Cited by 297Birth, Development, and HealthPancreatic function and diabetesGestational Diabetes Research and Management

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy

Taylor, Paul D., McConnell, Josie, Khan, Imran Y., Holemans, Kathleen, Lawrence, Kevin M., Asare-Anane, Henry, Persaud, Shanta J., Jones, Peter M., Petrie, Linda, Hanson, Mark A., Poston, Lucilla·2005·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00355.2004

Open this paper in CoChat — free account

Abstract

We previously reported that prenatal and suckling exposure to a maternal diet rich in animal fat leads to cardiovascular dysfunction in young adult rat offspring with subsequent development of dyslipidemia and hyperglycemia. We have further investigated glucose homeostasis in adult female offspring by euglycemic-hyperinsulinemic clamp and by dynamic assessment of glucose-stimulated insulin secretion in isolated, perifused pancreatic islet cells. Additionally, given the link between reduced mitochondrial DNA (mtDNA) content and the development of type 2 diabetes mellitus, we have measured mtDNA in organs from young adult animals. Sprague-Dawley rats were fed a diet rich in animal fat or normal chow throughout pregnancy and weaning. Infusion of insulin (5 mU·kg−1·min−1) resulted in a higher steady-state plasma insulin concentration in 1-year-old offspring of fat-fed dams (OHF, n = 4) vs. offspring of control dams (OC, n = 4, P < 0.01). Glucose-stimulated insulin secretion in isolated islets from 9-mo-old OHF was significantly reduced compared with OC ( n = 4, P < 0.05). Transmission electron micrography showed altered insulin secretory granule morphology in OHF pancreatic β-cells. Kidney mtDNA was reduced in 3-mo-old OHF [16S-to-18S gene ratio: OC ( n = 10) 1.05 ± 0.19 vs. OHF ( n = 10) 0.66 ± 0.06, P < 0.05]. At 6 mo, gene chip microarray of OHF aorta showed reduced expression of the mitochondrial genome. Prenatal and suckling exposure to a diet rich in animal fat leads to whole body insulin resistance and pancreatic β-cell dysfunction in adulthood, which is preceded by reduced tissue mtDNA content and altered mitochondrial gene expression.

Integrity signals

Registry

Crossref · 10.1152/ajpregu.00355.2004

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
Weyer, C., Bogardus, C., Mott, D. M., & Pratley, R. E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7231 · Cited by 1,940
NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older
Alexander, C. M., Landsman, P. B., Teutsch, S. M., & Haffner, S. M. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1210 · Cited by 1,475 · cited 1×
“Metabolic syndrome has reached epidemic proportions amongst Western populations, with an associated increase in childhood type 2 diabetes (2, 4).”
Background
Mitochondrial function in normal and diabetic β-cells
Maechler, P., & Wollheim, C. B. (2001) · Nature · doi:10.1038/414807a · Cited by 519
Mitochondrial Integrity and Function in Atherogenesis
Ballinger, S. W., Patterson, C., Knight-Lozano, C. A., Burow, D. L., Conklin, C. A., Hu, Z., Reuf, J., Horaist, C., Lebovitz, R. M., Hunter, G. C., et al. (2002) · Circulation · doi:10.1161/01.cir.0000023921.93743.89 · Cited by 476
Endothelial Cell Apoptosis: Biochemical Characteristics and Potential Implications for Atherosclerosis
Choy, J. C., Granville, D. J., Hunt, D. W. C., & McManus, B. M. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1419 · Cited by 451
The adipoinsular axis: effects of leptin on pancreatic β-cells
Kieffer, T. J., & Habener, J. F. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.1.e1 · Cited by 426
Lipid overload and overflow: metabolic trauma and the metabolic syndrome
UNGER, R. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2003.09.008 · Cited by 399
Gender-linked hypertension in offspring of lard-fed pregnant rats
Khan, I. Y., Taylor, P. D., Dekou, V., Seed, P. T., Lakasing, L., Graham, D., Dominiczak, A. F., Hanson, M. A., & Poston, L. (2003) · Hypertension · doi:10.1161/01.hyp.0000047511.97879.fc · Cited by 365
Self-citation
β-Cell Dysfunction Induced by Chronic Hyperglycemia: Current Ideas on Mechanism of Impaired Glucose-Induced Insulin Secretion
Leahy, J. L., Bonner‐Weir, S., & Weir, G. C. (1992) · Diabetes Care · doi:10.2337/diacare.15.3.442 · Cited by 360
Blood flow and muscle metabolism: a focus on insulin action
Clark, M. G., Wallis, M. G., Barrett, E. J., Keske, M. A., Richards, S. M., Clerk, L. H., & Rattigan, S. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00408.2002 · Cited by 359

