Evidence that the trans‐10,cis‐12 isomer of conjugated linoleic acid induces body composition changes in mice
Abstract
We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9,trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis-9,trans-11 and trans-9,trans-11 CLA isomers did not affect these biochemical activities. We conclude that CLA-associated body composition change results from feeding the trans-10,cis-12 isomer.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Despite compelling evidence that CLA supplementation can influence body composition in rodent models, human data are more modest.
“Moreover, despite compelling evidence that CLA supplementation can influence body composition in rodent models [134,135], human data are more modest [[136], [137], [138]].”
From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [135]
Cites
Official Methods of Analysis of
Helrick, K. (1980) · Analytical Chemistry · doi:10.1021/ac50052a726 · Cited by 59,351 · see citing works
(2023) · Oxford University Press eBooks · doi:10.1093/9780197610145.002.001 · Cited by 28,120 · see citing works
Chin, S. F., Liu, W., Storkson, J. M., Ha, Y. L., & Pariza, M. W. (1992) · Journal of Food Composition and Analysis · doi:10.1016/0889-1575(92)90037-k · Cited by 1,197 · see citing works
Self-citationEffect of conjugated linoleic acid on body composition in mice
Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., & Pariza, M. W. (1997) · Lipids · doi:10.1007/s11745-997-0109-x · Cited by 1,163 · see citing works
Self-citationConjugated linoleic acid and atherosclerosis in rabbits
Lee, K. N., Kritchevsky, D., & Parizaa, M. W. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90034-5 · Cited by 998 · see citing works
Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid
Ha, Y. L., Grimm, N. K., & Pariza, M. W. (1987) · Carcinogenesis · doi:10.1093/carcin/8.12.1881 · Cited by 929 · see citing works
Self-citationA stable, radioactive substrate emulsion for assay of lipoprotein lipase
Nilsson‐Ehle, P., & Schotz, M. C. (1976) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41752-3 · Cited by 841 · see citing works
Ha, Y. L., STORKSON, J. M., & Pariza, M. W. (1990) · PubMed · Cited by 669 · see citing works
Self-citationHouseknecht, K. L., Heuvel, J. P. V., Moya-Camarena, S. Y., Portocarrero, C. P., Peck, L. W., Nickel, K. P., & Belury, M. A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8303 · Cited by 643 · see citing works
Frost, S. C., & Lane, M. D. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89409-1 · Cited by 513 · see citing works
Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse
West, D. B., DeLany, J. P., Camet, P. M., Blohm, F., Truett, A. A., & Scimeca, J. A. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.3.r667 · Cited by 468 · see citing works
The effect of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs
Dugan, M. E. R., Aalhus, J. L., Schaefer, A. L., & Kramer, J. K. G. (1997) · Canadian Journal of Animal Science · doi:10.4141/a97-084 · Cited by 347 · see citing works
Conjugated Linoleic Acid Decreases Hepatic Stearoyl-CoA Desaturase mRNA Expression
Lee, K. N., Pariza, M. W., & Ntambi, J. M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8994 · Cited by 305 · see citing works
Self-citationSehat, N., Yurawecz, M. P., Roach, J. A. G., Mossoba, M. M., Kramer, J. K. G., & Ku, Y. (1998) · Lipids · doi:10.1007/s11745-998-0198-6 · Cited by 248 · see citing works
Metabolites of conjugated isomers of linoleic acid (CLA) in the rat
Sébédio, J. L., Juanéda, P., Dobson, G., Ramilison, I., Martin, J. C., Chardigny, J., & Christie, W. W. (1997) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(97)00015-5 · Cited by 183 · see citing works
A simple method for preparation of methyltrans‐10,cis‐12 octadecadienoate
Scholfield, C. R., & Koritala, S. V. (1970) · Journal of the American Oil Chemists Society · doi:10.1007/bf02609501 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The biologically active isomers of conjugated linoleic acid
Pariza, M. W., Park, Y., & Cook, M. E. (2001) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00008-x · Cited by 1,098 · see citing works
Self-citationD IETARY C ONJUGATED L INOLEIC A CID IN H EALTH : Physiological Effects and Mechanisms of Action
