New insights on oxidative stress in the artery wall

STOCKER, R.; KEANEY, J.F.

doi:10.1111/j.1538-7836.2005.01370.x

Cited by 188Atherosclerosis and Cardiovascular DiseasesNitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative Stress

New insights on oxidative stress in the artery wall

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STOCKER, R., KEANEY, J.F.·2005·Journal of Thrombosis and Haemostasis

DOI 10.1111/j.1538-7836.2005.01370.x

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Abstract

Atherosclerosis and its resultant cardiovascular events represent a state of heightened oxidative stress that is commonly thought to contribute to atherogenesis. The aim of this review is to summarize the data linking oxidative events to the pathogenesis of atherosclerosis. Despite abundant data supporting the presence of lipid and protein oxidation in the vascular wall, the poor performance of antioxidant strategies in limiting either atherosclerosis or cardiovascular events from atherosclerosis remain a fundamental problem for implicating oxidative stress as pathophysiologically important. Direct evidence that oxidative stress in general, and the oxidative modification of low-density lipoprotein in particular, is both necessary and sufficient for atherosclerosis has been difficult to find. There are many potential reasons for this difficulty, not the least of which is our lack of sufficient knowledge delineating the precise molecular events that beget oxidative stress in the vessel wall, and the precise mediators involved. Further investigation elucidating these oxidative events are required to provide us with the tools to limit oxidative stress at its source and ameliorate all of its secondary phenomena. Only then will we know what components of atherosclerosis are directly due to oxidative stress.

