The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Ciliated epithelial cell lifespan in the mouse trachea and lung
Open accessAbstract
The steady-state turnover of epithelial cells in the lung and trachea is highly relevant to investigators who are studying endogenous stem cells, manipulating gene expression in vivo, or using viral vectors for gene therapy. However, the average lifetime of different airway epithelial cell types has not previously been assessed using currently available genetic techniques. Here, we use Cre/loxP genetic technology to indelibly label a random fraction of ciliated cells throughout the airways of a cohort of mice and follow them in vivo for up to 18 mo. We demonstrate that ciliated airway epithelial cells are a terminally differentiated population. Moreover, their average half-life of 6 mo in the trachea and 17 mo in the lung is much longer than previously available estimates, with significant numbers of labeled cells still present after 18 mo.
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Cites
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
Hayashi, S., & McMahon, A. P. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0597 · Cited by 1,342
Evidence for Stem-Cell Niches in the Tracheal Epithelium
Borthwick, D. W., Shahbazian, M., Todd Krantz, Q., Dorin, J. R., & Randell, S. H. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.6.4217 · Cited by 414
Epithelial stem cells of the lung: privileged few or opportunities for many?
Rawlins, E. L., & Hogan, B. L. M. (2006) · Development · doi:10.1242/dev.02407 · Cited by 331
Self-citationLung development and repair: Contribution of the ciliated lineage
Rawlins, E. L., Ostrowski, L. E., Randell, S. H., & Hogan, B. L. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610770104 · Cited by 276
Self-citationAnisimov, V. N. (1982) · Experimental pathology · doi:10.1016/s0232-1513(82)80001-7 · Cited by 199
Joyner, A. L., & Zervas, M. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20884 · Cited by 175
Cre activity causes widespread apoptosis and lethal anemia during embryonic development
Naiche, L. A., & Papaioannou, V. E. (2007) · genesis · doi:10.1002/dvg.20353 · Cited by 149
Airway Epithelial Stem Cells and the Pathophysiology of Chronic Obstructive Pulmonary Disease
Randell, S. H. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200605-117sf · Cited by 135
Cited by
Rawlins, E. L., Okubo, T., Xue, Y., Brass, D. M., Auten, R. L., Hasegawa, H., Wang, F., & Hogan, B. L. M. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.04.002 · Cited by 853
Self-citationThe aging lung: Physiology, disease, and immunity
Schneider, J. L., Rowe, J. H., Garcia-de-Alba, C., Kim, C. F., Sharpe, A. H., & Haigis, M. C. (2021) · Cell · doi:10.1016/j.cell.2021.03.005 · Cited by 500
Mastorakos, P., da Silva, A. L., Chisholm, J., Song, E., Choi, W. K., Boyle, M. P., Morales, M. M., Hanes, J., & Suk, J. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1502281112 · Cited by 210
Human airway organoid engineering as a step toward lung regeneration and disease modeling
Tan, Q., Choi, K. M., Sicard, D., & Tschumperlin, D. J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.046 · Cited by 191
Plasticity in the lung: making and breaking cell identity
Tata, P. R., & Rajagopal, J. (2017) · Development · doi:10.1242/dev.143784 · Cited by 192
Metadata
- Authors
- Rawlins, E. L., & Hogan, B. L. M.
- Venue
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Published
- 2008-07
- Volume
- 295
- Issue
- 1
- Pages
- L231-L234
- ISSN
- 1040-0605 (ISSN-L)
- 1522-1504
- OpenAlex
- W1991519731
- Cited by
- 301
- References
- 13
- FWCI
- 13.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Rawlins, E. L., & Hogan, B. L. M. (2008). Ciliated epithelial cell lifespan in the mouse trachea and lung. American Journal of Physiology-Lung Cellular and Molecular Physiology. https://doi.org/10.1152/ajplung.90209.2008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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