The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Biochemistry of exercise-induced metabolic acidosis
Abstract
The development of acidosis during intense exercise has traditionally been explained by the increased production of lactic acid, causing the release of a proton and the formation of the acid salt sodium lactate. On the basis of this explanation, if the rate of lactate production is high enough, the cellular proton buffering capacity can be exceeded, resulting in a decrease in cellular pH. These biochemical events have been termed lactic acidosis. The lactic acidosis of exercise has been a classic explanation of the biochemistry of acidosis for more than 80 years. This belief has led to the interpretation that lactate production causes acidosis and, in turn, that increased lactate production is one of the several causes of muscle fatigue during intense exercise. This review presents clear evidence that there is no biochemical support for lactate production causing acidosis. Lactate production retards, not causes, acidosis. Similarly, there is a wealth of research evidence to show that acidosis is caused by reactions other than lactate production. Every time ATP is broken down to ADP and P i , a proton is released. When the ATP demand of muscle contraction is met by mitochondrial respiration, there is no proton accumulation in the cell, as protons are used by the mitochondria for oxidative phosphorylation and to maintain the proton gradient in the intermembranous space. It is only when the exercise intensity increases beyond steady state that there is a need for greater reliance on ATP regeneration from glycolysis and the phosphagen system. The ATP that is supplied from these nonmitochondrial sources and is eventually used to fuel muscle contraction increases proton release and causes the acidosis of intense exercise. Lactate production increases under these cellular conditions to prevent pyruvate accumulation and supply the NAD + needed for phase 2 of glycolysis. Thus increased lactate production coincides with cellular acidosis and remains a good indirect marker for cell metabolic conditions that induce metabolic acidosis. If muscle did not produce lactate, acidosis and muscle fatigue would occur more quickly and exercise performance would be severely impaired.
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In the citing paper
“During transport, the level of activity of the muscle increased significantly, which results in increased O2 consumption.”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“during intense musculoskeletal activity (i.e., long transportation), the production of lactic acid via glycolysis surpasses the body's lactate metabolism capacity; thus, lactic acid accumulates in the blood”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“To maintain normal blood pH, bicarbonate buffers the lactic acid, resulting in the production of water and CO2; this ultimately results in lower blood pH”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“The metabolic acidosis detected in calves transported for 12 h and 16 h can be explained by an increase in muscle activity, leading to lactic acid production, via glycolysis, that surpasses the body's lactate metabolism capacity”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“An increase in O2 consumption increases CO2 production”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“Previous studies indicate that although lactate and H+accumulation suggest greater ATP production from glucose or glycogen, this does not always improve sprint performance19,20.”
From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [20]
In the citing paper
“Despite this, glycolytic ATP production is known to enhance peak sprint performance during early sprints, which highlights the paradox of whether maximal glycolytic activity improves overall RSA performance20,31,36.”
From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [20]
In the citing paper
“Glycogen serves as an essential energy source for both anaerobic and aerobic pathways, and its depletion—or the reduced ability to utilize available glycogen—limits ATP resynthesis, leading to decreased endurance and performance17,20,37.”
From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [20]
Citations
Cites
Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition
Bernardi, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1127 · Cited by 1,546
Muscular exercise, lactic acid, and the supply and utilisation of oxygen
Hill, A., Long, C.-N.-H., & Lupton, H. (1924) · QJM · doi:10.1093/qjmed/os-16.62.135 · Cited by 1,380
Metabolic regulation via intracellular pH
Busa, W. B., & Nuccitelli, R. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.246.4.r409 · Cited by 669
Wollaston, W. H. (1810) · Philosophical Transactions of the Royal Society of London · doi:10.1098/rstl.1810.0002 · Cited by 624
Muscle Fatigue: Lactic Acid or Inorganic Phosphate the Major Cause?
Westerblad, H., Allen, D. G., & Lännergren, J. (2002) · Physiology · doi:10.1152/physiologyonline.2002.17.1.17 · Cited by 577
Margaria, R., Edwards, H. T., & Dill, D. B. (1933) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1933.106.3.689 · Cited by 576
Latchman, D. S. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89112-4 · Cited by 574
Hochachka, P. W., & Mommsen, T. P. (1983) · Science · doi:10.1126/science.6298937 · Cited by 572
Webster’s Ninth New Collegiate Dictionary
慈继伟 (1985) · 外语教学与研究：外国语文双月刊 · Cited by 547
The Elements of the Science of Nutrition.
