Loss of biliverdin reductase-A promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689 · see citing works

Oxyl radicals, redox-sensitive signalling cascades and antioxidants

Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930 · see citing works

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

Zha, J., Harada, H., Yang, E., Jockel, J., & Korsmeyer, S. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81382-3 · Cited by 2,578 · see citing works

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

del Peso, L., González‐García, M., Page, C., Herrera, R., & Núñez, G. (1997) · Science · doi:10.1126/science.278.5338.687 · Cited by 2,213 · see citing works

Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal Injury

Mishra, J., Ma, Q., Prada, A., Mitsnefes, M., Zahedi, K., Yang, J., Barasch, J., & Devarajan, P. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000088027.54400.c6 · Cited by 1,749 · see citing works

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

Kang, H. M., Ahn, S. H., Choi, P., Ko, Y.-A., Han, S. H., Chinga, F., Park, A. S. D., Tao, J., Sharma, K., Pullman, J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3762 · Cited by 1,555 · see citing works

Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment

† (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70102-0 · Cited by 800 · see citing works

Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy

Herman‐Edelstein, M., Scherzer, P., Tobar, A., Levi, M., & Gafter, U. (2013) · Journal of Lipid Research · doi:10.1194/jlr.p040501 · Cited by 652 · see citing works

Neutrophil Gelatinase-Associated Lipocalin: A Novel Early Urinary Biomarker for Cisplatin Nephrotoxicity

Mishra, J., Mori, K., Ma, Q., Kelly, C. N., Barasch, J. M., & Devarajan, P. (2004) · American Journal of Nephrology · doi:10.1159/000078452 · Cited by 534 · see citing works

Obesity, hypertension, and chronic kidney disease

Hall, J., Juncos, L., Wang, Z., Hall, M., do Carmo, J., & da Silva, A. (2014) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s39739 · Cited by 520 · see citing works

Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease

de Vries, A. P. J., Ruggenenti, P. L., Ruan, X. Z., Praga, M., Cruzado, J. M., Bajema, I. M., D’Agati, V. D., Lamb, H. J., Barlovič, D. P., Hojs, R., et al. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70065-8 · Cited by 503 · see citing works

Fatty Acid Regulation of Hepatic Gene Transcription

Jump, D. Β., Botolin, D., Wang, Y., Xu, J., Christian, B., & Demeure, O. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2503 · Cited by 477 · see citing works

Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis.

Haverty, T. P., Kelly, C. J., Hines, W. H., Amenta, P. S., Watanabe, M., Harper, R. A., Kefalides, N. A., & Neilson, E. G. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.4.1359 · Cited by 306 · see citing works

Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm

Abumrad, N. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00137-7 · Cited by 277 · see citing works

Bilirubin in the Liver–Gut Signaling Axis

Hamoud, A.-R. A., Weaver, L., Stec, D. E., & Hinds, T. D. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.01.002 · Cited by 257 · see citing works

Association of age and BMI with kidney function and mortality: a cohort study

Lü, J., Molnar, M. Z., Naseer, A., Mikkelsen, M. K., Kalantar‐Zadeh, K., & Kovesdy, C. P. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00128-x · Cited by 223 · see citing works

Multiple Metabolic Hits Converge on CD36 as Novel Mediator of Tubular Epithelial Apoptosis in Diabetic Nephropathy

Susztak, K., Ciccone, E., McCue, P., Sharma, K., & Böttinger, E. P. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020045 · Cited by 214 · see citing works

Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce Lipotoxicity

Herms, A., Bosch, M., Ariotti, N., Reddy, B. J. N., Fajardo, A., Fernández‐Vidal, A., Álvarez-Guaita, A., Fernandez-Rojo, M. A., Rentero, C., Tebar, F., et al. (2013) · Current Biology · doi:10.1016/j.cub.2013.06.032 · Cited by 193 · see citing works

Bilirubin Binding to PPARα Inhibits Lipid Accumulation

Stec, D. E., John, K., Trabbic, C. J., Luniwal, A., Hankins, M. W., Baum, J., & Hinds, T. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153427 · Cited by 193 · see citing works

Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9

Bauer, D. E., Canver, M. C., & Orkin, S. H. (2014) · Journal of Visualized Experiments · doi:10.3791/52118 · Cited by 158 · see citing works

Neutrophil Gelatinase-Associated Lipocalin in Patients with Autosomal-Dominant Polycystic Kidney Disease

