The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Biochemistry of exercise-induced metabolic acidosis
Abstract
The development of acidosis during intense exercise has traditionally been explained by the increased production of lactic acid, causing the release of a proton and the formation of the acid salt sodium lactate. On the basis of this explanation, if the rate of lactate production is high enough, the cellular proton buffering capacity can be exceeded, resulting in a decrease in cellular pH. These biochemical events have been termed lactic acidosis. The lactic acidosis of exercise has been a classic explanation of the biochemistry of acidosis for more than 80 years. This belief has led to the interpretation that lactate production causes acidosis and, in turn, that increased lactate production is one of the several causes of muscle fatigue during intense exercise. This review presents clear evidence that there is no biochemical support for lactate production causing acidosis. Lactate production retards, not causes, acidosis. Similarly, there is a wealth of research evidence to show that acidosis is caused by reactions other than lactate production. Every time ATP is broken down to ADP and P i , a proton is released. When the ATP demand of muscle contraction is met by mitochondrial respiration, there is no proton accumulation in the cell, as protons are used by the mitochondria for oxidative phosphorylation and to maintain the proton gradient in the intermembranous space. It is only when the exercise intensity increases beyond steady state that there is a need for greater reliance on ATP regeneration from glycolysis and the phosphagen system. The ATP that is supplied from these nonmitochondrial sources and is eventually used to fuel muscle contraction increases proton release and causes the acidosis of intense exercise. Lactate production increases under these cellular conditions to prevent pyruvate accumulation and supply the NAD + needed for phase 2 of glycolysis. Thus increased lactate production coincides with cellular acidosis and remains a good indirect marker for cell metabolic conditions that induce metabolic acidosis. If muscle did not produce lactate, acidosis and muscle fatigue would occur more quickly and exercise performance would be severely impaired.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“During transport, the level of activity of the muscle increased significantly, which results in increased O2 consumption.”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“during intense musculoskeletal activity (i.e., long transportation), the production of lactic acid via glycolysis surpasses the body's lactate metabolism capacity; thus, lactic acid accumulates in the blood”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“To maintain normal blood pH, bicarbonate buffers the lactic acid, resulting in the production of water and CO2; this ultimately results in lower blood pH”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“The metabolic acidosis detected in calves transported for 12 h and 16 h can be explained by an increase in muscle activity, leading to lactic acid production, via glycolysis, that surpasses the body's lactate metabolism capacity”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“An increase in O2 consumption increases CO2 production”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“Previous studies indicate that although lactate and H+accumulation suggest greater ATP production from glucose or glycogen, this does not always improve sprint performance19,20.”
From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [20]
In the citing paper
“Despite this, glycolytic ATP production is known to enhance peak sprint performance during early sprints, which highlights the paradox of whether maximal glycolytic activity improves overall RSA performance20,31,36.”
From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [20]
In the citing paper
“Glycogen serves as an essential energy source for both anaerobic and aerobic pathways, and its depletion—or the reduced ability to utilize available glycogen—limits ATP resynthesis, leading to decreased endurance and performance17,20,37.”
From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [20]
Citations
Cites
Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition
Bernardi, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1127 · Cited by 1,546
Muscular exercise, lactic acid, and the supply and utilisation of oxygen
Hill, A., Long, C.-N.-H., & Lupton, H. (1924) · QJM · doi:10.1093/qjmed/os-16.62.135 · Cited by 1,380
Metabolic regulation via intracellular pH
Busa, W. B., & Nuccitelli, R. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.246.4.r409 · Cited by 669
Wollaston, W. H. (1810) · Philosophical Transactions of the Royal Society of London · doi:10.1098/rstl.1810.0002 · Cited by 624
Muscle Fatigue: Lactic Acid or Inorganic Phosphate the Major Cause?
Westerblad, H., Allen, D. G., & Lännergren, J. (2002) · Physiology · doi:10.1152/physiologyonline.2002.17.1.17 · Cited by 577
Margaria, R., Edwards, H. T., & Dill, D. B. (1933) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1933.106.3.689 · Cited by 576
Latchman, D. S. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89112-4 · Cited by 574
Hochachka, P. W., & Mommsen, T. P. (1983) · Science · doi:10.1126/science.6298937 · Cited by 572
Webster’s Ninth New Collegiate Dictionary
慈继伟 (1985) · 外语教学与研究：外国语文双月刊 · Cited by 547
The Elements of the Science of Nutrition.
