Cited by 267Diabetes Treatment and ManagementIon Transport and Channel RegulationMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo

Cheeseman, C. I.·1997·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.1997.273.6.r1965

Open this paper in CoChat — free account

Abstract

The effect of in vivo infusion of the peptide hormone glucagon-like peptide 2 (GLP-2) on glucose transport across the rat jejunal brush-border membrane (BBM) was assessed using isolated membrane vesicles. A 2-h infusion of GLP-2 produced a marked acceleration of sodium-dependent glucose uptake into BBM vesicles with a significant overshoot. There was no change in vesicle space or permeability resulting from the hormone infusion. Kinetic analysis showed this stimulation to be the result of a threefold increase in the maximal rate of transport, with no consistent change in the affinity constant ( K m). The time course of this response showed that the effect was observable, but smaller, after only 30 min of hormone infusion and was maximal after 1 h. Sodium-dependent phloridzin binding to the membrane vesicles showed a parallel increase in maximal binding after 1 and 2 h of hormone infusion. Western blotting showed a similar increase in sodium-dependent glucose transporter 1 (SGLT-1) abundance. The effect of GLP-2 could be blocked by luminal brefeldin A or wortmannin. These results indicate that GLP-2 is able to induce trafficking of SGLT-1 from an intracellular pool into the BBM within 60 min and that phosphoinositol 3-kinase may well be involved in the intracellular signaling pathway in this response.

Integrity signals

Registry

Crossref · 10.1152/ajpregu.1997.273.6.r1965

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Expression cloning and cDNA sequencing of the Na+/glucose co-transporter
Hediger, M. A., Coady, M. J., Ikeda, T. S., & Wright, E. M. (1987) · Nature · doi:10.1038/330379a0 · Cited by 1,004
Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.
Okada, T., Kawano, Y., Sakakibara, T., Hazeki, O., & Ui, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41901-6 · Cited by 911
Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic
Lippincott‐Schwartz, J., Yuan, L. C., Tipper, C. H., AMHERDT, M., Orci, L., & Klausner, R. D. (1991) · Cell · doi:10.1016/0092-8674(91)90534-6 · Cited by 841
Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.
Yano, H., Nakanishi, S., Kimura, K. D., Hanai, N., Saitoh, Y., Fukui, Y., Nonomura, Y., & Matsuda, Y. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74466-4 · Cited by 725
Hamster preproglucagon contains the sequence of glucagon and two related peptides
Bell, G. I., Santerre, R. F., & Mullenbach, G. T. (1983) · Nature · doi:10.1038/302716a0 · Cited by 649
Fructose transporter in human spermatozoa and small intestine is GLUT5.
Burant, C., Takeda, J., Brot‐Laroche, E., Bell, G. I., & Davidson, N. O. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42067-4 · Cited by 545
Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.
Okada, T., Sakuma, L., Fukui, Y., Hazeki, O., & Ui, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41900-4 · Cited by 439
Homocellular regulatory mechanisms in sodium-transporting epithelia: avoidance of extinction by “flush-through”
Schultz, S. (1981) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1981.241.6.f579 · Cited by 283
Selective inhibition of transcytosis by brefeldin A in MDCK cells
Hunziker, W., Whitney, J. A., & Mellman, I. (1991) · Cell · doi:10.1016/0092-8674(91)90535-7 · Cited by 251
Basolateral to apical transcytosis in polarized cells is indirect and involves BFA and trimeric G protein sensitive passage through the apical endosome
Barroso, M., & Sztul, E. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.1.83 · Cited by 188

Show all 30 references

Research works printed but not linked: 6

Cheeseman C. I., 1989, Am. J. Physiol., 256, G878
Cheeseman C. I., 1996, Am. J. Physiol., 271, G477
Hardin J. A., 1996, Am. J. Physiol., 271, G509
Karasov W. H., 1987, Am. J. Physiol., 253, G54
Schultz S. G., 1981, Am. J. Physiol., 241, F579
Solberg D. H., 1987, Am. J. Physiol., 252, G574

