Antioxidant mechanism of heme oxygenase-1 involves an increase in superoxide dismutase and catalase in experimental diabetes

Role of Oxidative Stress in Development of Complications in Diabetes

Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,791 · see citing works

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

Rajagopalan, S., Kurz, S. D., Münzel, T. F., Tarpey, M. M., Freeman, B. Α., Griendling, K. K., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118623 · Cited by 2,441 · see citing works

Number and Migratory Activity of Circulating Endothelial Progenitor Cells Inversely Correlate With Risk Factors for Coronary Artery Disease

Vasa‐Nicotera, M., Fichtlscherer, S., Aicher, A., Adler, K., Urbich, C., Martin, H., Zeiher, A. M., & Dimmeler, S. (2001) · Circulation Research · doi:10.1161/hh1301.093953 · Cited by 2,328 · see citing works

Ferritin: a cytoprotective antioxidant strategem of endothelium.

Balla, G., Jacob, H., Balla, J., Rosenberg, M. E., Nath, K. A., Apple, F., Eaton, J. W., & Vercellotti, G. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37165-0 · Cited by 1,097 · see citing works

Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.

Morita, T., Perrella, M. A., Lee, M. E., & Kourembanas, S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1475 · Cited by 707 · see citing works

Vascular protection: superoxide dismutase isoforms in the vessel wall.

Faraci, F., & Didion, S. (2004) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000133604.20182.cf · Cited by 528 · see citing works

Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury

Otterbein, L. E., Zuckerbraun, B. S., Haga, M., Liu, F., Song, R., Usheva, A., Stachulak, C., Bodyak, N. D., Smith, R. N., Csizmadia, E., et al. (2003) · Nature Medicine · doi:10.1038/nm817 · Cited by 527 · see citing works

Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury

Otterbein, L. E., Kolls, J. K., Mantell, L. L., Cook, J. L., Alam, J., & Choi, A. M. K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5342 · Cited by 492 · see citing works

Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function

Milstien, S., & Katušić, Z. S. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1422 · Cited by 488 · see citing works

Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase.

Brüne, B., & Ullrich, V. (1987) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13029-0 · Cited by 472 · see citing works

Bilirubin Benefits: Cellular Protection by a Biliverdin Reductase Antioxidant Cycle

Sedlak, T. W., & Snyder, S. H. (2004) · PEDIATRICS · doi:10.1542/peds.113.6.1776 · Cited by 441 · see citing works

The Interstitium of the Human Arterial Wall Contains Very Large Amounts of Extracellular Superoxide Dismutase

Strålin, P., Karlsson, K., Johansson, B. O., & Marklund, S. L. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.11.2032 · Cited by 386 · see citing works

Induction of Heme Oxygenase-1 Suppresses Venular Leukocyte Adhesion Elicited by Oxidative Stress

Hayashi, S., Takamiya, R., Yamaguchi, T., Matsumoto, K., Tojo, S. J., Tamatani, T., Kitajima, M., Makino, N., Ishimura, Y., & Suematsu, M. (1999) · Circulation Research · doi:10.1161/01.res.85.8.663 · Cited by 350 · see citing works

Superoxide Dismutases

Beyer, W. F., Imlay, J. A., & Fridovich, I. (1991) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60843-0 · Cited by 347 · see citing works

Extracellular superoxide dismutase and cardiovascular disease

Fukai, T. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00328-0 · Cited by 345 · see citing works

Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity.

Abraham, N. G., Lavrovsky, Y., Schwartzman, M. L., Stoltz, R. A., Levere, R. D., Gerritsen, M. E., Shibahara, S., & Kappas, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6798 · Cited by 338 · see citing works

High Glucose Induces Antioxidant Enzymes in Human Endothelial Cells in Culture: Evidence Linking Hyperglycemia and Oxidative Stress

Ceriello, A., Russo, P. D., Amstad, P., & Cerutti, P. (1996) · Diabetes · doi:10.2337/diab.45.4.471 · Cited by 324 · see citing works

NO-mediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium

Motterlini, R., Foresti, R., Intaglietta, M., & Winslow, R. M. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.1.h107 · Cited by 317 · see citing works

An NADPH oxidase superoxide-generating system in the rabbit aorta

Pagano, P. J., Ito, Y., Tornheim, K., Gallop, P. M., Tauber, A. I., & Cohen, R. A. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.268.6.h2274 · Cited by 302 · see citing works

Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts

Petrache, I., Otterbein, L. E., Alam, J., Wiegand, G. W., & Choi, A. M. K. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.278.2.l312 · Cited by 293 · see citing works

Atherosclerosis and the Two Faces of Endothelial Nitric Oxide Synthase

Wever, R. M. F., Lüscher, T. F., Cosentino, F., & Rabelink, T. J. (1998) · Circulation · doi:10.1161/01.cir.97.1.108 · Cited by 292 · see citing works

Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL.

Ishikawa, K., Navab, M., Leitinger, N., Fogelman, A. M., & Lusis, A. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119634 · Cited by 289 · see citing works

High Glucose via Peroxynitrite Causes Tyrosine Nitration and Inactivation of Prostacyclin Synthase That Is Associated With Thromboxane/Prostaglandin H2 Receptor–Mediated Apoptosis and Adhesion Molecule Expression in Cultured Human Aortic Endothelial Cells

Zou, M.-H., Shi, C., & Cohen, R. A. (2002) · Diabetes · doi:10.2337/diabetes.51.1.198 · Cited by 262 · see citing works

Extracellular superoxide dismutase: a regulator of nitric oxide bioavailability.