Belury, M. A. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.021302.121842 · Cited by 815 · see citing works
Hasler, C. M. (2002) · Journal of Nutrition · doi:10.1093/jn/132.12.3772 · Cited by 717 · see citing works
Biological effects of conjugated linoleic acids in health and disease
Bhattacharya, A., Banu, J., Rahman, M., Causey, J., & Fernandes, G. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.02.009 · Cited by 663 · see citing works
Regulation and nutritional manipulation of milk fat: low-fat milk syndrome
Bauman, D. E., & Griinari, J. M. (2001) · Livestock Production Science · doi:10.1016/s0301-6226(01)00195-6 · Cited by 642 · see citing works
Dietary fatty acids and human health
Williams, C. M. (2000) · Annales de Zootechnie · doi:10.1051/animres:2000116 · Cited by 640 · see citing works
Raes, K., SMET, S. D., & Demeyer, D. I. (2003) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2003.09.001 · Cited by 634 · see citing works
Conjugated Linoleic Acid Reduces Body Fat Mass in Overweight and Obese Humans
Gudmundsen, O., Blankson, H., Stakkestad, J. A., Fagertun, H., Thom, E., & Wadstein, J. (2000) · Journal of Nutrition · doi:10.1093/jn/130.12.2943 · Cited by 595 · see citing works
Identification of the conjugated linoleic acid isomer that inhibits milk fat synthesis
Baumgard, L. H., Corl, B. A., Dwyer, D. A., Sæbø, A., & Bauman, D. E. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.1.r179 · Cited by 572 · see citing works
Improving functional value of meat products
Zhang, W., Xiao, S., Samaraweera, H., Lee, E. J., & Ahn, D. U. (2010) · Meat Science · doi:10.1016/j.meatsci.2010.04.018 · Cited by 517 · see citing works
Biosynthesis of conjugated linoleic acid in ruminants
Bauman, D. E., Baumgard, L. H., Corl, B. A., & Griinari, J. M. (2000) · Journal of Animal Science · doi:10.2527/jas2000.77e-suppl1f · Cited by 486 · see citing works
Ip, C. C. Y., Banni, S., Angioni, E., Carta, G., McGinley, J. N., Thompson, H. J., Barbano, D. M., & Bauman, D. E. (1999) · Journal of Nutrition · doi:10.1093/jn/129.12.2135 · Cited by 438 · see citing works
Risérus, U., Arner, P., Brismar, K., & Vessby, B. O. (2002) · Diabetes Care · doi:10.2337/diacare.25.9.1516 · Cited by 435 · see citing works
ISSN exercise & sport nutrition review: research & recommendations
Kreider, R. B., Wilborn, C. D., Taylor, L., Campbell, B., Almada, A. L., Collins, R., Cooke, M., Earnest, C. P., Greenwood, M., Kalman, D. S., et al. (2010) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-7-7 · Cited by 428 · see citing works
Implication of Conjugated Linoleic Acid (CLA) in Human Health
Dilzer, A., & Park, Y. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.501409 · Cited by 377 · see citing works
Self-citationden Hartigh, L. (2019) · Nutrients · doi:10.3390/nu11020370 · Cited by 371 · see citing works
Baumgard, L. H., Matitashvili, E. A., Corl, B. A., Dwyer, D. A., & Bauman, D. E. (2002) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(02)74294-x · Cited by 365 · see citing works
Dietary Conjugated Linoleic Acids Increase Lean Tissue and Decrease Fat Deposition in Growing Pigs
Ostrowska, E., Muralitharan, M., Cross, R. F., Bauman, D. E., & Dunshea, F. R. (1999) · Journal of Nutrition · doi:10.1093/jn/129.11.2037 · Cited by 363 · see citing works
Clément, L. C., Poirier, H., Niot, I., Bocher, V., Guerre-Millo, M., Krief, S., Staels, B., & Besnard, P. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m20008-jlr200 · Cited by 356 · see citing works
Mechanisms of Action of Conjugated Linoleic Acid: Evidence and Speculation
Pariza, M. W., Park, Y., & Cook, M. E. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22302.x · Cited by 355 · see citing works
Self-citationPerspective on the safety and effectiveness of conjugated linoleic acid
Pariza, M. W. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.1132s · Cited by 351 · see citing works
Self-citationLee, H.-Y., Park, J.-H., Seok, S.-H., Baek, M.-W., Kim, D.-J., Lee, K.-E., Paek, K.-S., Lee, Y., & Park, J.-H. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.05.007 · Cited by 342 · see citing works
German, J. B., & Dillard, C. J. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690590957098 · Cited by 316 · see citing works
Isomer-Specific Antidiabetic Properties of Conjugated Linoleic Acid
Ryder, J. W., Portocarrero, C. P., Song, X., Cui, L., Yu, M., COMBATSIARIS, T. P., Galuska, D., Bauman, D. E., Barbano, D. M., Charron, M. J., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1149 · Cited by 316 · see citing works
Conjugated linoleic acid and obesity control: efficacy and mechanisms
Wang, Y. W., & Jones, P. J. H. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802641 · Cited by 312 · see citing works
Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans
Whigham, L. D., Watras, A. C., & Schoeller, D. A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1203 · Cited by 312 · see citing works
Conjugated linoleic acid supplementation in humans—metabolic effects
Smedman, A., & Vessby, B. O. (2001) · Lipids · doi:10.1007/s11745-001-0784-7 · Cited by 305 · see citing works
White, S. L., Bertrand, J. A., Wade, M. R., Washburn, S. P., Green, J. T., & Jenkins, T. C. (2001) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(01)74676-0 · Cited by 300 · see citing works
Choi, Y., Kim, Y., Han, Y.-B., Park, Y., Pariza, M. W., & Ntambi, J. M. (2000) · Journal of Nutrition · doi:10.1093/jn/130.8.1920 · Cited by 297 · see citing works
Self-citationTricon, S., Burdge, G. C., Kew, S., Banerjee, T., Russell, J. J., Jones, E. L., Grimble, R. F., Williams, C. M., Yaqoob, P., & Calder, P. C. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.3.614 · Cited by 294 · see citing works
Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans
Gaullier, J., Halse, J., Høye, K., Kristiansen, K., Fagertun, H., Vik, H., & Gudmundsen, O. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.1118 · Cited by 292 · see citing works
Risérus, U., Berglund, L., & Vessby, B. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801659 · Cited by 284 · see citing works
Conjugated linoleic acid: implications for human health
Whigham, L. D., Cook, M. E., & Atkinson, R. L. (2000) · Pharmacological Research · doi:10.1006/phrs.2000.0735 · Cited by 283 · see citing works
Dietary Conjugated Linoleic Acid Reduces Rat Adipose Tissue Cell Size Rather than Cell Number
Azain, M. J., Hausman, D. B., Sisk, M. B., Flatt, W. P., & Jewell, D. E. (2000) · Journal of Nutrition · doi:10.1093/jn/130.6.1548 · Cited by 279 · see citing works
Antiobesity mechanisms of action of conjugated linoleic acid
Kennedy, A. J., Martinez, K., Schmidt, S. F., Mandrup, S., LaPoint, K., & McIntosh, M. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.08.003 · Cited by 271 · see citing works
Gaullier, J., Halse, J., Høye, K., Kristiansen, K., Fagertun, H., Vik, H., & Gudmundsen, O. (2005) · Journal of Nutrition · doi:10.1093/jn/135.4.778 · Cited by 269 · see citing works
Zambell, K. L., Keim, N. L., Loan, M. D. V., Gale, B., Benito, P., Kelley, D. S., & Nelson, G. J. (2000) · Lipids · doi:10.1007/s11745-000-0585-z · Cited by 269 · see citing works
Metabolic activities and probiotic potential of bifidobacteria
Russell, D. A., Ross, R. P., Fitzgerald, G. F., & Stanton, C. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.06.003 · Cited by 265 · see citing works
Baumgard, L. H., Sangster, J. K., & Bauman, D. E. (2001) · Journal of Nutrition · doi:10.1093/jn/131.6.1764 · Cited by 265 · see citing works
Raes, K., SMET, S. D., & Demeyer, D. I. (2001) · Animal Science · doi:10.1017/s1357729800058227 · Cited by 262 · see citing works
Health benefits of conjugated linoleic acid (CLA)
Koba, K., & Yanagita, T. (2013) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2013.10.001 · Cited by 249 · see citing works
Elias, S., & Innis, S. M. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.4.807 · Cited by 249 · see citing works
Healthier meat products as functional foods
Decker, E. A., & Park, Y. (2010) · Meat Science · doi:10.1016/j.meatsci.2010.04.021 · Cited by 248 · see citing works
Self-citationConjugated Linoleic Acid: Potential Health Benefits as a Functional Food Ingredient
Kim, J. H., Kim, Y., Kim, Y. J., & Park, Y. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-041715-033028 · Cited by 244 · see citing works
Self-citationRisérus, U., Vessby, B. O., Ärnlöv, J., & Basu, S. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.279 · Cited by 243 · see citing works
