The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Identification of an adult-specific glial progenitor cell
Abstract
We have found that glial progenitor cells isolated from the optic nerves of adult rats are fundamentally different from their counterparts in perinatal animals. In our studies on bipotential oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells, we have seen that O-2Aadutt progenitor cells can be distinguished from O-2Aperinatal progenitors by their morphology and antigenic pheno type, their much longer cell cycle time (65 h versus 18 h), slower rate of migration rate (4μmh-1versus 21μm h–1), and their time course of differentiation into oligodendrocytes or type-2 astrocytes in vitro (⩽3 days versus >5 days). At least some of the differences between 0–2Aadult and 0–2Aperinatal progenitor cells appear to be clearly related to the differing cellular requirements of the adult and perinatal central nervous system (CNS). The properties of the 0–2Aadult progenitor cells may make these cells ideally suited for the needs of the adult CNS, where rapid exponential increases in the number of oligodendrocytes and 0–2A progenitor cells would be inappropriate. However, the properties of the 0–2Aadult progenitor cells are such that they may not be able to replace oligodendrocytes in sufficient numbers to repair extensive or recurrent damage in the adult brain, such as in patients suffering from the human demyelinating disease multiple sclerosis. Moreover, available information about other tissues suggests that the transition from perinatal to adult progenitor cell types may rep resent a developmental mechanism of general import ance.
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Cites
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Self-citationGalactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture
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Cited by
Remyelination in the CNS: from biology to therapy
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Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis
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PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
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Oligodendrocytes: biology and pathology
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Metadata
- Authors
- Wolswijk, G., & Noble, M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1989-02-01
- Volume
- 105
- Issue
- 2
- Pages
- 387-400
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2133887238
- Cited by
- 485
- References
- 52
- FWCI
- 8.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wolswijk, G., & Noble, M. (1989). Identification of an adult-specific glial progenitor cell. Development. https://doi.org/10.1242/dev.105.2.387
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