(1911) · Archives of Internal Medicine · doi:10.1001/archinte.1911.00060040141010 · Cited by 477
Research works printed but not linked: 2
- Laski ME and Wesson DE. Lactic acidosis. In: Acid-Base and Electrolyte Disorders: A Companion to Brenner and Rector's The Kidney , edited by DuBose TD and Hamm LL. Philadelphia, PA: Saunders, 2002, p. 835–108
- 10.1152/ajpcell.1981.240.3.C121 · DOI
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Ligeza, T. S., Maciejczyk, M., Kałamała, P., Szyguła, Z., & Wyczesany, M. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2018.04.003 · Cited by 55
Minamiki, T., Tokito, S., & Menami, T. (2018) · Analytical Sciences · doi:10.2116/analsci.18sdn02 · Cited by 56
Chycki, J., Kurylas, A., Maszczyk, A., Golas, A., & Zajac, A. (2018) · PLOS ONE · doi:10.1371/journal.pone.0205708 · Cited by 55
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Pamenter, M. E. (2022) · Journal of Experimental Biology · doi:10.1242/jeb.196725 · Cited by 57
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Reaburn, P. R. J., & Dascombe, B. J. (2008) · European Review of Aging and Physical Activity · doi:10.1007/s11556-008-0041-6 · Cited by 58
Atlante, A., Lidia de, B. A. R. I., Bobba, A., Marra, E., & Passarella, S. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.08.003 · Cited by 53
Yuk, J., Simpson, M. J., & Simpson, A. J. (2013) · Environmental Pollution · doi:10.1016/j.envpol.2012.12.007 · Cited by 53
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Highly sensitive non-enzymatic lactate biosensor driven by porous nanostructured nickel oxide
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Liu, P. H., Aoi, W., Takami, M., Terajima, H., Tanimura, Y., Naito, Y., Itoh, Y., & Yoshikawa, T. (2014) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.13-110 · Cited by 52
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Prestes, J., Tibana, R. A., Sousa, E. D. A., Nascimento, D. D. C., Rocha, P. D. O., Camarço, N. F., de Sousa, N. M. F., & Willardson, J. M. (2017) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001923 · Cited by 54
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Huang, K., Wu, W.-T., Yang, F., Chiu, Y., Peng, T., Hsu, B., Liao, K., & Lee, R.-P. (2013) · Molecules · doi:10.3390/molecules18043825 · Cited by 50
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Liang, R., Chen, J., Shi, Y., Lü, Y., Suriyanarayanan, S., Xu, X., Zheng, X., Khan, K., & Su, C. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.04.145 · Cited by 50
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JONES, A. M., Wilkerson, D. P., BERGER, N. J. A., & Fulford, J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00056.2007 · Cited by 50
Ghareghani, M., Dokoohaki, S., Ghanbari, A., Farhadi, N., Zibara, K., Khodadoust, S., Parishani, M. R., Ghavamizadeh, M., & Sadeghi, H. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12678 · Cited by 49
Cunha‐Silva, H., & Arcos‐Martínez, M. J. (2018) · Talanta · doi:10.1016/j.talanta.2018.06.054 · Cited by 49
Repeatability and predictive value of lactate threshold concepts in endurance sports
Heuberger, J. A. A. C., Gal, P., Stuurman, F. E., Keizer, W. A. S. D. M., Miranda, Y. M., & Cohen, A. F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206846 · Cited by 61
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Korhonen, M. T., Suominen, H., & Mero, A. M. J. (2005) · Canadian Journal of Applied Physiology · doi:10.1139/h05-146 · Cited by 48
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Kovacs, M. S., & Baker, L. B. (2014) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-093223 · Cited by 50
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Marino, F. E., Gard, M., & Drinkwater, E. J. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2009.067611 · Cited by 48
A mitochondrial protein increases glycolytic flux
Matarneh, S. K., England, E. M., Scheffler, T. L., Yen, C., Wicks, J. C., Shi, H., & Gerrard, D. E. (2017) · Meat Science · doi:10.1016/j.meatsci.2017.06.007 · Cited by 48
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Boning, D. G., Strobel, G., Beneke, R., & Maassen, N. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00069.2005 · Cited by 48
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Li, Y., Dash, R. K., Kim, J., Saidel, G. M., & Cabrera, M. E. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00094.2008 · Cited by 46
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Schnuck, J. K., Sunderland, K., Kuennen, M. R., & Vaughan, R. A. (2016) · Physical Activity and Nutrition · doi:10.20463/jenb.2016.06.20.2.5 · Cited by 47
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Qin, L., Wang, W., You, S., Dong, J., Zhou, Y., & Wang, J. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s74306 · Cited by 47
Kappenstein, J., Ferrauti, A., Runkel, B., Fernández-Fernández, J., Müller, K., & Zange, J. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2712-x · Cited by 50
Ho, J. D., Dawes, D. M., Cole, J. B., Hottinger, J. C., Overton, K. G., & Miner, J. R. (2009) · Forensic Science International · doi:10.1016/j.forsciint.2009.05.016 · Cited by 46
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Willcocks, R. J., Williams, C. A., BARKER, A. R., Fulford, J., & Armstrong, N. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1495 · Cited by 45
Camic, C. L., Housh, T. J., Zuñiga, J. M., Hendrix, C. R., Bergstrom, H. C., Traylor, D. A., Schmidt, R. J., & Johnson, G. O. (2012) · Journal of Electromyography and Kinesiology · doi:10.1016/j.jelekin.2012.09.010 · Cited by 45
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Haramizu, S., Ota, N., Hase, T., & Murase, T. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01434.2010 · Cited by 47
Mossberg, K. A., Durham, W. J., Zgaljardic, D. J., Gilkison, C. R., Danesi, C. P., Sheffield-Moore, M., Masel, B. E., & Urban, R. J. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2016.4552 · Cited by 44
Volatile organic compound markers of psychological stress in skin: a pilot study
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Schmoller, A., Eberhardt, F., Jauch-Chara, K., Schweiger, U., Zabel, P., Peters, A., Schultes, B., & Oltmanns, K. (2009) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2009.02.014 · Cited by 43
Meyerspeer, M., Kemp, G. J., Mlynárik, V., Krššák, M., Szendroedi, J., Nowotny, P., Roden, M., & Moser, E. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21188 · Cited by 44
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Egger, F., Meyer, T., Such, U., & Hecksteden, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114729 · Cited by 47
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Mota, M. R., Dantas, R. A. E., Silva, I. O., Sales, M. M., Sotero, R. D. C., Venâncio, P. E. M., Júnior, J. T., Chaves, S. N., & de Lima, F. D. (2017) · Open Access Journal of Sports Medicine · doi:10.2147/oajsm.s127948 · Cited by 43
Juybari, K. B., Ebrahimi, G., Momeni‐Moghaddam, M. A., Asadikaram, G., Torkzadeh‐Mahani, M., Akbari, M., Mirzamohammadi, S., Karimi, A., & Nematollahi, M. H. (2017) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2017.11.010 · Cited by 43
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Specific Circuit Training in Young Judokas
Baudry, S., & Roux, P. (2009) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2009.10599548 · Cited by 50
Kemp, G. J., Boning, D. G., Beneke, R., & Maassen, N. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00662.2005 · Cited by 43
Effect of sodium bicarbonate and beta-alanine supplementation on maximal sprint swimming
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Holviala, J., HÄKKINEN, A. H., Karavirta, L., Nyman, K., Izquierdo, M., Gorostiaga, E. M., Avela, J., Korhonen, J., Knuutila, V.-P., Kraemer, W. J., et al. (2010) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181dba178 · Cited by 43
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Gerdle, B. U. C., Ernberg, M. M., Mannerkorpi, K., Larsson, B. K., Kosek, E., Christidis, N., & Ghafouri, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162010 · Cited by 46
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Rezende, N. S., Swinton, P. A., de Oliveira, L. F., da Silva, R. P., Silva, V. D. E., Nemezio, K., Yamaguchi, G. D. C., Artioli, G. G., Gualano, B., Saunders, B., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00913 · Cited by 40
Hietavala, E., Puurtinen, R., Kainulainen, H., & Mero, A. A. (2012) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-9-50 · Cited by 39
