The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Biochemistry of exercise-induced metabolic acidosis
Abstract
The development of acidosis during intense exercise has traditionally been explained by the increased production of lactic acid, causing the release of a proton and the formation of the acid salt sodium lactate. On the basis of this explanation, if the rate of lactate production is high enough, the cellular proton buffering capacity can be exceeded, resulting in a decrease in cellular pH. These biochemical events have been termed lactic acidosis. The lactic acidosis of exercise has been a classic explanation of the biochemistry of acidosis for more than 80 years. This belief has led to the interpretation that lactate production causes acidosis and, in turn, that increased lactate production is one of the several causes of muscle fatigue during intense exercise. This review presents clear evidence that there is no biochemical support for lactate production causing acidosis. Lactate production retards, not causes, acidosis. Similarly, there is a wealth of research evidence to show that acidosis is caused by reactions other than lactate production. Every time ATP is broken down to ADP and P i , a proton is released. When the ATP demand of muscle contraction is met by mitochondrial respiration, there is no proton accumulation in the cell, as protons are used by the mitochondria for oxidative phosphorylation and to maintain the proton gradient in the intermembranous space. It is only when the exercise intensity increases beyond steady state that there is a need for greater reliance on ATP regeneration from glycolysis and the phosphagen system. The ATP that is supplied from these nonmitochondrial sources and is eventually used to fuel muscle contraction increases proton release and causes the acidosis of intense exercise. Lactate production increases under these cellular conditions to prevent pyruvate accumulation and supply the NAD + needed for phase 2 of glycolysis. Thus increased lactate production coincides with cellular acidosis and remains a good indirect marker for cell metabolic conditions that induce metabolic acidosis. If muscle did not produce lactate, acidosis and muscle fatigue would occur more quickly and exercise performance would be severely impaired.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“During transport, the level of activity of the muscle increased significantly, which results in increased O2 consumption.”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“during intense musculoskeletal activity (i.e., long transportation), the production of lactic acid via glycolysis surpasses the body's lactate metabolism capacity; thus, lactic acid accumulates in the blood”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“To maintain normal blood pH, bicarbonate buffers the lactic acid, resulting in the production of water and CO2; this ultimately results in lower blood pH”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“The metabolic acidosis detected in calves transported for 12 h and 16 h can be explained by an increase in muscle activity, leading to lactic acid production, via glycolysis, that surpasses the body's lactate metabolism capacity”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“An increase in O2 consumption increases CO2 production”
From A randomized controlled trial investigating the effect of transport duration and age at transport on surplus dairy calves: Part II. Impact on hematological variables. (2023) · cites this paper as Robergs et al., 2004
In the citing paper
“Previous studies indicate that although lactate and H+accumulation suggest greater ATP production from glucose or glycogen, this does not always improve sprint performance19,20.”
From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [20]
In the citing paper
“Despite this, glycolytic ATP production is known to enhance peak sprint performance during early sprints, which highlights the paradox of whether maximal glycolytic activity improves overall RSA performance20,31,36.”
From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [20]
In the citing paper
“Glycogen serves as an essential energy source for both anaerobic and aerobic pathways, and its depletion—or the reduced ability to utilize available glycogen—limits ATP resynthesis, leading to decreased endurance and performance17,20,37.”
From Evaluating bioenergetic pathway contributions from single to multiple sprints (2024) · cites this paper as [20]
Citations
Cites
Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition
Bernardi, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1127 · Cited by 1,546
Muscular exercise, lactic acid, and the supply and utilisation of oxygen
Hill, A., Long, C.-N.-H., & Lupton, H. (1924) · QJM · doi:10.1093/qjmed/os-16.62.135 · Cited by 1,380
Metabolic regulation via intracellular pH
Busa, W. B., & Nuccitelli, R. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.246.4.r409 · Cited by 669
Wollaston, W. H. (1810) · Philosophical Transactions of the Royal Society of London · doi:10.1098/rstl.1810.0002 · Cited by 624
Muscle Fatigue: Lactic Acid or Inorganic Phosphate the Major Cause?
