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Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells
Abstract
Rab10, a mammalian homolog of the yeast Sec4p protein, has previously been associated with endocytic recycling and biosynthetic membrane transport in cultured epithelia and with Glut4 translocation in adipocytes. Here, we report that Rab10 associates with primary cilia in renal epithelia in culture and in vivo. In addition, we find that Rab10 also colocalizes with exocyst proteins at the base of nascent cilia, and physically interacts with the exocyst complex, as detected with anti-Sec8 antibodies. These data suggest that membrane transport to the primary cilum may be mediated by interactions between Rab10 and an exocyst complex located at the cilium base.
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Association of RAB10 with the exocyst complex has been reported in renal epithelial cells.
“Association of RAB10 with the exocyst complex has also been reported in renal epithelial cells (45).”
From The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes (2022) · cites this paper as [45]
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Vertebrate Smoothened functions at the primary cilium
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Patched1 Regulates Hedgehog Signaling at the Primary Cilium
Rohatgi, R., Milenkovic, L., & Scott, M. P. (2007) · Science · doi:10.1126/science.1139740 · Cited by 1,426
Nachury, M. V., Loktev, A. V., Zhang, Q., Westlake, C. J., Peränen, J., Merdes, A., Slusarski, D. C., Scheller, R. H., Bazan, J. F., Sheffield, V. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.053 · Cited by 1,384
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Satir, P., & Christensen, S. T. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.040705.141236 · Cited by 1,142 · cited 1×
“THE PRIMARY CILIUM, ONCE RELEGATED as a biological curiosity, has come to be appreciated as a fundamentally important cellular organelle, involved in cell signaling and critical to tissue development in multicellular organisms (61).”
BackgroundHEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium
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Rab Proteins and the Compartmentalization of the Endosomal System
Wandinger-Ness, A., & Zerial, M. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022616 · Cited by 586
Dhekne, H. S., Yanatori, I., Gomez, R. C., Tonelli, F., Diez, F., Schüle, B., Steger, M., Alessi, D. R., & Pfeffer, S. R. (2018) · eLife · doi:10.7554/elife.40202 · Cited by 240
GSK3β-Dzip1-Rab8 Cascade Regulates Ciliogenesis after Mitosis
Zhang, B., Zhang, T., Wang, G., Wang, G., Chi, W., Jiang, Q., & Zhang, C. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002129 · Cited by 60
Khan, T. G., Ginsburg, D., & Emmer, B. T. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100248 · Cited by 21
Metadata
- Authors
- Babbey, C. M., Bacallao, R. L., & Dunn, K. W.
- Affiliations
- Department of Medicine, Division of Nephrology, Indiana University Medical Center, Indianapolis, Indiana
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2010-09
- Volume
- 299
- Issue
- 3
- Pages
- F495-F506
- ISSN
- 1931-857X
- 1522-1466
- Cited by
- 81
- References
- 6
- Language
- en
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