The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Modest maternal protein restriction fails to program adult hypertension in female rats
Abstract
Modest maternal dietary protein restriction in the rat leads to hypertension in adult male offspring. The purpose of this study was to determine whether female rats are resistant to developing the increased blood pressure seen in male rats after maternal protein restriction. Pregnant rats were fed a normal protein (19%, NP) or low-protein (8.5%, LP) diet throughout gestation. Renal renin protein and ANG II levels were reduced by 50–65% in male LP compared with NP pups, but were not suppressed in female LP compared with female NP. Mean arterial pressure in conscious, chronically instrumented adult female offspring (22 wk) was not different in LP (LP: 120 ± 3 mmHg vs. NP: 121 ± 2 mmHg), and glomerular filtration rate was also not different in LP vs. NP. The number of glomeruli per kidney was similar in adult LP and NP female offspring (LP: 26,050 ± 2,071 vs. NP: 26,248 ± 1,292, NP), and individual glomerular volume was also not different (LP: 0.92 ± 0.11 10 6 μm 3, LP vs. NP: 1.07 ± 0.11 10 6 μm 3); the total volume of all glomeruli per kidney was also not significantly different. Thus female rats are relatively resistant to the programming for adult hypertension by perinatal protein restriction that we have described in males. This resistance may be due to the fact that modest maternal protein restriction does not reduce the number of glomeruli with which females are endowed as it does in males. The intrarenal renin-angiotensin system during development may play a key role in this protective effect of female gender.
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Cites
Fetal and placental size and risk of hypertension in adult life.
Barker, D. J., Bull, A. R., Osmond, C., & Simmonds, S. J. (1990) · BMJ · doi:10.1136/bmj.301.6746.259 · Cited by 1,728
Cited by
Effect of In Utero and Early-Life Conditions on Adult Health and Disease
Gluckman, P. D., Hanson, M. A., Cooper, C., & Thornburg, K. L. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0708473 · Cited by 3,898
Boys live dangerously in the womb
Eriksson, J. G., Kajantie, E., Osmond, C., Thornburg, K., & Barker, D. J. P. (2010) · American Journal of Human Biology · doi:10.1002/ajhb.20995 · Cited by 590
Programming of adult blood pressure by maternal protein restriction: Role of nephrogenesis
Woods, L. L., Weeks, D. A., & Rasch, R. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00511.x · Cited by 353
Self-citationPinheiro, A. R., Salvucci, I. D. M., Aguila, M. B., & Mandarim-de-Lacerda, C. A. (2008) · Clinical Science · doi:10.1042/cs20070302 · Cited by 153
Khorram, O., Ghazi, R., Chuang, T.-D., Han, G., Naghi, J., Ni, Y., & Pearce, W. J. (2014) · Reproductive Sciences · doi:10.1177/1933719113508819 · Cited by 22
Metadata
- Authors
- Woods, L. L., Ingelfinger, J. R., & Rasch, R.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2005-10
- Volume
- 289
- Issue
- 4
- Pages
- R1131-R1136
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2114953276
- Cited by
- 221
- References
- 1
- FWCI
- 9.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Woods, L. L., Ingelfinger, J. R., & Rasch, R. (2005). Modest maternal protein restriction fails to program adult hypertension in female rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.00037.2003
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