Sorted by citations

Items 201–266 of 266

Comparative Effects of Allulose, Fructose, and Glucose on the Small Intestine
Suzuki, T., Sato, Y., Kadoya, S., Takahashi, T., Otomo, M., Kobayashi, H., Aoki, K., Kantake, M., Sugiyama, M., & Ferraris, R. P. (2022) · Nutrients · doi:10.3390/nu14153230 · Cited by 6
Glucagon-like peptide 2: an update
Shin, E. D., Drucker, D. J., & Brubaker, P. L. (2005) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/01.med.0000150855.40298.db · Cited by 6
Treatment of suckling rats with GLP-2 plus dexamethasone increases the ileal uptake of fatty acids in later life
Iordache, C., Drozdowski, L. A., Clandinin, M. T., Wild, G., Todd, Z., & Thomson, A. B. R. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00047.2004 · Cited by 6
Developmental Regulation of the Expression of Nutrient Transporter and BrushBorder Membrane Hydrolase Genes in the Small Intestine of Piglets
Xiao, X. K. (2005) · VTechWorks (Virginia Tech) · Cited by 6
Dexamethasone and GLP‐2 Given to Lactating Rat Dams Influence Glucose Uptake in Suckling and Postweanling Offspring
Drozdowski, L. A., Iordache, C., Clandinin, M. T., Wild, G., Todd, Z., & Thomson, A. B. R. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108324874 · Cited by 5
Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice
Aoki, K., Suzuki, T., Hui, F., Nakano, T., Yanazawa, K., Yonamine, M., Fujita, S.-I., Sugasawa, T., Yoshida, Y., Omi, N., et al. (2021) · Nutrients · doi:10.3390/nu13051735 · Cited by 5
The Human Na+ Glucose Cotransporter Is a Molecular Water Pump
Tappenden, K. A. (1999) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607199023003173 · Cited by 5
Current understanding of insulin dysregulation and its relationship with carbohydrate and protein metabolism in horses
Loos, C. M. M., & Urschel, K. L. (2025) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2025.106940 · Cited by 5
Glycemic Impact of Non-Nutritive Sweeteners in Health and Type 2 Diabetes
Rose, B. D., Kreuch, D., Wu, T., Horowitz, Rayner, C. K., Page, A. J., Miller, C., & Young, R. L. (2026) · Nutrition Reviews · doi:10.1093/nutrit/nuaf313 · Cited by 5
Different phlorizin binding properties to porcine mucosa of the jejunum and ileum in relation to SGLT1 activity
Herrmann, J., Møller, N., Lange, P., & Breves, G. (2016) · Journal of Animal Science · doi:10.2527/jas.2015-9702 · Cited by 4
A starch-rich treat affects enteroinsular responses in ponies
Sibthorpe, P. E. M., Fitzgerald, D. M., Chen, L., Sillence, M. N., & de Laat, M. A. (2022) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.22.06.0272 · Cited by 4
The chondrichthyan glucagon-like peptide 3 regulates hepatic ketone metabolism in the Pacific spiny dogfish Squalus suckleyi
Weinrauch, A. M., Bouyoucos, I. A., Conlon, J. M., & Anderson, W. G. (2024) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2024.114470 · Cited by 4
Lipid malabsorption persists after weaning in rats whose dams were given GLP‐2 and dexamethasone
Iordache, C., Drozdowski, L. A., Clandinin, M. T., Wild, G., Todd, Z., & Thomson, A. B. R. (2005) · Lipids · doi:10.1007/s11745-005-1478-x · Cited by 4
Effects of Insulin-like Growth Factor-I and its Analogue, Long-R 3 -IGF-I, on Intestinal Absorption of 3- O -methyl- d -glucose are Less Pronounced than Gut Mucosal Growth Responses
Garnaut, S. M., Howarth, G. S., & Read, L. C. (2002) · Growth Factors · doi:10.1080/08977190290022194 · Cited by 4
Maternal dexamethasone and GLP-2 have early effects on intestinal sugar transport in their suckling rat offspring
