on prostaglandin biosynthesis in tissues.
Marshall, P. J., Kulmacz, R. J., & Lands, W. E. M. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61380-8 · Cited by 221 · see citing works
Tate, R. M., Morris, H. G., Schroeder, W. R., et al. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111458 · Cited by 215 · see citing works
Omar, H. Α., Cherry, P. D., Mortelliti, M. P., Burke-Wolin, T., & Wolin, M. S. (1991) · Circulation Research · doi:10.1161/01.res.69.3.601 · Cited by 212 · see citing works
Self-citationUngvari, Z. I., Csiszár, A., Huang, A., Kaminski, P. M., Wolin, M. S., & Koller, Á. (2003) · Circulation · doi:10.1161/01.cir.0000079165.84309.4d · Cited by 200 · see citing works
Self-citationWolin, M. S., Ahmad, M., & Gupte, S. A. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00060.2005 · Cited by 188 · see citing works
Self-citationWolin, M. S., Wood, K. S., & Ignarro, L. J. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33448-3 · Cited by 186 · see citing works
Self-citationDiabetes Mellitus Impairs Vasodilation to Hypoxia in Human Coronary Arterioles
Miura, H., Wachtel, R. E., Loberiza, F. R., Saito, T., Miura, M., Nicolosi, A. C., & Gutterman, D. D. (2003) · Circulation Research · doi:10.1161/01.res.0000052671.53256.49 · Cited by 185 · see citing works
Activation of a local renin angiotensin system in podocytes by glucose
Durvasula, R. V., & Shankland, S. J. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00266.2007 · Cited by 162 · see citing works
Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing
Waypa, G. B., & Schumacker, P. T. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00722.2004 · Cited by 162 · see citing works
Oeckler, R. A., Kaminski, P. M., & Wolin, M. S. (2003) · Circulation Research · doi:10.1161/01.res.0000051860.84509.ce · Cited by 157 · see citing works
Self-citationDéliot, N., Hernando, N., Horst-Liu, Z., Gisler, S. M., Capuano, P., Wagner, C. A., Bacic, D., O'Brien, S., Biber, J., & Murer, H. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00456.2004 · Cited by 130 · see citing works
Redox status in the control of pulmonary vascular tone.
Archer, S., Will, J. A., & Weir, E. K. (1986) · PubMed · Cited by 128 · see citing works
Chronic High Pressure-Induced Arterial Oxidative Stress
Ungvari, Z. I., Csiszár, A., Kaminski, P. M., Wolin, M. S., & Koller, Á. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63290-7 · Cited by 122 · see citing works
Self-citationMohazzab, K. M., & Wolin, M. S. (1994) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1994.267.6.l823 · Cited by 122 · see citing works
Self-citationGupte, S. A., Kaminski, P. M., Floyd, B. C., Agarwal, R., Ali, N., Ahmad, M., Edwards, J. G., & Wolin, M. S. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00629.2004 · Cited by 120 · see citing works
Self-citationBagi, Z. A., Koller, Á., & Kaley, G. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00235.2003 · Cited by 113 · see citing works
Superoxide anion inhibits cGMP-associated bovine pulmonary arterial relaxation
Cherry, P. D., Omar, H. Α., Farrell, K. A., Stuart, J. S., & Wolin, M. S. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.259.4.h1056 · Cited by 112 · see citing works
Self-citationCsiszár, A., Labinskyy, N., Xiangmin, Z., Hu, F., Serpillon, S., Huang, Z., Ballabh, P., Levy, R. J., Hintze, T. H., Wolin, M. S., et al. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00339.x · Cited by 111 · see citing works
Self-citationXanthine oxidoreductase in respiratory and cardiovascular disorders
Boueiz, A. R., Damarla, M., & Hassoun, P. M. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00007.2008 · Cited by 98 · see citing works
ON THE REACTION OF CATALASE PEROXIDES WITH ACCEPTORS
Chance, B. (1950) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)56500-5 · Cited by 88 · see citing works
Mohazzab-H., K. M., Kaminski, P. M., Fayngersh, R. P., & Wolin, M. S. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.3.h1044 · Cited by 86 · see citing works
Self-citationH2O2 and cGMP may function as an O2 sensor in the pulmonary artery
Burke-Wolin, T., & Wolin, M. S. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.66.1.167 · Cited by 81 · see citing works
Self-citationZou, M.-H., & Bachschmid, M. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.1.135 · Cited by 80 · see citing works
Gupte, S. A., Arshad, M., Viola, S., et al. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00229.2003 · Cited by 66 · see citing works
Ungvari, Z. I., Wolin, M. S., & Csiszár, A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1121 · Cited by 64 · see citing works
Self-citationMingone, C. J., Gupte, S. A., Chow, J. L., Ahmad, M., Abraham, N. G., & Wolin, M. S. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00482.2005 · Cited by 63 · see citing works
Self-citationMohazzab-H., K. M., Fayngersh, R. P., Kaminski, P. M., & Wolin, M. S. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.269.5.l637 · Cited by 63 · see citing works
Self-citationHypoxia promotes relaxation of bovine coronary arteries through lowering cytosolic NADPH
Gupte, S. A., & Wolin, M. S. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00615.2005 · Cited by 60 · see citing works
Self-citationOxygen sensing in hypoxic pulmonary vasoconstriction: using new tools to answer an age‐old question
Waypa, G. B., & Schumacker, P. T. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2007.041236 · Cited by 58 · see citing works
Winger, J. A., Derbyshire, E. R., & Marletta, M. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606327200 · Cited by 55 · see citing works
Gao, Q., & Wolin, M. S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00316.2008 · Cited by 54 · see citing works