Mechanisms of body fat modulation by conjugated linoleic acid (CLA)
Park, Y., & Pariza, M. W. (2006) · Food Research International · doi:10.1016/j.foodres.2006.11.002 · Cited by 242 · see citing works
Self-citationNoone, E., Roche, H. M., Nugent, A. P., & Gibney, M. J. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002615 · Cited by 240 · see citing works
Review of the roles of conjugated linoleic acid in health and disease
Yang, B. K., Chen, H., Stanton, C., Ross, R. P., Zhang, H., Chen, Y. Q., & Chen, W. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.03.050 · Cited by 235 · see citing works
Regulation of Fat Synthesis by Conjugated Linoleic Acid: Lactation and the Ruminant Model , ,
Bauman, D. E., Perfield, J. W., Harvatine, K. J., & Baumgard, L. H. (2008) · Journal of Nutrition · doi:10.1093/jn/138.2.403 · Cited by 234 · see citing works
Factors Affecting Conjugated Linoleic Acid Content in Milk and Meat
Dhiman, T. R., Nam, S., & Ure, A. L. (2005) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390591034463 · Cited by 230 · see citing works
Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat
Mougios, V., Matsakas, A., Petridou, A., Ring‐Dimitriou, S., Sagredos, A. N., Melissopoulou, A., Tsigilis, N., & Nikolaidis, M. G. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00177-2 · Cited by 224 · see citing works
Terpstra, A. H. M. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.3.352 · Cited by 222 · see citing works
Isomer-specific regulation of metabolism and PPARγ signaling by CLA in human preadipocytes
Brown, J. M., Sandberg, M. B., Jensen, S. S., Morrison, R. F., STORKSON, J. M., Lea-Currie, R., Pariza, M. W., Mandrup, S., & McIntosh, M. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300001-jlr200 · Cited by 222 · see citing works
Self-citationIsomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism
Evans, M. E., Brown, J. M., & McIntosh, M. K. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00211-5 · Cited by 219 · see citing works
Conjugated linoleic acid (CLA): A ruminant fatty acid with beneficial effects on human health
McGuire, M. A., & McGuire, M. K. (2000) · Journal of Animal Science · doi:10.2527/jas2000.00218812007700es0033x · Cited by 219 · see citing works
Antimutagenic and some other effects of conjugated linoleic acid
Kritchevsky, D. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500000581 · Cited by 218 · see citing works
O'Quinn, P. R., Nelssen, J. L., Goodband, R. D., & Tokach, M. D. (2000) · Animal Health Research Reviews · doi:10.1017/s1466252300000049 · Cited by 207 · see citing works
Efficacy and safety of dietary supplements containing CLA for the treatment of obesity
Larsen, T. M., Toubro, S., & Astrup, A. V. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r300011-jlr200 · Cited by 205 · see citing works
Trans-Vaccenic Acid Is Desaturated to Conjugated Linoleic Acid in Mice
Santora, J. E., Palmquist, D. L., & Roehrig, K. L. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.208 · Cited by 204 · see citing works
Evans, M., Geigerman, C., Cook, J., Curtis, L., Kuebler, B., & McIntosh, M. (2000) · Lipids · doi:10.1007/s11745-000-0599-6 · Cited by 201 · see citing works
A comprehensive analysis of the composition, health benefits, and safety of apple pomace
Skinner, R. C., Gigliotti, J. C., Ku, K., & Tou, J. C. L. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy033 · Cited by 199 · see citing works
West, D. B., Blohm, F., Truett, A. A., & DeLany, J. P. (2000) · Journal of Nutrition · doi:10.1093/jn/130.10.2471 · Cited by 198 · see citing works
Park, Y., STORKSON, J. M., Ntambi, J. M., Cook, M. E., Sih, C. J., & Pariza, M. W. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00074-3 · Cited by 192 · see citing works
Self-citationGavino, V. C., Gavino, G. R., Leblanc, M.-J., & Tuchweber, B. (2000) · Journal of Nutrition · doi:10.1093/jn/130.1.27 · Cited by 191 · see citing works
Belury, M. A., Mahon, A. K., & Banni, S. (2003) · Journal of Nutrition · doi:10.1093/jn/133.1.257s · Cited by 190 · see citing works
Role of fatty acids in adipocyte growth and development1,2
Azain, M. J. (2004) · Journal of Animal Science · doi:10.2527/2004.823916x · Cited by 189 · see citing works
