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Cited by 44Birth, Development, and HealthEpigenetics and DNA MethylationGenetic Syndromes and Imprinting

Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress

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Christoforou, Efthimia R., Sferruzzi-Perri, Amanda N.·2020·Cellular and Molecular Life Sciences
DOI 10.1007/s00018-020-03566-zPMC PMC7658077
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Abstract

The results of different human epidemiological datasets provided the impetus to introduce the now commonly accepted theory coined as ‘developmental programming’, whereby the presence of a stressor during gestation predisposes the growing fetus to develop diseases, such as metabolic dysfunction in later postnatal life. However, in a clinical setting, human lifespan and inaccessibility to tissue for analysis are major limitations to study the molecular mechanisms governing developmental programming. Subsequently, studies using animal models have proved indispensable to the identification of key molecular pathways and epigenetic mechanisms that are dysregulated in metabolic organs of the fetus and adult programmed due to an adverse gestational environment. Rodents such as mice and rats are the most used experimental animals in the study of developmental programming. This review summarises the molecular pathways and epigenetic mechanisms influencing alterations in metabolic tissues of rodent offspring exposed to in utero stress and subsequently programmed for metabolic dysfunction. By comparing molecular mechanisms in a variety of rodent models of in utero stress, we hope to summarise common themes and pathways governing later metabolic dysfunction in the offspring whilst identifying reasons for incongruencies between models so to inform future work. With the continued use and refinement of such models of developmental programming, the scientific community may gain the knowledge required for the targeted treatment of metabolic diseases that have intrauterine origins.

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  • Exposure to a diverse array of suboptimal maternal environments, including nutritionally unbalanced diets, low oxygen availability, and high body mass index (BMI) during gestation, modifies the risk of the offspring developing obesity.

    “Extensions of this work using human population and experimental animal data have shown that exposure to a diverse array of suboptimal maternal environments, including nutritionally unbalanced diets, low oxygen availability, and high body mass index (BMI) during gestation, modifies the risk of the offspring developing obesity [9, 10].”

    From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [10]

    The ‘Adipose lipid metabolism and morphology’ section links maternal undernutrition, protein restriction and high-fat diets to increased offspring body adiposity. The ‘Rodent models of developmental programming’ and ‘Alterations in DNA methylation in response to in utero stressors’ sections also discuss maternal obesity and gestational hypoxia, but link them to offspring metabolic disease or metabolic syndrome rather than specifically to obesity risk. The source therefore supports the broader metabolic-programming claim, but not the obesity-specific outcome for every exposure listed. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Christoforou, E. R., & Sferruzzi-Perri, A. N.
Affiliations
University of Cambridge (GB)
Corresponding author
Sferruzzi-Perri, Amanda N.
ORCID
Venue
Cellular and Molecular Life Sciences
Publisher
Springer Science and Business Media LLC
Published
2020-06-03
Volume
77
Issue
23
Pages
4861-4898
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
DOI
10.1007/s00018-020-03566-z
PMC
PMC7658077
OpenAlex
W3030004809
Cited by
44
References
12
Citations by year
2026: 3 · 2025: 8 · 2024: 4 · 2023: 13 · 2022: 4 · 2021: 10 · 2020: 2
FWCI
1.60
Type
journal article
Language
en
Open access
Licence
Locations
  • Cellular and Molecular Life Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • Apollo (cc-by)
  • Apollo
Funders
  • Royal Society (RG74249)
  • Lister Institute of Preventive Medicine (RG93692)
  • Medical Research Council (RG93186)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords
developmental programming, fetal programming, metabolic dysfunction, epigenetic mechanisms, rodent models, metabolic tissues, metabolic disorders, molecular pathways
MeSH terms
Animals, Disease Models, Animal, Insulin, Liver, Metabolism, Rodentia, Stress, Physiological, Epigenesis, Genetic

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