Bolignano, D., Coppolino, G., Campo, S., Aloisi, C., Nicocia, G., Frisina, N., & Buemi, M. (2007) · American Journal of Nephrology · doi:10.1159/000103912 · Cited by 155 · see citing works

Biliverdin reductase isozymes in metabolism

O’Brien, L., Hosick, P. A., John, K., Stec, D. E., & Hinds, T. D. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.02.001 · Cited by 142 · see citing works

Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

Hinds, T. D., Burns, K. A., Hosick, P. A., McBeth, L., Nestor‐Kalinoski, A. L., Drummond, H. A., AlAmodi, A. A., Hankins, M. W., Heuvel, J. P. V., & Stec, D. E. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.731703 · Cited by 136 · see citing works

New Insights into Biliverdin Reductase Functions: Linking Heme Metabolism to Cell Signaling

Maines, M. D. (2005) · Physiology · doi:10.1152/physiol.00029.2005 · Cited by 135 · see citing works

Metabolic Substrates, Cellular Energy Production, and the Regulation of Proximal Tubular Transport

Mandel, L. J. (1985) · Annual Review of Physiology · doi:10.1146/annurev.ph.47.030185.000505 · Cited by 119 · see citing works

Serum bilirubin levels are inversely associated with nonalcoholic fatty liver disease

Kwak, M., Kim, D., Chung, G. E., Kang, S. J., Park, M. J., Kim, Y. J., Yoon, J., & Lee, H.-S. (2012) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2012.18.4.383 · Cited by 118 · see citing works

Biliverdin reductase and bilirubin in hepatic disease

Weaver, L., Hamoud, A.-R. A., Stec, D. E., & Hinds, T. D. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00026.2018 · Cited by 98 · see citing works

Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes

Martínez-García, C., Izquierdo‐Lahuerta, A., Vivas, Y., Velasco, I., Yeo, T.-K., Chen, S., & Medina‐Gómez, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142291 · Cited by 97 · see citing works

Mice with hyperbilirubinemia due to Gilbert’s syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα

Hinds, T. D., Hosick, P. A., Chen, S., Tukey, R. H., Hankins, M. W., Nestor‐Kalinoski, A. L., & Stec, D. E. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00396.2016 · Cited by 91 · see citing works

Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell

Soumura, M., Kume, S., Isshiki, K., Takeda, N., Araki, S., Tanaka, Y., Sugimoto, T., Chin‒Kanasaki, M., Nishio, Y., Haneda, M., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.10.012 · Cited by 81 · see citing works

Lipotoxicity in renal proximal tubular cells: Relationship between endoplasmic reticulum stress and oxidative stress pathways

Katsoulieris, E. N., Mabley, J. G., Samai, M. H., Sharpe, M. A., Green, I. C., & Chatterjee, P. K. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.021 · Cited by 80 · see citing works

Intrarenal renin-angiotensin system mediates fatty acid-induced ER stress in the kidney

Li, C., Lin, Y., Luo, R., Chen, S., Wang, F., Zheng, P., Levi, M., Yang, T., & Wang, W. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00223.2015 · Cited by 67 · see citing works

Serum bilirubin levels are lower in overweight asymptomatic middle-aged adults: An early indicator of metabolic syndrome?

Pražnikar, Z. J., Petelin, A., Jurdana, M., & Žiberna, L. (2013) · Metabolism · doi:10.1016/j.metabol.2013.01.011 · Cited by 65 · see citing works

Variants in the UGT1A1 Gene and the Risk of Pediatric Nonalcoholic Fatty Liver Disease

Lin, Y., Chang, P., Hu, F., Chang, M., & Ni, Y. (2009) · PEDIATRICS · doi:10.1542/peds.2008-3087 · Cited by 64 · see citing works

Biliverdin Reductase: PKC Interaction at the Cross-Talk of MAPK and PI3K Signaling Pathways

Maines, M. D. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1805 · Cited by 61 · see citing works

Targeting the fatty acid transport protein CD36, a class B scavenger receptor, in the treatment of renal disease

Yokoi, H., & Yanagita, M. (2016) · Kidney International · doi:10.1016/j.kint.2016.01.009 · Cited by 58 · see citing works

Serum Bilirubin Level Is Inversely Associated With Nonalcoholic Steatohepatitis in Children

Puri, K., Nobili, V., Melville, K., Corte, C. D., Sartorelli, M. R., López, R., Feldstein, A. E., & Alkhouri, N. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318291fefe · Cited by 55 · see citing works

Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway

Liu, Y., Wang, X., Ahmed, N., Kong, Z., Hong, Y., Wang, C., & Zhang, J. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.120 · Cited by 54 · see citing works

The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis

Chen, Y., Varghese, Z., & Ruan, X. Z. (2014) · Genes & Diseases · doi:10.1016/j.gendis.2014.07.007 · Cited by 54 · see citing works

Glucuronidation and UGT isozymes in bladder: new targets for the treatment of uroepithelial carcinomas?

