The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Structural and functional changes in the kidneys of high-fat diet-induced obese mice
Abstract
Metabolic syndrome has been reported to be associated with chronic kidney disease, but the mechanisms remain unclear. Although feeding of a high-fat diet (HFD) to C57BL/6 mice is reported to induce systemic metabolic abnormalities and subsequent renal injuries, such as albuminuria, similar to human metabolic syndrome, alterations in HFD-induced renal injuries have not been fully elucidated in detail. We therefore investigated the structural and functional changes in the kidneys of C57BL/6 mice on a HFD. Six-week-old mice were fed a low-fat diet (LFD; 10% of total calories from fat) or a HFD (60% fat) for 12 wk. Mice fed a HFD showed significant increases in body weight, systolic blood pressure, plasma insulin, glucose, and triglycerides compared with those on a LFD. Accompanying these systemic changes, mice on a HFD showed albuminuria, an increase in glomerular tuft area, and mesangial expansion. These systemic and renal alterations in mice on a HFD were prevented by body weight control with the dietary restriction of feeding a HFD. Furthermore, mice on a HFD showed renal pathophysiological alterations including renal lipid accumulation, an increased accumulation of type IV collagen in glomeruli, an increase in macrophage infiltration in the renal medulla, an increase in urinary 8-hydroxy-2′-deoxyguanosine excretion, and impaired sodium handling. In conclusion, this study suggests that local metabolic alterations in the kidney play important roles in the development of renal injury associated with metabolic syndrome in addition to systemic metabolic changes and an increase in body weight.
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Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis
D'Agati, V. D., Chagnac, A., de Vries, A. P. J., Levi, M., Porrini, E., Herman-Edelstein, M., & Praga, M. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.75 · Cited by 716
Jiang, S.-Z., Lu, W., Zong, X.-F., Ruan, H.-Y., & Liu, Y. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3667 · Cited by 445
Rodent Models for Metabolic Syndrome Research
Panchal, S. K., & Brown, L. (2011) · BioMed Research International · doi:10.1155/2011/351982 · Cited by 408
Fatty Kidney, Hypertension, and Chronic Kidney Disease: The Framingham Heart Study
Foster, M. C., Hwang, S.-J., Porter, S. A., Massaro, J. M., Hoffmann, U., & Fox, C. S. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.175315 · Cited by 356
Kitada, M., Kume, S., Imaizumi, N., & Koya, D. (2011) · Diabetes · doi:10.2337/db10-0386 · Cited by 345
Self-citation
Metadata
- Authors
- Deji, N., Kume, S., Araki, S.-I., Soumura, M., Sugimoto, T., Isshiki, K., Chin-Kanasaki, M., Sakaguchi, M., Koya, D., Haneda, M., Kashiwagi, A., & Uzu, T.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2009-01
- Volume
- 296
- Issue
- 1
- Pages
- F118-F126
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2135985828
- Cited by
- 262
- References
- 55
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Deji, N., Kume, S., Araki, S.-I., Soumura, M., Sugimoto, T., Isshiki, K., Chin-Kanasaki, M., Sakaguchi, M., Koya, D., Haneda, M., Kashiwagi, A., & Uzu, T. (2009). Structural and functional changes in the kidneys of high-fat diet-induced obese mice. American Journal of Physiology-Renal Physiology. https://doi.org/10.1152/ajprenal.00110.2008
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