Sex differentiation of t–e circadian system in the golden hamster
Abstract
The effect of estradiol benzoate (EB) on free-running circadian activity rhythms was studied in gonadectomized hamsters maintained in constant dim illumination. EB shortened the period (tau) of the female, but not of the male circadian activity rhythm. Responsiveness of the circadian system to EB was subject to sexual differentiation. The circadian period of wheel running by female hamsters given a single injection of testosterone propionate on the day of birth did not shorten in response to EB in adulthood. This failure to respond to EB also was observed in normal male hamsters, and was different from the response shown by normal females. Preliminary data suggest that tau of the activity rhythm of males castrated on the day of birth is shortened during EB treatment in adulthood. The differential effects of estradiol on tau are related to anatomic differences between the sexes in neural connections of the substrate for circadian rhythms.
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Gonadal hormones can influence other circadian parameters including endogenous period, rhythm amplitude, range of entrainment, zeitgeber sensitivity, and oscillator coupling.
“Gonadal hormones can influence other circadian parameters as well, including endogenous period [7, 23, 47, 49, 91, 129, 212], rhythm amplitude [8, 17, 100], range of entrainment [49], zeitgeber sensitivity [23, 51, 79, 81], and oscillator coupling [126, 128, 187].”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [212]
Gonadal hormones are already known to have species-specific effects during adulthood.
“This would not be an unprecedented conclusion, as gonadal hormones are already known to have species-specific effects during adulthood.”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [212]
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BackgroundThe neuroendocrine control of the circadian system: Adolescent chronotype
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“E-mail address: hagenaue@umich.edu (M.H. Hagena 0018-506X/$ – see front matter © 2011 Elsevier Inc. Al doi:10.1016/j.yhbeh.2011.03.001 a b s t r a c t a r t i c l e i n f o”
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Estrous Cyclicity Modulates Circadian Rhythms In Female Syrian Hamsters
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Result
- Authors
- Zucker, I., Fitzgerald, K. M., & Morin, L. P.
- ORCID
- Morin, L. P.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1980-01-01
- Volume
- 238
- Issue
- 1
- Pages
- R97-R101
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2199744762
- Cited by
- 35
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- circadian rhythm, sex differences, estradiol benzoate, testosterone propionate, circadian period, gonadectomy, golden hamster, castration
- MeSH terms
- Animals, Castration, Circadian Rhythm, Estradiol, Female, Cricetinae, Male, Mesocricetus, Motor Activity, Running, Sex Factors, Time Factors
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