Sundararaghavan, V. L., Sindhwani, P., & Hinds, T. D. (2016) · Oncotarget · doi:10.18632/oncotarget.12277 · Cited by 51 · see citing works

Unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease: A favorable endogenous response

Kumar, R. K., Rastogi, A., Maras, J. S., & Sarin, S. K. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.11.017 · Cited by 35 · see citing works

A Novel Fluorescence-Based Assay for the Measurement of Biliverdin Reductase Activity

Adeosun, S. O., Moore, K. H., Lang, D., Nwaneri, A. C., Hinds, T. D., & Stec, D. E. (2017) · doi:10.20455/ros.2018.809 · Cited by 31 · see citing works

Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young Obese

Belo, L., Nascimento, H., Kohlová, M., Bronze-da-Rocha, E., Fernandes, J. C., Costa, E. M., Catarino, C., Aires, L., Mansilha, H. F., Rocha‐Pereira, P., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098467 · Cited by 29 · see citing works

Relationship between Serum Bilirubin Levels and Metabolic Syndrome in Patients with Schizophrenia Spectrum Disorders

Karadağ, F., Şengül, C. B., Enli, Y., Karakülah, K., Alaçam, H., Kaptanoğlu, B., Kalkancı, Ö., & Herken, H. (2017) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2017.15.2.153 · Cited by 24 · see citing works

Overexpression of biliverdin reductase enhances resistance to chemotherapeutics

Florczyk, U., Gołda, S., Zieba, A., Cisowski, J., Józkowicz, A., & Dulak, J. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.09.003 · Cited by 23 · see citing works

Some physical and immunological properties of ox kidney biliverdin reductase

Rigney, E., Phillips, O. M., & Mantle, T. J. (1988) · Biochemical Journal · doi:10.1042/bj2550431 · Cited by 12 · see citing works

Obesity, kidney dysfunction and hypertension: mechanistic links

Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0145-4 · Cited by 654 · see citing works

Lipid Accumulation and Chronic Kidney Disease

Gai, Z., Wang, T., Visentin, M., Kullak-Ublick, G. A., Fu, X., & Wang, Z. (2019) · Nutrients · doi:10.3390/nu11040722 · Cited by 431 · see citing works

Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways

Badmus, O. O., Hillhouse, S. A., Anderson, C. D., Hinds, T. D., & Stec, D. E. (2022) · Clinical Science · doi:10.1042/cs20220572 · Cited by 372 · see citing works

Heme Oxygenase-1: An Anti-Inflammatory Effector in Cardiovascular, Lung, and Related Metabolic Disorders

Ryter, S. W. (2022) · Antioxidants · doi:10.3390/antiox11030555 · Cited by 281 · see citing works

Bilirubin as a metabolic hormone: the physiological relevance of low levels

Creeden, J. F., Gordon, D. M., Stec, D. E., & Hinds, T. D. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00405.2020 · Cited by 233 · see citing works

Association of metabolic syndrome and chronic kidney disease

Scurt, F. G., Ganz, M. J., Herzog, C., Bose, K., Mertens, P. R., & Chatzikyrkou, C. (2024) · Obesity Reviews · doi:10.1111/obr.13649 · Cited by 155 · see citing works

Bilirubin, a Cardiometabolic Signaling Molecule

Hinds, T. D., & Stec, D. E. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11130 · Cited by 114 · see citing works

Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways

Duvigneau, J. C., Esterbauer, H., & Kozlov, A. V. (2019) · Antioxidants · doi:10.3390/antiox8100475 · Cited by 108 · see citing works

Loss of hepatic PPARα promotes inflammation and serum hyperlipidemia in diet-induced obesity

