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Cited by 221Muscle metabolism and nutritionAdvanced MRI Techniques and ApplicationsBiochemical effects in animals

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Increase of total creatine in human brain after oral supplementation of creatine-monohydrate

Dechent, P., Pouwels, P. J. W., Wilken, B., Hanefeld, F., Frahm, J.·1999·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.1999.277.3.r698
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Abstract

The effect of oral creatine supplementation on brain metabolite concentrations was investigated in gray matter, white matter, cerebellum, and thalamus of healthy young volunteers by means of quantitative localized proton magnetic resonance spectroscopy in vivo (2.0 T, stimulated echo acquisition mode sequence; repetition time = 6,000 ms, echo time = 20 ms, middle interval = 10 ms, automated spectral evaluation). Oral consumption of 4 × 5 g creatine-monohydrate/day for 4 wk yielded a statistically significant increase (8.7% corresponding to 0.6 mM, P < 0.001) of the mean concentration of total creatine (tCr) when averaged across brain regions and subjects ( n = 6). The data revealed considerable intersubject variability (3.5–13.3%), with the smallest increases observed for the two male volunteers with the largest body weights. A regional analysis resulted in significant increases of tCr in gray matter (4.7%), white matter (11.5%), and cerebellum (5.4%) and was most pronounced in thalamus (14.6% corresponding to 1.0 mM). Other findings were significant decreases of N-acetyl-containing compounds in cerebellum and thalamus as well as of choline-containing compounds in thalamus. All cerebral metabolic alterations caused by oral Cr were reversible, as evidenced by control measurements at least 3 mo after the diet. This work demonstrates that excess consumption of Cr yields regionally dependent increases of the tCr concentration in human brain over periods of several weeks.

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Crossref · 10.1152/ajpregu.1999.277.3.r698

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Research works printed but not linked: 3

  1. Frahm J., 1990, J. Magn. Reson., 90, 464
  2. Hagenfeldt L., 1994, Muscle Nerve, 17, 1236
  3. Walker J. B., 1979, Advances in Enzymology, 50, 177

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Metadata

Authors
Dechent, P., Pouwels, P. J. W., Wilken, B., Hanefeld, F., & Frahm, J.
Affiliations
  • Max Planck Institute for Biophysical Chemistry (DE)
  • University of Göttingen (DE)
ORCID
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
1999-09-01
Volume
277
Issue
3
Pages
R698-R704
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.1999.277.3.r698
OpenAlex
W2139463702
Semantic Scholar
003706525d905e44e3829feebb7f2f8bf0f758c4
Cited by
221
References
21
Citations by year
2026: 12 · 2025: 6 · 2024: 13 · 2023: 11 · 2022: 5 · 2021: 10 · 2020: 4 · 2019: 10 · 2018: 10 · 2017: 6 · 2016: 10 · 2015: 11 · 2014: 6 · 2013: 8 · 2012: 13
FWCI
2.47
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Physiology (medical) › Biochemical effects in animals
Keywords
creatine supplementation, creatine monohydrate, total creatine, brain metabolites, regional brain differences, gray matter, white matter, cerebellum, thalamus, choline-containing compounds, body weight
MeSH terms
Administration, Oral, Adult, Brain, Creatine, Diet, Female, Humans, Magnetic Resonance Imaging, Male

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