Oury, T. D., Day, B. J., & Crapo, J. D. (1996) · PubMed · Cited by 256 · see citing works

The Biological Significance and Physiological Role of Heme Oxygenase

Abraham, N. G., Drummond, G. S., Lutton, J. D., & Kappas, A. (1996) · Cellular Physiology and Biochemistry · doi:10.1159/000154819 · Cited by 247 · see citing works

The direct effect of carbon monoxide on K Ca channels in vascular smooth muscle cells

Wang, R. T., Wu, L., & Wang, Z. (1997) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050398 · Cited by 228 · see citing works

[31] Antioxidant activities of bile pigments: Biliverdin and bilirubin

Stocker, R., McDonagh, A. F., Glazer, A. N., & Ames, B. N. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86123-d · Cited by 205 · see citing works

Endotoxin-Induced Mortality Is Related to Increased Oxidative Stress and End-Organ Dysfunction, Not Refractory Hypotension, in Heme Oxygenase-1–Deficient Mice

Wiesel, P., Patel, A. P., DiFonzo, N., Marria, P. B., Sim, C. U., Pellacani, A. U. E., Maemura, K., LeBlanc, B. W., Marino, K., Doerschuk, C. M., et al. (2000) · Circulation · doi:10.1161/01.cir.102.24.3015 · Cited by 191 · see citing works

Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors

Kaide, J.-I., Zhang, F., Wei, Y., Jiang, H., Yu, C., Wang, W., Balazy, M., Abraham, N. G., & Nasjletti, A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11218 · Cited by 184 · see citing works

Induction of Heme Oxygenase-1 Inhibits NAD(P)H Oxidase Activity by Down-regulating Cytochrome b558 Expression via the Reduction of Heme Availability

Taillé, C., Benna, J. E., Lanone, S., Dang, M.-C., Ogier‐Denis, É., Aubier, M., & Boczkowski, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310661200 · Cited by 181 · see citing works

Bilirubin inhibits the activation of superoxide-producing NADPH oxidase in a neutrophil cell-free system

Kwak, J., Takeshige, K., Cheung, B. S., & Minakami, S. (1991) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(91)90478-i · Cited by 164 · see citing works

Carbon monoxide and cerebral microvascular tone in newborn pigs

Leffler, C. W., Nasjletti, A., Yu, C., Johnson, R. A., Fedinec, A. L., & Walker, N. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.5.h1641 · Cited by 158 · see citing works

Heme Oxygenase-1 Attenuates Glucose-Mediated Cell Growth Arrest and Apoptosis in Human Microvessel Endothelial Cells

Abraham, N. G., Kushida, T., McClung, J. A., Weiss, M. B., Quan, S., Lafaro, R., Darżynkiewicz, Z., & Wolin, M. S. (2003) · Circulation Research · doi:10.1161/01.res.0000091828.36599.34 · Cited by 150 · see citing works

Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1

Qadri, I., Iwahashi, M., Capasso, J. M., Hopken, M. W., Flores, S. C., Schaack, J. B., & Simon, F. R. (2004) · Biochemical Journal · doi:10.1042/bj20031587 · Cited by 149 · see citing works

Role of peroxynitrite in altered fetal-placental vascular reactivity in diabetes or preeclampsia

Kossenjans, W., Eis, A., Sahay, R., Brockman, D. E., & Myatt, L. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.278.4.h1311 · Cited by 141 · see citing works

Adeno-Associated Virus Vector-Mediated Transgene Integration into Neurons and Other Nondividing Cell Targets

Wu, P., Phillips, M. I., Bui, J., & Terwilliger, E. F. (1998) · Journal of Virology · doi:10.1128/jvi.72.7.5919-5926.1998 · Cited by 137 · see citing works

Psychotropic Medication in Children: A Study From The Netherlands

Schirm, E., Tobi, H., ZITO, J. M., & den Berg, L. T. W. D. J. (2001) · PEDIATRICS · doi:10.1542/peds.108.2.e25 · Cited by 131 · see citing works

Cytosolic NADPH may regulate differences in basal Nox oxidase-derived superoxide generation in bovine coronary and pulmonary arteries

Gupte, S. A., Kaminski, P. M., Floyd, B. C., Agarwal, R., Ali, N., Ahmad, M., Edwards, J. G., & Wolin, M. S. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00629.2004 · Cited by 120 · see citing works

Heme-ligating Histidines in Flavocytochromeb 558

Biberstine-Kinkade, K. J., DeLeo, F. R., Epstein, R. I., Leroy, B. A., Nauseef, W. M., & Dinauer, M. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103327200 · Cited by 109 · see citing works

Overexpression of human heme oxygenase-1 attenuates endothelial cell sloughing in experimental diabetes

Abraham, N. G., Rezzani, R., Rodella, L. F., Kruger, A. L., Taller, D., Volti, G. L., Goodman, A. I., & Kappas, A. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01187.2003 · Cited by 109 · see citing works

12-Lipoxygenase is increased in glucose-stimulated mesangial cells and in experimental diabetic nephropathy

Kang, S., Adler, S. G., Nast, C. C., LaPage, J. A., Gu, J., Nadler, J. L., & Natarajan, R. D. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.0590041354.x · Cited by 102 · see citing works

Mode of Inhibitory Action of Bilirubin on Protein Kinase C

Sano, K., Nakamura, H., & Matsuo, T. (1985) · Pediatric Research · doi:10.1203/00006450-198506000-00017 · Cited by 94 · see citing works

Non-enzymic glycation of human extracellular superoxide dismutase

Adachi, T., Ohta, H., Hirano, K., Hayashi, K., & Marklund, S. L. (1991) · Biochemical Journal · doi:10.1042/bj2790263 · Cited by 88 · see citing works

Sustained Hypertension in the Rat Induced by Chronic Blockade of Nitric Oxide Production