Stec, D. E., Gordon, D. M., Hipp, J., Hong, S., Mitchell, Z. L., Franco, N. R., Robison, J., Anderson, C. D., Stec, D. F., & Hinds, T. D. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00153.2019 · Cited by 102 · see citing works

Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α

Gordon, D. M., Neifer, K. L., Hamoud, A.-R. A., Hawk, C. F., Nestor‐Kalinoski, A. L., Miruzzi, S. A., Morran, M. P., Adeosun, S. O., Sarver, J. G., Erhardt, P., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013700 · Cited by 99 · see citing works

Novel insight into perirenal adipose tissue: A neglected adipose depot linking cardiovascular and chronic kidney disease

Huang, N., Mao, E.-W., Hou, N., Liu, Y., Han, F., & Sun, X. (2020) · World Journal of Diabetes · doi:10.4239/wjd.v11.i4.115 · Cited by 89 · see citing works

Perirenal adipose tissue inflammation: novel insights linking metabolic dysfunction to renal diseases

Hammoud, S. H., AlZaim, I., Al-Dhaheri, Y., Eid, A. H., & El-Yazbi, A. F. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.707126 · Cited by 87 · see citing works

Perirenal Adipose Tissue—Current Knowledge and Future Opportunities

Grigoraş, A., Balan, R. A., Căruntu, I.-D., Giuşcă, S. E., Lozneanu, L., Avădănei, E. R., Rusu, A., Riscanu, L., & Amălinei, C. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061291 · Cited by 79 · see citing works

Reactive Oxygen Species (ROS) and Antioxidants as Immunomodulators in Exercise: Implications for Heme Oxygenase and Bilirubin

Thomas, D. T., DelCimmuto, N. R., Flack, K. D., Stec, D. E., & Hinds, T. D. (2022) · Antioxidants · doi:10.3390/antiox11020179 · Cited by 78 · see citing works

Kidney Damage Caused by Obesity and Its Feasible Treatment Drugs

Wang, M., Wang, Z., Chen, Y., & Dong, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020747 · Cited by 79 · see citing works

Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK–SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue

Hinds, T. D., Kipp, Z. A., Xu, M., Yiannikouris, F. B., Morris, A. J., Stec, D. F., Wahli, W., & Stec, D. E. (2021) · Cells · doi:10.3390/cells11010004 · Cited by 71 · see citing works

RNA sequencing in human HepG2 hepatocytes reveals PPAR-α mediates transcriptome responsiveness of bilirubin

Gordon, D. M., Blomquist, T. M., Miruzzi, S. A., McCullumsmith, R. E., Stec, D. E., & Hinds, T. D. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00028.2019 · Cited by 69 · see citing works

Bilirubin Safeguards Cardiorenal and Metabolic Diseases: a Protective Role in Health

Hinds, T. D., & Stec, D. E. (2019) · Current Hypertension Reports · doi:10.1007/s11906-019-0994-z · Cited by 64 · see citing works

The association between dyslipidemia and the incidence of chronic kidney disease in the general Zhejiang population: a retrospective study

Liang, X., Ye, M., Tao, M., Zheng, D., Cai, R., Zhu, Y., Jin, J., & He, Q. (2020) · BMC Nephrology · doi:10.1186/s12882-020-01907-5 · Cited by 61 · see citing works

Update on the Pathogenesis, Diagnosis, and Treatment of Diabetic Tubulopathy

Liu, D., Chen, X., He, W., Lu, M., Li, Q., Zhang, S., Xie, J., Zhang, Y., & Wang, W. (2024) · Integrative Medicine in Nephrology and Andrology · doi:10.1097/imna-d-23-00029 · Cited by 60 · see citing works

Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice

Stec, D. E., Gordon, D. M., Nestor-Kalinoski, A. L., Donald, M. C., Mitchell, Z. L., Creeden, J. F., & Hinds, T. D. (2020) · Biomolecules · doi:10.3390/biom10030387 · Cited by 50 · see citing works

Obesity and chronic kidney disease: prevalence, mechanism, and management

Yim, H. E., & Yoo, K. H. (2021) · Korean Journal of Pediatrics · doi:10.3345/cep.2021.00108 · Cited by 53 · see citing works

Renal lipotoxicity: Insights from experimental models

de Castro, B. B. A., Foresto‐Neto, O., Câmara, N. O. S., & Sanders‐Pinheiro, H. (2021) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13556 · Cited by 48 · see citing works