Flagged first, then by citations

Show all 37 references

Sorted by citations

Items 101–200 of 296

Interaction between maternal obesity and post-natal over-nutrition on skeletal muscle metabolism
Simar, D., Chen, H., Lambert, K., Mercier, J. G., & Morris, M. J. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.11.007 · Cited by 55
Mitochondrial ion transport pathways: Role in metabolic diseases
Cardoso, A. R., Queliconi, B. B., & Kowaltowski, A. J. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.12.017 · Cited by 54
Intergenerational transmission of insulin resistance and type 2 diabetes
Poston, L. (2010) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2010.11.011 · Cited by 55
Self-citation
The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review
Zimmerman, B., Kundu, P., Rooney, W. D., & Raber, J. (2021) · Molecules · doi:10.3390/molecules26113406 · Cited by 53
Differential roles of NADPH oxidases in vascular physiology and pathophysiology
Griendling, K. K. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s317 · Cited by 52
Nutritional developmental epigenomics: immediate and long-lasting effects
Attig, L., Gabory, A., & Junien, C. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s002966511000008x · Cited by 56
Exposure to lard-based high-fat diet during fetal and lactation periods modifies breast cancer susceptibility in adulthood in rats
Andrade, F. D. O., Fontelles, C. C., Rosim, M., de Oliveira, T. F., Loureiro, A. P. D. M., Mancini‐Filho, J., Rogero, M. M., Moreno, F. S., de Assis, S., Barbisan, L. F., et al. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.02.002 · Cited by 50
Influence of maternal overnutrition and gestational diabetes on the programming of metabolic health outcomes in the offspring: experimental evidence
Pereira, T. J., Gruber, B. L. M., Kereliuk, S. M., & Dolinsky, V. W. (2014) · Biochemistry and Cell Biology · doi:10.1139/bcb-2014-0141 · Cited by 52
Maternal nutrient restriction during pregnancy differentially alters the unfolded protein response in adipose and renal tissue of obese juvenile offspring
Sharkey, D., Gardner, D. S., Fainberg, H. P., Sebert, S. P., Bos, P., Wilson, V., Bell, R. C., Symonds, M. E., & Budge, H. (2008) · The FASEB Journal · doi:10.1096/fj.08-114330 · Cited by 51
Sucrose feeding during pregnancy and lactation elicits distinct metabolic response in offspring of an inbred genetic model of metabolic syndrome
Šedová, L., Šeda, O., Kazdová, L., Chylíková, B., Hamet, P., Tremblay, J., Křen, V., & Krenová, D. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00526.2006 · Cited by 51
In Utero Exposure to Maternal Obesity and Diabetes: Animal Models That Identify and Characterize Implications for Future Health
Nathanielsz, P. W., Poston, L., & Taylor, P. D. (2007) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2007.03.006 · Cited by 50
Self-citation
The intrauterine metabolic environment modulates the gene expression pattern in fetal rat islets: prevention by maternal taurine supplementation
Reusens, B., Sparre, T., Kalbe, L., Bouckenooghe, T., Theys, N., Kruhøffer, M., Orntoft, T. F., Nerup, J., & Remacle, C. (2008) · Diabetologia · doi:10.1007/s00125-008-0956-5 · Cited by 49
Maternal malnutrition programs the endocrine pancreas in progeny
Reusens, B., Theys, N., Dumortier, O., Goosse, K., & Remacle, C. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.000729 · Cited by 52
Maternal fats and pregnancy complications: Implications for long-term health
Khaire, A. A., Wadhwani, N. S., Madiwale, S. D., & Joshi, S. (2020) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2020.102098 · Cited by 49
Influence of Maternal Dysmetabolic Conditions During Pregnancy on Cardiovascular Disease
Palinski, W., Nicolaides, E., Liguori, A., & Claudio Napoli, A. (2009) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-009-9108-7 · Cited by 49
External influences on the fetus and their long-term consequences
Phillips, D. I. (2006) · Lupus · doi:10.1177/0961203306069354 · Cited by 49
Developmental origins of health and disease: experimental and human evidence of fetal programming for metabolic syndrome