Johnson, R. A., & Freeman, R. K. (1992) · American Journal of Hypertension · doi:10.1093/ajh/5.12.919 · Cited by 88 · see citing works

Oxygen-elicited responses in calf coronary arteries: role of H2O2 production via NADH-derived superoxide

Mohazzab-H., K. M., Kaminski, P. M., Fayngersh, R. P., & Wolin, M. S. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.3.h1044 · Cited by 86 · see citing works

Increased Carbon Monoxide in Exhaled Air of Critically Ill Patients

Scharte, M., Bone, H.-G., Aken, H. V., & Meyer, J. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1936 · Cited by 85 · see citing works

A Single Dose of Sn-Mesoporphyrin Prevents Development of Severe Hyperbilirubinemia in Glucose-6-Phosphate Dehydrogenase-Deficient Newborns

Kappas, A., Drummond, G. S., & Valaes, T. (2001) · PEDIATRICS · doi:10.1542/peds.108.1.25 · Cited by 84 · see citing works

Heme oxygenase-1 prevents superoxide anion-associated endothelial cell sloughing in diabetic rats

Quan, S., Kaminski, P. M., Yang, L. M., Morita, T., Inaba, M., Ikehara, S., Goodman, A. I., Wolin, M. S., & Abraham, N. G. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.086 · Cited by 78 · see citing works

Expression of human heme oxygenase-1 in the thick ascending limb attenuates angiotensin II–mediated increase in oxidative injury11See Editorial by Chang and Perrella, p. 1968

Quan, S., Yang, L., Shnouda, S., Schwartzman, M. L., Nasjletti, A., Goodman, A. I., & Abraham, N. G. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00562.x · Cited by 77 · see citing works

Protection From Ischemic Heart Injury by a Vigilant Heme Oxygenase-1 Plasmid System

Tang, Y., Tang, Y., Zhang, Y. C., Qian, K., Shen, L., & Phillips, M. I. (2004) · Hypertension · doi:10.1161/01.hyp.0000120152.27263.87 · Cited by 73 · see citing works

Heme oxygenase-1 is upregulated in the rat heart in response to chronic administration of angiotensin II

Ishizaka, N., Aizawa, T., Mori, I., Taguchi, J., Yazaki, Y., Nagai, R., & Ohno, M. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.2.h672 · Cited by 63 · see citing works

The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin.

Kappas, A., Simionatto, C. S., Drummond, G. S., Sassa, S., & Anderson, K. E. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.3.896 · Cited by 59 · see citing works

TNF-α-mediated cell death is attenuated by retrovirus delivery of human heme oxygenase-1 gene into human microvessel endothelial cells

Kushida, T., Volti, G. L., Goodman, A. I., & Abraham, N. G. (2002) · Transplantation Proceedings · doi:10.1016/s0041-1345(02)03506-6 · Cited by 46 · see citing works

The site of nonenzymic glycation of human extracellular-superoxide dismutase in vitro

Adachi, T., Ohta, H., HAYASHI, K., Hirano, K., & Marklund, S. L. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90016-a · Cited by 40 · see citing works

CO modulates pulmonary vascular response to acute hypoxia: relation to endothelin

Zhang, F., Kaide, J.-I., Yang, L., Jiang, H., Quan, S., Kemp, R., Gong, W., Balazy, M., Abraham, N. G., & Nasjletti, A. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00678.2002 · Cited by 38 · see citing works

Hypoxia enhances a cGMP-independent nitric oxide relaxing mechanism in pulmonary arteries

Mingone, C. J., Gupte, S. A., Iesaki, T., & Wolin, M. S. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00362.2002 · Cited by 32 · see citing works

In vivo role of heme oxygenase in ischemic coronary vasodilation

Nishikawa, Y., Stepp, D. W., Merkus, D., Jones, D. W., & Chilian, W. M. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00671.2003 · Cited by 28 · see citing works

Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications

Ryter, S. W., Alam, J., & Choi, A. M. K. (2006) · Physiological Reviews · doi:10.1152/physrev.00011.2005 · Cited by 2,308 · see citing works

Mechanisms of Cell Death in Oxidative Stress

Ryter, S. W., Kim, H. P., Hoetzel, A., Park, J. W., Nakahira, K., Wang, X., & Choi, A. M. K. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.49 · Cited by 1,262 · see citing works

Pharmacological and Clinical Aspects of Heme Oxygenase

Abraham, N. G., & Kappas, A. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.07104 · Cited by 1,115 · see citing works

Hyperglycemia and Oxidative Stress: An Integral, Updated and Critical Overview of Their Metabolic Interconnections

González, P., Lozano, P., Ros, G., & Solano, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119352 · Cited by 891 · see citing works

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

Sivitz, W. I., & Yorek, M. A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2531 · Cited by 742 · see citing works

Hyperglycemia and Glycation in Diabetic Complications

Nègre‐Salvayre, A., Salvayre, R., Augè, N., Pamplona, R., & Portero‐Otín, M. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2484 · Cited by 424 · see citing works

Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro

Mukhopadhyay, P., Rajesh, M., Bátkai, S., Kashiwaya, Y., Haskó, G., Liaudet, L., Szabó, C., & Pacher, P. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00795.2008 · Cited by 377 · see citing works

Heme oxygenase and the cardiovascular–renal system

Abraham, N. G., & Kappas, A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.03.010 · Cited by 356 · see citing works

Health functionality of apigenin: A review

Ali, F. R., Rahul, R., Naz, F., Jyoti, S., & Siddique, Y. H. (2016) · International Journal of Food Properties · doi:10.1080/10942912.2016.1207188 · Cited by 344 · see citing works

