The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Physiological significance of α2-adrenergic receptor subtype diversity: one receptor is not enough
Abstract
α 2-Adrenergic receptors mediate part of the diverse biological effects of the endogenous catecholamines epinephrine and norepinephrine. Three distinct subtypes of α 2-adrenergic receptors, α 2A, α 2B, α 2C, have been identified from multiple species. Because of the lack of sufficiently subtype-selective ligands, the specific biological functions of these receptor subtypes were largely unknown until recently. Gene-targeted mice carrying deletions in the genes encoding for individual α 2-receptor subtypes have added important new insight into the physiological significance of adrenergic receptor diversity. Two different strategies have emerged to regulate adrenergic signal transduction. Some biological functions are controlled by two counteracting α 2-receptor subtypes, e.g., α 2A-receptors decrease sympathetic outflow and blood pressure, whereas the α 2B-subtype increases blood pressure. Other biological functions are regulated by synergistic α 2-receptor subtypes. The inhibitory presynaptic feedback loop that tightly regulates neurotransmitter release from adrenergic nerves also requires two receptor subtypes, α 2A and α 2C. Similarly, nociception is controlled at several levels by one of the three α 2-receptor subtypes. Further investigation of the specific function of α 2-subtypes will greatly enhance our understanding of the relevance of closely related receptor proteins and point out novel therapeutic strategies for subtype-selective drug development.
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Cites
International Union of Pharmacology nomenclature of adrenoceptors.
Bylund, D. B., Eikenberg, D. C., Hieble, J. P., Langer, S. Z., Lefkowitz, R. J., Minneman, K. P., Molinoff, P. B., Ruffolo, R. R., & Trendelenburg, U. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06780-8 · Cited by 1,218
Psaty, B. M., Lumley, T., Furberg, C. D., Schellenbaum, G., Pahor, M., Alderman, M. H., & Weiss, N. S. (2003) · JAMA · doi:10.1001/jama.289.19.2534 · Cited by 1,088
Psaty, B. M. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540330061036 · Cited by 875
Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing
Yaksh, T. L. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90537-4 · Cited by 586
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
Hein, L., Altman, J. D., & Kobilka, B. K. (1999) · Nature · doi:10.1038/46040 · Cited by 520
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MacMillan, L. B., Hein, L., Smith, M. S., Piascik, M. T., & Limbird, L. E. (1996) · Science · doi:10.1126/science.273.5276.801 · Cited by 489
Self-citationCardiovascular Regulation in Mice Lacking α 2 -Adrenergic Receptor Subtypes b and c
Link, R. E., Desai, K., Hein, L., Stevens, M. E., Chruscinski, A., Bernstein, D., Barsh, G. S., & Kobilka, B. K. (1996) · Science · doi:10.1126/science.273.5276.803 · Cited by 467
Self-citationβ-Blockers in Congestive Heart Failure: A Bayesian Meta-Analysis
Brophy, J. M., Joseph, L., & Rouleau, J. L. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-7-200104030-00008 · Cited by 389
NEW AGENTS FOR SEDATION IN THE INTENSIVE CARE UNIT
Maze, M., Scarfini, C., & Cavaliere, F. (2001) · Critical Care Clinics · doi:10.1016/s0749-0704(05)70185-8 · Cited by 366
Lakhlani, P. P., MacMillan, L. B., Guo, T. Z., McCool, B. A., Lovinger, D. M., Maze, M., & Limbird, L. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9950 · Cited by 360
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Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice
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Metadata
- Authors
- Philipp, M., Brede, M., & Hein, L.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2002-08-01
- Volume
- 283
- Issue
- 2
- Pages
- R287-R295
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W1987249287
- Cited by
- 318
- References
- 74
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Philipp, M., Brede, M., & Hein, L. (2002). Physiological significance of α2-adrenergic receptor subtype diversity: one receptor is not enough. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.00123.2002
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