Cited by 815Fatty Acid Research and HealthLipid metabolism and biosynthesisAdipose Tissue and Metabolism

Evidence that the trans‐10,cis‐12 isomer of conjugated linoleic acid induces body composition changes in mice

Park, Yeonhwa, Storkson, Jayne M., Albright, Karen J., Liu, Wei, Pariza, Michael W.·1999·Lipids

Abstract

We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9,trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis-9,trans-11 and trans-9,trans-11 CLA isomers did not affect these biochemical activities. We conclude that CLA-associated body composition change results from feeding the trans-10,cis-12 isomer.

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Crossref · 10.1007/s11745-999-0358-8

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  • Despite compelling evidence that CLA supplementation can influence body composition in rodent models, human data are more modest.

    “Moreover, despite compelling evidence that CLA supplementation can influence body composition in rodent models [134,135], human data are more modest [[136], [137], [138]].”

    From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [135]

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Authors
Park, Y., Storkson, J. M., Albright, K. J., Liu, W., & Pariza, M. W.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
Pariza, Michael W.
Venue
Lipids
Publisher
Wiley
Published
1999-03
Volume
34
Issue
3
Pages
235-241
ISSN
  • 0024-4201 (ISSN-L)
  • 1558-9307
OpenAlex
W2057643905
Cited by
815
References
16
Citations by year
2026: 4 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 13 · 2019: 8 · 2018: 5 · 2017: 18 · 2016: 18 · 2015: 16 · 2014: 14 · 2013: 28 · 2012: 35
FWCI
49.28
Type
journal article
Language
en
Open access
closed
Locations
  • Lipids (publishedVersion)
  • PubMed (publishedVersion)
  • ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
Funders
Wisconsin Alumni Research Foundation
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
conjugated linoleic acid, body composition, adipocytes, lipoprotein lipase, triglycerides, glycerol release, fat deposition, dietary fatty acids
MeSH terms
Animals, Body Composition, Body Weight, Dose-Response Relationship, Drug, Female, Isomerism, Linoleic Acids, Lipoprotein Lipase, Male, Mice, Inbred ICR, Triglycerides, 3T3 Cells, Adipocytes, Mice

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