The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Measurement of local cerebral blood flow with iodo [14C] antipyrine
Abstract
The autoradiographic diffusible tracer technique for the measurement of local cerebral blood flow was originally designed for use with the radioactive, inert gas 131I-labeled trifluoroiodomethane and is applicable only with tracers that exhibit unrestricted diffusion through the blood-brain barrier. Because of the technical problems associated with the use of gaseous tracers, a suitable nonvolatile tracer has been sought. [14C] Antipyrine has been used previously and found to be unsuitable because of limitations in its diffusion through the blood-brain barrier. An analogue of [14C]antipyrine, iodo [14C]antipyrine, exhibits higher partition coefficients than [14C]antipyrine between nonpolar solvents and water and might, therefore, be expected to diffuse more freely through the barrier. Its use as the tracer in the local blood flow technique leads to values considerably above those obtained with [14C]antipyrine in the rat and cat and essentially the same as those obtained with the gas trifluoro[131I]iodomethane in the cat. Iodo[14C]antipyrine appears, therefore, to be a satisfactory nonvolatile tracer for the measurement of local cerebral blood flow.
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Cites
Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000
Self-citationPermeability limitation in estimation of local brain blood flow with [14C]antipyrine
Eckman, W., Phair, R., Fenstermacher, J., Patlak, C., Kennedy, C., & Sokoloff, L. (1975) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1975.229.1.215 · Cited by 85
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Cited by
Nagasawa, H., & Kogure, K. (1989) · Stroke · doi:10.1161/01.str.20.8.1037 · Cited by 522
Methodology of brain perfusion imaging
Barbier, E. L., Lamalle, L., & Décorps, M. (2001) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1073 · Cited by 404
Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat
Memezawa, H., Minamisawa, H., Smith, M.-L., & Siesj�, B. K. (1992) · Experimental Brain Research · doi:10.1007/bf00229002 · Cited by 310
Regional cerebral blood flow decreases during chronic and acute hyperglycemia.
Duckrow, R. B., Beard, D. C., & Brennan, R. W. (1987) · Stroke · doi:10.1161/01.str.18.1.52 · Cited by 158
Ethanol Reduces Metabolic Uncoupling Following Experimental Head Injury
KELLY, D. F., KOZLOWSKI, D. A., HADDAD, E., ECHIVERRI, A., HOVDA, D. A., & LEE, S. M. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.261 · Cited by 82
Metadata
- Authors
- Sakurada, O., Kennedy, C., Jehle, J., Brown, J. D., Carbin, G. L., & Sokoloff, L.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 1978-01-01
- Volume
- 234
- Issue
- 1
- Pages
- H59-H66
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W2169142949
- Cited by
- 926
- References
- 2
- FWCI
- 16.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sakurada, O., Kennedy, C., Jehle, J., Brown, J. D., Carbin, G. L., & Sokoloff, L. (1978). Measurement of local cerebral blood flow with iodo [14C] antipyrine. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.1978.234.1.h59
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