The DOI matches its Crossref record; 171 of the 172 references it cites were found in a registry or an index.
Obesity and hypertension: two epidemics or one?
Abstract
The association between obesity and hypertension is well documented, although the exact nature of this relation remains unclear. Sympathetic nervous and renin-angiotensin-aldosterone system activation appear to play an important role in the sodium and water retention, rightward shift in the pressure-natriuresis, and blood pressure elevation observed in obese individuals. Visceral obesity and the ectopic deposition of adipose tissue may be important in the activation of these systems and in the target organ damage that ensues. Weight loss is critical in the effective management of obesity hypertension and the accompanying target organ damage, although recidivism rates are high. However, prevention of weight gain should be the major priority for combating hypertension and its consequences in the future. The present review will provide an overview of our understanding of the etiology, pathophysiology, and treatment of obesity hypertension. Our focus is on the state of knowledge in humans. The potential role of abdominal obesity is considered throughout our review. We refer to relevant animal literature for supportive evidence and where little or no data in humans are available.
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In the citing paper
“Part of this variability may relate to differences in VAT, which seems to be more closely correlated with increased SNA and hypertension than does overall adiposity156.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [156]
In the citing paper
“Angiotensin is thought to cause sympathoexcitation, so there may be additive effects of renin-angiotensin and sympathetic activation with respect to blood pressure elevation and cardiac remodeling in obesity (67).”
From Cardiac remodeling in obesity (2008) · cites this paper as [67]
In the citing paper
“Furthermore, increased activity of this system has been implicated in human obesity hypertension (67, 96).”
From Cardiac remodeling in obesity (2008) · cites this paper as [67]
Citations
Cites
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Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
Mokdad, A. H., Ford, E. S., Bowman, B. A., Dietz, W. H., Vinicor, F., Bales, V. S., & Marks, J. S. (2003) · JAMA · doi:10.1001/jama.289.1.76 · Cited by 5,866
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Epidemiology of Obstructive Sleep Apnea: A Population Health Perspective
Young, T., Peppard, P. E., & Gottlieb, D. J. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2109080 · Cited by 4,244
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Obesity and the risk of heart failure
Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093
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Uric Acid and Cardiovascular Risk
Feig, D. I., Kang, D., & Johnson, R. J. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800885 · Cited by 2,467
Changes in Arterial Stiffness and Wave Reflection With Advancing Age in Healthy Men and Women
Mitchell, G. F., Parise, H., Benjamin, E. J., Larson, M. G., Keyes, M. J., Vita, J. A., Vasan, R. S., & Levy, D. A. (2004) · Hypertension · doi:10.1161/01.hyp.0000128420.01881.aa · Cited by 1,507
Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2015) · Circulation Research · doi:10.1161/circresaha.116.305697 · Cited by 1,360
Self-citationAbel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Sympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease
Malpas, S. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00007.2009 · Cited by 696
Metadata
- Authors
- Davy, K. P., & Hall, J. E.
- Affiliations
- Virginia Tech (US)
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2004-05
- Volume
- 286
- Issue
- 5
- Pages
- R803-R813
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2094878829
- Cited by
- 280
- References
- 172
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 4 · 2023: 10 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 11 · 2018: 6 · 2017: 13 · 2016: 14 · 2015: 9 · 2014: 12 · 2013: 20 · 2012: 22
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K02HL067227, R01HL062283, P01HL051971)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, hypertension, abdominal obesity, visceral obesity, sympathetic nervous system, renin-angiotensin-aldosterone system, sodium and water retention, pressure natriuresis, target organ damage, weight loss, weight gain prevention, pathophysiology
- MeSH terms
- Animals, Disease Outbreaks, Humans, Hypertension, Obesity
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