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GABA release in the dorsal raphe nucleus: role in the control of REM sleep
Open accessAbstract
The cessation of firing of serotonergic dorsal raphe neurons is a key controlling event of rapid eye movement (REM) sleep. We tested the hypothesis that this cessation of activity is due to gamma-aminobutyric acid (GABA) release using the in vivo microdialysis technique. We found that REM sleep is accompanied by a selective increase in GABA release, but not by a change in glutamate or glycine release in the dorsal raphe nucleus. Microinjection of the GABA agonist muscimol into the dorsal raphe increased REM sleep, although microperfusion of the GABA antagonist picrotoxin blocked REM sleep. These results implicate GABA release as a critical element in the production of the REM sleep state and in the control of discharge in serotonergic neurons across the sleep/wake cycle.
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Cites
Chronic benzodiazepine treatment decreases postsynaptic GABA sensitivity
Gallager, D. W., Lakoski, J. M., Gonsalves, S. F., & Rauch, S. L. (1984) · Nature · doi:10.1038/308074a0 · Cited by 280
Cited by
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks
Pace-Schott, E. F., & Hobson, J. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn895 · Cited by 937
The human raphe nuclei and the serotonergic system
Hornung, J.-P. (2003) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2003.10.002 · Cited by 742
Activity of Serotonergic Neurons in Behaving Animals
Jacobs, B. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00012-3 · Cited by 317
Circadian and wakefulness-sleep modulation of cognition in humans
Wright, K. P., Lowry, C. A., & LeBourgeois, M. K. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00050 · Cited by 209
Metadata
- Authors
- Nitz, D., & Siegel, J.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1997-07-01
- Volume
- 273
- Issue
- 1
- Pages
- R451-R455
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2273601764
- Cited by
- 230
- References
- 1
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Nitz, D., & Siegel, J. (1997). GABA release in the dorsal raphe nucleus: role in the control of REM sleep. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.1997.273.1.r451
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