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Vascular Effects Following Homozygous Disruption of p47 phox: An Essential Component of NADPH Oxidase
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Mass spectrometric quantification of amino acid oxidation products in proteins: insights into pathways that promote LDL oxidation in the human artery wall
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Altered Tetrahydrobiopterin Metabolism in Atherosclerosis
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Vascular superoxide production by NAD(P)H oxidase: association with endothelial dysfunction and clinical risk factors.
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Dietary and pharmacological antioxidants in atherosclerosis
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Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice
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Site-Specific Antiatherogenic Effect of Probucol in Apolipoprotein E–Deficient Mice
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α‐Tocopherol does not inhibit hypochlorite‐induced oxidation of apolipoprotein B‐100 of low‐density lipoprotein
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Regression of Atherosclerosis in Monkeys Reduces Vascular Superoxide Levels
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Proteoglycans and lipoproteins in atherosclerosis
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p-Hydroxyphenylacetaldehyde, an Aldehyde Generated by Myeloperoxidase, Modifies Phospholipid Amino Groups of Low Density Lipoprotein in Human Atherosclerotic Intima
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Lipoprotein-proteoglycan complexes from atherosclerotic lesions promote cholesteryl ester accumulation in human monocytes/macrophages.
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Elevated levels of protein-bound p-hydroxyphenylacetaldehyde, an amino-acid-derived aldehyde generated by myeloperoxidase, are present in human fatty streaks, intermediate lesions and advanced atherosclerotic lesions
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Elevated concentrations of C-reactive protein in subjects with Type 2 diabetes mellitus are moderately influenced by glycemic control
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Endothelial dysfunction and vascular disease - a 30th anniversary update
Vanhoutte, P. M., Shimokawa, H., Feletou, M., & Tang, E. H. C. (2017) · Acta Physiologica · doi:10.1111/apha.12646 · Cited by 937 · see citing works
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Impact of Oxidative Stress on the Heart and Vasculature
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Oxidized LDL: Diversity, Patterns of Recognition, and Pathophysiology
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Pathological aspects of lipid peroxidation
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Cardiovascular Morbidity in Obstructive Sleep Apnea
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Dietary advanced lipid oxidation endproducts are risk factors to human health
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Molecular mechanism of α-tocopherol action
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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples
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Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models
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Intervention strategies to inhibit protein carbonylation by lipoxidation‐derived reactive carbonyls
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Indoor Particles Affect Vascular Function in the Aged
Bräuner, E. V., Forchhammer, L., Möller, P., Barregård, L., Gunnarsen, L., Afshari, A., Wåhlin, P., Glasius, M., Dragsted, L. O., Basu, S., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200704-632oc · Cited by 265 · see citing works
The relationships among hyperuricemia, endothelial dysfunction, and cardiovascular diseases: Molecular mechanisms and clinical implications
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A novel function of red wine polyphenols in humans: prevention of absorption of cytotoxic lipid peroxidation products
Gorelik, S., Ligumsky, M., Kohen, R., & Kanner, J. (2007) · The FASEB Journal · doi:10.1096/fj.07-9041com · Cited by 215 · see citing works
The role of oxidative stress in atherosclerosis.
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Oxygen, the Lead Actor in the Pathophysiologic Drama: Enactment of the Trinity of Normoxia, Hypoxia, and Hyperoxia in Disease and Therapy
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ROS-responsive microspheres for on demand antioxidant therapy in a model of diabetic peripheral arterial disease
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Gamma-glutamyl transferase and the risk of atherosclerosis and coronary heart disease
Ndrepepa, G., Colleran, R., & Kastrati, A. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.11.026 · Cited by 168 · see citing works
MALDI-TOF MS in lipidomics
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Vascular endothelium dysfunction: a conservative target in metabolic disorders
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Lipoxidation in cardiovascular diseases
Gianazza, E., Brioschi, M., Fernandez, A. M., & Banfi, C. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101119 · Cited by 152 · see citing works