Drozdowski, L. A., Iordache, C., Clandinin, M. T., Todd, Z., Gonnet, M., Wild, G., Uwiera, R. R. E., & Thomson, A. B. R. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.07.006 · Cited by 4
Gastrointestinal Peptide Hormones Regulating Energy and Glucose Homeostasis
Drucker, D. J. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50009-x · Cited by 4
Glucagon and Glucagon‐like Peptide Production and Degradation
Kieffer, T. J., Hussain, M. A., & Habener, J. F. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070208 · Cited by 4
A biological function for glucagon-like peptide-2
Husain, M. (1998) · European Journal of Endocrinology · doi:10.1530/eje.0.1390265 · Cited by 4
Influence of postruminal casein infusion and exogenous glucagon-like peptide 2 administration on the jejunal mucosal transcriptome in cattle
Trotta, R. J., Swanson, K. C., Klotz, J. L., & Harmon, D. L. (2024) · PLoS ONE · doi:10.1371/journal.pone.0308983 · Cited by 3
Emerging drugs for the treatment of short bowel syndrome
Frau, T., Khatib, M. E., de Dreuille, B., Billiauws, L., Nuzzo, A., & Joly, F. (2024) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2024.2357567 · Cited by 3
Gut Hormones and Inflammatory Bowel Disease
Weng, J., & Lo, C. C. (2025) · Biomolecules · doi:10.3390/biom15071013 · Cited by 4
Digestion et absorption dans l'intestin grêle
Brazier, F., Delcenserie, R., & Dupas, J. (2002) · EMC - Gastro-entérologie · doi:10.1016/s1155-1968(02)00051-2 · Cited by 3
Fundamental and Applied Studies on Transport and Metabolism of Electrolytes and Glucose-Aim to Contact with Molecular Biology
Suketa, Y. (2002) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.122.507 · Cited by 3
Functional expression of the short isoform of the murine leptin receptor Ob-Rc (muB1.219) inXenopus laevis oocytes
Barrenetxe, J., Palacios, R., Barber, A., & Lostao, M. P. (2003) · Journal of Physiology and Biochemistry · doi:10.1007/bf03179877 · Cited by 3
Chapter 19 Intestinal absorption of nutrients during early development of vertebrates: adaptive responses to dietary inputs
(2002) · Biology of growing animals · doi:10.1016/s1877-1823(09)70135-3 · Cited by 2
Studies in vitro of equine intestinal glucagon-like peptide-2 secretion
Sibthorpe, P. E. M., Fitzgerald, D. M., Sillence, M. N., & de Laat, M. A. (2024) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2024.105179 · Cited by 1
Butyrate-Induced Expression of Proglucagon: Implications for Enteroendocrine Signaling and Intestinal Growth
Woodard, J. (2010) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign) · Cited by 1
Studies on glucagon-like peptide-2 (GLP-2) and the equine gastrointestinal tract
Sibthorpe, P. E. M. (2022) · Queensland University of Technology · doi:10.5204/thesis.eprints.232700 · Cited by 1
Influence of cane molasses inclusion to dairy cow diets during the transition period on rumen epithelial development and a proposed mechanism of rumen epithelial development
Miller, W. F. (2011) · K-State Research Exchange (Kansas State University) · Cited by 1
The effect of glucagon-like peptide-2 and intraluminal nutrients on intestinal adaptation in a rat model of short bowel syndrome
Lai, S. W. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/28080 · Cited by 1
Hexose Transport Across Mammalian Epithelia
Cheeseman, C. I. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-229-2_14
Self-citation
[Glucagon-like peptide-2: its physiological effect on gut].
Sato, S., & Miura, S. (2011) · PubMed
Islet Amyloid Polypeptide/GLP‐1/Exendin
