Cited by 267Diabetes Treatment and ManagementIon Transport and Channel RegulationMetabolism, Diabetes, and Cancer

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Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo

Cheeseman, C. I.·1997·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.1997.273.6.r1965

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Abstract

The effect of in vivo infusion of the peptide hormone glucagon-like peptide 2 (GLP-2) on glucose transport across the rat jejunal brush-border membrane (BBM) was assessed using isolated membrane vesicles. A 2-h infusion of GLP-2 produced a marked acceleration of sodium-dependent glucose uptake into BBM vesicles with a significant overshoot. There was no change in vesicle space or permeability resulting from the hormone infusion. Kinetic analysis showed this stimulation to be the result of a threefold increase in the maximal rate of transport, with no consistent change in the affinity constant ( K m). The time course of this response showed that the effect was observable, but smaller, after only 30 min of hormone infusion and was maximal after 1 h. Sodium-dependent phloridzin binding to the membrane vesicles showed a parallel increase in maximal binding after 1 and 2 h of hormone infusion. Western blotting showed a similar increase in sodium-dependent glucose transporter 1 (SGLT-1) abundance. The effect of GLP-2 could be blocked by luminal brefeldin A or wortmannin. These results indicate that GLP-2 is able to induce trafficking of SGLT-1 from an intracellular pool into the BBM within 60 min and that phosphoinositol 3-kinase may well be involved in the intracellular signaling pathway in this response.

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Authors: Cheeseman, C. I.
Affiliations: University of Alberta (CA)
Corresponding author: Cheeseman, C. I.
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 1997-12-01
Volume: 273
Issue: 6
Pages: R1965-R1971
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.1997.273.6.r1965
OpenAlex: W2174791196
Cited by: 267
References: 30
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 6 · 2014: 17 · 2013: 9 · 2012: 11
FWCI: 5.13
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: glucagon-like peptide-2, SGLT1, glucose transport, intestinal glucose absorption, phosphoinositide 3-kinase signaling, brefeldin A, wortmannin
MeSH terms: Wortmannin, Androstadienes, Animals, Cyclopentanes, Glucagon-Like Peptides, Gastrointestinal Hormones, Glucose, Infusions, Intravenous, Intestinal Mucosa, Jejunum, Kinetics, Membrane Glycoproteins, Microvilli, Monosaccharide Transport Proteins, Peptides, Phlorhizin, Sodium, Brefeldin A, Sodium-Glucose Transporter 1, Rats, Glucagon-Like Peptide 2

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Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo

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