Bilirubin Levels Are Negatively Correlated with Adiposity in Obese Men and Women, and Its Catabolized Product, Urobilin, Is Positively Associated with Insulin Resistance

Kipp, Z. A., Xu, M., Bates, E. A., Lee, W., Kern, P. A., & Hinds, T. D. (2023) · Antioxidants · doi:10.3390/antiox12010170 · Cited by 47 · see citing works

Severe Hypertriglyceridaemia and Chylomicronaemia Syndrome—Causes, Clinical Presentation, and Therapeutic Options

Bashir, B., Ho, J. H., DOWNIE, P. F., Hamilton, P., Ferns, G. A., Datta, D. B. N., Cegla, J., Wierzbicki, A. S., Dawson, C., Jenkinson, F., et al. (2023) · Metabolites · doi:10.3390/metabo13050621 · Cited by 45 · see citing works

High-fat diet causes mitochondrial damage and downregulation of mitofusin-2 and optic atrophy-1 in multiple organs

Zheng, P., Ma, W., Gu, Y., Wu, H., Bian, Z., Liu, N., Yang, D., & Chen, X. (2023) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.22-73 · Cited by 46 · see citing works

A Simple and Cost Effective Turn off Fluorescence Sensor for Biliverdin and Bilirubin Based on L-Cysteine Modulated Copper Nanoclusters

Anand, S. K., Mathew, M. R., & Kumar, K. G. (2019) · Journal of Fluorescence · doi:10.1007/s10895-019-02470-5 · Cited by 43 · see citing works

CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation

Gordon, D. M., Adeosun, S. O., Ngwudike, S. I., Anderson, C. D., Hall, J. E., Hinds, T. D., & Stec, D. E. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108072 · Cited by 42 · see citing works

Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity

Cimini, F. A., Arena, A., Barchetta, I., Tramutola, A., Ceccarelli, V., Lanzillotta, C., Fontana, M., Bertoccini, L., Leonetti, F., Capoccia, D., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.02.021 · Cited by 39 · see citing works

Elucidating ascorbate and aldarate metabolism pathway characteristics via integration of untargeted metabolomics and transcriptomics of the kidney of high-fat diet-fed obese mice

Liang, H., & Song, K. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300705 · Cited by 35 · see citing works

Bilirubin bioconversion to urobilin in the gut-liver-kidney axis: A biomarker for insulin resistance in the Cardiovascular-Kidney-Metabolic (CKM) Syndrome

Kipp, Z. A., Badmus, O. O., Stec, D. E., Hall, B., & Hinds, T. D. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156081 · Cited by 33 · see citing works

Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease

Bates, E. A., Kipp, Z. A., Martinez, G. J., Badmus, O. O., Soundarapandian, M. M., Foster, D. J., Xu, M., Creeden, J. F., Greer, J. R., Morris, A. J., et al. (2023) · Biomolecules · doi:10.3390/biom13020252 · Cited by 33 · see citing works

Childhood Obesity: Insight into Kidney Involvement

Carullo, N., Zicarelli, M., Michael, A., Faga, T., Battaglia, Y., Pisani, A., Perticone, M., Costa, D., Ielapi, N., Coppolino, G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417400 · Cited by 27 · see citing works

A dual channel optical sensor for biliverdin and bilirubin using glutathione capped copper nanoclusters

Anand, S. K., Mathew, M. R., & Kumar, K. G. (2021) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2021.113379 · Cited by 29 · see citing works

Heme oxygenase, biliverdin reductase, and bilirubin pathways regulate oxidative stress and insulin resistance: a focus on diabetes and therapeutics

Lee, W., Kipp, Z. A., Pauss, S. N., Martinez, G. J., Bates, E. A., Badmus, O. O., Stec, D. E., & Hinds, T. D. (2025) · Clinical Science · doi:10.1042/cs20242825 · Cited by 27 · see citing works

Bilirubin Nanoparticle Treatment in Obese Mice Inhibits Hepatic Ceramide Production and Remodels Liver Fat Content

Kipp, Z. A., Martinez, G. J., Bates, E. A., Maharramov, A., Flight, R. M., Moseley, H., Morris, A. J., Stec, D. E., & Hinds, T. D. (2023) · Metabolites · doi:10.3390/metabo13020215 · Cited by 26 · see citing works

Assessment of the impact of glyphosate and 2,4-D herbicides on the kidney injury and transcriptome changes in obese mice fed a Western diet

Romualdo, G. R., de Souza, J. L. H., Valente, L. C., & Barbisan, L. F. (2023) · Toxicology Letters · doi:10.1016/j.toxlet.2023.08.003 · Cited by 25 · see citing works

Fatty kidney: A possible future for chronic kidney disease research

Kanbay, M., Çöpür, S., Demiray, A., Sag, A. A., Covic, A. C., Ortíz, A., & Tuttle, K. R. (2022) · European Journal of Clinical Investigation · doi:10.1111/eci.13748 · Cited by 24 · see citing works

Sex Difference in the Associations among Obesity-Related Indices with Incident Hypertension in a Large Taiwanese Population Follow-Up Study

Lee, W.-C., Wu, P.-Y., Huang, J., Tsai, Y., Chiu, Y., Chen, S., Chang, J., & Chen, H. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12060972 · Cited by 24 · see citing works

The role of perirenal adipose tissue deposition in chronic kidney disease progression: Mechanisms and therapeutic implications

Qiu, X., Lan, X., Li, L., Chen, H., ZHANG, N., Zheng, X., & Xie, X. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122866 · Cited by 24 · see citing works

Advances of Iron and Ferroptosis in Diabetic Kidney Disease

Chu, J., Wang, K., Lu, L., Zhao, H., Hu, J., Xiao, W., & Wu, Q. (2024) · Kidney International Reports · doi:10.1016/j.ekir.2024.04.012 · Cited by 23 · see citing works

Biliverdin reductase as a target in drug research and development: Facts and hypotheses

Mancuso, C. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.06.034 · Cited by 20 · see citing works

Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a–C5aR1 Pathway

Bisht, K., Canesin, G., Cheytan, T., Li, M., Németh, Z., Csizmadia, E., Woodruff, T. M., Stec, D. E., Bulmer, A. C., Otterbein, L. E., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1701443 · Cited by 19 · see citing works

Hypercaloric Diet Promotes Metabolic Disorders and Impaired Kidney Function

Meléndez-Salcido, C. G., Ramı́rez-Emiliano, J., & Pérez‐Vázquez, V. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612829666221020162955 · Cited by 17 · see citing works

Bilirubin Hepatic and Intestinal Transport and Catabolism: Physiology, Pathophysiology, and Benefits

Kipp, Z. A., Pauss, S. N., Martinez, G. J., Hinds, T. D., & Lee, W. (2025) · Antioxidants · doi:10.3390/antiox14111326 · Cited by 16 · see citing works

Novel Function for Bilirubin as a Metabolic Signaling Molecule: Implications for Kidney Diseases

Stec, D. E., Tiribelli, C., Badmus, O. O., & Hinds, T. D. (2022) · Kidney360 · doi:10.34067/kid.0000062022 · Cited by 16 · see citing works

The potential mechanisms underlying the modulating effect of perirenal adipose tissue on hypertension: Physical compression, paracrine, and neurogenic regulation

Sun, J.-Y., Su, Z., Yang, J., Sun, W. Y., & Kong, X. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122511 · Cited by 14 · see citing works

Si-Miao-Yong-An (SMYA) Decoction May Protect the Renal Function Through Regulating the Autophagy-Mediated Degradation of Ubiquitinated Protein in an Atherosclerosis Model

Zhu, Z., Song, K., Huang, W., Li, H., Yang, H., Bai, Y.-Q., Guo, K., Yang, R., Lou, W., Xia, C., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00837 · Cited by 14 · see citing works

Exposure to ambient air pollution and metabolic kidney diseases: evidence from the Northeast China Biobank

Zhang, Y., Xia, Y., Chang, Q., Ji, C., Zhao, Y., & Zhang, H. (2023) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfad042 · Cited by 13 · see citing works

Biliverdin reductase-A protein levels are reduced in type 2 diabetes and are associated with poor glycometabolic control

Cimini, F. A., Barchetta, I., Zuliani, I., Pagnotta, S. E., Bertoccini, L., Dule, S., Zampieri, M., Reale, A., Baroni, M. G., Cavallo, M. G., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119913 · Cited by 13 · see citing works

Urobilin Derived from Bilirubin Bioconversion Binds Albumin and May Interfere with Bilirubin Interacting with Albumin: Implications for Disease Pathology