Baggio, L. L., & Drucker, D. J. (2003) · Wiley eBooks · doi:10.1002/0470862092.d0209
Regulation of renal brush-border glucose transport in response to metabolic dysregulation
Chichger, H. (2011) · UCL Discovery (University College London)
A atividade simpática regula, via proteína cinase A (PKA), a proteína cotransportadora Na+/glicose 1 (SGLT1) em glândula salivar: efeitos do Diabetes Mellitus e da hipertensão arterial.
Silva, R. S. (2010) · doi:10.11606/t.42.2010.tde-20052010-135156
Regulation of monosaccharide transporter proteins in the small intestine
Miura, S. (2002) · Journal of Gastroenterology · doi:10.1007/s005350200075
An unusual case of abdominal pain: Figure 1
Yazaki, N., Shiiba, K., Ishii, S., Mizoi, T., Miura, K., Oyama, A., Tanaka, N., Murata, Y., & Sasaki, I. (2004) · Gut · doi:10.1136/gut.2003.023929
IDENTIFICATION AND CHARA CTERIZATION OF THE GLUCAGON-LIKE PEPTIDE-2 HORMONAL SYSTEM IN RUMINANTS
Taylor-Edwards, C. C. (2009) · UKnowledge (University of Kentucky)
antibody SGLT1 in rat organs with an improved Revised immunolocalization of the Na+-D-glucose
Koepsell, H., Sabolić, I., Balen, D., Ljubojević, M., Breljak, D., Brzica, H., & Žlender, V. (2008)
The Effect of Insulin and Insulin Resistance on Glucagon-like Peptide-1 Secretion from the Intestinal L Cell
Lim, G. E. (2010) · TSpace (University of Toronto)
The Role of the GLP-2 Receptor in Intestinal and Islet Adaptation to Changes in Nutrient Availability
Bahrami, J. (2011) · TSpace (University of Toronto)
The Acute Regulation of Intestinal Chylomicron Secretion by Glucagon-like Peptides
Hsieh, J. (2012) · TSpace (University of Toronto)
Plasticité des cellules intestinales : nature et fonction
Gall, M. L., Bado, A., & Beyec, J. L. (2017) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2016.12.002
Regulation of Glucose Uptake and Transporter Expression in the North Pacific Spiny Dogfish (Squalus suckleyi)
Deck, C. A. (2016) · uO Research (University of Ottawa) · doi:10.20381/ruor-582
Butyrate-induced upregulation of intestinal glucose transport and signaling pathways represent a possible nutrient therapy for individuals with malabsorptive disorders
Mangian, H. J. (2014) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Humoral Factors in Intestinal
Fuller, P. J. (2000)
Role of Glucagon-like Peptide-2 in Rodent Models of Colon Cancer
Trivedi, S. (2011) · TSpace (University of Toronto)
The Effect of Glucagon-like Peptide-2 on Insulin-like Growth Factor-1 in Murine Intestinal Subepithelial Myofibroblasts
Leen, J. (2010) · TSpace (University of Toronto)
THE INFLUENCE OF PROBIOTIC LACTOBACILLI ON GLUCOSE UPTAKE BY CACO-2 CELLS.
Rooj, A. K. (2007)
Classical and Novel Hormonal Influences on Renal Tubular Transport, and the Emerging Concept of Intracrine Regulation
Capasso, G., Debnam, E. S., Cutillas, P. R., Brunski, N. J., & Unwin, R. J. (2008) · Elsevier eBooks · doi:10.1016/b978-012088488-9.50038-3
Molecular identification of single hormone-encoding proglucagon cDNA isoforms from squamates and their abundant expression
Suzuki, Y., Kurakata, E., Yoshida, A., Kobayashi, A., & Park, M. K. (2018) · Gene · doi:10.1016/j.gene.2018.07.011
Tuning the intestinal barrier through the neuroendocrine control of ABC pumps expression
Marı́n, J. J. G. (2020) · Acta Physiologica · doi:10.1111/apha.13544
Novel Roles of GLP-1 and GLP-2 in the Regulation of Hepatic Lipid/Lipoprotein Homeostasis and the Involvement of BAT Activation
Taher, J. (2017) · TSpace (University of Toronto)