(1911) · Archives of Internal Medicine · doi:10.1001/archinte.1911.00060040141010 · Cited by 477
Research works printed but not linked: 2
- Laski ME and Wesson DE. Lactic acidosis. In: Acid-Base and Electrolyte Disorders: A Companion to Brenner and Rector's The Kidney , edited by DuBose TD and Hamm LL. Philadelphia, PA: Saunders, 2002, p. 835–108
- 10.1152/ajpcell.1981.240.3.C121 · DOI
Cited by
Sorted by citations
Skeletal muscle fatigue: cellular mechanisms
Allen, D. G., Lamb, G. D., & Westerblad, H. (2008) · Physiological Reviews · doi:10.1152/physrev.00015.2007 · Cited by 2,495
Myocardial Fatty Acid Metabolism in Health and Disease
Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,228
The Science and Translation of Lactate Shuttle Theory
Brooks, G. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.008 · Cited by 1,486
Endurance exercise performance: the physiology of champions
Joyner, M. J., & Coyle, E. F. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.143834 · Cited by 1,307
Fragala, M. S., Cadore, E. L., Dorgo, S., Izquierdo, M., Kraemer, W. J., Peterson, M. D., & Ryan, E. D. (2019) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003230 · Cited by 1,290
The Acidic Tumor Microenvironment as a Driver of Cancer
Boedtkjer, E., & Pedersen, S. F. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034627 · Cited by 1,293
Electrochemical Tattoo Biosensors for Real-Time Noninvasive Lactate Monitoring in Human Perspiration
Jia, W., Bandodkar, A. J., Valdés-Ramírez, G., Windmiller, J. R., Yang, Z., Ramírez, J., Chan, G., & Wang, J. (2013) · Analytical Chemistry · doi:10.1021/ac401573r · Cited by 862
Haas, R., Smith, J., Rocher-Ros, V., Nadkarni, S., Montero‐Melendez, T., D’Acquisto, F., Bland, E. J., Bombardieri, M., Pitzalis, C., Perretti, M., et al. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002202 · Cited by 800
Lactate Threshold Concepts: How Valid are They?
Faude, O., Kindermann, W., & Meyer, T. (2009) · Sports Medicine · doi:10.2165/00007256-200939060-00003 · Cited by 882
Périard, J. D., Eijsvogels, T. M. H., & Daanen, H. A. M. (2021) · Physiological Reviews · doi:10.1152/physrev.00038.2020 · Cited by 774
Using Recovery Modalities between Training Sessions in Elite Athletes
Barnett, A. H. (2006) · Sports Medicine · doi:10.2165/00007256-200636090-00005 · Cited by 639
Analysis and Interpretation of Microplate-Based Oxygen Consumption and pH Data
Divakaruni, A. S., Paradyse, A. R., Ferrick, D. A., Murphy, A. N., & Jastroch, M. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-801415-8.00016-3 · Cited by 543
Romero‐Garcia, S., Moreno‐Altamirano, M. M. B., Prado-García, H., & Sánchez‐García, F. J. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00052 · Cited by 529
Muscle metabolic responses to exercise above and below the “critical power” assessed using 31 P-MRS
JONES, A. M., Wilkerson, D. P., DiMenna, F. J., Fulford, J., & Poole, D. C. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00731.2007 · Cited by 479
Lactic Acid and Exercise Performance
Cairns, S. P. (2006) · Sports Medicine · doi:10.2165/00007256-200636040-00001 · Cited by 445
Lactate metabolism: historical context, prior misinterpretations, and current understanding
Ferguson, B. S., Rogatzki, M. J., Goodwin, M. L., Kane, D. A., Rightmire, Z. B., & Gladden, L. B. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3795-6 · Cited by 485
Functions of astrocytes and their potential as therapeutic targets
Kimelberg, H., & Nedergaard, M. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.07.006 · Cited by 423
Jaswal, J. S., Keung, W., Wang, W., Ussher, J. R., & Lopaschuk, G. D. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.015 · Cited by 401
Interaction among Skeletal Muscle Metabolic Energy Systems during Intense Exercise
Baker, J. S., McCormick, M. C., & Robergs, R. A. (2010) · Journal of Nutrition and Metabolism · doi:10.1155/2010/905612 · Cited by 460
Self-citationAn Examination and Critique of Current Methods to Determine Exercise Intensity