Westerblad, H., Allen, D. G., & Lännergren, J. (2002) · Physiology · doi:10.1152/physiologyonline.2002.17.1.17 · Cited by 577
Margaria, R., Edwards, H. T., & Dill, D. B. (1933) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1933.106.3.689 · Cited by 576
Latchman, D. S. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89112-4 · Cited by 574
Hochachka, P. W., & Mommsen, T. P. (1983) · Science · doi:10.1126/science.6298937 · Cited by 572
Webster’s Ninth New Collegiate Dictionary
慈继伟 (1985) · 外语教学与研究：外国语文双月刊 · Cited by 547
The Elements of the Science of Nutrition.
(1911) · Archives of Internal Medicine · doi:10.1001/archinte.1911.00060040141010 · Cited by 477
Research works printed but not linked: 2
- Laski ME and Wesson DE. Lactic acidosis. In: Acid-Base and Electrolyte Disorders: A Companion to Brenner and Rector's The Kidney , edited by DuBose TD and Hamm LL. Philadelphia, PA: Saunders, 2002, p. 835–108
- 10.1152/ajpcell.1981.240.3.C121 · DOI
Cited by
Sorted by citations
Items 301–400 of 1,000
Anti-Fatigue Effect of Prunus Mume Vinegar in High-Intensity Exercised Rats
Kim, J.-H., Cho, H.-D., Won, Y., Hong, S., Moon, K., & Seo, K. (2020) · Nutrients · doi:10.3390/nu12051205 · Cited by 36
Schwiete, C., Franz, A., Roth, C., & Behringer, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.663665 · Cited by 36
Strength and Conditioning for Professional Boxing: Recommendations for Physical Preparation
Ruddock, A. D., Wilson, D. C., Thompson, S. W., Hembrough, D., & Winter, E. M. (2016) · Strength & Conditioning Journal · doi:10.1519/ssc.0000000000000217 · Cited by 35
Monocarboxylate transporters facilitate succinate uptake into brown adipocytes
Reddy, A. J., Winther, S., Tran, N., Xiao, H., Jakob, J., Garrity, R., Smith, A., Ordonez, M., Laznik-Bogoslavski, D., Rothstein, J. D., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00981-5 · Cited by 36
Rohrig, R., Rönn, T., Lendemans, S., Feldkamp, T., de GROOT, H., & Petrat, F. (2012) · Shock · doi:10.1097/shk.0b013e31825b4ed9 · Cited by 35
Non-invasive lactate- and pH-monitoring in porcine meat using Raman spectroscopy and chemometrics
Nache, M., Scheier, R., Schmidt, H., & Hitzmann, B. (2015) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/j.chemolab.2015.02.002 · Cited by 36
de Freitas, M. C., Rossi, F. E., Colognesi, L. A., de Oliveira, J. V. N. S., Zanchi, N. E., Lira, F. S., Cholewa, J. M., & Gobbo, L. A. (2018) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002897 · Cited by 35
Saoi, M., Percival, M. E., Nemr, C. R., Li, A., Gibala, M. J., & Britz‐McKibbin, P. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00149 · Cited by 34
Chen, F., Zhu, K., Chen, L., Ouyang, L., Chen, C., Gu, L., Jiang, Y., Wang, Z., Lin, Z., Zhang, Q., et al. (2019) · Journal of Ginseng Research · doi:10.1016/j.jgr.2019.02.005 · Cited by 35
Caffeine and sodium bicarbonate supplementation alone or together improve karate performance
Rezaei, S., Akbari, K., Gahreman, D. E., Sarshin, A., Tabben, M., Kaviani, M., Sadeghinikoo, A., Koozehchian, M. S., & Naderi, A. (2019) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-019-0313-8 · Cited by 35
The Relationship between CrossFit® Performance and Laboratory-Based Measurements of Fitness
Zeitz, E. K., Cook, L. F., Dexheimer, J. D., Lemez, S., Leyva, W. D., Terbio, I. Y., Tran, J. R., & Jo, E. (2020) · Sports · doi:10.3390/sports8080112 · Cited by 35
Towards Detecting Biceps Muscle Fatigue in Gym Activity Using Wearables
Elshafei, M., & Shihab, E. (2021) · Sensors · doi:10.3390/s21030759 · Cited by 35
Hara, Y., Kume, S., Kataoka, Y., & Watanabe, N. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08501 · Cited by 30
Muscle damage alters the metabolic response to dynamic exercise in humans: a31P-MRS study
Davies, R. C., Eston, R. G., Fulford, J., Rowlands, A. V., & JONES, A. M. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01021.2010 · Cited by 35
Robles-Romo, A., Zenteno‐Savín, T., & Racotta, I. S. (2016) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/j.jembe.2016.01.016 · Cited by 35
What does glycolysis make and why is it important?