The Role of the Insulin-like Growth Factor-1 Receptor in Intestinal Microvillus Structure and Lipid Handling, and its Requirement in Glucagon-like Peptide-2 Signaling and a Western Diet
Markovic, M. A. (2020) · TSpace (University of Toronto)
Faculty Opinions recommendation of Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes.
Naftalin, R. J. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718020724.793479145
Long term exposure to sucralose alters the sense of sweet tastants in an intestinal enteroendocrine cell model
Cai, S., Wu, Y., Xin, Y., Gu, X., Wang, Y., Jin, R., Zha, L., Yu, Z., Lu, Y., Ding, W., et al. (2022) · International Food Research Journal · doi:10.47836/ifrj.29.1.14
L’intestin un organe endocrine : de la physiologie aux implications thérapeutiques en nutrition
Beyec, J. L., Ledoux, S., Coëffier, M., & Gall, M. L. (2022) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2021.12.179 · Cited by 2
Therapeutic peptidomimetics in metabolic diseases
Sirhan, W., & Piran, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-820141-1.00023-6
Oral and post-oral factors controlling energy balance in GF rodents
Swartz, T. D., & Covașă, M. (2012) · OpenGrey (Institut de l'Information Scientifique et Technique)
The effect of Lactococcus lactis-produced Epidermal Growth Factor on the Growth and Intestine Development of Early-Weaned Pigs
Bedford, A. (2014) · The Atrium (University of Guelph)
Intestinal and skin homeostasis : targeting inflammation and cancer
El‐Jamal, N. (2012) · theses.fr (ABES) · doi:10.70675/19534eecz98c4z48b2z92f6z0eb4d568fe93
Rôle et régulation de la protéine kinase AMPK au niveau intestinal
Harmel, É. (2012) · theses.fr (ABES) · doi:10.70675/0223f181zd1b3z4a87zadd0zd62495c76b6c
Effets des enképhalines sur la contractilité intestinale : conséquences sur l'axe intestin-cerveau-périphérie dans le contrôle du métabolisme glucidique
Bessac, A. (2020) · theses.fr (ABES) · doi:10.70675/f11cd9b9zb198z454az9c2fz08ca0bfdd5d9
Modulation de la fonction de barrière intestinale et des jonctions serrées par les N-acyl homosérine lactones, molécules du quorum sensing bactérien
Aguanno, D. (2020) · theses.fr (ABES) · doi:10.70675/b56c7041z5357z4f20z9868z8dd1575778ce
Syndrome de grêle court : efficacité et facteurs prédictifs d'efficacité d'un traitement par analogues du GLP-2
de Dreuille, B. (2023) · doi:10.70675/f18619c9z4015z4041zae75z8e3c7679f344
Nutrition in Burns
Wang, S., & Deng, S. (2014) · Springer eBooks · doi:10.1007/978-94-017-8575-4_16

Authors: Cheeseman, C. I.
Affiliations: University of Alberta (CA)
Corresponding author: Cheeseman, C. I.
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 1997-12-01
Volume: 273
Issue: 6
Pages: R1965-R1971
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.1997.273.6.r1965
OpenAlex: W2174791196
Cited by: 267
References: 30
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 6 · 2014: 17 · 2013: 9 · 2012: 11
FWCI: 5.13
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: glucagon-like peptide-2, SGLT1, glucose transport, intestinal glucose absorption, phosphoinositide 3-kinase signaling, brefeldin A, wortmannin
MeSH terms: Wortmannin, Androstadienes, Animals, Cyclopentanes, Glucagon-Like Peptides, Gastrointestinal Hormones, Glucose, Infusions, Intravenous, Intestinal Mucosa, Jejunum, Kinetics, Membrane Glycoproteins, Microvilli, Monosaccharide Transport Proteins, Peptides, Phlorhizin, Sodium, Brefeldin A, Sodium-Glucose Transporter 1, Rats, Glucagon-Like Peptide 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks