Humoral nature of hypoglycemia in muscular exercise
Abstract
Muscular exercise leads to hypoglycemia. The ‘glucose transport theory’ of insulin action places cellular entry of glucose as the limiting step in its rate of metabolism at rest as well as under exercise. Activation of entry of appropriate sugars by exercise, as a primary event, leads to the augmented rates of glucose metabolism seen with contraction of muscles. The mechanism of hypoglycemia of exercise is shown to be humoral in character. Blood and lymphatic fluid of working dogs, both normal or diabetic, are shown to develop hypoglycemic properties during exercise which can be transferred to resting preparations. This hypoglycemic factor of muscle work is highly labile and appears to be quite distinct from insulin.
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One or several humoral factors are released from contracting muscles to the blood.
“Thus, it was obvious that 1 or several humoral factors had to be released from contracting muscles to the blood (3).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [3]
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- Authors
- Goldstein, M. S.
- Affiliations
- Department of Metabolic and Endocrine Research, Michael Reese Hospital, Chicago, Illinois
- Corresponding author
- Goldstein, M. S.
- Venue
- American Journal of Physiology-Legacy Content
- Publisher
- American Physiological Society
- Published
- 1961-01-01
- Volume
- 200
- Issue
- 1
- Pages
- 67-70
- ISSN
- 0002-9513 (ISSN-L)
- OpenAlex
- W2266685404
- Cited by
- 73
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2013: 1
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Legacy Content (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- exercise-induced hypoglycemia, glucose transport, insulin action, muscle glucose metabolism, lymph, diabetic dogs
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