Brooks, G. A. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00308.2010 · Cited by 35
Anwer, S., Li, H., Antwi‐Afari, M. F., Umer, W., Mehmood, I., Al‐Hussein, M., & Wong, A. Y. L. (2021) · Journal of Building Engineering · doi:10.1016/j.jobe.2021.103348 · Cited by 34
Pinho, C. A., Tromm, C. B., Tavares, Â. M. V., da Silva, L. A., Silveira, P. C. L., de Souza, C. T., Benetti, M., & Pinho, R. A. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.01.018 · Cited by 34
Ketoacidosis – Where Do the Protons Come From?
Green, A., & Bishop, R. E. (2019) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2019.01.005 · Cited by 36
Shao, X., He, J., Liang, R., Lü, Y., Shi, Y., Wang, Y., Zheng, X., Zhang, S., & Wang, T. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.05.050 · Cited by 34
Efficiency of cycling exercise: Quantification, mechanisms, and misunderstandings
MacDougall, K. B., Falconer, T. M., & MacIntosh, B. R. (2022) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14149 · Cited by 35
Ives, S. J., Andtbacka, R. H. I., Noyes, R. D., Morgan, R. G., Gifford, J. R., Park, S., Symons, J. D., & Richardson, R. S. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.066613 · Cited by 34
High-Velocity Intermittent Running
Smith‐Ryan, A. E., Fukuda, D. H., Stout, J. R., & Kendall, K. L. (2012) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e318267922b · Cited by 34
Apaoblaza, A., Galaz, A., Strobel, P., Ramírez‐Reveco, A., Jerez-Timaure, N., & Gallo, C. (2014) · Meat Science · doi:10.1016/j.meatsci.2014.11.008 · Cited by 34
Wang, D., Luo, C., Li, Q., Zheng, T., Gao, P., Wang, B., & Duan, Z. (2023) · Scientific Reports · doi:10.1038/s41598-023-42330-8 · Cited by 33
Overview of Lactate Metabolism and the Implications for Athletes
(2013) · American journal of sports science and medicine · doi:10.12691/ajssm-1-3-3 · Cited by 33
Yang, W., Park, S., Kim, T., Jeon, H.-J., Heine, O., & Gehlert, S. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1147321 · Cited by 33
Boning, D. G., Klarholz, C., Himmelsbach, B., Hütler, M., & Maassen, N. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0453-4 · Cited by 33
Effect of aerobic training status on both maximal lactate steady state and critical power
Greco, C. C., Caritá, R. A. C., Dekerle, J., & Denadai, B. S. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h2012-047 · Cited by 33
Acute Antioxidant Supplementation Improves Endurance Performance in Trained Athletes
Bentley, D. J., Dank, S., Coupland, R., Midgley, A. W., & Spence, I. (2012) · Research in Sports Medicine · doi:10.1080/15438627.2011.608050 · Cited by 32
Ngan, A. K., & Wang, Y. S. (2009) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2009.08.003 · Cited by 32
White, G. E., & Wells, G. D. (2015) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000677 · Cited by 32
Aedma, M., Timpmann, S., & Ööpik, V. (2013) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.23.6.601 · Cited by 32
Nucleolar stress regulation of endometrial receptivity in mouse models and human cell lines
Hu, W., Liang, Y., Luo, J., Gu, X., Chen, Z., Fu, T., Zhu, Y., Lin, S., Diao, H., Jia, B., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2071-6 · Cited by 32
Narayanan, J. S., & Slaughter, G. E. (2020) · IEEE Sensors Journal · doi:10.1109/jsen.2019.2963405 · Cited by 32
Recent Advances in Wearable Sensors for the Monitoring of Sweat: A Comprehensive Tendency Summary
Xing, Z., Hui, J., Lin, B., Wu, Z., & Mao, H. (2023) · Chemosensors · doi:10.3390/chemosensors11090470 · Cited by 35