Peçanha, T., Brito, L. C., Fecchio, R. Y., de Sousa, P. N., da Silva, N. D., Pio-Abreu, A., da Silva, G. V., Mion‐Junior, D., & Forjaz, C. L. M. (2016) · The Journal of Physiology · doi:10.1113/jp272851 · Cited by 40
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de Freitas, M. C., Cholewa, J. M., Gobbo, L. A., de Oliveira, J. V. N. S., Lira, F. S., & Rossi, F. E. (2017) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002329 · Cited by 39
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Steinberg, A. A. (2021) · Medicine Science and the Law · doi:10.1177/0025802420988370 · Cited by 46
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Boning, D. G., Klarholz, C., Himmelsbach, B., Hütler, M., & Maassen, N. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0328-0 · Cited by 39
Yuk, J., Simpson, M. J., & Simpson, A. J. (2012) · Ecotoxicology · doi:10.1007/s10646-012-0884-5 · Cited by 38
Nitecka-Buchta, A., Buchta, P., Tabeńska-Bosakowska, E., Walczyńska-Dragon, K., & Baron, S. (2014) · BioMed Research International · doi:10.1155/2014/296053 · Cited by 38
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Kuan, I., Savage, R. L., Duffull, S. B., Walker, R. J., & Wright, D. F. B. (2019) · Drug Safety · doi:10.1007/s40264-019-00854-x · Cited by 38
Hoshino, D., Tamura, Y., Masuda, H., Matsunaga, Y., & Hatta, H. (2015) · Physiological Reports · doi:10.14814/phy2.12555 · Cited by 41
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Mooney, E., Raw, C., & Hughes, D. (2014) · Topics in companion animal medicine · doi:10.1053/j.tcam.2014.09.005 · Cited by 37
Meadows, E., Flynn, J. M., & Klein, W. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016184 · Cited by 35
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Jarvis, K. J., Woodward, M. K., Debold, E. P., & Walcott, S. (2018) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-018-9499-7 · Cited by 37
Dolan, E., Saunders, B., Harris, R. C., Bicudo, J. E. P. W., Bishop, D. J., Sale, C., & Gualano, B. (2019) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2019.04.017 · Cited by 37
Sridharan, V., Guichard, J. L., Bailey, R. M., Kasiganesan, H., Beeson, C. C., & Wright, G. L. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00100.2006 · Cited by 37
Tuhay, G., Pein, M. C., Masevicius, F. D., Kutscherauer, D. O., & Dubín, A. (2008) · Critical Care · doi:10.1186/cc6896 · Cited by 37
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Maughan, R., & IOC Medical Commission (2008) · Wiley eBooks · doi:10.1002/9781444303315 · Cited by 37
Mellon, E. A., Lee, S., Pickup, S., Kim, S., Goldstein, S. C., Floyd, T. F., Poptani, H., Delikatny, E. J., Reddy, R. D., & Glickson, J. D. (2009) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22141 · Cited by 36
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Miller, P. R., Skoog, S. A., Edwards, T. L., Wheeler, D. R., Xiao, X., Brozik, S. M., Polsky, R., & Narayan, R. J. (2012) · Journal of Visualized Experiments · doi:10.3791/4067 · Cited by 36
Beardsall, J. W., McLean, M. F., Cooke, S. J., Wilson, B. C., Dadswell, M. J., Redden, A. M., & Stokesbury, M. J. W. (2013) · Transactions of the American Fisheries Society · doi:10.1080/00028487.2013.806347 · Cited by 36
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Metadata
- Authors
- Robergs, R. A., Ghiasvand, F., & Parker, D.
- Affiliations
- University of New Mexico (US)
- ORCID
- Robergs, Robert A.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2004-09
- Volume
- 287
- Issue
- 3
- Pages
- R502-R516
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2171756298
- Cited by
- 1,304
- References
- 66
- Citations by year
- 2026: 58 · 2025: 60 · 2024: 71 · 2023: 75 · 2022: 82 · 2021: 82 · 2020: 71 · 2019: 54 · 2018: 81 · 2017: 62 · 2016: 53 · 2015: 51 · 2014: 70 · 2013: 63 · 2012: 58
- FWCI
- 74.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Faculty of Health
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- lactic acidosis, lactic acid production, muscle fatigue, proton release, ATP regeneration, glycolysis, phosphagen system, mitochondrial respiration, oxidative phosphorylation, pyruvate accumulation, NAD+ regeneration, exercise performance
- MeSH terms
- Acidosis, Acidosis, Lactic, Animals, Buffers, Humans, Models, Biological, Protons, Exercise, Lactic Acid, History, 18th Century, History, 20th Century
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