Suzuki, R., Noguchi, R., Ota, T., Abe, M., Miyashita, K., & Kawada, T. (2001) · Lipids · doi:10.1007/s11745-001-0746-0 · Cited by 186 · see citing works
Modulation of hepatic steatosis by dietary fatty acids
Ferramosca, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i7.1746 · Cited by 185 · see citing works
Albers, R., van der Wielen, R. P. J., Brink, E. J., Hendriks, H., Dorovska‐Taran, V., & Mohede, I. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601585 · Cited by 183 · see citing works
Lee, K., Paek, K., Lee, H. Y., Park, J. H., & Lee, Y. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03336.x · Cited by 175 · see citing works
Dietary conjugated linoleic acid and body composition
Wang, Y., & Jones, P. J. H. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.6.1153s · Cited by 175 · see citing works
Conjugated Linoleic Acid Induces Human Adipocyte Delipidation
Brown, J. M., Sandberg, M. B., Chung, S., Fabiyi, O., Morrison, R. F., Mandrup, S., & McIntosh, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401766200 · Cited by 173 · see citing works
Norris, L. E., Collene, A. L., Asp, M. L., Hsu, J. C., Liu, L.-F., Richardson, J., Li, D., Bell, D., Osei, K., Jackson, R. D., et al. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27371 · Cited by 171 · see citing works
Modulation of inflammation and immunity by dietary conjugated linoleic acid
Viladomiu, M., Hontecillas, R., & Bassaganya-Riera, J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.095 · Cited by 174 · see citing works
trans-10,cis-12 CLA inhibits differentiation of 3T3-L1 adipocytes and decreases PPARγ expression
Kang, K., Liu, W., ALBRIGHT, K. J., Park, Y., & Pariza, M. W. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00413-3 · Cited by 170 · see citing works
Self-citationA natural solution for obesity: Bioactives for the prevention and treatment of weight gain. A review
Torres‐Fuentes, C., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2014) · Nutritional Neuroscience · doi:10.1179/1476830513y.0000000099 · Cited by 168 · see citing works
Palombo, J. D., Ganguly, A., Bistrian, B. R., & Menard, M. P. (2002) · Cancer Letters · doi:10.1016/s0304-3835(01)00796-0 · Cited by 168 · see citing works
Dietary Conjugated Linoleic Acid Reduces Adiposity in Lean but Not Obese Zucker Rats
Sisk, M. B., Hausman, D. B., Martin, R. J., & Azain, M. J. (2001) · Journal of Nutrition · doi:10.1093/jn/131.6.1668 · Cited by 160 · see citing works
Chung, S., Brown, J. M., Provo, J. N., Hopkins, R. G., & McIntosh, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508159200 · Cited by 158 · see citing works
Peters, J. M., Park, Y., Gonzalez, F. J., & Pariza, M. W. (2001) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(01)00155-x · Cited by 158 · see citing works
Self-citationDietary polyunsaturated fatty acids as inducers of apoptosis: implications for cancer
Serini, S., Piccioni, E., Merendino, N., & Calviello, G. (2009) · APOPTOSIS · doi:10.1007/s10495-008-0298-2 · Cited by 157 · see citing works
Anti‐obesity effects of conjugated linoleic acid, docosahexaenoic acid, and eicosapentaenoic acid
Li, J., Huang, C. J., & Xie, D. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700399 · Cited by 157 · see citing works
Terpstra, A. H. M. (2001) · Journal of Nutrition · doi:10.1093/jn/131.7.2067 · Cited by 155 · see citing works
Kamphuis, M. M. J. W., Lejeune, M. P. G. M., Saris, W. H. M., & Westerterp‐Plantenga, M. S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802304 · Cited by 154 · see citing works
Takahashi, Y., Kushiro, M., Shinohara, K., & Ide, T. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(03)00038-6 · Cited by 154 · see citing works
Terpstra, A. H. M., Beynen, A. C., Everts, H., Kocsis, S., Katan, M., & Zock, P. L. (2002) · Journal of Nutrition · doi:10.1093/jn/132.5.940 · Cited by 154 · see citing works
Conjugated Linoleic Acid Isomers and Mammary Cancer Prevention
Ip, C. C. Y., Dong, Y., Ip, M. M., Banni, S., Carta, G., Angioni, E., Murru, E., Spada, S., Melis, M. P., & Sæbø, A. (2002) · Nutrition and Cancer · doi:10.1207/s15327914nc431_6 · Cited by 153 · see citing works
Khan, S. A., & Heuvel, J. P. V. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(03)00098-6 · Cited by 152 · see citing works
Conjugated linoleic acid (CLA): Good or bad trans fat?