Training to Failure and Beyond in Mainstream Resistance Exercise Programs
Willardson, J. M., Norton, L. E., & Wilson, G. (2010) · Strength and conditioning journal · doi:10.1519/ssc.0b013e3181cc2a3a · Cited by 36
Pereira-Ferrero, V. H., Gama, M. C. T., Sousa, F. A. D. B., Lewis, T. G., Gobatto, C. A., & Manchado-Gobatto, F. D. B. (2015) · Scientific Reports · doi:10.1038/srep10489 · Cited by 32
Carbohydrate restriction: Friend or foe of resistance-based exercise performance?
Cholewa, J. M., Newmire, D. E., & Zanchi, N. E. (2018) · Nutrition · doi:10.1016/j.nut.2018.09.026 · Cited by 36
Effect of water-based recovery on blood lactate removal after high-intensity exercise
Lucertini, F., Gervasi, M., D'amen, G., Sisti, D., Rocchi, M., Stocchi, V., & Benelli, P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184240 · Cited by 31
Quittmann, O. J., Abel, T., Zeller, S., Foitschik, T., & Strüder, H. K. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-3879-y · Cited by 31
Siegler, J. C., Bell-Wilson, J. A., Mermier, C. M., Faria, E. W., & Robergs, R. A. (2006) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.16.1.92 · Cited by 31
Self-citationBotek, M., Krejčí, J., McKune, A. J., Valenta, M., & Sládečková, B. (2021) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003979 · Cited by 31
Guilherme, J. P. L. F., Bosnyák, E., Semenova, E. A., Szmodis, M., Griff, A., Móra, Á., Almási, G., Trájer, E., Udvardy, A., Kostryukova, E., et al. (2021) · Biology of Sport · doi:10.5114/biolsport.2021.101638 · Cited by 33
Quadriceps Muscle Energetics during Incremental Exercise in Children and Adults
BARKER, A. R., Welsman, J. R., Fulford, J., Welford, D., & Armstrong, N. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181cabaeb · Cited by 31
Cè, E., Limonta, E., Maggioni, M. A., Rampichini, S., Veicsteinas, A., & Esposito, F. (2012) · Journal of Sports Sciences · doi:10.1080/02640414.2012.753158 · Cited by 31
Coso, J. D., Hamouti, N., Aguado-Jiménez, R., & Mora‐Rodríguez, R. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1248-6 · Cited by 30
Nelis, J. L. D., Bose, U., Broadbent, J. A., Hughes, J. M., Sikes, A. L., Anderson, A. R., Caron, K., Schmoelzl, S., & Colgrave, M. L. (2022) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12935 · Cited by 31
Dolan, E., Saunders, B., Dantas, W. S., Murai, I. H., Roschel, H., Artioli, G. G., Harris, R. C., Bicudo, J. E. P. W., Sale, C., & Gualano, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-32636-3 · Cited by 30
Ischemic Preconditioning Improves Strength Endurance Performance
Carvalho, L., & Barroso, R. (2019) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002846 · Cited by 30
Jauchem, J. R. (2009) · Forensic Science Medicine and Pathology · doi:10.1007/s12024-009-9126-4 · Cited by 30
Myocardial fatty acid utilization as a determinant of cardiac efficiency and function
Jaswal, J. S., & Ussher, J. R. (2009) · Clinical Lipidology · doi:10.2217/clp.09.18 · Cited by 29
Adrenergic-β2 receptor polymorphism and athletic performance
Sarpeshkar, V., & Bentley, D. J. (2010) · Journal of Human Genetics · doi:10.1038/jhg.2010.42 · Cited by 30
Nache, M., Hinrichs, J., Scheier, R., Schmidt, H., & Hitzmann, B. (2016) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/j.chemolab.2016.03.011 · Cited by 30
Activation of brain lactate receptor GPR81 aggravates exercise-induced central fatigue
Li, J., Xia, Y., Xu, H., Xiong, R., Zhao, Y., Li, P., Yang, T., Huang, Q., & Shan, F. (2022) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00094.2022 · Cited by 29