Jamnick, N. A., Pettitt, R. W., Granata, C., Pyne, D. B., & Bishop, D. J. (2020) · Sports Medicine · doi:10.1007/s40279-020-01322-8 · Cited by 424
Lactate in the Tumor Microenvironment: An Essential Molecule in Cancer Progression and Treatment
Pérez‐Tomás, R., & Pérez-Guillén, I. (2020) · Cancers · doi:10.3390/cancers12113244 · Cited by 418
Raedschelders, K., Ansley, D. M., & Chen, D. D. Y. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.11.004 · Cited by 393
Lactate kinetics in human tissues at rest and during exercise
van Hall, G. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02122.x · Cited by 346
Handbook of Fermented Meat and Poultry
(2007) · Wiley eBooks · doi:10.1002/9780470376430 · Cited by 347
Lactate – a signal coordinating cell and systemic function
Philp, A., Macdonald, A. L., & Watt, P. (2005) · Journal of Experimental Biology · doi:10.1242/jeb.01961 · Cited by 328
Faria, E. W., Parker, D., & Faria, I. E. (2005) · Sports Medicine · doi:10.2165/00007256-200535040-00002 · Cited by 321
Self-citationTattoo‐Based Wearable Electrochemical Devices: A Review
Bandodkar, A. J., Jia, W., & Wang, J. (2015) · Electroanalysis · doi:10.1002/elan.201400537 · Cited by 321
Blood flow restriction training and the exercise pressor reflex: a call for concern
Spranger, M. D., Krishnan, A. C., Levy, P. D., O’Leary, D. S., & Smith, S. A. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00208.2015 · Cited by 293
Lactate in human sweat: a critical review of research to the present day
Derbyshire, P. J., Barr, H., Davis, F., & Higson, S. P. J. (2012) · The Journal of Physiological Sciences · doi:10.1007/s12576-012-0213-z · Cited by 280
Lactate as a Metabolite and a Regulator in the Central Nervous System
Proia, P., Liegro, C. M. D., Schiera, G., Fricano, A., & Liegro, I. D. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091450 · Cited by 290
pH-gated succinate secretion regulates muscle remodeling in response to exercise
Reddy, A., Bozi, L. H. M., Yaghi, O. K., Mills, E. L., Xiao, H., Nicholson, H. E., Paschini, M., Paulo, J. A., Garrity, R., Laznik-Bogoslavski, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.039 · Cited by 279
Physiological Differences Between Cycling and Running: Lessons from Triathletes
Millet, G. P., Vleck, V. E., & Bentley, D. J. (2009) · Sports Medicine · doi:10.2165/00007256-200939030-00002 · Cited by 329
Hashim, A. I., Zhang, X., Wojtkowiak, J. W., Martinez, G. V., & Gillies, R. J. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1644 · Cited by 265
The Physiology of the World Record Holder for the Women's Marathon
JONES, A. M. (2006) · International Journal of Sports Science & Coaching · doi:10.1260/174795406777641258 · Cited by 256
Exercise and Blood Flow Restriction
Pope, Z. K., Willardson, J. M., & Schoenfeld, B. J. (2013) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3182874721 · Cited by 236
Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle
Bergersen, L. H. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.062 · Cited by 223
Payen, V. L., Porporato, P. E., Baselet, B., & Sonveaux, P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2098-5 · Cited by 226
An evolutionary hybrid cellular automaton model of solid tumour growth
Gerlee, P., & Anderson, A. R. A. (2007) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2007.01.027 · Cited by 222
Lactic Acidosis: From Sour Milk to Septic Shock
Fall, P. J., & Szerlip, H. M. (2005) · Journal of Intensive Care Medicine · doi:10.1177/0885066605278644 · Cited by 197
Functions of Mature Mammalian Astrocytes: A Current View
Kimelberg, H. K. (2010) · The Neuroscientist · doi:10.1177/1073858409342593 · Cited by 218
Suwa, M., Nakano, H., Radak, Z. O., & Kumagai, S. (2008) · Metabolism · doi:10.1016/j.metabol.2008.02.017 · Cited by 198
Physiological effects of hyperchloraemia and acidosis
Handy, J. M., & Soni, N. (2008) · British Journal of Anaesthesia · doi:10.1093/bja/aen148 · Cited by 189
