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Cited by 463Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Interactions of oxidants with vascular signaling systems

Wolin, Michael S.·2000·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/01.atv.20.6.1430
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Abstract

Abstract—Individual reactive oxygen species (ROS) and oxidation products of NO interact with vascular signaling mechanisms in ways that appear to have fundamental roles in the control of vascular physiological and pathophysiological function. The activities of ROS-producing systems (including various NADPH and NADH oxidases, xanthine oxidase, and NO synthase) in endothelium and/or vascular smooth muscle are controlled by receptor activation, oxygen tension, metabolic processes, and physiological forces associated with blood pressure and flow. This review focuses on how the chemical properties and metabolic sensing interactions of individual ROS (including superoxide anion, hydrogen peroxide, and peroxynitrite) interact with cellular regulatory systems to produce vascular responses. These species appear to often function through producing selective alterations in individual heme or thiol redox–regulated systems (including guanylate cyclase, cyclooxygenase, mitochondrial electron transport, and tyrosine phosphatases) to initiate physiological responses through signaling pathways that control phospholipases, protein kinases, ion channels, contractile proteins, and gene expression.

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Crossref · 10.1161/01.atv.20.6.1430

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  • Superoxide radicals, hydrogen peroxide, singlet oxygen and hypochlorous acid HOCl are generated in the cell membrane through the action of the enzymes NADPH oxidase, myeloperoxidase and xanthine oxidase.

    “Superoxide radicals, hydrogen peroxide, singlet oxygen and hypochlorous acid HOCl are generated in the cell membrane through the action of the enzymes NADPH oxidase, myeloperoxidase and xanthine oxidase [35,36].”

    From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [35]

  • Other enzymes, such as lipooxygenase and cyclooxygenase also generate ROS during the synthesis of leukotrienes, thromboxanes and prostaglandins.

    “Other enzymes, such as lipooxygenase and cyclooxygenase also generate ROS during the synthesis of leukotrienes, thromboxanes and prostaglandins [35].”

    From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [35]

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Authors
Wolin, M. S.
Affiliations
New York Medical College (US)
Corresponding author
Wolin, Michael S.
ORCID
Wolin, Michael S.
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2000-06
Volume
20
Issue
6
Pages
1430-1442
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
DOI
10.1161/01.atv.20.6.1430
OpenAlex
W2133872346
Cited by
463
References
110
Citations by year
2025: 1 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 9 · 2016: 8 · 2015: 6 · 2014: 15 · 2013: 19 · 2012: 16
FWCI
4.75
Type
journal article
Language
en
Open access
closed
Locations
  • Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (P01HL043023, HL 43023, HL-31069)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
reactive oxygen species, vascular signaling, superoxide, hydrogen peroxide, peroxynitrite, NADPH oxidase, NADH oxidase, xanthine oxidase, nitric oxide synthase, endothelium, vascular smooth muscle, thiol redox regulation, guanylate cyclase, cyclooxygenase, mitochondrial electron transport chain, protein tyrosine phosphatase, protein kinases, ion channels, vascular contractility, gene expression
MeSH terms
Animals, Blood Vessels, Endothelium, Vascular, Humans, Muscle, Smooth, Vascular, Signal Transduction, Oxidants, Reactive Oxygen Species

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