Izrayeel, A. M. D., Ahuja, A., Gupta, N., Bachala, S. K., & Rastogi, V. K. (2024) · European Polymer Journal · doi:10.1016/j.eurpolymj.2024.113189 · Cited by 28
de Oliveira, H. A., Antônio, E. L., Silva, F. A., de Carvalho, P. D. T. C., Feliciano, R. D. S., Yoshizaki, A., Vieira, S. S., de Melo, B. L., Leal‐Junior, E. C. P., Marcos, R. L., et al. (2018) · Journal of Sports Sciences · doi:10.1080/02640414.2018.1457419 · Cited by 29
Dietary Acid-Base Balance in High-Performance Athletes
Baranauskas, M., Jablonskienė, V., Abaravičius, J. A., Samsonienė, L., & Stukas, R. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17155332 · Cited by 32
Endothelial metabolism in pulmonary vascular homeostasis and acute respiratory distress syndrome
Stevens, R. P., Paudel, S. S., Johnson, S., Stevens, T., & Lee, J. (2021) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00131.2021 · Cited by 32
Li, S., Guo, R., Yu, T., Shiming, L. I., Han, T., & Yu, W. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191911936 · Cited by 29
Sietsema, K. E. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-4710-0.00025-0 · Cited by 29
Guðjónsdóttir, M., Gunnlaugsson, V. N., Finnbogadóttir, G. A., Sveinsdóttir, K., Magnússon, H., Arason, S., & Rustad, T. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01808.x · Cited by 28
Effects of dietary Acid load on exercise metabolism and anaerobic exercise performance.
Caciano, S. L., Inman, C. L., Gockel-Blessing, E., & Weiss, E. P. (2015) · PubMed Central · Cited by 27
Lee, S.-H., Kim, B., Park, D., & Kim, U. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00687.2017 · Cited by 30
Hyperlactatemia: An Update on Postoperative Lactate
Stephens, E. H., Epting, C. L., Backer, C. L., & Wald, E. (2020) · World Journal for Pediatric and Congenital Heart Surgery · doi:10.1177/2150135120903977 · Cited by 28
The influence of intracellular lactate and H+ on cell volume in amphibian skeletal muscle
Usher‐Smith, J. A., Fraser, J. A., Bailey, P. S. J., Griffin, J. L., & Huang, C. L.-H. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108316 · Cited by 28
Effects of stimulation frequency, amplitude, and impulse width on muscle fatigue
Behringer, M., Grützner, S., Montag, J. C. K., McCourt, M., Ring, M., & Mester, J. (2015) · Muscle & Nerve · doi:10.1002/mus.24893 · Cited by 28
Frassetto, L. A., & Sébastian, A. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.04.031 · Cited by 28
Perimortal Muscle Metabolism and its Effects on Meat Quality
England, E. M., Matarneh, S. K., Scheffler, T. L., & Gerrard, D. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100593-4.00004-7 · Cited by 35
Nalbandian, H. M., Radak, Z. O., & Takeda, M. (2017) · Sports · doi:10.3390/sports5020040 · Cited by 27
Effect of Body Composition on Respiratory Compensation Point During an Incremental Test
Maciejczyk, M., Więcek, M., Szymura, J., Cempla, J., Wiecha, S., Szyguła, Z., & Brown, L. E. (2013) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000347 · Cited by 27
Performance Enhancing Diets and the PRISE Protocol to Optimize Athletic Performance
Arciero, P. J., Miller, V. J., & Ward, E. G. (2015) · Journal of Nutrition and Metabolism · doi:10.1155/2015/715859 · Cited by 33
Is lactate production related to muscular fatigue? A pedagogical proposition using empirical facts
de Macedo, D. V., Lazarim, F. L., da Silva, F. O. C., Tessutti, L. S., & Hohl, R. (2009) · AJP Advances in Physiology Education · doi:10.1152/advan.00039.2009 · Cited by 27
Effect of Two Types of Active Recovery on Fatigue and Climbing Performance.