Correia, M. L., Volpato, A. M., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2011) · Journal of Human Hypertension · doi:10.1038/jhh.2011.61 · Cited by 51
Pathophysiological basis for compromised health beyond generations: role of maternal high-fat diet and low-grade chronic inflammation
Zhou, D., & Pan, Y. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.06.011 · Cited by 50
Hepatic and very low-density lipoprotein fatty acids in obese offspring of overfed dams
Bouanane, S., Merzouk, H., Benkalfat, N. B., Mokhtari-Soulimane, N. A., Merzouk, S. A., Gresti, J., Tessier, C., & Narce, M. (2010) · Metabolism · doi:10.1016/j.metabol.2010.04.003 · Cited by 47
Epigenetic Basis for Fetal Origins of Age-Related Disease
Thompson, R. F., & Einstein, F. (2010) · Journal of Women's Health · doi:10.1089/jwh.2009.1408 · Cited by 51
Maternal High Fat Diet Alters Skeletal Muscle Mitochondrial Catalytic Activity in Adult Male Rat Offspring
Pileggi, C. A., Hedges, C. P., Segovia, S. A., Markworth, J. F., Durainayagam, B. R., Gray, C. L., Zhang, X. D., Barnett, M. P. G., Vickers, M. H., Hickey, A. J., et al. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00546 · Cited by 47
Beneficial effects of Aloe vera gel on lipid profile, lipase activities and oxidant/antioxidant status in obese rats
Rahoui, W., Merzouk, H., Haci, I. A. E., Bettioui, R., Azzi, R., & Bénali, M. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.07.050 · Cited by 47
A maternal diet of fatty fish reduces body fat of offspring compared with a maternal diet of beef and a post‐weaning diet of fish improves insulin sensitivity and lipid profile in adult C 57 BL /6 male mice
Hussain, A., Nookaew, I., Khoomrung, S., Andersson, L., Larsson, I., Hulthén, L., Jansson, N., Jakubowicz, R., Nilsson, S., Sandberg, A., et al. (2013) · Acta Physiologica · doi:10.1111/apha.12130 · Cited by 46
Pregestational maternal obesity impairs endocrine pancreas in male F1 and F2 progeny
Graus‐Nunes, F., Frantz, E. D. C., Lannes, W. R., Menezes, M. C. D. S., Mandarim‐de‐Lacerda, C. A., & Souza‐Mello, V. (2014) · Nutrition · doi:10.1016/j.nut.2014.08.002 · Cited by 45
Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress
Christoforou, E. R., & Sferruzzi-Perri, A. N. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03566-z · Cited by 44
Sexual Dimorphism in Non-Mendelian Inheritance
Vigé, A., Gallou‐Kabani, C., & Junien, C. (2008) · Pediatric Research · doi:10.1203/pdr.0b013e318165b896 · Cited by 45
Programming by maternal obesity: a pathway to poor cardiometabolic health in the offspring
Inzani, I., & Ozanne, S. E. (2022) · Proceedings of The Nutrition Society · doi:10.1017/s0029665122001914 · Cited by 45
Dietary fat impacts fetal growth and metabolism: uptake of chylomicron remnant core lipids by the placenta
Rebholz, S. L., Burke, K. T., Yang, Q., Tso, P., & Woollett, L. A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00619.2010 · Cited by 42
Maternal Obesity during the Preconception and Early Life Periods Alters Pancreatic Development in Early and Adult Life in Male Mouse Offspring
Bringhenti, I., Moraes-Teixeira, J. A., Cunha, M. R., Ornellas, F., Mandarim‐de‐Lacerda, C. A., & Águila, M. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055711 · Cited by 42
Nutrition and reproduction
DelCurto, H., Wu, G., & Satterfield, M. C. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328361f96d · Cited by 43
Nutritional models of the developmental programming of adult health and disease
Symonds, M. E., & Budge, H. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109001049 · Cited by 42
Sex differences of microglia in the healthy brain from embryonic development to adulthood and across lifestyle influences
Bobotis, B. C., Braniff, O., Gargus, M., Akinluyi, E. T., Awogbindin, I. O., & Tremblay, M.-È. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110752 · Cited by 40
Early life influences on obesity risk: maternal overnutrition and programming of obesity
Morris, M. J. (2009) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.09.45 · Cited by 40
Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Adiposity and Anxiety-Like Behaviors in Male Rat Offspring
