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Cited by 31Birth, Development, and HealthDiet, Metabolism, and DiseaseGestational Diabetes Research and Management

Maternal exercise modifies body composition and energy substrates handling in male offspring fed a high-fat/high-sucrose diet

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Quiclet, Charline, Dubouchaud, Hervé, Berthon, Phanélie, Sanchez, Hervé, Vial, Guillaume, Siti, Farida, Fontaine, Eric, Batandier, Cécile +1 more·2017·The Journal of Physiology
DOI 10.1113/jp274739PMC PMC5709334
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Abstract

Key points: Maternal training during gestation enhances offspring body composition and energy substrates handling in early adulthood. Offspring nutrition also plays a role as some beneficial effects of maternal training during gestation disappear after consumption of a high‐fat diet. Maternal exercise during gestation has been reported to modify offspring metabolism and health. Whether these effects are exacerbated when offspring are receiving a high‐fat diet remains unclear. Our purpose was to evaluate the effect of maternal exercise before and during gestation on the offspring fed a high‐fat/high‐sucrose diet (HF) by assessing its body composition, pancreatic function and energy substrates handling by two major glucose‐utilizing tissues: liver and muscle. Fifteen‐week‐old nulliparous female Wistar rats exercised 4 weeks before as well as during gestation at a constant submaximal intensity (TR) or remained sedentary (CT). At weaning, pups from each group were fed either a standard diet (TRCD or CTCD) or a high‐fat/high‐sucrose diet (TRHF or CTHF) for 10 weeks. Offspring from TR dams gained less weight compared to those from CT dams. Selected fat depots were larger with the HF diet compared to control diet (CD) but significantly smaller in TRHF compared to CTHF. Surprisingly, the insulin secretion index was higher in islets from HF offspring compared to CD. TR offspring showed a higher muscle insulin sensitivity estimated by the ratio of phosphorylated protein kinase B to total protein kinase B compared with CT offspring (+48%, P < 0.05). With CD, permeabilized isolated muscle fibres from TR rats displayed a lower apparent affinity constant ( K m ) for pyruvate and palmitoyl coenzyme A as substrates compared to the CT group (−46% and −58%, respectively, P < 0.05). These results suggest that maternal exercise has positive effects on young adult offspring body composition and on muscle carbohydrate and lipid metabolism depending on the nutritional status.

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  • In general, the most significant effects of maternal exercise on offspring metabolic health are observed when maternal exercise begins before mating and is continued throughout pregnancy.

    “In general, the most significant effects are observed when maternal exercise begins before mating and is continued throughout pregnancy.”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [133]

    The Discussion reports improved body-weight and fat-mass outcomes in offspring after maternal exercise before and during gestation. But the study compares that schedule with no exercise, not with exercise begun at other times, so it does not establish that this schedule generally produces the most significant effects. (LLM, conf=0.86)

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  • Several groups have shown that enforced maternal treadmill exercise or voluntary wheel running had significant effects on the metabolic health of male and female offspring.

    “Several groups have shown that enforced maternal treadmill exercise or voluntary wheel running had significant effects on the metabolic health of male and female offspring [131,132,133,134,135,136].”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [133]

    The Methods (page not available) describe maternal motorized-treadmill exercise and state that only male pups were studied. The Discussion reports changes in offspring body composition and metabolism, while the Introduction discusses voluntary-wheel studies by other groups. This paper supports effects in male offspring, but its own findings do not establish metabolic effects in female offspring or from voluntary wheel running. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Maternal exercise attenuated weight gain and adiposity in 3-month-old offspring fed a high-fat and high-sucrose diet.

    “Moreover, maternal exercise also attenuated weight gain and adiposity in 3-month-old offspring fed a high-fat and high-sucrose diet [133].”

    From Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease (2022) · cites this paper as [133]

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  1. Triplitt C, Solis‐Herrera C, Reasner C, DeFronzo RA & Cersosimo E (2000). Classification of diabetes mellitus In Endotext, ed. De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, Koch C, Korbonits M, McLachlan R, New M, Purnell J, Rebar R, Singer F. & Vinik A. MDText.com, Inc., South Dartmouth, MA, USA. [Google Scholar]

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Authors
Quiclet, C., Dubouchaud, H., Berthon, P., Sanchez, H., Vial, G., Siti, F., Fontaine, E., Batandier, C., & Couturier, K.
Affiliations
  • Inserm (FR)
  • Université Savoie Mont Blanc (FR)
  • French Armed Biomedical Research Institute, Brétigny‐sur‐Orge France
  • Université Grenoble Alpes Laboratory of Fundamental and Applied Bioenergetics (LBFA) Grenoble France
Corresponding author
Quiclet, Charline
ORCID
Venue
The Journal of Physiology
Publisher
Wiley
Published
2017-10-25
Volume
595
Issue
23
Pages
7049-7062
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jp274739
PMC
PMC5709334
OpenAlex
W2786054803
Cited by
31
References
59
Citations by year
2026: 4 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 3
FWCI
3.29
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Institut National de la Santé et de la Recherche Médicale
  • Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords
maternal physical activity, offspring body composition, high-fat high-sugar diet, substrate metabolism, insulin secretion, pancreatic islets, skeletal muscle insulin sensitivity, Akt, pyruvate uptake, fat depots
MeSH terms
Insulin Secretion, Animals, Body Composition, Cells, Cultured, Energy Metabolism, Female, Insulin, Male, Physical Conditioning, Animal, Pregnancy, Rats, Wistar, Muscle, Skeletal, Dietary Sucrose, Lipid Metabolism, Insulin-Secreting Cells, Rats, Diet, High-Fat

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