Park, Y. (2009) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2008.12.002 · Cited by 151 · see citing works
Self-citationFat burners: nutrition supplements that increase fat metabolism
Jeukendrup, A. E., & Randell, R. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00908.x · Cited by 150 · see citing works
Conjugated linoleic acid isomer effects in atherosclerosis: Growth and regression of lesions
Kritchevsky, D., Tepper, S. A., Wright, S., Czarnecki, S. K., Wilson, T. A., & Nicolosi, R. J. (2004) · Lipids · doi:10.1007/s11745-004-1273-8 · Cited by 147 · see citing works
Brown, J. M., Halvorsen, Y.-D., Lea-Currie, Y. R., Geigerman, C., & McIntosh, M. K. (2001) · Journal of Nutrition · doi:10.1093/jn/131.9.2316 · Cited by 147 · see citing works
Invited review: The anti-inflammatory properties of dairy lipids
Lordan, R., & Zabetakis, I. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-12224 · Cited by 146 · see citing works
Effects of Two Conjugated Linoleic Acid Isomers on Body Fat Mass in Overweight Humans
Malpuech‐Brugère, C., de Venne, W. P. H. G. V., Mensink, R. P., Arnal, M. A., Morio, B., Brandolini, M., Sæbø, A., Lassel, T. S., Chardigny, J., Sébédio, J. L., et al. (2004) · Obesity Research · doi:10.1038/oby.2004.68 · Cited by 144 · see citing works
Conjugated linoleic acid and the control of cancer and obesity
Pariza, M. W. (1999) · Toxicological Sciences · doi:10.1093/toxsci/52.suppl_1.107 · Cited by 143 · see citing works
Self-citationColonic anti-inflammatory mechanisms of conjugated linoleic acid
Bassaganya-Riera, J. (2002) · Clinical Nutrition · doi:10.1054/clnu.2002.0594 · Cited by 142 · see citing works
Beppu, F., Hosokawa, M., Tanaka, L., Kohno, H., Tanaka, T., & Miyashita, K. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.01.007 · Cited by 138 · see citing works
CLA isomers in milk fat from cows fed diets with high levels of unsaturated fatty acids
Collomb, M., Sieber, R., & Bütikofer, U. (2004) · Lipids · doi:10.1007/s11745-004-1239-x · Cited by 135 · see citing works
Du, ., & Ahn, D. U. (2002) · Poultry Science · doi:10.1093/ps/81.3.428 · Cited by 135 · see citing works
Evans, N. P., Misyak, S. A., Schmelz, E. M., Guri, A. J., Hontecillas, R., & Bassaganya-Riera, J. (2010) · Journal of Nutrition · doi:10.3945/jn.109.115642 · Cited by 129 · see citing works
- Authors
- Park, Y., Storkson, J. M., Albright, K. J., Liu, W., & Pariza, M. W.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Pariza, Michael W.
- Venue
- Lipids
- Publisher
- Wiley
- Published
- 1999-03
- Volume
- 34
- Issue
- 3
- Pages
- 235-241
- ISSN
- 0024-4201 (ISSN-L)
- 1558-9307
- OpenAlex
- W2057643905
- Cited by
- 815
- References
- 16
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 13 · 2019: 8 · 2018: 5 · 2017: 18 · 2016: 18 · 2015: 16 · 2014: 14 · 2013: 28 · 2012: 35
- FWCI
- 49.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lipids (publishedVersion)
- PubMed (publishedVersion)
- ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
- Funders
- Wisconsin Alumni Research Foundation
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- conjugated linoleic acid, body composition, adipocytes, lipoprotein lipase, triglycerides, glycerol release, fat deposition, dietary fatty acids
- MeSH terms
- Animals, Body Composition, Body Weight, Dose-Response Relationship, Drug, Female, Isomerism, Linoleic Acids, Lipoprotein Lipase, Male, Mice, Inbred ICR, Triglycerides, 3T3 Cells, Adipocytes, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review