Ramírez-López, M. T., Vázquez, M., Bîndilă, L., Lomazzo, E., Hofmann, C., Blanco, R. N., Alén, F., Antón, M., Decara, J. M., Ouro, D., et al. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00339 · Cited by 40
Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice.
Chechi, K., & Cheema, S. K. (2006) · PubMed Central · Cited by 38
Perinatal Protein Malnutrition Affects Mitochondrial Function in Adult and Results in a Resistance to High Fat Diet-Induced Obesity
Jousse, C., Muranishi, Y., Parry, L., Montaurier, C., Even, P. C., Launay, J., Carraro, V., Maurin, A., Avérous, J., Chaveroux, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104896 · Cited by 38
Fetal Programming of the Neuroendocrine-Immune System and Metabolic Disease
Fisher, R. E., Steele, M. A., & Karrow, N. A. (2012) · Journal of Pregnancy · doi:10.1155/2012/792934 · Cited by 43
Consequences of gestational diabetes to the brain and behavior of the offspring
Sousa, R. A. L. D., TORRES, Y. S., Figueiredo, C. P., Passos, G. F., & Clarke, J. R. (2017) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720170264 · Cited by 41
Nutritional programming of adult disease
Buckley, A. J., Jaquiery, A. L., & Harding, J. E. (2005) · Cell and Tissue Research · doi:10.1007/s00441-005-1095-7 · Cited by 38
Differential Effects of Exposure to Maternal Obesity or Maternal Weight Loss during the Periconceptional Period in the Sheep on Insulin Signalling Molecules in Skeletal Muscle of the Offspring at 4 Months of Age
Nicholas, L. M., Morrison, J. L., Rattanatray, L., Ozanne, S. E., Kleemann, D. O., Walker, S. K., MacLaughlin, S. M., Zhang, S., Martin‐Gronert, M. S., & McMillen, I. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084594 · Cited by 37
Review article: Developmental mismatch: consequences for later cardiorespiratory health
Pike, K. C., Hanson, M. A., & Godfrey, K. M. (2007) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2007.01603.x · Cited by 37
Self-citation
Maternal Malnutrition in the Etiopathogenesis of Psychiatric Diseases: Role of Polyunsaturated Fatty Acids
Morgese, M. G., & Trabace, L. (2016) · Brain Sciences · doi:10.3390/brainsci6030024 · Cited by 40
Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease
Kereliuk, S. M., & Dolinsky, V. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084467 · Cited by 34
The impact of early life gut colonization on metabolic and obesogenic outcomes: what have animal models shown us?
Wallace, J. G., Gohir, W., & Sloboda, D. M. (2015) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174415001518 · Cited by 37
Maternal dietary fat intake during gestation and lactation alters tissue fatty acid composition in the adult offspring of C57Bl/6 mice
Chechi, K., Herzberg, G. R., & Cheema, S. K. (2010) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2010.06.001 · Cited by 35
Developmental Origins of Cardiometabolic Diseases: Role of the Maternal Diet
Costa‐Silva, J. H., Simões-Alves, A. C., & Fernandes, M. P. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00504 · Cited by 34
Beneficial effects of quercetin–iron complexes on serum and tissue lipids and redox status in obese rats
Imessaoudene, A., Merzouk, H., Berroukeche, F., Mokhtari-Soulimane, N. A., Bensenane, B., Cherrak, A., Merzouk, S. A., & Elhabiri, M. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.11.011 · Cited by 34
Decreased basal insulin secretion from pancreatic islets of pups in a rat model of maternal obesity
Zambrano, E., Sosa-Larios, T. C., Calzada, L., Ibáñez, C. A., Mendoza-Rodríguez, C. A., Morales, A., & Morimoto, S. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0321 · Cited by 32
Effect of folic acid supplementation on hepatic antioxidant function and mitochondrial-related gene expression in weanling intrauterine growth retarded piglets
Liu, J., Yao, Y., Yu, B., Mao, X., Huang, Z., & Chen, D. (2012) · Livestock Science · doi:10.1016/j.livsci.2012.02.027 · Cited by 32
Nonlinear Relationship between Birth Weight and Visceral Fat in Adolescents
Stansfield, B. K., Fain, M. E., Bhatia, J. J. S., Gutin, B., Nguyen, J., & Pollock, N. K. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.04.012 · Cited by 32