Self-citationNO elicits prolonged relaxation of bovine pulmonary arteries via endogenous peroxynitrite generation
Davidson, C. A., Kaminski, P. M., & Wolin, M. S. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.273.2.l437 · Cited by 50 · see citing works
Self-citationO2-dependent modulation of calf pulmonary artery tone by lactate: potential role of H2O2 and cGMP
Omar, H. A., Mohazzab, K. M., Mortelliti, M. P., et al. (1993) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1993.264.2.l141 · Cited by 47 · see citing works
Inhibition of cGMP-associated pulmonary arterial relaxation to H2O2 and O2 by ethanol
Burke-Wolin, T., & Wolin, M. S. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.258.5.h1267 · Cited by 46 · see citing works
Self-citationRole of pentose phosphate pathway-derived NADPH in hypoxic pulmonary vasoconstriction
Gupte, S. A., Okada, T., McMurtry, I. F., & Oka, M. (2005) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2005.08.002 · Cited by 45 · see citing works
NADPH and heme redox modulate pulmonary artery relaxation and guanylate cyclase activation by NO
Gupte, S. A., Rupawalla, T., Phillibert, D., & Wolin, M. S. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.6.l1124 · Cited by 39 · see citing works
Self-citationIesaki, T., & Wolin, M. S. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.11.2359 · Cited by 35 · see citing works
Self-citationInfluence of glutathione peroxidase on coronary artery responses to alterations in P o 2and H2O2
Mohazzab-H., K. M., Agarwal, R., & Wolin, M. S. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.1.h235 · Cited by 34 · see citing works
Self-citationKim, M. K., Han, I. S., Koh, S. D., et al. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00397.2005 · Cited by 32 · see citing works
Mingone, C. J., Gupte, S. A., Ali, N., et al. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00331.2005 · Cited by 31 · see citing works
Cytosolic NADH redox and thiol oxidation regulate pulmonary arterial force through ERK MAP kinase
Oeckler, R. A., Arcuino, E., Ahmad, M., et al. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00223.2004 · Cited by 28 · see citing works
Nitric oxide inhibits pulmonary artery catalase and H2O2-associated relaxation
Mohazzab-H., K. M., Fayngersh, R. P., & Wolin, M. S. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.5.h1900 · Cited by 27 · see citing works
Self-citationOxygen metabolites and vasodilator mechanisms in rat cremasteric arterioles
Wolin, M. S., Rodenburg, J. M., Messina, E. J., et al. (1987) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1987.252.6.h1159 · Cited by 23 · see citing works
Self-citationAscorbate activates soluble guanylate cyclase via H2O2-metabolism by catalase
Cherry, P., & Wolin, M. S. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90023-3 · Cited by 20 · see citing works
Self-citationMingone, C. J., Ahmad, M., Gupte, S. A., Chow, J. L., & Wolin, M. S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00846.2007 · Cited by 20 · see citing works
Self-citationReflections of a Fortunate Biochemist
Fridovich, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100040200 · Cited by 12 · see citing works
Ahmad, M., Xiangmin, Z., Kelly, M. R., et al. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.1174.3 · Cited by 5 · see citing works
Wolin, M. S., & Abraham, N. G. (2006) · Hypertension · doi:10.1161/01.hyp.0000242338.42238.d6 · Cited by 5 · see citing works
Self-citationAhmad, M., Kaminski, P. M., & Wolin, M. S. (2007) · The FASEB Journal · Cited by 4 · see citing works
Self-citationGupte, S. A., Hintze, T. H., & Wolin, M. S. (2006) · The FASEB Journal · doi:10.1096/fasebj.20.4.a724-b · Cited by 1 · see citing works
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Cytoprotective Effects of Hydrogen Sulfide in Novel Rat Models of Non-Erosive Esophagitis
Zayachkivska, O., Havryluk, O., Hrycevych, N., Bula, N., Grushka, O., & Wallace, J. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110688 · Cited by 34 · see citing works
“It has been proposed that post-prandial hyperglycemia initiates a shift in redox systems, characterized by cellular membrane injury by free radicals, as well as reduced circulating homocysteine levels [56].”
BackgroundTherapeutics Targeting of Dysregulated Redox Equilibrium and Endothelial Dysfunction
Risbano, M. G., & Gladwin, M. T. (2013) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-662-45805-1_13 · Cited by 32 · see citing works
- Authors
- Wolin, M. S.
- Affiliations
- New York Medical College (US)
- Corresponding author
- Wolin, Michael S.
- ORCID
- Wolin, Michael S.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2009-03
- Volume
- 296
- Issue
- 3
- Pages
- H539-H549
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- PMC
- PMC2660242
- OpenAlex
- W2144920190
- Cited by
- 133
- References
- 80
- Citations by year
- 2026: 1 · 2024: 6 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 20 · 2012: 12
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL043023, HL 66331, R01HL066331, HL 43023, HL-31069, R01HL031069)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- reactive oxygen species, redox signaling, vascular smooth muscle, soluble guanylate cyclase, cyclic GMP, NAD(P)H, NADPH oxidase, mitochondria, oxygen sensing, hypoxia, hydrogen peroxide, nitric oxide, heme biosynthesis, vasorelaxation, coronary arteries, pulmonary artery
- MeSH terms
- Aging, Animals, Hypoxia, Calcium, Cyclic GMP, Guanylate Cyclase, Heme Oxygenase (Decyclizing), Humans, Mitochondria, Muscle, Muscle, Smooth, Vascular, Nitric Oxide, Oxidation-Reduction, Vascular Diseases, Vasoconstriction, Vasodilation, Signal Transduction, Reactive Oxygen Species, NADPH Oxidases
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