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

Pan, H., Guan, D., Liu, X., Li, J., Wang, L., Wu, J., Zhou, J., Zhang, W., Ren, R., Zhang, W., et al. (2016) · Cell Research · doi:10.1038/cr.2016.4 · Cited by 334 · see citing works

Treatment of Obese Diabetic Mice With a Heme Oxygenase Inducer Reduces Visceral and Subcutaneous Adiposity, Increases Adiponectin Levels, and Improves Insulin Sensitivity and Glucose Tolerance

Li, M., Kim, D. H., Tsenovoy, P. L., Peterson, S. J., Rezzani, R., Rodella, L. F., Aronow, W. S., Ikehara, S., & Abraham, N. G. (2008) · Diabetes · doi:10.2337/db07-1764 · Cited by 311 · see citing works

Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review

Unuofin, J. O., & Lebelo, S. L. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1356893 · Cited by 322 · see citing works

Heme oxygenase-1: A provenance for cytoprotective pathways in the kidney and other tissues

Nath, K. A. (2006) · Kidney International · doi:10.1038/sj.ki.5001565 · Cited by 301 · see citing works

Constitutive Endocytosis of CD163 Mediates Hemoglobin-Heme Uptake and Determines the Noninflammatory and Protective Transcriptional Response of Macrophages to Hemoglobin

Schaer, C. A., Schoedon, G., Imhof, A., Kurrer, M. O., & Schaer, D. J. (2006) · Circulation Research · doi:10.1161/01.res.0000247067.34173.1b · Cited by 267 · see citing works

Superoxide Dismutase Administration: A Review of Proposed Human Uses

Rosa, A. C., Corsi, D., Cavi, N., Bruni, N., & Dosio, F. (2021) · Molecules · doi:10.3390/molecules26071844 · Cited by 286 · see citing works

A review of the molecular mechanisms of hyperglycemia‐induced free radical generation leading to oxidative stress

Yaribeygi, H., Atkin, S., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27164 · Cited by 226 · see citing works

Resveratrol increases vascular oxidative stress resistance

Ungvari, Z. I., Orosz, Z. Z., Rivera, A., Labinskyy, N., Xiangmin, Z., Olson, S. C., Podlutsky, A. J., & Csiszár, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01258.2006 · Cited by 239 · see citing works

Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes

Makino, A., Scott, B. T., & Dillmann, W. H. (2010) · Diabetologia · doi:10.1007/s00125-010-1770-4 · Cited by 223 · see citing works

Heme oxygenase-1 protects tumor cells against photodynamic therapy-mediated cytotoxicity

Nowis, D., Legat, M., Grzela, T., Niderla, J., Wilczek, E., Wilczynski, G. M., Głodkowska‐Mrówka, E., Mrówka, P., Issat, T., Dulak, J., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209378 · Cited by 185 · see citing works

An update of Nrf2 activators and inhibitors in cancer prevention/promotion

Pouremamali, F., Pouremamali, A., Dadashpour, M., Soozangar, N., & Jeddi, F. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00906-3 · Cited by 172 · see citing works

Carbon Monoxide and Bilirubin

Ryter, S. W., Morse, D., & Choi, A. M. K. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0333tr · Cited by 164 · see citing works

HO-1 overexpression and underexpression: Clinical implications

Drummond, G. S., Baum, J., Greenberg, M., Lewis, D., & Abraham, N. G. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108073 · Cited by 142 · see citing works

Reactive oxygen species and the control of vascular function

Wolin, M. S. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01167.2008 · Cited by 133 · see citing works

Cardiovascular Effects of Caffeic Acid and Its Derivatives: A Comprehensive Review

Silva, H., & Lopes, N. M. F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.595516 · Cited by 129 · see citing works

Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome

Abraham, N. G., Junge, J. M., & Drummond, G. S. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.09.003 · Cited by 123 · see citing works

Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects

Xiong, J., Wang, K., Yuan, C., Xing, R., Ni, J., Hu, G., Chen, F., & Wang, X. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2809 · Cited by 120 · see citing works

HO-1 expression increases mesenchymal stem cell-derived osteoblasts but decreases adipocyte lineage

Vanella, L., Kim, D. H., Asprinio, D. E., Peterson, S. J., Barbagallo, I. A., Vanella, A., Goldstein, D. V., Ikehara, S., Kappas, A., & Abraham, N. G. (2009) · Bone · doi:10.1016/j.bone.2009.10.012 · Cited by 119 · see citing works

Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9

Lin, C., Shen, S.-C., Hou, W., Yang, L., & Chen, Y. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2199 · Cited by 119 · see citing works

Therapeutic Roles of Heme Oxygenase-1 in Metabolic Diseases: Curcumin and Resveratrol Analogues as Possible Inducers of Heme Oxygenase-1

Son, Y. H., Lee, J. H., Chung, H., & Pae, H. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/639541 · Cited by 115 · see citing works

Pharmacotherapy against Oxidative Stress in Chronic Kidney Disease: Promising Small Molecule Natural Products Targeting Nrf2-HO-1 Signaling

Uddin, M. J., Kim, E. H., Hannan, M. A., & Ha, H. (2021) · Antioxidants · doi:10.3390/antiox10020258 · Cited by 112 · see citing works

Molecular Regulation of Tumor Angiogenesis and Perfusion via Redox Signaling

Miller, T. W., Isenberg, J. S., & Roberts, D. D. (2009) · Chemical Reviews · doi:10.1021/cr8005125 · Cited by 111 · see citing works

Heme Oxygenase-1 Enhances Renal Mitochondrial Transport Carriers and Cytochrome c Oxidase Activity in Experimental Diabetes

Noia, M. A. D., Driesche, S. V., Palmieri, F., Yang, L. M., Quan, S., Goodman, A. I., & Abraham, N. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510595200 · Cited by 111 · see citing works