Epigenetic regulation during mammalian oogenesis
Bromfield, J. J., Messamore, W. G., & Albertini, D. F. (2007) · Reproduction Fertility and Development · doi:10.1071/rd07181 · Cited by 32
Maternal exercise modifies body composition and energy substrates handling in male offspring fed a high-fat/high-sucrose diet
Quiclet, C., Dubouchaud, H., Berthon, P., Sanchez, H., Vial, G., Siti, F., Fontaine, E., Batandier, C., & Couturier, K. (2017) · The Journal of Physiology · doi:10.1113/jp274739 · Cited by 31
Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition
Elsakr, J. M., Dunn, J. C., Tennant, K. G., Zhao, S. K., Kroeten, K., Pasek, R. C., Takahashi, D. L., Dean, T. A., Edwards, D. R. V., McCurdy, C. E., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.03.010 · Cited by 31
Animal Models of Type 1 and Type 2 Diabetes Mellitus
King, A., & Austin, A. L. F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00010-3 · Cited by 34
Developmental programming of lipid metabolism and aortic vascular function in C57BL/6 mice: a novel study suggesting an involvement of LDL-receptor
Chechi, K., McGuire, J. J., & Cheema, S. K. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90932.2008 · Cited by 31
Metabolic Disorders and Oxidative Stress Programming in Offspring of Rats Fed a High-fat Diet During Lactation: Effects of a Vinifera Grape Skin (ACH09) Extract
Emiliano, A. F., de Carvalho, L. C. R. M., Cordeiro, V. S. C., da Costa, C. A., de Oliveira, P. R. B., Queiroz, E. F., Moreira, D. D. C., Boaventura, G. T., de Moura, R. S., & Resende, Â. C. (2011) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3182244a51 · Cited by 29
Twenty-five years since the discovery of endothelium-derived relaxing factor (EDRF): does a dysfunctional endothelium contribute to the development of type 2 diabetes?
Triggle, C. R., Howarth, A. G., Cheng, Z. J., & Ding, H. (2005) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y05-069 · Cited by 29
Impact and mechanisms of fetal physiological programming
Schwartz, J., & Morrison, J. L. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00698.2004 · Cited by 28
High-fat/fructose feeding during prenatal and postnatal development in female rats increases susceptibility to renal and metabolic injury later in life
Flynn, E. R., Alexander, B. T., Lee, J., Hutchens, Z. M., & Maric‐Bilkan, C. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00433.2012 · Cited by 26
Maternal exposure to high‐fat diet during pregnancy and lactation predisposes normal weight offspring mice to develop hepatic inflammation and insulin resistance
Saengnipanthkul, S., Noh, H. L., Friedline, R. H., Suk, S., Choi, S. H., Acosta, N. K., Tran, D. A., Hu, X., Inashima, K., Kim, A. M., et al. (2021) · Physiological Reports · doi:10.14814/phy2.14811 · Cited by 33
Drosophila melanogaster : An emerging model of transgenerational effects of maternal obesity
Brookheart, R. T., & Duncan, J. G. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.12.003 · Cited by 25
Maternal Immunization Affects In Utero Programming of Insulin Resistance and Type 2 Diabetes
Eberle, C., Merki, E., Yamashita, T., Johnson, S., Armando, A. M., Quehenberger, O., Claudio Napoli, A., & Palinski, W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045361 · Cited by 26
Exercise Improves Glucose Disposal and Insulin Signaling in Pregnant Mice Fed a High Fat Diet
Carter, L. G., & Tenlep, S. Y. N. (2015) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000634 · Cited by 23
Hypothalamic oxidative stress and inflammation, and peripheral glucose homeostasis in Sprague-Dawley rat offspring exposed to maternal and postnatal chocolate and soft drink
Gerstenberg, M. K., Nilsson, C., Nielsen, M. O., Grove, K. L., & Raun, K. (2018) · Nutrition and Diabetes · doi:10.1038/s41387-018-0051-z · Cited by 23
Sucrose‐rich feeding during rat pregnancy‐lactation and/or after weaning alters glucose and lipid metabolism in adult offspring
D’Alessandro, M. E., Oliva, M. E., Ferreira, M. D. R., Selenscig, D. A., Lombardo, Y. B., & Chicco, A. G. (2012) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2012.05720.x · Cited by 23
Rapid neonatal weight gain in rats results in a renal ubiquinone (CoQ) deficiency associated with premature death