The thermoregulation system and how it works
(2018) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-63912-7.00001-1 · Cited by 186
Method for high‐resolution imaging of creatine in vivo using chemical exchange saturation transfer
Kogan, F., Haris, M., Singh, A. K., Cai, K., DeBrosse, C., Nanga, R. P. R., Hariharan, H., & Reddy, R. D. (2013) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24641 · Cited by 176
Lactate as a Signaling Molecule That Regulates Exercise-Induced Adaptations
Nalbandian, M., & Takeda, M. (2016) · Biology · doi:10.3390/biology5040038 · Cited by 174
Thread-based multiplexed sensor patch for real-time sweat monitoring
Terse-Thakoor, T., Punjiya, M., Matharu, Z., Lyu, B., Ahmad, M., Giles, G. E., Owyeung, R. E., Alaimo, F., Baghini, M. S., Brunyé, T. T., et al. (2020) · npj Flexible Electronics · doi:10.1038/s41528-020-00081-w · Cited by 172
Gupta, G. S. (2022) · Inflammation · doi:10.1007/s10753-022-01680-7 · Cited by 181
Ergogenic Effects of Sodium Bicarbonate
McNaughton, L. R., Siegler, J. C., & Midgley, A. W. (2008) · Current Sports Medicine Reports · doi:10.1249/jsr.0b013e31817ef530 · Cited by 170
Lancha Junior, A. H., de Salles Painelli, V., Saunders, B., & Artioli, G. G. (2015) · Sports Medicine · doi:10.1007/s40279-015-0397-5 · Cited by 167
Hickey, D. P., Reid, R. C., Milton, R. D., & Minteer, S. D. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.09.013 · Cited by 160
Garami, A., Shimansky, Y. P., Rumbus, Z., Vizin, R. C. L., Farkas, N., Hegyi, J., Szakacs, Z., Solymar, M., Csenkey, A., Chiche, D. A., et al. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107474 · Cited by 159
Lactate metabolism in chronic liver disease
Jeppesen, J. B., Mortensen, C., Bendtsen, F., & Møller, S. (2013) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2013.773591 · Cited by 158
Anti-fatigue activity of polysaccharides extract from Radix Rehmanniae Preparata
Tan, W. H., Yu, K.-Q., Liu, Y., Ouyang, M., Yan, M.-H., Ren, L., & Zhao, X. (2011) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2011.09.019 · Cited by 157
Physiological functions of peroxisome proliferator-activated receptor β
Neels, J. G., & Grimaldi, P. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00027.2013 · Cited by 161
Review of Biguanide (Metformin) Toxicity
Wang, G. S., & Hoyte, C. O. (2018) · Journal of Intensive Care Medicine · doi:10.1177/0885066618793385 · Cited by 164
Wearable multiplexed biosensor system toward continuous monitoring of metabolites
Yokus, M. A., Songkakul, T., Pozdin, V. A., Bozkurt, A., & Daniele, M. A. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112038 · Cited by 153
Redox balance is key to explaining full vs. partial switching to low-yield metabolism
van Hoek, M. J., & Merks, R. M. (2012) · BMC Systems Biology · doi:10.1186/1752-0509-6-22 · Cited by 131
Is fatigue all in your head? A critical review of the central governor model
Weir, J. P., Beck, T. W., Cramer, J. T., & Housh, T. J. (2006) · British Journal of Sports Medicine · doi:10.1136/bjsm.2005.023028 · Cited by 150
Gagaoua, M., Terlouw, C. E. M., Mullen, A. M., Franco, D., Warner, R. D., Lorenzo, J. M., Purslow, P. P., Gerrard, D. E., Hopkins, D. L., TROY, D. J., et al. (2020) · Meat Science · doi:10.1016/j.meatsci.2020.108311 · Cited by 158
Carbohydrate metabolism in meat animals
Pösö, A. R., & Puolanne, E. (2005) · Meat Science · doi:10.1016/j.meatsci.2004.12.017 · Cited by 146
Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation
Woods, P. S., Kimmig, L. M., Meliton, A. Y., Sun, K. A., Tian, Y., O’Leary, E. M., Gökalp, G. A., Hamanaka, R. B., & Mutlu, G. M. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0244oc · Cited by 145
The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells
Prochownik, E. V., & Wang, H. (2021) · Cells · doi:10.3390/cells10040762 · Cited by 150
Metformin and other antidiabetic agents in renal failure patients
Lalau, J., Arnouts, P., Sharif, A., & Broe, M. E. D. (2014) · Kidney International · doi:10.1038/ki.2014.19 · Cited by 147
