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Cited by 113Neonatal Respiratory Health ResearchPregnancy and preeclampsia studiesBirth, Development, and Health

Intrauterine growth restriction delays surfactant protein maturation in the sheep fetus

Orgeig, Sandra, Crittenden, Tamara A., Marchant, Ceilidh, McMillen, I. Caroline, Morrison, Janna L.·2010·American Journal of Physiology-Lung Cellular and Molecular Physiology
DOI 10.1152/ajplung.00226.2009
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Abstract

Pulmonary surfactant is synthesized by type II alveolar epithelial cells to regulate the surface tension at the air-liquid interface of the air-breathing lung. Developmental maturation of the surfactant system is controlled by many factors including oxygen, glucose, catecholamines, and cortisol. The intrauterine growth-restricted (IUGR) fetus is hypoxemic and hypoglycemic, with elevated plasma catecholamine and cortisol concentrations. The impact of IUGR on surfactant maturation is unclear. Here we investigate the expression of surfactant protein (SP) A, B, and C in lung tissue of fetal sheep at 133 and 141 days of gestation (term 150 ± 3 days) from control and carunclectomized Merino ewes. Placentally restricted (PR) fetuses had a body weight <2 SD from the mean of control fetuses and a mean gestational Pa O 2<17 mmHg. PR fetuses had reduced absolute, but not relative, lung weight, decreased plasma glucose concentration, and increased plasma cortisol concentration. Lung SP-A, -B, and -C protein and mRNA expression was reduced in PR compared with control fetuses at both ages. SP-B and -C but not SP-A mRNA expression and SP-A but not SP-B or -C protein expression increased with gestational age. Mean gestational Pa O 2was positively correlated with SP-A, -B, and -C protein and SP-B and -C mRNA expression in the younger cohort. SP-A and -B gene expression was inversely related to plasma cortisol concentration. Placental restriction, leading to chronic hypoxemia and hypercortisolemia in the carunclectomy model, results in significant inhibition of surfactant maturation. These data suggest that IUGR fetuses are at significant risk of lung complications, especially if born prematurely.

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  • A growth-restricted fetus has fewer insulin-producing beta cells and reduced vascularization in the pancreas, and compromised structure and maturation of the brain, lungs, and liver.

    “In addition, the pancreas has fewer insulin-producing beta cells and reduced vascularization (159, 340, 473), and the structure and maturation of the brain (142), lungs (358, 359, 424, 460) and liver (209, 474) are compromised.”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [424]

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Authors
Orgeig, S., Crittenden, T. A., Marchant, C., McMillen, I. C., & Morrison, J. L.
Affiliations
University of South Australia (AU)
Corresponding author
Morrison, Janna L.
ORCID
Venue
American Journal of Physiology-Lung Cellular and Molecular Physiology
Publisher
American Physiological Society
Published
2010-04
Volume
298
Issue
4
Pages
L575-L583
ISSN
  • 1040-0605 (ISSN-L)
  • 1522-1504
DOI
10.1152/ajplung.00226.2009
OpenAlex
W2152017985
Cited by
113
References
50
Citations by year
2026: 8 · 2025: 9 · 2024: 9 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 9 · 2018: 8 · 2017: 3 · 2016: 7 · 2015: 10 · 2014: 10 · 2013: 7 · 2012: 8
FWCI
5.02
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Lung Cellular and Molecular Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
fetal growth restriction, pulmonary surfactant, surfactant protein A, surfactant protein B, surfactant protein C, fetal sheep, fetal hypoxemia, hypercortisolism, cortisol, alveolar type II cells, lung development, preterm birth, pulmonary complications
MeSH terms
Animals, Hypoxia, Blood Gas Analysis, Body Weight, Female, Fetal Growth Retardation, Fetus, Hydrocortisone, Hypoglycemia, Lung, Organ Size, Pregnancy, Regression Analysis, RNA, Messenger, Sheep, Gene Expression Regulation, Developmental, Pulmonary Surfactant-Associated Proteins, Pulmonary Surfactant-Associated Protein A, Pulmonary Surfactant-Associated Protein B, Pulmonary Surfactant-Associated Protein C

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