Increase in heme oxygenase-1 levels ameliorates renovascular hypertension

Botros, F. T., Schwartzman, M. L., Stier, C. T., Goodman, A. I., & Abraham, N. G. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00745.x · Cited by 110 · see citing works

Up-Regulation of Heme Oxygenase Provides Vascular Protection in an Animal Model of Diabetes through Its Antioxidant and Antiapoptotic Effects

Kruger, A. L., Peterson, S. J., Schwartzman, M. L., Fusco, H. N., McClung, J. A., Weiss, M. B., Shenouda, S. K., Goodman, A. I., Goligorsky, M. S., Kappas, A., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.107482 · Cited by 109 · see citing works

Heme oxygenase: the key to renal function regulation

Abraham, N. G., Cao, J. J., Sacerdoti, D., Li, X., & Drummond, G. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90449.2008 · Cited by 102 · see citing works

Overexpression of heme oxygenase-1 increases human osteoblast stem cell differentiation

Barbagallo, I. A., Vanella, A., Peterson, S. J., Kim, D., Tibullo, D., Giallongo, C., Vanella, L., Parrinello, N. L., Palumbo, G. A., Raimondo, F. D., et al. (2009) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-009-0134-y · Cited by 102 · see citing works

Downregulation of NADPH oxidase, antioxidant enzymes, and inflammatory markers in the heart of streptozotocin-induced diabetic rats by N-acetyl- l -cysteine

Guo, Z., Xia, Z., Jiang, J., & McNeill, J. H. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01328.2005 · Cited by 98 · see citing works

Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats

L’Abbate, A., Neglia, D., Vecoli, C., Novelli, M., Ottaviano, V., Baldi, S., Barsacchi, R., Paolicchi, A., Masiello, P., Drummond, G. S., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00826.2007 · Cited by 95 · see citing works

Genetic Variability in Iron-Related Oxidative Stress Pathways (Nrf2, NQ01, NOS3, andHO-1), Iron Intake, and Risk of Postmenopausal Breast Cancer

Hong, C., Ambrosone, C. B., Ahn, J., Choi, J., McCullough, M. L., Stevens, V. L., Rodriguez, C., Thun, M. J., & Calle, E. E. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0247 · Cited by 95 · see citing works

The Protective Effect of Lavender Essential Oil and Its Main Component Linalool against the Cognitive Deficits Induced by D‐Galactose and Aluminum Trichloride in Mice

Xu, P., Wang, K., Lü, C., Dong, L., Gao, L., Yan, M., Aibai, S., Yang, Y., & Liu, X. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/7426538 · Cited by 94 · see citing works

Protective effects of morin on lipopolysaccharide/ d -galactosamine-induced acute liver injury by inhibiting TLR4/NF-κB and activating Nrf2/HO-1 signaling pathways

Tian, Y., Li, Z., Shen, B., Zhang, Q., & Feng, H. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.02.010 · Cited by 92 · see citing works

Heme Oxygenase-1 Promotes the Persistence of Leishmania chagasi Infection

Luz, N. F., Andrade, B. B., Feijó, D. F., Araújo-Santos, T., Carvalho, G. Q., Andrade, D., Abánades, D. R., de Melo, E. V., Silva, A. M., Brodskyn, C., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103072 · Cited by 89 · see citing works

Advanced glycation end products impair the migration, adhesion and secretion potentials of late endothelial progenitor cells

Li, H., Zhang, X., Guan, X., Cui, X., Wang, Y., Chu, H., & Cheng, M. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-46 · Cited by 90 · see citing works

Long-Term Treatment with the Apolipoprotein A1 Mimetic Peptide Increases Antioxidants and Vascular Repair in Type I Diabetic Rats

Peterson, S. J., Husney, D., Kruger, A. L., Olszanecki, R., Ricci, F., Rodella, L. F., Stacchiotti, A., Rezzani, R., McClung, J. A., Aronow, W. S., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.119479 · Cited by 90 · see citing works

Haem oxygenase delays programmed cell death in wheat aleurone layers by modulation of hydrogen peroxide metabolism

Wu, M., Huang, J., Xu, S., Ling, T., Xie, Y., & Shen, W. (2010) · Journal of Experimental Botany · doi:10.1093/jxb/erq261 · Cited by 88 · see citing works

Gating the Radical Hemoglobin to Macrophages: The Anti-Inflammatory Role of CD163, a Scavenger Receptor

Schaer, D. J., Alayash, A. I., & Buehler, P. W. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1576 · Cited by 88 · see citing works

Heme oxygenase-1 protects against radiocontrast-induced acute kidney injury by regulating anti-apoptotic proteins

Goodman, A. I., Olszanecki, R., Yang, L. M., Quan, S., Li, M., Omura, S., Stec, D. E., & Abraham, N. G. (2007) · Kidney International · doi:10.1038/sj.ki.5002447 · Cited by 87 · see citing works

Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocin-induced diabetes

Ndisang, J. F., & Jadhav, A. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90783.2008 · Cited by 87 · see citing works

Inhibition of miR-92a Suppresses Oxidative Stress and Improves Endothelial Function by Upregulating Heme Oxygenase-1 in db/db Mice

Gou, L., Zhao, L., Song, W., Wang, L., Liu, J., Zhang, H., Huang, Y., Lau, C. W., Yao, X., Tian, X. Y., et al. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7005 · Cited by 86 · see citing works

Effect of hydroalcoholic Allium ampeloprasum extract on oxidative stress, diabetes mellitus and dyslipidemia in alloxan-induced diabetic rats

Rahimi‐Madiseh, M., Heidarian, E., Kheiri, S., & Rafieian‐Kopaei, M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.028 · Cited by 88 · see citing works

