The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Effect of a maldistribution of microvascular blood flow on capillary O2 extraction in sepsis
Abstract
Inherent in the remote organ injury caused by sepsis is a profound maldistribution of microvascular blood flow. Using a 24-h rat cecal ligation and perforation model of sepsis, we studied O 2 transport in individual capillaries of the extensor digitorum longus (EDL) skeletal muscle. We hypothesized that erythrocyte O 2 saturation (So 2) levels within normally flowing capillaries would provide evidence of either a mitochondrial failure (increased So 2) or an O 2 transport derangement (decreased So 2). Using a spectrophotometric functional imaging system, we found that sepsis caused 1) an increase in stopped flow capillaries (from 10 to 38%, P < 0.05), 2) an increase in the proportion of fast-flow to normal-flow capillaries ( P< 0.05), and 3) a decrease in capillary venular-end So 2 levels from 58.4 ± 20.0 to 38.5 ± 21.2%, whereas capillary arteriolar-end So 2 levels remained unchanged compared with the sham group. Capillary O 2 extraction increased threefold ( P < 0.05) and was directly related to the degree of stopped flow in the EDL. Thus impaired O 2 transport in early stage sepsis is likely the result of a microcirculatory dysfunction.
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Bone, R. C., Balk, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · Chest · doi:10.1378/chest.101.6.1644 · Cited by 13,198
Self-citationMicrocirculatory oxygenation and shunting in sepsis and shock
Ince, C., & Sinaasappel, M. (1999) · Critical Care Medicine · doi:10.1097/00003246-199907000-00031 · Cited by 542
Bateman, R. M., Jagger, J. E., Sharpe, M. D., Ellsworth, M. L., Mehta, S., & Ellis, C. G. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.6.h2848 · Cited by 390
Self-citationMicrovascular perfusion is impaired in a rat model of normotensive sepsis.
Lam, C., Tyml, K., Martin, C. M., & Sibbald, W. J. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117562 · Cited by 360
Self-citationUnno, N., Wang, H., Menconi, M., Tytgat, S., Larkin, V, Smith, M., Morin, M., Chavez, A., Hodin, R., & Fink, M. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9322519 · Cited by 278
Skeletal muscle partial pressure of oxygen in patients with sepsis
BOEKSTEGERS, P., WEIDENHÖFER, S., KAPSNER, T., & WERDAN, K. (1994) · Critical Care Medicine · doi:10.1097/00003246-199404000-00021 · Cited by 245
Ronco, J. J., Phang, P. T., Walley, K. R., Wiggs, B., Fenwick, J. C., & Russell, J. A. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/143.6.1267 · Cited by 191
Boekstegers, P., Weidenhöfer, S., Pilz, G., et al. (1991) · Infection · doi:10.1007/bf01645355 · Cited by 135
Heterogeneity of gut capillary transit times and impaired gut oxygen extraction in endotoxemic pigs
Humer, M. F., Phang, P. T., Friesen, B. P., Allard, M. F., Goddard, C. M., & Walley, K. R. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.2.895 · Cited by 133
Ellsworth, M. L., Popel, A. S., & Pittman, R. N. (1988) · Microvascular Research · doi:10.1016/0026-2862(88)90089-1 · Cited by 119
Cited by
Microvascular alterations in patients with acute severe heart failure and cardiogenic shock
De Backer, D., Creteur, J., Dubois, M.-J., Sakr, Y., & Vincent, J.-L. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.07.006 · Cited by 472
Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock
De Backer, D., Orbegozo Cortes, D., Donadello, K., & Vincent, J.-L. (2014) · Virulence · doi:10.4161/viru.26482 · Cited by 393
The capillary bed offers the largest hemodynamic resistance to the cortical blood supply
Gould, I. G., Tsai, P., Kleinfeld, D., & Linninger, A. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16671146 · Cited by 252
Doerschug, K. C., Delsing, A. S., Schmidt, G. A., & Ashare, A. (2010) · Critical Care · doi:10.1186/cc8887 · Cited by 119
The influence of sepsis on erythrocytes morphology: case report and literature review
Department of Medicine, V. G. W. U. O. A., Nicolescu, C. M., Moldovan, S. D., & Department of Medicine, V. G. W. U. O. A. (2024) · Romanian Journal of Morphology and Embryology · doi:10.47162/rjme.65.1.15 · Cited by 6
Metadata
- Authors
- Ellis, C. G., Bateman, R. M., Sharpe, M. D., Sibbald, W. J., & Gill, R.
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 2002-01-01
- Volume
- 282
- Issue
- 1
- Pages
- H156-H164
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W1836591545
- Cited by
- 278
- References
- 24
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ellis, C. G., Bateman, R. M., Sharpe, M. D., Sibbald, W. J., & Gill, R. (2002). Effect of a maldistribution of microvascular blood flow on capillary O2 extraction in sepsis. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.2002.282.1.h156
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