Hultmann, L., Phú, T. M., Tobiassen, T. I., Aas-Hansen, Ø., & Rustad, T. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.03.038 · Cited by 141
Effect of Recovery Mode on Repeated Sprint Ability in Young Basketball Players
Castagna, C., Abt, G., Manzi, V., Annino, G., Padua, E., & D'Ottavio, S. (2008) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31816a4281 · Cited by 141
Lactate oxidation at the mitochondria: a lactate-malate-aspartate shuttle at work
Kane, D. A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00366 · Cited by 142
Robey, R. B., Weisz, J., Kuemmerle, N. B., Salzberg, A. C., Berg, A. S., Brown, D. G., Maurer, L. L., Palorini, R., Al‐Mulla, F., Al-Temaimi, R. A., et al. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv037 · Cited by 143
Lactate: a multifunctional signaling molecule
Lee, T.-Y. (2021) · Journal of Yeungnam Medical Science · doi:10.12701/yujm.2020.00892 · Cited by 142
Singh, N. K., Chung, S., Chang, A., Wang, J., & Hall, D. A. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115097 · Cited by 144
Neuromuscular Function after a Bout of Low-Load Blood Flow–Restricted Exercise
Cook, S. B., Murphy, B. G., & LaBarbera, K. E. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31826c6fa8 · Cited by 133
Kuwahara, H., Horie, T., Ishikawa, S., Tsuda, C., Kawakami, S., Noda, Y., Kaneko, T., Tahara, S., Tachibana, T., Okabe, M., et al. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.02.011 · Cited by 130
Lactic acid buffering, nonmetabolic CO2 and exercise hyperventilation: A critical reappraisal
Péronnet, F., & Aguilaniu, B. (2005) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2005.04.005 · Cited by 128
Seheult, J. N., Fitzpatrick, G. J., & Boran, G. P. (2016) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0438 · Cited by 128
Hooren, B. V., & Peake, J. M. (2018) · Sports Medicine · doi:10.1007/s40279-018-0916-2 · Cited by 134
Smith, A. E., Walter, A. A., Graef, J. L., Kendall, K. L., Moon, J. R., Lockwood, C. M., Fukuda, D. H., Beck, T. W., Cramer, J. T., & Stout, J. R. (2009) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-6-5 · Cited by 123
The Science of Speed: Determinants of Performance in the 100 m Sprint
Majumdar, A. S., & Robergs, R. A. (2011) · International Journal of Sports Science & Coaching · doi:10.1260/1747-9541.6.3.479 · Cited by 122
Self-citationpH inactivation of phosphofructokinase arrests postmortem glycolysis
England, E. M., Matarneh, S. K., Scheffler, T. L., Wachet, C., & Gerrard, D. E. (2014) · Meat Science · doi:10.1016/j.meatsci.2014.07.019 · Cited by 120
Terlouw, C. E. M., Picard, B. B., Deiss, V., Berri, C., Hocquette, J.-F. J.-F., Lebret, B., Lefèvre, F., Hamill, R. M., & Gagaoua, M. (2021) · Foods · doi:10.3390/foods10010084 · Cited by 120
Leal‐Junior, E. C. P., Lopes‐Martins, R. Á. B., Baroni, B. M., Marchi, T. D., Rossi, R. P., Grosselli, D., Generosi, R. A., de Godoi, V., Basso, M., Mancalossi, J. L., et al. (2009) · Photomedicine and Laser Surgery · doi:10.1089/pho.2008.2350 · Cited by 118
Leal‐Junior, E. C. P., Lopes‐Martins, R. Á. B., de Almeida, P., Ramos, L., Iversen, V. V., & Bjordal, J. M. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1321-1 · Cited by 117
Hall, M. M., Rajasekaran, S., Thomsen, T. W., & Peterson, A. R. (2016) · PM&R · doi:10.1016/j.pmrj.2015.10.018 · Cited by 119
A "Lactatic" Perspective on Metabolism
Gladden, L. B. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31815fa580 · Cited by 113
Gerdle, B. U. C., Ghafouri, B., Ernberg, M. M., & Larsson, B. (2014) · Journal of Pain Research · doi:10.2147/jpr.s59144 · Cited by 112
Role of metabolic stress for enhancing muscle adaptations: Practical applications
de Freitas, M. C., Gerosa-Neto, J., Zanchi, N. E., Lira, F. S., & Rossi, F. E. (2017) · World Journal of Methodology · doi:10.5662/wjm.v7.i2.46 · Cited by 124
Serum lactate as a novel potential biomarker in multiple sclerosis
