The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Nephron adaptation to renal injury or ablation
Abstract
In early stages of permanent renal injury or extensive ablation, structural and functional adaptations associated with hypertrophy partially compensate for nephron losses. Glomerulotubular balance is maintained in these conditioned nephrons by intrinsic tubule and peritubular capillary adaptations that parallel single nephron glomerular filtration rate (SNGFR). Studies of Na+-H+ exchange in renal cortical brush border membrane vesicles indicate that tubule functional adaptation is not tied to loss of renal mass per se but rather to factors such as dietary protein content that set the level of SNGFR. Likewise, the structural heterogeneity that follows chronic renal injury or extreme ablation of renal mass is less a consequence of nephron injury than of adaptation linked to dietary protein intake. Indeed, since dietary protein restriction blunts the need for compensatory glomerular hyperfiltration, there is neither a stimulus for nephron hypertrophy nor for enhanced tubule ion and fluid transport. In rats with remnant kidneys, experimentally induced diabetes mellitus, or severe hypertension, increases in glomerular pressures and flows precede proteinuria, glomerular sclerosis, and azotemia. Protein restriction prevents these hemodynamic adaptations as well as the late complications. Similar conclusions appear to be applicable to a wide spectrum of clinical circumstances characterized by reduced nephron number.
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Cites
Epstein, F. H., Brenner, B. M., Meyer, T. W., & Hostetter, T. H. (1982) · New England Journal of Medicine · doi:10.1056/nejm198209093071104 · Cited by 2,075
Self-citationHyperfiltration in remnant nephrons: a potentially adverse response to renal ablation
Hostetter, T. H., Olson, J. L., Rennke, H. G., Venkatachalam, M. A., & Brenner, B. M. (1981) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1981.241.1.f85 · Cited by 1,680
Self-citationThe Effect of Age on Creatinine Clearance in Men: A Cross-sectional and Longitudinal Study
Rowe, J. W., Andres, R., Tobin, J. D., Norris, A. H., & Shock, N. W. (1976) · Journal of Gerontology · doi:10.1093/geronj/31.2.155 · Cited by 1,104
Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass.
Anderson, S., Meyer, T. W., Rennke, H. G., & Brenner, B. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112013 · Cited by 932
Self-citationGlomerular hemodynamics in experimental diabetes mellitus
Hostetter, T. H., Troy, J. L., & Brenner, B. M. (1981) · Kidney International · doi:10.1038/ki.1981.33 · Cited by 790
Self-citationYu, B. P., Masoro, E. J., Murata, I., Bertrand, H. A., & Lynd, F. T. (1982) · Journal of Gerontology · doi:10.1093/geronj/37.2.130 · Cited by 580
Cutmarks made by stone tools on bones from Olduvai Gorge, Tanzania
Potts, R., & Shipman, P. (1981) · Nature · doi:10.1038/291577a0 · Cited by 575
Zatz, R., Meyer, T. W., Rennke, H. G., & Brenner, B. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.17.5963 · Cited by 526
Self-citationRenal functional reserve in humans
Bosch, J. P., Saccaggi, A., Lauer, A., Ronco, C., Belledonne, M., & Glabman, S. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)90873-2 · Cited by 513
A progressive glomerulosclerosis occurring in partial five-sixths nephrectomized rats.
Shimamura, T., & Morrison, A. B. (1975) · PubMed · Cited by 450
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Glomerular hyperfiltration: definitions, mechanisms and clinical implications
Helal, I., Fick-Brosnahan, G. M., Reed-Gitomer, B., & Schrier, R. W. (2012) · Nature Reviews Nephrology · doi:10.1038/nrneph.2012.19 · Cited by 673
Renal Autoregulation in Health and Disease
Carlström, M., Wilcox, C. S., & Arendshorst, W. J. (2015) · Physiological Reviews · doi:10.1152/physrev.00042.2012 · Cited by 485
Mechanisms involved in the developmental programming of adulthood disease
Warner, M. J., & Ozanne, S. E. (2010) · Biochemical Journal · doi:10.1042/bj20091861 · Cited by 316
Durvasula, R. V., Petermann, A. T., Hiromura, K., Blonski, M., Pippin, J., Mundel, P., Pichler, R., Griffin, S., Couser, W. G., & Shankland, S. J. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00362.x · Cited by 313
Vasopressin: a novel target for the prevention and retardation of kidney disease?
Bankir, L., Bouby, N., & Ritz, E. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.22 · Cited by 214
Metadata
- Authors
- Brenner, B. M.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 1985-09-01
- Volume
- 249
- Issue
- 3
- Pages
- F324-F337
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2231812784
- Cited by
- 641
- References
- 45
- FWCI
- 15.89
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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