Valenzuela, P. L., de la Villa, P., & Ferragut, C. (2015) · Europe PMC (PubMed Central) · Cited by 27
Bugaj, O., Zieliński, J., Kusy, K., Kantanista, A., Wieliński, D., & Guzik, P. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00600 · Cited by 27
Principles of Meat Fermentation
Puolanne, E., & Petäjä, E. (2014) · doi:10.1002/9781118522653.ch3 · Cited by 27
A brief review on physiological commitment in basketball: An interpretative key
Altavilla, G., & Raiola, G. (2019) · Autumn Conferences of Sports Science · doi:10.14198/jhse.2019.14.proc1.07 · Cited by 26
Anders, N. R., Eide, I., Lerfall, J., Roth, B., & Breen, M. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228454 · Cited by 26
Meligi, N. M., Ismail, S. A., & Tawfik, N. S. (2020) · Toxicology Research · doi:10.1093/toxres/tfaa077 · Cited by 26
Nien, Y., Kang, Z.-X., Su, T.-Y., Ho, C.-S., Chou, J.-C., Lai, C.-H., Kuo, P., Lai, T.-Y., Dong, Z.-X., Chen, Y.-Y., et al. (2021) · Polymers · doi:10.3390/polym13132062 · Cited by 26
Botek, M., Khanna, D., Krejčí, J., Valenta, M., McKune, A. J., Sládečková, B., & Klimešová, I. (2022) · Nutrients · doi:10.3390/nu14030508 · Cited by 26
Tarasov, K. V., Chakir, K., Riordon, D. R., Lyashkov, A. E., Ahmet, I., Perino, M. G., Silvester, A. J., Zhang, J., Wang, M., Lukyanenko, Y., et al. (2022) · eLife · doi:10.7554/elife.80949 · Cited by 23
Hadrévi, J., Ghafouri, B., Larsson, B. K., Gerdle, B. U. C., & Hellström, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073285 · Cited by 26
Effects of β-Alanine on Body Composition and Performance Measures in Collegiate Women
Outlaw, J. J., Smith‐Ryan, A. E., Buckley, A. L., Urbina, S. L., Hayward, S. E., Wingfield, H. L., Campbell, B. I., Foster, C. A., Taylor, L. W., & Wilborn, C. (2014) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000665 · Cited by 30
Acid–base pathophysiology after 130 years: confusing, irrational and controversial
Berend, K. (2012) · Journal of Nephrology · doi:10.5301/jn.5000191 · Cited by 26
Boning, D. G., & Maassen, N. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00162.2008 · Cited by 26
Dutra, Y. M., Malta, E. D. S., Elias, A. S., Broatch, J. R., & Zagatto, A. M. (2022) · Sports Medicine · doi:10.1007/s40279-022-01714-y · Cited by 25
Lactic Acid Regulation: A Potential Therapeutic Option in Rheumatoid Arthritis
Wang, Q., Asenso, J., Xiao, N., Gao, J., Xiao, F., Kuai, J., Wei, W., & Wang, C. (2022) · Journal of Immunology Research · doi:10.1155/2022/2280973 · Cited by 25
An examination of neuromuscular and metabolic fatigue thresholds
Bergstrom, H. C., Housh, T. J., Cochrane, K. C., Jenkins, N. D. M., Lewis, R. W., Jr., Traylor, D. A., Zuñiga, J. M., Schmidt, R. J., Johnson, G. O., & Cramer, J. T. (2013) · Physiological Measurement · doi:10.1088/0967-3334/34/10/1253 · Cited by 25
Harter, T. S., Shartau, R. B., Baker, D. W., Jackson, D. C., Val, A. L., & Brauner, C. J. (2014) · Journal of Comparative Physiology B · doi:10.1007/s00360-014-0838-8 · Cited by 25