Upregulation of Endothelial and Inducible Nitric Oxide Synthase Expression by Reactive Oxygen Species
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Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart
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Inflammation in the vascular bed: Importance of vitamin C
Aguirre, R., & May, J. M. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.05.002 · Cited by 141 · see citing works
Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment
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The urokinase system in the pathogenesis of atherosclerosis
Fuhrman, B. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.10.044 · Cited by 118 · see citing works
Oxidative Stress in Severely Obese Persons Is Greater in Those With Insulin Resistance
Tinahones, F. J., Murri, M., Garrido‐Sánchez, L., García‐Almeida, J. M., García‐Serrano, S., García-Arnés, J. A., & García‐Fuentes, E. (2008) · Obesity · doi:10.1038/oby.2008.536 · Cited by 114 · see citing works
Vitamins and cardiovascular disease
Honarbakhsh, S., & Schachter, M. (2008) · British Journal Of Nutrition · doi:10.1017/s000711450809123x · Cited by 111 · see citing works
Antioxidant Vitamins and Their Use in Preventing Cardiovascular Disease
Farbstein, D., Kozak-Blickstein, A., & Levy, A. P. (2010) · Molecules · doi:10.3390/molecules15118098 · Cited by 107 · see citing works
Effects of PCSK9 Targeting: Alleviating Oxidation, Inflammation, and Atherosclerosis
Punch, E., Klein, J., Diaba‐Nuhoho, P., Morawietz, H., & Garelnabi, M. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.023328 · Cited by 101 · see citing works
Exposure to ambient concentrations of particulate air pollution does not influence vascular function or inflammatory pathways in young healthy individuals
Bräuner, E. V., Möller, P., Barregård, L., Dragsted, L. O., Glasius, M., Wåhlin, P., Vinzents, P. S., Raaschou‐Nielsen, O., & Loft, S. H. (2008) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-5-13 · Cited by 98 · see citing works
Antioxidant Enzyme Activity and Coronary Heart Disease: Meta-analyses of Observational Studies
Flores‐Mateo, G., Carrillo-Santisteve, P., Elosúa, R., Güallar, E., Marrugat, J., Bleys, J., & Covas, M. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp112 · Cited by 96 · see citing works
The effect of strawberries in a cholesterol-lowering dietary portfolio
Jenkins, D. J. A., Nguyen, T. H., Kendall, C. W. C., Faulkner, D. A., Bashyam, B., Kim, I. J., Ireland, C., Patel, D. K., Vidgen, E., Josse, A. R., et al. (2008) · Metabolism · doi:10.1016/j.metabol.2008.07.018 · Cited by 92 · see citing works
Akt Regulates the Survival of Vascular Smooth Muscle Cells via Inhibition of FoxO3a and GSK3
Allard, D., Figg, N. L., Bennett, M. R., & Littlewood, T. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710098200 · Cited by 86 · see citing works
Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions
Craige, S. M., Kant, S., Reif, M., Chen, K., Pei, Y., Angoff, R., Sugamura, K., Fitzgibbons, T., & Keaney, J. F. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.07.004 · Cited by 85 · see citing works
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The molecular sources of reactive oxygen species in hypertension
Puddu, P., Puddu, G. M., Cravero, E., Rosati, M., & Muscari, A. (2008) · Blood Pressure · doi:10.1080/08037050802029954 · Cited by 82 · see citing works
Oxidized LDL in human carotid plaques is related to symptomatic carotid disease and lesion instability
Sigala, F., Kotsinas, A., Savvari, P., Filis, K., Markantonis, S. L., Iliodromitis, E. K., Gorgoulis, V. G., & Andreadou, I. (2010) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2010.03.047 · Cited by 81 · see citing works
Amphiphilic/Bipolar Metallocorroles That Catalyze the Decomposition of Reactive Oxygen and Nitrogen Species, Rescue Lipoproteins from Oxidative Damage, and Attenuate Atherosclerosis in Mice
Haber, A., Mahammed, A., Fuhrman, B., Volkova, N., Coleman, R., Hayek, T., Aviram, M., & Gross, Z. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200801149 · Cited by 81 · see citing works
Lipid Profiling following Intake of the Omega 3 Fatty Acid DHA Identifies the Peroxidized Metabolites F4-Neuroprostanes as the Best Predictors of Atherosclerosis Prevention
Gladine, C., Newman, J. W. I., Durand, T., Pedersen, T. L., Galano, J., Demougeot, C., Berdeaux, O., Pujos‐Guillot, E., Mazur, A., & Comte, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089393 · Cited by 78 · see citing works
C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo
Devaraj, S., Dasu, M. R. K., Singh, U. S., Rao, L. V. M., & Jialal, I. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.060 · Cited by 78 · see citing works
Telomere length and its associations with oxidized-LDL carotid artery distensibility and smoking
Staessen, J. A. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e176 · Cited by 69 · see citing works
Distribution of zinc, copper and iron in biological samples of Pakistani myocardial infarction (1st, 2nd and 3rd heart attack) patients and controls
Kazi, T. G., Afridi, H. I., Kazi, N. G., Jamali, M. K., Arain, M. B., Sarfraz, R. A., Jalbani, N. B., Ansari, R., Shah, A. Q., Memon, A. R., et al. (2008) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.12.004 · Cited by 68 · see citing works
The association between pre-hypertension status and oxidative stress markers related to atherosclerotic disease: The ATTICA study
