Cited by 22Birth, Development, and HealthPregnancy and preeclampsia studiesAngiogenesis and VEGF in Cancer

Excess Maternal Glucocorticoids in Response to In Utero Undernutrition Inhibit Offspring Angiogenesis

Open access
Khorram, Omid, Ghazi, Reza, Chuang, Tsai-Der, Han, Guang, Naghi, Joshua, Ni, Youping, Pearce, William J.·2014·Reproductive Sciences

Abstract

To test the hypothesis that inhibition of offspring angiogenesis by maternal undernutrition (MUN) is mediated by maternal glucocorticoids, 3 groups of dams were studied: controls received ad libitum food; MUN dams were food restricted by 50% from day 10 of gestation; and metyrapone (MET) dams were food restricted and treated with 0.5 mg/mL of MET, a glucocorticoid synthesis inhibitor. The MUN reduced birth weights, reduced vascular endothelial growth factor (VEGF) abundance in P1 aortas, reduced VEGF and VEGF-R2 abundances in P1 mesenteric arterioles, reduced arteriolar endothelial nitric oxide synthase abundance, reduced microvessel density in the anterior tibialis, reduced endothelial cell branching in culture, reduced arteriolar immunoreactivity for proliferating cell nuclear antigen (PCNA), increased active caspase 3 in P1 mesenteric arterioles, and decreased matrix metalloproteinase (MMP)-2 and MMP-9 abundances in lysates of P1 aortas. All of these effects were prevented by treatment with metyrapone. Collectively, these findings suggest that reduced angiogenesis in MUN offspring involves direct inhibitory effects of maternal glucorticoid on fetal VEGF and its receptors.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1177/1933719113508819

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Resultant exposure to elevated levels of cortisol may contribute to developmental programming of the fetal hypothalamic-pituitary-adrenal axis and other organ systems.

    “Resultant exposure to elevated levels of cortisol may contribute to developmental programming of the fetal hypothalamic-pituitary-adrenal axis and other organ systems (127, 129, 306).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [306]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Seckl JR. 11beta-hydroxysteroid dehydrogenases: changing glu- cocorticoid action. Curr Opin Pharmacol. 2004;4(6):597-602.

Cited by

Sorted by citations

Authors
Khorram, O., Ghazi, R., Chuang, T.-D., Han, G., Naghi, J., Ni, Y., & Pearce, W. J.
Affiliations
  • Harbor–UCLA Medical Center (US)
  • Loma Linda University (US)
Corresponding author
Khorram, Omid
Venue
Reproductive Sciences
Published
2014-05
Volume
21
Issue
5
Pages
601-611
ISSN
  • 1933-7191 (ISSN-L)
  • 1933-7205
OpenAlex
W2064190876
Cited by
22
References
71
Citations by year
2026: 2 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 1
FWCI
2.48
Type
journal article
Language
en
Open access
Locations
  • Reproductive Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Heart Association (4290098)
  • National Institutes of Health (HD31226)
  • National Institute of Neurological Disorders and Stroke (R01NS076945)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01-HD-31226, R03HD054920, P01HD031226)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords
maternal undernutrition, maternal glucocorticoids, angiogenesis, fetal growth restriction, metyrapone, vascular endothelial growth factor, VEGF receptor 2, endothelial nitric oxide synthase, microvessel density, apoptosis, caspase-3, matrix metalloproteinases, aorta, mesenteric arterioles, tibialis anterior
MeSH terms
Animals, Cells, Cultured, Female, Fetal Growth Retardation, Glucocorticoids, Maternal-Fetal Exchange, Pregnancy, Biomarkers, Rats, Sprague-Dawley, Neovascularization, Physiologic, Malnutrition, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review