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Cited by 72Exercise and Physiological ResponsesCell death mechanisms and regulationImmunotoxicology and immune responses

Exercise affects tissue lymphocyte apoptosis via redox-sensitive and Fas-dependent signaling pathways

Krüger, K., Frost, S., Most, E., Völker, K., Pallauf, J., Mooren, F. C.·2009·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
DOI 10.1152/ajpregu.90994.2008
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Abstract

Intensive and exhaustive exercise induces an activation of blood T-lymphocytes, which seems to be terminated by apoptotic processes in the postexercise period. Here, we report that exercise-induced T-lymphocyte apoptosis is a systemic phenomenon occurring in various lymphoid and nonlymphoid tissues. The apoptosis rate could be related to exercise intensity and type. Although in some tissues, such as the spleen and Peyer's patches, an early start of apoptosis (1–3 h postexercise) could be detected, a delayed apoptosis (24 h postexercise) was observed in lung, bone marrow, and lymph nodes. Further analysis showed a similar apoptosis distribution among lymphocyte subpopulations. We tested whether components of the extrinsic or the intrinsic apoptotic pathways or both were involved in these processes. Elevated levels of lipid peroxidation-product malondialdehyde (MDA), indicating an increased production of reactive oxygen species (ROS), were found after exercise in Peyer's patches, lung, and spleen, but not in lymph nodes. Application of N-acetyl-cysteine (NAC) prevented exercise-induced T-cell apoptosis completely in spleen and bone marrow, partially in lung and Peyer's patches, while it was ineffective in lymph nodes. Additionally, exercise addressed the Fas-mediated apoptosis. The percentage of Fas-receptor (Fas+) and Fas-ligand positive (FasL+) lymphocytes was enhanced in Peyer's patches after exercise. Moreover, FasL+ T cells were increased in the lung, while in lymph nodes Fas+ cells were increased. The critical role of Fas signaling in exercise-induced apoptosis was supported by using Fas-deficient MRL/lpr-mice. In Fas-deficient mice, exercise-induced T-lymphocyte apoptosis was prevented in spleen, lung, bone marrow, and lymph nodes, but not in Peyer's patches. These data demonstrate that exercise-induced lymphocyte apoptosis is a transient systemic process with tissue-type specific apoptosis-inducing mechanisms, whose relevance for the adaptive immune competence remains to be shown.

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  • Lymphocyte apoptosis occurs post-exercise in tissues that are thought to be the homing destination of mobilised cells in mice.

    “This assertion is partly supported by observations in mice, showing that lymphocyte apoptosis occurs post-exercise in tissues that are thought to be the homing destination of mobilised cells (Kruger et al. 2009).”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Kruger et al. 2009

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Authors
Krüger, K., Frost, S., Most, E., Völker, K., Pallauf, J., & Mooren, F. C.
Affiliations
Justus-Liebig-Universität Gießen (DE)
ORCID
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Published
2009-05
Volume
296
Issue
5
Pages
R1518-R1527
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
DOI
10.1152/ajpregu.90994.2008
OpenAlex
W2100203899
Cited by
72
References
37
Citations by year
2026: 4 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 2 · 2018: 11 · 2017: 2 · 2016: 6 · 2015: 8 · 2014: 3 · 2013: 7 · 2012: 5
FWCI
3.73
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
physical activity, T cell apoptosis, Fas signaling, Fas ligand, redox signaling, reactive oxygen species, lipid peroxidation, malondialdehyde, N-acetylcysteine, Peyer's patches, spleen, lung, bone marrow, lymph nodes, MRL/lpr mice, adaptive immunity
MeSH terms
Acetylcysteine, Animals, Male, Malondialdehyde, Mice, Inbred C57BL, Oxidation-Reduction, Physical Conditioning, Animal, T-Lymphocytes, Signal Transduction, Free Radical Scavengers, Apoptosis, Oxidative Stress, fas Receptor, Mice, Inbred MRL lpr, Models, Animal, Mice, Fas Ligand Protein

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