Williams, K. I., Suryadevara, P., Zhan, C., Hinds, T. D., & Kipp, Z. A. (2025) · Biomedicines · doi:10.3390/biomedicines13020302 · Cited by 9 · see citing works

Evaluation of buffalo, cow, goat and camel milk consumption on multiple health outcomes in male and female Sprague Dawley rats

Amr, M., EL-DINN, M. M., & Farid, A. (2023) · International Dairy Journal · doi:10.1016/j.idairyj.2023.105760 · Cited by 9 · see citing works

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Ye, M., Yang, M., Dai, W., Li, H., Zhou, X. C., Chen, Y., & He, L. (2023) · Pharmaceuticals · doi:10.3390/ph16091256 · Cited by 9 · see citing works

Role of dysfunctional peri-organ adipose tissue in metabolic disease

Zhang, K., Zhang, J., Kan, C., Tian, H., Ma, Y., Huang, N., Han, F., Hou, N., & Sun, X. (2023) · Biochimie · doi:10.1016/j.biochi.2023.03.015 · Cited by 9 · see citing works

Perirenal Adipose Tissue: Clinical Implication and Therapeutic Interventions

Fazeli, S. A., Nourollahi, S., Alirezaei, A., Mirhashemi, S. H., Davarian, A., & Hosseini, I. (2024) · Indian Journal of Nephrology · doi:10.25259/ijn_532_23 · Cited by 7 · see citing works

Association between cumulative average triglyceride glucose-body mass index and the risk of CKD onset

Wang, Y., Chen, B., Zang, C., & Hou, J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1525078 · Cited by 6 · see citing works

Assessing Association Between Circulating Bilirubin Levels and the Risk of Frailty: An Observational and Mendelian Randomization Study

Wu, J., Xu, J., Zou, H., Ouyang, Y., Li, S., Wu, L., Zhang, J., Yin, M., Ye, D., & Ni, J. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13642 · Cited by 5 · see citing works

Species-specific histological characterizations of renal tubules and collecting ducts in the kidneys of cats and dogs

Kira, S., Namba, T., Hiraishi, M., Nakamura, T., Otani, Y., Kon, Y., & Ichii, O. (2024) · PLoS ONE · doi:10.1371/journal.pone.0306479 · Cited by 4 · see citing works

Molecular Insight into Obesity-Associated Nephropathy: Clinical Implications and Possible Strategies for its Management

Gupta, H., & Bhandari, U. (2024) · Current Drug Targets · doi:10.2174/0113894501314788241008115712 · Cited by 4 · see citing works

Ectopic lipid deposition in kidney diseases: mechanisms in specific cell types and therapeutic strategies

Zhong, Q., Zhang, Y., Sun, D., Peng, J., Zhang, P., Wang, R., Cao, L., Chen, H., Wu, C., & He, Z. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1788998 · Cited by 3 · see citing works

Matricaria pubescens (desf.) Sch. Bip. Supplementation prevent high-fat diet-induced kidney damage in obese rats

Chenna, H., Khelef, Y., Zengin, G., Yılmaz, M. A., Çakır, O., Halimi, I., Djouder, C., Tarhan, A., Boumendjel, M., Boumendjel, A., et al. (2025) · Comparative Clinical Pathology · doi:10.1007/s00580-025-03654-1 · Cited by 3 · see citing works

A Wide-Proteome Analysis to Identify Molecular Pathways Involved in Kidney Response to High-Fat Diet in Mice

Dozio, E., Maffioli, E., Vianello, E., Nonnis, S., Scalvini, F. G., Spatola, L., Roccabianca, P., Tedeschi, G., & Romanelli, M. M. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073809 · Cited by 3 · see citing works

Metabolic Dysfunction-Associated Steatotic Liver Disease and Chronic Kidney Disease: Unraveling Connections and Advancing Therapies

Lian, K., Fan, Q., Sheng, S., Zhang, K., Sun, X., Kan, C., Pan, R., & Guo, Z. (2025) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/s44411-025-00189-3 · Cited by 2 · see citing works

Dapagliflozin regulates autophagy in nephropathy associated with non-diabetic obesity via elevated plasma β-hydroxybutyrate levels

Kong, Y., Peng, X., Fan, W., Zhang, L., Wu, Y., Zheng, M., & Shan, C. (2026) · Biochemical Journal · doi:10.1042/bcj20240504 · Cited by 2 · see citing works

Perinephric fat volume and its negative correlation with the eGFR according to a population health screening: a cross-sectional study