Amorini, A. M., Nociti, V., Petzold, A., Gasperini, C., Quartuccio, M. E., Lazzarino, G., Pietro, V. D., Belli, A., Signoretti, S., Vagnozzi, R., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.04.005 · Cited by 111
Thomas, C., Bishop, D. J., Lambert, K., Mercier, J. G., & Brooks, G. A. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00250.2011 · Cited by 110
Regulation of post-mortem glycolysis in ruminant muscle
Ferguson, D. M., & Gerrard, D. E. (2014) · Animal Production Science · doi:10.1071/an13088 · Cited by 108
A ‘New’ Method to Normalise Exercise Intensity
Lansley, K. E., DiMenna, F. J., Bailey, S. J., & JONES, A. M. (2011) · International Journal of Sports Medicine · doi:10.1055/s-0031-1273754 · Cited by 108
Proteomic biomarkers of beef colour
Gagaoua, M., Hughes, J. M., Terlouw, C. E. M., Warner, R. D., Purslow, P. P., Lorenzo, J. M., & Picard, B. B. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.05.005 · Cited by 107
Applying physicochemical principles to skeletal muscle acid-base status
Lindinger, M. I., Kowalchuk, J. M., & Heigenhauser, G. J. F. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00225.2005 · Cited by 107
Effects of Four Recovery Methods on Repeated Maximal Rock Climbing Performance
Heyman, E., de Geus, B., MERTENS, I., & MEEUSEN, R. R. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318195107d · Cited by 106
Bendable Electro-chemical Lactate Sensor Printed with Silver Nano-particles
Abrar, M. A., Dong, Y., Lee, P. K., & Kim, W. S. (2016) · Scientific Reports · doi:10.1038/srep30565 · Cited by 105
Metcalfe, R. S., Koumanov, F., Ruffino, J. S., Stokes, K., Holman, G. D., Thompson, D., & Vollaard, N. B. J. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3217-6 · Cited by 114
e, J. E., Bishop, D. J., Hill-Haas, S. V., DAWSON, B. T., & Goodman, C. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-005-0056-x · Cited by 104
Extracellular vesicles and energy metabolism
Ronquist, G. K. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.10.044 · Cited by 101
Influence of pacing strategy on O2 uptake and exercise tolerance
JONES, A. M., Wilkerson, D. P., Vanhatalo, A., & Burnley, M. (2008) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2007.00725.x · Cited by 99
Choi, Y. M., Ryu, Y., & Kim, B. C. (2007) · Meat Science · doi:10.1016/j.meatsci.2006.11.009 · Cited by 98
The tortuous path of lactate shuttle discovery: From cinders and boards to the lab and ICU
Brooks, G. A. (2020) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2020.02.006 · Cited by 106
Garami, A., Pákai, E., McDonald, H. A., Reilly, R. M., Gomtsyan, A. R., Corrigan, J. J., Pintér, E., Zhu, D., Lehto, S. G., Gavva, N. R., et al. (2018) · Acta Physiologica · doi:10.1111/apha.13038 · Cited by 95
Wu, H., Huang, H., & Zhao, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1211221 · Cited by 103
Metadata
- Authors
- Robergs, R. A., Ghiasvand, F., & Parker, D.
- Affiliations
- University of New Mexico (US)
- ORCID
- Robergs, Robert A.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2004-09
- Volume
- 287
- Issue
- 3
- Pages
- R502-R516
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2171756298
- Cited by
- 1,304
- References
- 66
- Citations by year
- 2026: 58 · 2025: 60 · 2024: 71 · 2023: 75 · 2022: 82 · 2021: 82 · 2020: 71 · 2019: 54 · 2018: 81 · 2017: 62 · 2016: 53 · 2015: 51 · 2014: 70 · 2013: 63 · 2012: 58
- FWCI
- 74.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Faculty of Health
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- lactic acidosis, lactic acid production, muscle fatigue, proton release, ATP regeneration, glycolysis, phosphagen system, mitochondrial respiration, oxidative phosphorylation, pyruvate accumulation, NAD+ regeneration, exercise performance
- MeSH terms
- Acidosis, Acidosis, Lactic, Animals, Buffers, Humans, Models, Biological, Protons, Exercise, Lactic Acid, History, 18th Century, History, 20th Century
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
