Widespread reward-system activation in obese women in response to pictures of high-calorie foods
Abstract
Behavioral studies have suggested that exaggerated reactivity to food cues, especially those associated with high-calorie foods, may be a factor underlying obesity. This increased motivational potency of foods in obese individuals appears to be mediated in part by a hyperactive reward system. We used a Philips 3T magnet and fMRI to investigate activation of reward-system and associated brain structures in response to pictures of high-calorie and low-calorie foods in 12 obese compared to 12 normal-weight women. A regions of interest (ROI) analysis revealed that pictures of high-calorie foods produced significantly greater activation in the obese group compared to controls in medial and lateral orbitofrontal cortex, amygdala, nucleus accumbens/ventral striatum, medial prefrontal cortex, insula, anterior cingulate cortex, ventral pallidum, caudate, putamen, and hippocampus. For the contrast of high-calorie vs. low-calorie foods, the obese group also exhibited a larger difference than the controls did in all of the same regions of interest except for the putamen. Within-group contrasts revealed that pictures of high-calorie foods uniformly stimulated more activation than low-calorie foods did in the obese group. By contrast, in the control group, greater activation by high-calorie foods was seen only in dorsal caudate, whereas low-calorie foods were more effective than high-calorie foods in the lateral orbitofrontal cortex, medial prefrontal cortex, and anterior cingulate cortex. In summary, compared to normal-weight controls, obese women exhibited greater activation in response to pictures of high-calorie foods in a large number of regions hypothesized to mediate motivational effects of food cues.
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The hypothesis of compensatory overeating is consistent with preclinical evidence that decreased DA activity in the VTA results in a dramatic increase in consumption of high-fat foods.
“The hypothesis of compensatory overeating is consistent with preclinical evidence showing that decreased DA activity in VTA results in a dramatic increase in the consumption of high-fat foods (89).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [89]
Preclinical studies showing decreased VTA DA activity causes dramatic increase in high-fat food consumption partially support the compensation hypothesis.
“Preclinical studies showing that decreased DA activity in VTA results in a dramatic increase in the consumption of high-fat foods (47) partially support this hypothesis.”
From The Addictive Dimensionality of Obesity (2013) · cites this paper as [47]
Preclinical evidence shows that decreased DA activity in the VTA results in a dramatic increase in the consumption of high-fat foods.
“This hypothesis is consistent with preclinical evidence showing that decreased DA activity in VTA results in a dramatic increase in the consumption of high-fat foods (Stoeckel et al 2008).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Stoeckel et al 2008
The study focused on a specific dietary factor by controlling for calorie content, macronutrient composition, ingredient sources, and food form.
“Third, we focused on a spe-cific dietary factor by controlling for calorie content, macronutrient composition, ingredient sources, and food form, instead of comparing grossly different foods (eg, cheesecake compared with vegetables) (6,10,31,32).”
From Effects of dietary glycemic index on brain regions related to reward and craving in men (2013) · cites this paper as [10]
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Self-citation
- Authors
- Stoeckel, L. E., Weller, R. E., Cook, E. W., Twieg, D. B., Knowlton, R. C., & Cox, J. E.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Stoeckel, Luke E.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 41
- Issue
- 2
- Pages
- 636-647
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2074382500
- Cited by
- 857
- References
- 122
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 18 · 2023: 33 · 2022: 47 · 2021: 49 · 2020: 57 · 2019: 47 · 2018: 81 · 2017: 53 · 2016: 59 · 2015: 64 · 2014: 59 · 2013: 57 · 2012: 79
- FWCI
- 45.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Procter and Gamble
- University of Alabama at Birmingham
- Deutsches Krebsforschungszentrum
- National Center for Research Resources (M01RR00032, M01RR000032)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- obesity, food reward, high-calorie foods, food cue reactivity, reward systems, orbitofrontal cortex, amygdala, nucleus accumbens, ventral striatum, medial prefrontal cortex, anterior cingulate cortex, insula, caudate nucleus, putamen, hippocampus, women
- MeSH terms
- Adult, Brain, Brain Mapping, Cues, Female, Food, Food Preferences, Humans, Magnetic Resonance Imaging, Obesity, Photic Stimulation, Reward
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