Cited by 280Blood Pressure and Hypertension StudiesRenin-Angiotensin System StudiesCardiovascular Disease and Adiposity

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Obesity and hypertension: two epidemics or one?

Davy, Kevin P., Hall, John E.·2004·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00707.2003

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Abstract

The association between obesity and hypertension is well documented, although the exact nature of this relation remains unclear. Sympathetic nervous and renin-angiotensin-aldosterone system activation appear to play an important role in the sodium and water retention, rightward shift in the pressure-natriuresis, and blood pressure elevation observed in obese individuals. Visceral obesity and the ectopic deposition of adipose tissue may be important in the activation of these systems and in the target organ damage that ensues. Weight loss is critical in the effective management of obesity hypertension and the accompanying target organ damage, although recidivism rates are high. However, prevention of weight gain should be the major priority for combating hypertension and its consequences in the future. The present review will provide an overview of our understanding of the etiology, pathophysiology, and treatment of obesity hypertension. Our focus is on the state of knowledge in humans. The potential role of abdominal obesity is considered throughout our review. We refer to relevant animal literature for supportive evidence and where little or no data in humans are available.

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Authors: Davy, K. P., & Hall, J. E.
Affiliations: Virginia Tech (US)
ORCID: Davy, Kevin P.
Hall, John E.
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2004-05
Volume: 286
Issue: 5
Pages: R803-R813
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00707.2003
OpenAlex: W2094878829
Cited by: 280
References: 172
Citations by year: 2026: 2 · 2025: 9 · 2024: 4 · 2023: 10 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 11 · 2018: 6 · 2017: 13 · 2016: 14 · 2015: 9 · 2014: 12 · 2013: 20 · 2012: 22
FWCI: 11.67
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (K02HL067227, R01HL062283, P01HL051971)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: obesity, hypertension, abdominal obesity, visceral obesity, sympathetic nervous system, renin-angiotensin-aldosterone system, sodium and water retention, pressure natriuresis, target organ damage, weight loss, weight gain prevention, pathophysiology
MeSH terms: Animals, Disease Outbreaks, Humans, Hypertension, Obesity

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Obesity and hypertension: two epidemics or one?

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