Carbon monoxide and biliverdin prevent endothelial cell sloughing in rats with type I diabetes

Rodella, L. F., Lamon, B. D., Rezzani, R., Sangras, B., Goodman, A. I., Falck, J. R., & Abraham, N. G. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.02.018 · Cited by 81 · see citing works

Novel insights into redox system and the mechanism of redox regulation

Wang, X., & Hai, C. (2016) · Molecular Biology Reports · doi:10.1007/s11033-016-4022-y · Cited by 82 · see citing works

The non-canonical functions of the heme oxygenases

Vanella, L., Barbagallo, I. A., Tibullo, D., Forte, S., Zappalà, A., & Volti, G. L. (2016) · Oncotarget · doi:10.18632/oncotarget.11923 · Cited by 79 · see citing works

Protective effect of forsythiaside A on lipopolysaccharide/d-galactosamine-induced liver injury

Pan, C., Zhou, G., Chen, W.-L., Zhuge, L., Jin, L., Zheng, Y., Lin, W., & Pan, Z. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.03.009 · Cited by 79 · see citing works

Targeting Heme Oxygenase

Peterson, S. J., & Frishman, W. H. (2009) · Cardiology in Review · doi:10.1097/crd.0b013e31819d813a · Cited by 79 · see citing works

Diabetes Impairs the Vascular Recruitment of Normal Stem Cells by Oxidant Damage, Reversed by Increases in pAMPK, Heme Oxygenase-1, and Adiponectin

Sambuceti, G., Morbelli, S. D., Vanella, L., Kusmic, C., Marini, C., Massollo, M., Augeri, C., Corselli, M., Ghersi, C., Chiavarina, B., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0800 · Cited by 79 · see citing works

Heme Oxygenase-2 Deficiency Contributes to Diabetes-Mediated Increase in Superoxide Anion and Renal Dysfunction

Goodman, A. I., Chander, P. N., Rezzani, R., Schwartzman, M. L., Regan, R. F., Rodella, L. F., Türkseven, S., Lianos, E. A., Dennery, P. A., & Abraham, N. G. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004121082 · Cited by 78 · see citing works

Up-Regulating the Hemeoxygenase System Enhances Insulin Sensitivity and Improves Glucose Metabolism in Insulin-Resistant Diabetes in Goto-Kakizaki Rats

Ndisang, J. F., & Jadhav, A. (2009) · Endocrinology · doi:10.1210/en.2008-1370 · Cited by 77 · see citing works

Up-Regulating the Heme Oxygenase System with Hemin Improves Insulin Sensitivity and Glucose Metabolism in Adult Spontaneously Hypertensive Rats

Ndisang, J. F., Lane, N., Syed, N., & Jadhav, A. (2009) · Endocrinology · doi:10.1210/en.2009-0471 · Cited by 76 · see citing works

Role of heme oxygenase in preserving vascular bioactive NO

Pae, H., Son, Y. H., Kim, N., Jeong, H. J., Chang, K. C., & Chung, H. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.08.002 · Cited by 76 · see citing works

Subcellular Localization of Oxidants and Redox Modulation of Endothelial Nitric Oxide Synthase

Maron, B. A., & Michel, T. M. (2012) · Circulation Journal · doi:10.1253/circj.cj-12-1207 · Cited by 75 · see citing works

Caffeic acid phenethyl ester protects against oxidative stress and dampens inflammation via heme oxygenase 1

Stähli, A., Maheen, C. U., Strauß, F. J., Eick, S., Sculean, A., & Gruber, R. (2019) · International Journal of Oral Science · doi:10.1038/s41368-018-0039-5 · Cited by 76 · see citing works

HO-1 induction lowers blood pressure and superoxide production in the renal medulla of angiotensin II hypertensive mice

Vera, T., Kelsen, S., Yanes, L. L., Reckelhoff, J. F., & Stec, D. E. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00601.2006 · Cited by 75 · see citing works

Anti‐atherogenic effect of statins: role of nitric oxide, peroxynitrite and haem oxygenase‐1

Heeba, G. H., Moselhy, M., Hassan, M., Khalifa, M. M., Gryglewski, R., & Maliñski, T. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00125.x · Cited by 73 · see citing works

Multiple Antioxidants Improve Cardiac Complications and Inhibit Cardiac Cell Death in Streptozotocin-Induced Diabetic Rats

Kumar, S., Prasad, S., & Sitasawad, S. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067009 · Cited by 73 · see citing works

The Heme Oxygenase System Abates Hyperglycemia in Zucker Diabetic Fatty Rats by Potentiating Insulin-Sensitizing Pathways

Ndisang, J. F., Lane, N., & Jadhav, A. (2008) · Endocrinology · doi:10.1210/en.2008-0239 · Cited by 73 · see citing works

Long-term overexpression of heme oxygenase 1 promotes tau aggregation in mouse brain by inducing tau phosphorylation

Hui, Y., Wang, D., Li, W., Zhang, L., Jin, J., Ma, N., Zhou, L., Nakajima, O., Zhao, W., & Gao, X. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-102061 · Cited by 71 · see citing works

D‐4F, an apoA‐I mimetic peptide, inhibits proliferation and tumorigenicity of epithelial ovarian cancer cells by upregulating the antioxidant enzyme MnSOD

Ganapathy, E., Su, F., Meriwether, D., Devarajan, A., Grijalva, V. R., Gao, F., Chattopadhyay, A., Anantharamaiah, G. M., Navab, M., Fogelman, A. M., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.26079 · Cited by 71 · see citing works

The Anti-Inflammatory, Anti-Oxidative, and Anti-Apoptotic Benefits of Stem Cells in Acute Ischemic Kidney Injury

