Cited by 302Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

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An NADPH oxidase superoxide-generating system in the rabbit aorta

Pagano, P. J., Ito, Y., Tornheim, K., Gallop, P. M., Tauber, A. I., Cohen, R. A.·1995·American Journal of Physiology-Heart and Circulatory Physiology

DOI 10.1152/ajpheart.1995.268.6.h2274

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Abstract

Superoxide anion can modulate vascular smooth muscle tone and potentially affect the growth response in vascular disease. The present studies were undertaken to characterize the source of superoxide in rabbit aorta. Rings of aorta (5 mm) were incubated in physiological salt solution (PSS) for 30 min at 37 degrees C in the presence of 10 mM diethyldithiocarbamate (DDC) with or without inhibitors of superoxide-generating systems. Rings were then placed in PSS containing 250 microM lucigenin at 37 degrees C in the presence or absence of inhibitors, and changes in amounts of superoxide were determined by measuring chemiluminescence (units). The inhibitors of xanthine oxidase, oxypurinol (300 microM), and of mitochondrial NADH dehydrogenase, rotenone (50 microM), had no significant effect on superoxide levels. An inhibitor of NADPH oxidase, iodonium thiophen, caused a concentration-dependent inhibition of superoxide anion (12.49 +/- 1.48 vs 5.27 +/- 1.81 and 2.30 +/- 0.36 units, control vs 7 microM and 70 microM iodonium thiopen, respectively). A structurally related iodonium compound, diphenyleneiodonium (20 microM), caused a 78% reduction in basal and DDC-evoked superoxide levels. In the presence or absence of DDC, exogenous administration of NADPH (10 microM-1 mM), but not NADP (1 mM), elicited a concentration-dependent rise in superoxide levels that was inhibited by iodonium thiophen. Particulate fractions of whole aortic tissue exhibited NADPH-dependent superoxide production that was inhibited by 1 microM diphenyleneiodonium.(ABSTRACT TRUNCATED AT 250 WORDS)

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Authors: Pagano, P. J., Ito, Y., Tornheim, K., Gallop, P. M., Tauber, A. I., & Cohen, R. A.
Affiliations: Robert Dawson Evans Department of Clinical Research, UniversityMedical Center, Boston 02118, USA.
ORCID: Pagano, P. J.
Ito, Y.
Tauber, A. I.
Cohen, R. A.
Venue: American Journal of Physiology-Heart and Circulatory Physiology
Publisher: American Physiological Society
Published: 1995-06-01
Volume: 268
Issue: 6
Pages: H2274-H2280
ISSN: 0363-6135 (ISSN-L)
1522-1539
DOI: 10.1152/ajpheart.1995.268.6.h2274
OpenAlex: W2219200263
Cited by: 302
References: 24
Citations by year: 2026: 2 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 7 · 2014: 7 · 2013: 6 · 2012: 5
FWCI: 7.50
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p50hl047124-04, 5r01hl038731-08)
National Heart, Lung, and Blood Institute (HL-38731, R01HL031607, HL 47124, HL31607)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: NADPH oxidase, superoxide, rabbit aorta, vascular smooth muscle, diphenyleneiodonium, diethyldithiocarbamate, chemiluminescence, xanthine oxidase, mitochondrial NADH dehydrogenase, vascular tone
MeSH terms: Animals, Aorta, Thoracic, Ditiocarb, Kinetics, Male, Muscle, Smooth, Vascular, NADH, NADPH Oxidoreductases, NADP, Onium Compounds, Oxypurinol, Rabbits, Rotenone, Subcellular Fractions, Superoxides, Thiophenes, NADPH Oxidases, In Vitro Techniques

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An NADPH oxidase superoxide-generating system in the rabbit aorta

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