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Cited by 46Estrogen and related hormone effectsPregnancy and preeclampsia studiesHormonal and reproductive studies

Estrogen and progesterone effects on transcapillary fluid dynamics.

Stachenfeld, Nina S., Keefe, David L., Palter, Steven F.·2001·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.2001.281.4.r1319
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Abstract

The purpose of this study was to determine estrogen (E 2) and progesterone (P 4) effects on atrial natriuretic peptide (ANP) control of plasma volume (PV) and transcapillary fluid dynamics. To this end, we suppressed reproductive function in 12 women (age 21–35 yr) using a gonadotropin releasing-hormone (GnRH) analog (leuprolide acetate) for 5 wk. During the 5th week, the women either received 4 days of E 2 administration (17β-estradiol, transdermal patch, 0.1 mg/day) or 4 days of E 2 with P 4 administration (vaginal gel, 90 mg P 4 twice per day). At the end of the 4th and 5th week of GnRH analog and hormone administration, we determined PV (Evans blue dye) and changes in PV and forearm capillary filtration coefficient (CFC) during a 120-min infusion of ANP (5 ng · kg body wt−1 · min−1). Preinfusion PV was estimated from Evans blue dye measurement taken over the last 30 min of infusion based on changes in hematocrit. E 2 treatment did not affect preinfusion PV relative to GnRH analog alone (45.3 ± 3.1 vs. 45.4 ± 3.1 ml/kg). During ANP infusion CFC was greater during E 2 treatment compared with GnRH analog alone (6.5 ± 1.4 vs. 4.9 ± 1.4 μl · 100 g−1 · min−1 mmHg−1, P < 0.05). The %PV loss during ANP infusion was similar for E 2 and GnRH analog-alone treatments (−0.8 ± 0.2 and −1.0 ± 0.2 ml/kg, respectively), indicating the change in CFC had little systemic effect on ANP-related changes in PV. Estimated baseline PV was reduced by E 2-P 4 treatment. During ANP infusion CFC was ∼30% lower during E 2-P 4 (6.0 ± 0.5 vs. 4.3 ± 4.3 μl · 100 g−1 · min−1 mmHg−1, P < 0.05), and the PV loss during ANP infusion was attenuated (−0.9 ± 0.2 and −0.2 ± 0.2 ml/kg for GnRH analog-alone and E 2-P 4 treatments, respectively). Thus the E 2-P 4 treatment lowered CFC and reduced PV loss during ANP infusion.

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Crossref · 10.1152/ajpregu.2001.281.4.r1319

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  • Estrogens tend to raise plasma volume, whereas progesterone tends to lower it, through effects on capillary fluid dynamics or Starling forces.

    “Estrogens tend to increase, whereas progesterone tends to decrease, plasma volume (22,23,25) through effects on capillary fluid dynamics or Starling forces (18,24,30).”

    From Sex Hormone Effects on Body Fluid Regulation (2008) · cites this paper as [24]

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Authors
Stachenfeld, N. S., Keefe, D. L., & Palter, S. F.
Affiliations
Brown University (US)
ORCID
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2001-10-01
Volume
281
Issue
4
Pages
R1319-R1329
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.2001.281.4.r1319
OpenAlex
W2099195144
Cited by
46
References
33
Citations by year
2026: 1 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2012: 1
FWCI
0.72
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
estrogen, progesterone, atrial natriuretic peptide, plasma volume, capillary filtration coefficient, GnRH analogues, leuprolide, women, fluid balance, vasopressin, aldosterone, sodium excretion, plasma renin activity, plasma osmolality
MeSH terms
Adult, Blood Pressure, Blood Volume, Capillaries, Capillary Permeability, Cardiac Output, Drug Administration Routes, Estradiol, Estrogens, Female, Fertility Agents, Female, Forearm, Hematocrit, Humans, Infusions, Intravenous, Gonadotropin-Releasing Hormone, Atrial Natriuretic Factor, Progesterone, Stroke Volume, Veins, Leuprolide, Hot Flashes

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