Chrysohoou, C. A., Panagiotakos, D. B., Pitsavos, C. S., Skoumas, J., Economou, M., Papadimitriou, L., & Stefanadis, C. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.04.030 · Cited by 62 · see citing works
Oxidative mechanisms and atherothrombotic cardiovascular disease
Leopold, J. A., & Loscalzo, J. (2008) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2008.02.001 · Cited by 62 · see citing works
Critical limb ischaemia is characterised by an increased production of whole blood reactive oxygen species and expression of TREM-1 on neutrophils
Dopheide, J. F., Doppler, C. E. J., Scheer, M., Obst, V., Radmacher, M.-C., Radsak, M. P., Gori, T., Warnholtz, A., Fottner, C., Münzel, T. F., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.05.029 · Cited by 57 · see citing works
Phenolic Antioxidants and Antiatherogenic Effects of Marula (Sclerocarrya birrea Subsp.caffra) Fruit Juice in Healthy Humans
Borochov‐Neori, H., Judeinstein, S., Greenberg, A., Fuhrman, B., Attias, J., Volkova, N., Hayek, T., & Aviram, M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801467m · Cited by 57 · see citing works
Expression of lipoprotein-associated phospholipase A2 in carotid artery plaques predicts long-term cardiac outcome
Herrmann, S. M., Mannheim, D., Wohlert, C., Versari, D., Meyer, F. B., McConnell, J. P., Gössl, M., Lerman, L. O., & Lerman, A. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp309 · Cited by 57 · see citing works
The Putative Role of Mitochondrial Dysfunction in Hypertension
Puddu, P., Puddu, G. M., Cravero, E., Pascalis, S. D., & Muscari, A. (2007) · Clinical and Experimental Hypertension · doi:10.1080/10641960701613852 · Cited by 56 · see citing works
MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway
Coatrieux, C., Sanson, M., Nègre‐Salvayre, A., Parini, A., Hannun, Y. A., Itohara, S., Salvayre, R., & Augè, N. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.036 · Cited by 54 · see citing works
Hypoxia–reoxygenation‐induced endothelial barrier failure: role of RhoA, Rac1 and myosin light chain kinase
Aslam, M., Schlüter, K., Rohrbach, S., Rafiq, A., Nazli, S., Piper, H. M., Noll, T., Schulz, R., & Gündüz, D. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.237834 · Cited by 53 · see citing works
Catalytic antioxidant therapy by metallodrugs: lessons from metallocorroles
Haber, A., & Gross, Z. (2015) · Chemical Communications · doi:10.1039/c4cc08715a · Cited by 53 · see citing works
Vascular smooth muscle cells activate PI3K/Akt pathway to attenuate myocardial ischemia/reperfusion-induced apoptosis and autophagy by secreting bFGF
Ye, G., Fu, Q., Jiang, L., & Li, Z. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.113 · Cited by 51 · see citing works
Impairment of Macrophage Cholesterol Efflux by Cholesterol Hydroperoxide Trafficking: Implications for Atherogenesis Under Oxidative Stress
Korytowski, W., Wawak, K., Pabisz, P., Schmitt, J. C., Chadwick, A. C., Sahoo, D., & Girotti, A. W. (2015) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.115.306210 · Cited by 49 · see citing works
Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment
Kavurma, M. M., Figg, N. L., Bennett, M. R., Mercer, J. R., Khachigian, L. M., & Littlewood, T. D. (2007) · Biochemical Journal · doi:10.1042/bj20070380 · Cited by 49 · see citing works
LDL protein nitration: Implication for LDL protein unfolding
Hamilton, R. T., Asatryan, L., Nilsen, J., Isas, J. M., Gallaher, T. K., Sawamura, T., & Hsiai, T. K. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.07.026 · Cited by 48 · see citing works
Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis in endothelial Nox4 transgenic mouse lines
Chen, L., Hou, X., Xiao, J. M., Kuroda, J., Ago, T., Sadoshima, J., Cohen, R. A., & Tong, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.007 · Cited by 46 · see citing works
Over-expression of angiotensin II type 2 receptor (agtr2) decreases collagen accumulation in atherosclerotic plaque
Dandapat, A., Hu, C. P., Chen, J., Liu, Y., Khan, J. A., Remeo, F., Carey, R. M., Hermonat, P. L., & Mehta, J. L. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.11.061 · Cited by 45 · see citing works
Regulation of Hepatic Paraoxonase-1 Expression
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Authors: STOCKER, R., & KEANEY, J. F.
Affiliations: UNSW Sydney (AU)
Boston University (US)
Corresponding author: STOCKER, R.
ORCID: STOCKER, R.
KEANEY, J.F.
Venue: Journal of Thrombosis and Haemostasis
Publisher: Elsevier BV
Published: 2005-08
Volume: 3
Issue: 8
Pages: 1825-1834
ISSN: 1538-7836 (ISSN-L)
DOI: 10.1111/j.1538-7836.2005.01370.x
OpenAlex: W2090041595
Cited by: 188
References: 100
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 13 · 2017: 4 · 2016: 12 · 2015: 13 · 2014: 12 · 2013: 11 · 2012: 15
FWCI: 1.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6342 d)
Locations: Journal of Thrombosis and Haemostasis (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords: oxidative stress, atherosclerosis, atherogenesis, arterial wall, lipid peroxidation, protein oxidation, LDL oxidation, antioxidant therapy, cardiovascular disease
MeSH terms: Animals, Arteries, Cardiovascular Diseases, Cardiovascular System, Endothelium, Vascular, Free Radicals, Humans, Inflammation, Lipoproteins, LDL, Models, Biological, Oxygen, Oxidative Stress, NADPH Oxidases, Atherosclerosis, Lipid Metabolism

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New insights on oxidative stress in the artery wall

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