Lee, K., Tseng, W., Yang, C., & Tarng, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143529 · Cited by 71 · see citing works

Ameliorative action of cyanobacterial phycoerythrin on CCl4-induced toxicity in rats

Soni, B., Visavadiya, N. P., & Madamwar, D. (2008) · Toxicology · doi:10.1016/j.tox.2008.03.008 · Cited by 68 · see citing works

Antioxidant Inhibitors Potentiate the Cytotoxicity of Photodynamic Therapy

Kimani, S. G., Phillips, J. B., Bruce, J. I., MacRobert, A. J., & Golding, J. P. (2011) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2011.01022.x · Cited by 68 · see citing works

Upregulation of the heme oxygenase system ameliorates postprandial and fasting hyperglycemia in type 2 diabetes

Ndisang, J. F., Lane, N., & Jadhav, A. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90241.2008 · Cited by 67 · see citing works

EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice

Cao, J. J., Singh, S. P., McClung, J. A., Joseph, G. U., Vanella, L., Barbagallo, I. A., Jiang, H., Falck, J. R., Arad, M., Shapiro, J. I., et al. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00093.2017 · Cited by 65 · see citing works

Antioxidant Blueberry Anthocyanins Induce Vasodilation via PI3K/Akt Signaling Pathway in High-Glucose-Induced Human Umbilical Vein Endothelial Cells

Huang, W., Hutabarat, R. P., Chai, Z., Zheng, T., Zhang, W., & Li, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051575 · Cited by 64 · see citing works

Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2‐linked heme oxygenase 1 induction

Park, S. Y., Lee, S. W., Shin, H. K., Chung, W. T., Lee, W. S., Rhim, B. Y., Hong, K. W., & Kim, C. D. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27291 · Cited by 63 · see citing works

Metabolic syndrome increases endogenous carbon monoxide production to promote hypertension and endothelial dysfunction in obese Zucker rats

Johnson, F. K., Johnson, R. A., Durante, W., Jackson, K. E., Stevenson, B. K., & Peyton, K. J. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00308.2005 · Cited by 61 · see citing works

Kinetics of ROS generation induced by polycyclic aromatic hydrocarbons and organic extracts from ambient air particulate matter in model human lung cell lines

Líbalová, H., Milcová, A., Červená, T., Vrbova, K., Rössnerová, A., Nováková, Z. V., Topinka, J., & Rössner, P. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.01.006 · Cited by 61 · see citing works

Lentiviral-Human Heme Oxygenase Targeting Endothelium Improved Vascular Function in Angiotensin II Animal Model of Hypertension

Cao, J. J., Sodhi, K., Inoue, K., Quilley, J., Rezzani, R., Rodella, L. F., Vanella, L., Germinario, L., Stec, D. E., Abraham, N. G., et al. (2010) · Human Gene Therapy · doi:10.1089/hum.2010.059 · Cited by 60 · see citing works

Hemin Therapy Improves Kidney Function in Male Streptozotocin-Induced Diabetic Rats: Role of the Heme Oxygenase/Atrial Natriuretic Peptide/Adiponectin Axis

Ndisang, J. F., & Jadhav, A. (2013) · Endocrinology · doi:10.1210/en.2013-1050 · Cited by 60 · see citing works

Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action

Hearn, J. M., Hughes, G. M., Romero‐Canelón, I., Munro, A. F., Rubio‐Ruíz, B., Liu, Z., Carragher, N. O., & Sadler, P. J. (2017) · Metallomics · doi:10.1039/c7mt00242d · Cited by 59 · see citing works

Lipid Autacoids in Inflammation and Injury Responses: A Matter of Privilege

Gronert, K. (2008) · Molecular Interventions · doi:10.1124/mi.8.1.7 · Cited by 59 · see citing works

Guanosine prevents behavioral alterations in the forced swimming test and hippocampal oxidative damage induced by acute restraint stress

Bettio, L. E. B., Freitas, A. E., Neis, V. B., Santos, D. B., Ribeiro, C. M., da Rosa, P. B., Farina, M., & Rodrigues, A. L. S. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.10.002 · Cited by 59 · see citing works

Cultured astrocytes from heme oxygenase‐1 knockout mice are more vulnerable to heme‐mediated oxidative injury

Chen‐Roetling, J., Benvenisti‐Zarom, L., & Regan, R. F. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20681 · Cited by 56 · see citing works

Oxidative Stress and Heme Oxygenase‐1 Regulated Human Mesenchymal Stem Cells Differentiation

Vanella, L., Sanford, C., Kim, D. H., Abraham, N. G., & Ebraheim, N. A. (2012) · International Journal of Hypertension · doi:10.1155/2012/890671 · Cited by 55 · see citing works

Ergothioneine mitigates cisplatin-evoked nephrotoxicity via targeting Nrf2, NF-κB, and apoptotic signaling and inhibiting γ-glutamyl transpeptidase

Salama, S. A., Abd‐Allah, G. M., Mohamadin, A. M., Elshafey, M. M., & Gad, H. S. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119572 · Cited by 53 · see citing works

Heme Impairs Prostaglandin E2 and TGF-β Production by Human Mononuclear Cells via Cu/Zn Superoxide Dismutase: Insight into the Pathogenesis of Severe Malaria

Andrade, B. B., Araújo-Santos, T., Luz, N. F., Khouri, R., Bozza, M. T., Camargo, L. M. A., Barral, A. M. P., Borges, V. M., & Barral‐Netto, M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904179 · Cited by 53 · see citing works

Interaction Among Heme Oxygenase, Nuclear Factor-κB, and Transcription Activating Factors in Cardiac Hypertrophy in Hypertension

Jadhav, A., Torlakovic, E., & Ndisang, J. F. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114801 · Cited by 52 · see citing works

