The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Glycosaminoglycan polymerization may enable osmotically inactive Na+storage in the skin
Abstract
Osmotically inactive skin Na+storage is characterized by Na+accumulation without water accumulation in the skin. Negatively charged glycosaminoglycans (GAGs) may be important in skin Na+storage. We investigated changes in skin GAG content and key enzymes of GAG chain polymerization during osmotically inactive skin Na+storage. Female Sprague-Dawley rats were fed a 0.1% or 8% NaCl diet for 8 wk. Skin GAG content was measured by Western blot analysis. mRNA content of key dermatan sulfate polymerization enzymes was measured by real-time PCR. The Na+concentration in skin was determined by dry ashing. Skin Na+concentration during osmotically inactive Na+storage was 180–190 mmol/l. Increasing skin Na+coincided with increasing GAG content in cartilage and skin. Dietary NaCl loading coincided with increased chondroitin synthase mRNA content in the skin, whereas xylosyl transferase, biglycan, and decorin content were unchanged. We conclude that osmotically inactive skin Na+storage is an active process characterized by an increased GAG content in the reservoir tissue. Inhibition or disinhibition of GAG chain polymerization may regulate osmotically inactive Na+storage.
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Cites
High dietary sodium chloride consumption may not induce body fluid retention in humans
Heer, M., Baisch, F., Kropp, J., Gerzer, R., & Drummer, C. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.278.4.f585 · Cited by 285 · cited 3×
“First, our observations could explain the discrepancies reported in various Na balance studies (6, 15).”
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Cited by
Machnik, A., Neuhofer, W., Jantsch, J., Dahlmann, A., Tammela, T., Machura, K., Park, J.-K., Beck, F.-X., Müller, D. N., Derer, W., et al. (2009) · Nature Medicine · doi:10.1038/nm.1960 · Cited by 963
Self-citationWiig, H., & Swartz, M. A. (2012) · Physiological Reviews · doi:10.1152/physrev.00037.2011 · Cited by 722
Arrigo, M., Jessup, M., Mullens, W., Reza, N., Shah, A. M., Sliwa, K., & Mebazaa, A. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0151-7 · Cited by 574
Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension
Barbaro, N. R., Foss, J. D., Kryshtal, D. O., Tsyba, N., Kumaresan, S., Xiao, L., Mernaugh, R. L., Itani, H. A., Loperena, R., Chen, W., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.002 · Cited by 282
Self-citationBody Fluid Dynamics: Back to the Future
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Metadata
- Authors
- Titze, J., Shakibaei, M., Schafflhuber, M., Schulze-Tanzil, G., Porst, M., Schwind, K. H., Dietsch, P., & Hilgers, K. F.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2004-07
- Volume
- 287
- Issue
- 1
- Pages
- H203-H208
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W1988006144
- Cited by
- 330
- References
- 1
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Titze, J., Shakibaei, M., Schafflhuber, M., Schulze-Tanzil, G., Porst, M., Schwind, K. H., Dietsch, P., & Hilgers, K. F. (2004). Glycosaminoglycan polymerization may enable osmotically inactive Na+storage in the skin. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.01237.2003
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