Zhang, X., Zhou, Y., Bo, D., Liu, J., Cui, X., & Zhang, Z. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2516208 · Cited by 1 · see citing works

Relationship between nontraditional lipid parameters and the risk of type 2 diabetes in individuals recovered from dyslipidemia: a cohort study

Wang, Y., Chen, Z., He, Z., Qin, H., Wu, K., Zheng, H., Fu, P., Cai, Z., Wu, W., Lan, Y., et al. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1610091 · Cited by 1 · see citing works

Isolated dyslipidemia triggers early kidney injury through fibrotic remodeling, subcellular lipid accumulation, and AMPK overexpression

Ousmaal, M. E. F., Gaceb, A., Benali, A., & Giaimis, J. (2025) · Ultrastructural Pathology · doi:10.1080/01913123.2025.2575988 · Cited by 1 · see citing works

The Inflammation Effect in the Association Between Bilirubin and Chronic Kidney Disease in Patients with Type 2 Diabetes: A Retrospective Cohort Study

Chen, Y., Wang, S., Chen, X., Sun, B., Cheng, Y., Li, X., & Chen, L. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s578233 · Cited by 1 · see citing works

Lipids, atherosclerosis, and microvascular disease: Translating basic science into pharmacotherapeutics

Bashir, B., Iqbal, Z., Schofield, J. D., & Soran, H. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99991-5.00012-7 · Cited by 1 · see citing works

Metabolisches Syndrom und Nierenkrankheiten

Ganz, M. J., Bender, S. T., Gross, C., Bose, K., Mertens, P. R., & Scurt, F. G. (2022) · Die Nephrologie · doi:10.1007/s11560-022-00595-6 · Cited by 1 · see citing works

Deletion of Nudt19 Increases Albuminuria in Mice Fed a High Fat DietPreprint

Saporito, D. C., King, R. D., Vickers, S. D., Wyda, E. A., Balaji, S., KING, J. A. C., & Leonardi, R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.22.644727 · Cited by 1 · see citing works

Loss of the CoA-degrading enzyme NUDT19 exacerbates albuminuria and disrupts renal lipid homeostasis in high fat diet-fed mice

Saporito, D. C., King, R. D., Vickers, S. D., Wyda, E. A., Balaji, S., Kolandaivelu, S., Billington, N., King, J. A., & Leonardi, R. (2026) · Scientific Reports · doi:10.1038/s41598-026-36136-7

Citrate‐Dependent Activation of Acetyl CoA Carboxylase Promotes Renal Lipid Accumulation in a Rat Model of Chronic Kidney Disease

Sanz‐Gómez, M., Linillos-Pradillo, B., de la Rosa, R. F., Aránguez, I., Kreutz, R. H., Garcı́a, A., Barbas, C., Plaza, A., & Fernández‐Alfonso, M. S. (2026) · Acta Physiologica · doi:10.1111/apha.70219

Loss of biliverdin reductase‐A (BVRA) promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells

Adeosun, S. O., Gordon, D. M., Weeks, M. F., Moore, K. H., Hall, J. E., Hinds, T. D., & Stec, D. E. (2018) · The FASEB Journal · doi:10.1096/fasebj.2018.32.1_supplement.849.1

Obesity-related proximal tubulopathy: an emerging threat to kidney health

Yamamoto, T., Nakamura, J., Takabatake, Y., & Isaka, Y. (2023) · Autophagy Reports · doi:10.1080/27694127.2023.2200341 · Cited by 3 · see citing works

Targeting RNF145 in Renal Proximal Tubular Cells Protects against Lipotoxicity in Diabetes

Simons, M., Hipp, L., & Loza‐Valdes, A. (2024) · Journal of the American Society of Nephrology · doi:10.1681/asn.2024kgb0kmbc

Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD

Udi, S., Hinden, L., Earley, B. J., Drori, A., Reuveni, N., Hadar, R., Çınar, R., Nemirovski, A., & Tam, J. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016101085 · Cited by 99 · see citing works

Lipolysis-Stimulated Lipoprotein Receptor in Proximal Tubule, BMP-SMAD Signaling, and Kidney Disease

Jiang, M., Wang, X., Chen, Z., Wang, X., An, Y., Ding, L., Xu, M., Fan, B., Jiao, P., Wang, C., et al. (2024) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000000000382 · Cited by 3 · see citing works