Cited by 285Cancer, Hypoxia, and MetabolismAnalytical Chemistry and SensorsOptical Imaging and Spectroscopy Techniques

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Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents

Braun, Rod D., Lanzen, Jennifer L., Snyder, Stacey A., Dewhirst, Mark W.·2001·American Journal of Physiology-Heart and Circulatory Physiology

DOI 10.1152/ajpheart.2001.280.6.h2533

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Abstract

In this study we compare oxygen tension (Po 2) histograms measured with O 2 microelectrodes and a new optical Po 2 measurement device, the OxyLite, in normal tissues (mouse spleen and thymus) and in tumors (R3230Ac in rats) ( n = 5–6). The transient response to glucose infusion or 100% O 2 breathing (hyperoxia) was also measured in tumors. Po 2 histograms of spleen and thymus with the two devices were not different. The OxyLite tumor Po 2 histogram, however, was left-shifted compared with the microelectrode (median Po 2 1.0 vs. 4.0 mmHg, P = 0.016). Both probes responded to acute hyperglycemia with a mean increase of 3–6 mmHg, but the microelectrode change was not significant. The OxyLite consistently recorded large Po 2 increases (∼28 mmHg) with hyperoxia, whereas the microelectrode response was variable. The OxyLite averages Po 2 over an area that contains interstitial and vascular components, whereas the microelectrode measures a more local Po 2. This study demonstrates the importance of considering the features of the measurement device when studying tissues with heterogeneous Po 2 distributions (e.g., tumors).

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Authors: Braun, R. D., Lanzen, J. L., Snyder, S. A., & Dewhirst, M. W.
Affiliations: Duke Medical Center (US)
ORCID: Dewhirst, Mark W.
Venue: American Journal of Physiology-Heart and Circulatory Physiology
Publisher: American Physiological Society
Published: 2001-06-01
Volume: 280
Issue: 6
Pages: H2533-H2544
ISSN: 0363-6135 (ISSN-L)
1522-1539
DOI: 10.1152/ajpheart.2001.280.6.h2533
OpenAlex: W1842875237
Cited by: 285
References: 40
Citations by year: 2026: 5 · 2025: 4 · 2024: 11 · 2023: 5 · 2022: 16 · 2021: 14 · 2020: 19 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 14 · 2013: 18 · 2012: 19
FWCI: 4.62
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Sensors
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
Keywords: tissue oxygen tension, tumor hypoxia, oxygen microelectrodes, spleen, thymus, hyperoxia, glucose infusion
MeSH terms: Adenocarcinoma, Administration, Inhalation, Animals, Female, Glucose, Infusions, Intravenous, Mammary Neoplasms, Experimental, Mice, Inbred DBA, Microelectrodes, Neoplasm Transplantation, Oxygen, Partial Pressure, Polarography, Rats, Inbred F344, Spleen, Thymus Gland, Reproducibility of Results, Cell Hypoxia, Mice, Rats

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Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents

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