Shelley, P., Tarry‐Adkins, J. L., Martin‐Gronert, M. S., Poston, L., Heales, S., Clark, J. B., Ozanne, S. E., & McConnell, J. M. L. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.10.002 · Cited by 23
Self-citation
Maternal nutrition and offspring’s adulthood NCD’s: a review
Pasternak, Y., Aviram, A., Poraz, I., & Hod, M. (2012) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2012.745505 · Cited by 23
Influence of maternal obesity, diet and exercise on epigenetic regulation of adipocytes
Dhasarathy, A., Roemmich, J. N., & Claycombe, K. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.10.003 · Cited by 23
Dietary Flax Oil During Pregnancy and Lactation Retards Disease Progression in Rat Offspring With Inherited Kidney Disease
Sankaran, D., Bankovic‐Calic, N., Peng, C. Y.-C., Ogborn, M. R., & Aukema, H. M. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000245912.78078.d5 · Cited by 23
Metabolic programming in pregnancy: studies in animal models
Langley‐Evans, S. C. (2007) · Genes & Nutrition · doi:10.1007/s12263-007-0005-x · Cited by 23
Maternal high‐fat diet promotes onset of diabetes in rat offspring
Ohta, T., Toriniwa, Y., Ryumon, N., Inaba, N., Hirao, T., Yamanaka, S., 前野孝之, Sakakibara, W., Sumikawa, M., Chiba, K., et al. (2016) · Animal Science Journal · doi:10.1111/asj.12606 · Cited by 23
Developmental programming of insulin resistance: are androgens the culprits?
Puttabyatappa, M., Sargis, R. M., & Padmanabhan, V. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0044 · Cited by 22
Supplementation with a prebiotic (polydextrose) in obese mouse pregnancy improves maternal glucose homeostasis and protects against offspring obesity
Maragkoudaki, X., Naylor, M., Papacleovoulou, G., Stolarczyk, É., Rees, D., Pombo, J., Abu‐Hayyeh, S., Czajka, A., Howard, J. K., Malik, A. N., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-00682-5 · Cited by 21
Self-citation
Nutrition, Epigenetic Mechanisms, and Human Disease
Maulik, N., & Maulik, G. (2010) · CRC Press eBooks · doi:10.1201/b10449 · Cited by 22
Programmed aortic dysfunction and reduced Na+,K+‐ATPase activity present in first generation offspring of lard‐fed rats does not persist to the second generation
Armitage, J. A., Ishibashi, A., Balachandran, A., Jensen, R. I., Poston, L., & Taylor, P. D. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2006.036202 · Cited by 22
Self-citation
Effects of Nutrient Intake during Pregnancy and Lactation on the Endocrine Pancreas of the Offspring
Moullé, V. S., & Parnet, P. (2019) · Nutrients · doi:10.3390/nu11112708 · Cited by 24
Metabolic and melanocortin gene expression alterations in male offspring of obese mice
Gout, J., Sarafian, D., Mutel, E., Vigier, M., Rajas, F., Mithieux, G., Bégeot, M., & Naville, D. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.021 · Cited by 21
Maternal supplementation with n-3 long chain polyunsaturated fatty acids during perinatal period alleviates the metabolic syndrome disturbances in adult hamster pups fed a high-fat diet after weaning
Kasbi-Chadli, F., Boquien, C., Simard, G., Ulmann, L., Mimouni, V., Leray, V., Meynier, A., Ferchaud‐Roucher, V., Champ, M. M. J., Nguyen, P., et al. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.03.003 · Cited by 21
Alteration of mitochondrial function in adult rat offspring of malnourished dams
Reusens, B. (2011) · World Journal of Diabetes · doi:10.4239/wjd.v2.i9.149 · Cited by 23
Hypermethylation of Cox5a Promoter Is Associated with Mitochondrial Dysfunction in Skeletal Muscle of High Fat Diet-Induced Insulin Resistant Rats
Gong, Y., Liu, Y.-Y., Li, J., Su, L., Yu, S., Zhu, X., Cao, X., & Xiao, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113784 · Cited by 20
Maternal Fat Feeding Augments Offspring Nephron Endowment in Mice
Hokke, S., Puelles, V. G., Armitage, J. A., Fong, K. J., Bertram, J. F., & Cullen‐McEwen, L. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161578 · Cited by 20
Short-term and long-term effects of submaximal maternal exercise on offspring glucose homeostasis and pancreatic function