Heme Oxygenase: A Target Gene for Anti-Diabetic and Obesity

Abraham, N. G., Tsenovoy, P. L., McClung, J. A., & Drummond, G. S. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208783597371 · Cited by 51 · see citing works

Bone marrow stem cell transplant into intra-bone cavity prevents type 2 diabetes: Role of heme oxygenase-adiponectin

Abraham, N. G., Li, M., Vanella, L., Peterson, S. J., Ikehara, S., & Asprinio, D. E. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.12.005 · Cited by 51 · see citing works

Hemin therapy attenuates kidney injury in deoxycorticosterone acetate-salt hypertensive rats

Jadhav, A., Torlakovic, E., & Ndisang, J. F. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00510.2007 · Cited by 51 · see citing works

Physiological significance of heme oxygenase in hypertension

Cao, J. J., Inoue, K., Li, X., Drummond, G., & Abraham, N. G. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.10.025 · Cited by 49 · see citing works

Ambroxol, a mucolytic agent, boosts HO ‐1, suppresses NF‐κB , and decreases the susceptibility of the inflamed rat colon to apoptosis: A new treatment option for treating ulcerative colitis

Cavalu, S. D., Sharaf, H., Saber, S., Youssef, M. E., Abdelhamid, A. M., Mourad, A. A. E., Ibrahim, S., Allam, S., Elgharabawy, R. M., El-Ahwany, E. G., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202200749r · Cited by 48 · see citing works

Puerarin protects against high glucose-induced acute vascular dysfunction: Role of heme oxygenase-1 in rat thoracic aorta

Meng, X., Ni, C., Zhu, L., Shen, Y., Wang, L., & Chen, Y. (2008) · Vascular Pharmacology · doi:10.1016/j.vph.2008.11.003 · Cited by 47 · see citing works

High fat diet enhances cardiac abnormalities in SHR rats: Protective role of heme oxygenase-adiponectin axis

Cao, J. J., Sodhi, K., Puri, N., Monu, S. R., Rezzani, R., & Abraham, N. G. (2011) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-3-37 · Cited by 47 · see citing works

Interdiction of the Diabetic State in NOD Mice by Sustained Induction of Heme Oxygenase: Possible Role of Carbon Monoxide and Bilirubin

Li, M., Peterson, S. J., Husney, D., Inaba, M., Guo, K., Terada, E., Morita, T., Patil, K., Kappas, A., Ikehara, S., et al. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1568 · Cited by 47 · see citing works

The heme oxygenase system attenuates pancreatic lesions and improves insulin sensitivity and glucose metabolism in deoxycorticosterone acetate hypertension

Ndisang, J. F., & Jadhav, A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.91000.2008 · Cited by 46 · see citing works

Chronic HO-1 induction with cobalt protoporphyrin (CoPP) treatment increases oxygen consumption, activity, heat production and lowers body weight in obese melanocortin-4 receptor-deficient mice

Csongrádi, É., Docarmo, J. M., Dubinion, J. H., Vera, T., & Stec, D. E. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.78 · Cited by 46 · see citing works

Copper Transporter ATP7A Protects Against Endothelial Dysfunction in Type 1 Diabetic Mice by Regulating Extracellular Superoxide Dismutase

Varadarajan, S., Urao, N., Oshikawa, J., McKinney, R. D., Llanos, R. M., Mercer, J. F. B., Ushio‐Fukai, M., & Fukai, T. (2013) · Diabetes · doi:10.2337/db12-1228 · Cited by 46 · see citing works

Heme Oxygenase 1: A Defensive Mediator in Kidney Diseases

Grünenwald, A., Roumenina, L. T., & Frimat, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042009 · Cited by 43 · see citing works

Enhanced Skeletal Muscle Expression of Extracellular Superoxide Dismutase Mitigates Streptozotocin-Induced Diabetic Cardiomyopathy by Reducing Oxidative Stress and Aberrant Cell Signaling

Call, J. A., Chain, K. H., Martin, K. S., Lira, V. A., Okutsu, M., Zhang, M., & Yan, Z. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001540 · Cited by 45 · see citing works

Up-Regulation of Heme Oxygenase Provides Vascular Protection in an Animal Model of Diabetes through Its Antioxidant and Antiapoptotic Effects

Kruger, A. L., Peterson, S. J., Schwartzman, M. L., Fusco, H. N., McClung, J. A., Weiss, M. B., Shenouda, S. K., Goodman, A. I., Goligorsky, M. S., Kappas, A., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.107482 · Cited by 109 · see citing works

Heme oxygenase-1 gene expression increases vascular relaxation and decreases inducible nitric oxide synthase in diabetic rats.

Movahedian, A., Türkseven, S., Mingone, C. J., Gupte, S. A., Wolin, M. S., & Abraham, N. G. (2005) · PubMed · Cited by 50 · see citing works

Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic

Kruger, A. L., Peterson, S. J., Schwartzman, M. L., Fusco, H., Mcclung, J. A., Weiss, M., Shenouda, S., Goodman, A. I., Goligorsky, M. S., & Abraham, N. G. (2006)

Heme oxygenase-1 prevents superoxide anion-associated endothelial cell sloughing in diabetic rats

Quan, S., Kaminski, P. M., Yang, L. M., Morita, T., Inaba, M., Ikehara, S., Goodman, A. I., Wolin, M. S., & Abraham, N. G. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.086 · Cited by 78 · see citing works

Overexpression of human heme oxygenase-1 attenuates endothelial cell sloughing in experimental diabetes

Abraham, N. G., Rezzani, R., Rodella, L. F., Kruger, A. L., Taller, D., Volti, G. L., Goodman, A. I., & Kappas, A. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01187.2003 · Cited by 109 · see citing works