Hernández‐Torres, R. P., Ramos‐Jiménez, A., Torres-Durán, P. V., Romero-González, J., Mascher, D., Posadas‐Romero, C., & Juárez-Oropeza, M. A. (2008) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2007.12.002 · Cited by 25
Kandikattu, H. K., Venuprasad, M. P., Pal, A. K., & Khanum, F. (2014) · Industrial Crops and Products · doi:10.1016/j.indcrop.2014.01.043 · Cited by 25
Esterhammer, R., Schocke, M. F. H., Gorny, O., Posch, L., Messner, H., Jaschke, W. R., Fraedrich, G., & Greiner, A. (2007) · Molecular Imaging and Biology · doi:10.1007/s11307-007-0118-z · Cited by 24
Dunne, A., Crampton, D., & Egaña, M. (2012) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2012.11.884 · Cited by 25
Lessons from Popper for science, paradigm shifts, scientific revolutions and exercise physiology
Robergs, R. A. (2017) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2017-000226 · Cited by 25
Self-citationHarter, T. S., & Brauner, C. J. (2017) · Fish physiology · doi:10.1016/bs.fp.2017.09.001 · Cited by 25
Inoue, D. S., Panissa, V. L. G., Monteiro, P. A., Gerosa-Neto, J., Rossi, F. E., Antunes, B. M., Franchini, É., Cholewa, J. M., Gobbo, L. A., & Lira, F. S. (2015) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001281 · Cited by 25
Dunst, A. K., Manunzio, C., Feldmann, A., & Hesse, C. (2023) · Biology of Sport · doi:10.5114/biolsport.2023.122481 · Cited by 25
The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses
Vardam-Kaur, T., Banuelos, A., Gabaldon-Parish, M., Macedo, B. D. G., Salgado, C. L., Wanhainen, K. M., Zhou, M. H., van Dijk, S., Santiago-Carvalho, I., Beniwal, A., et al. (2024) · iScience · doi:10.1016/j.isci.2024.110290 · Cited by 25
Adams, T., Stacey, E., Stacey, S., & Martín, D. (2012) · British Journal of Hospital Medicine · doi:10.12968/hmed.2012.73.2.72 · Cited by 24
Metadata
- Authors
- Robergs, R. A., Ghiasvand, F., & Parker, D.
- Affiliations
- University of New Mexico (US)
- ORCID
- Robergs, Robert A.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2004-09
- Volume
- 287
- Issue
- 3
- Pages
- R502-R516
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2171756298
- Cited by
- 1,304
- References
- 66
- Citations by year
- 2026: 58 · 2025: 60 · 2024: 71 · 2023: 75 · 2022: 82 · 2021: 82 · 2020: 71 · 2019: 54 · 2018: 81 · 2017: 62 · 2016: 53 · 2015: 51 · 2014: 70 · 2013: 63 · 2012: 58
- FWCI
- 74.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Faculty of Health
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- lactic acidosis, lactic acid production, muscle fatigue, proton release, ATP regeneration, glycolysis, phosphagen system, mitochondrial respiration, oxidative phosphorylation, pyruvate accumulation, NAD+ regeneration, exercise performance
- MeSH terms
- Acidosis, Acidosis, Lactic, Animals, Buffers, Humans, Models, Biological, Protons, Exercise, Lactic Acid, History, 18th Century, History, 20th Century
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
