The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Identification of the conjugated linoleic acid isomer that inhibits milk fat synthesis
Abstract
Conjugated linoleic acids (CLA) are octadecadienoic fatty acids that have profound effects on lipid metabolism. Our previous work showed that CLA (mixture of isomers) markedly reduced milk fat synthesis. In this study, our objective was to evaluate the effects of specific CLA isomers. Multiparous Holstein cows were used in a 3 × 3 Latin square design, and treatments were 4-day abomasal infusions of 1) skim milk (control), 2) 9,11 CLA supplement, and 3) 10,12 CLA supplement. CLA supplements provided 10 g/day of the specific CLA isomer ( cis-9, trans-11 or trans-10, cis-12). Treatments had no effect on intake, milk yield, or milk protein yield. Only the 10,12 CLA supplement affected milk fat, causing a 42 and 44% reduction in milk fat percentage and yield, respectively. Milk fat composition revealed that de novo synthesized fatty acids were extensively reduced. Increases in ratios of C 14:0 to C 14:1 and C 18:0 to C 18:1 indicated the 10,12 CLA supplement also altered Δ 9-desaturase. Treatments had minimal effects on plasma concentrations of glucose, nonesterified fatty acids, insulin, or insulin-like growth factor-I. Overall, results demonstrate that trans-10, cis-12 CLA is the isomer responsible for inhibition of milk fat synthesis.
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Citations
Cites
Effect of conjugated linoleic acid on body composition in mice
Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., & Pariza, M. W. (1997) · Lipids · doi:10.1007/s11745-997-0109-x · Cited by 1,163
Park, Y., Storkson, J. M., Albright, K. J., Liu, W., & Pariza, M. W. (1999) · Lipids · doi:10.1007/s11745-999-0358-8 · Cited by 815
Cited by
N UTRITIONAL R EGULATION OF M ILK F AT S YNTHESIS
Bauman, D. E., & Griinari, J. M. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.011702.073408 · Cited by 1,163
Self-citationThe Composition of Bovine Milk Lipids: January 1995 to December 2000
Jensen, R. G. (2002) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(02)74079-4 · Cited by 1,076
Diet, rumen biohydrogenation and nutritional quality of cow and goat milk fat
Chilliard, Y., Glasser, F., Ferlay, A., Bernard, L., Rouel, J., & Doreau, M. (2007) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.200700080 · Cited by 859
Chilliard, Y., Ferlay, A., Mansbridge, R. M., & Doreau, M. (2000) · Annales de Zootechnie · doi:10.1051/animres:2000117 · Cited by 686
Regulation and nutritional manipulation of milk fat: low-fat milk syndrome
Bauman, D. E., & Griinari, J. M. (2001) · Livestock Production Science · doi:10.1016/s0301-6226(01)00195-6 · Cited by 642
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Metadata
- Authors
- Baumgard, L. H., Corl, B. A., Dwyer, D. A., Saebø, A., & Bauman, D. E.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2000-01-01
- Volume
- 278
- Issue
- 1
- Pages
- R179-R184
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2112222367
- Cited by
- 571
- References
- 2
- FWCI
- 67.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Baumgard, L. H., Corl, B. A., Dwyer, D. A., Saebø, A., & Bauman, D. E. (2000). Identification of the conjugated linoleic acid isomer that inhibits milk fat synthesis. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.2000.278.1.r179
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