Quiclet, C., Farida, S. N., Dubouchaud, H., Vial, G., Berthon, P. M., Fontaine, E. M., Batandier, C., & Couturier, K. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00126.2016 · Cited by 22
Influence of birth weight on gene regulators of lipid metabolism and utilization in subcutaneous adipose tissue and skeletal muscle of neonatal pigs
Williams, P. J., Marten, N., Wilson, V. G., Litten-Brown, J. C., Corson, A. M., Clarke, L., Symonds, M. E., & Mostyn, A. (2009) · Reproduction · doi:10.1530/rep-08-0445 · Cited by 20
Acute and perinatal programming effects of a fat‐rich diet on rat muscle mitochondrial function and hepatic lipid accumulation
Hellgren, L. I., Jensen, R. I., Waterstradt, M. S. G., Quistorff, B., & Lauritzen, L. (2014) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.12458 · Cited by 18
Adult offspring of high-fat diet-fed dams can have normal glucose tolerance and body composition
Platt, K. M., Charnigo, R. J., & Pearson, K. J. (2014) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174414000154 · Cited by 20
In utero nutritional stress as a cause of obesity: Altered relationship between body fat, leptin levels and caloric intake in offspring into adulthood
Sertié, R. A. L., Kang, M., ANTIPENKO, J. P., Liu, X., Maianu, L., Habegger, K. M., & Garvey, W. T. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117764 · Cited by 18
Developmental Programming and Glucolipotoxicity: Insights on Beta Cell Inflammation and Diabetes
Cerf, M. E. (2020) · Metabolites · doi:10.3390/metabo10110444 · Cited by 19
Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids
Quehenberger, O., Yamashita, T., Armando, A. M., Dennis, E. A., & Palinski, W. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.03.044 · Cited by 19
Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb
Diniz, M. S., Grilo, L. F., Tocantins, C., Falcão‐Pires, I., & Pereira, S. P. (2023) · Metabolites · doi:10.3390/metabo13070845 · Cited by 17
Response characteristics of the mitochondrial DNA genome in developmental health and disease
Knudsen, T. B., & Green, M. L. (2004) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20028 · Cited by 18
Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a Maternal Low-Protein Diet
Engeham, S., Mdaki, K. S., Jewell, K., Austin, R., Lehner, A. N., & Langley‐Evans, S. C. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/989037 · Cited by 17
Developmental Conditioning of the Vasculature
Clough, G. F. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140037 · Cited by 22
The Endocrine–Metabolic Axis Regulation in Offspring Exposed to Maternal Obesity—Cause or Consequence in Metabolic Disease Programming?
Grilo, L. F., Diniz, M. S., Tocantins, C., Areia, A. L., & Pereira, S. P. (2022) · Obesities · doi:10.3390/obesities2030019 · Cited by 16
Impact of Early Onset Obesity and Hypertension on the Unfolded Protein Response in Renal Tissues of Juvenile Sheep
Sharkey, D., Fainberg, H. P., Wilson, V., Harvey, E., Gardner, D. S., Symonds, M. E., & Budge, H. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.122812 · Cited by 16
Maternal Fat Supplementation during Late Pregnancy and Lactation Influences the Development of Hepatic Steatosis in Offspring Depending on the Fat Source
Llopis, M., Sánchez, J., Priego, T., Palou, A., & Picó, C. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf405161e · Cited by 16
Nutritional Models of Type 2 Diabetes Mellitus
Mühlhäusler, B. S., Toop, C., & Gentili, S. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9882-1_3 · Cited by 15
Obesity Before Birth
Lustig, R. H. (2010) · Endocrine updates · doi:10.1007/978-1-4419-7034-3 · Cited by 23
Effect of postnatal overfeeding on the male and female Wistar rat reproductive parameters
Costa, V. M. G., Andreazzi, A. E., Bolotari, M., de Lade, C. G., Guerra, M. O., & Peters, V. M. (2019) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174419000163 · Cited by 15
Mechanisms behind early life nutrition and adult disease outcome
Velkoska, E. (2011) · World Journal of Diabetes · doi:10.4239/wjd.v2.i8.127 · Cited by 15
Developmental programming of the pancreatic islet by in utero overnutrition.
Elsakr, J. M., & GANNON, M. A. (2017) · PubMed · Cited by 15

Authors: Taylor, P. D., McConnell, J., Khan, I. Y., Holemans, K., Lawrence, K. M., Asare-Anane, H., Persaud, S. J., Jones, P. M., Petrie, L., Hanson, M. A., & Poston, L.
Affiliations: King's College London (GB)
ORCID: Taylor, Paul D.
Persaud, Shanta J.
Jones, Peter M.
Hanson, Mark A.
Poston, Lucilla
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2005-01
Volume: 288
Issue: 1
Pages: R134-R139
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00355.2004
OpenAlex: W2135070381
Cited by: 297
References: 37
Citations by year: 2025: 1 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 10 · 2019: 14 · 2018: 13 · 2017: 13 · 2016: 20 · 2015: 11 · 2014: 29 · 2013: 14 · 2012: 18
FWCI: 13.07
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: British Heart Foundation
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords: maternal high-fat diet, prenatal exposure, offspring, glucose homeostasis, insulin resistance, glucose-stimulated insulin secretion, beta-cell dysfunction, insulin secretory granules, mitochondrial DNA, mitochondrial gene expression, kidney mitochondria, aorta, type 2 diabetes, dyslipidemia, hyperglycemia, cardiovascular dysfunction
MeSH terms: Adipose Tissue, Animals, Blood Glucose, Body Weight, Dietary Fats, Female, Homeostasis, Insulin, Insulin Resistance, Islets of Langerhans, Lipids, Mitochondria, Pregnancy, Prenatal Exposure Delayed Effects, Gene Expression, Rats, Sprague-Dawley, Leptin, Metabolic Syndrome, Prenatal Nutritional Physiological Phenomena, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks